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Article Open Access

Correlation between PTEN gene polymorphism and oral squamous cell carcinoma

  • Authors:
    • Min Liu
    • Hongning Song
    • Zaichen Xing
    • Guo Lu
    • Junfu Li
    • Daiyun Chen
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Affiliated Hospital of Taishan Medical University, Taian, Shandong 271000, P.R. China, First People's Hospital in Ningyang County, Taian, Shandong 271400, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1755-1760
    |
    Published online on: June 24, 2019
       https://doi.org/10.3892/ol.2019.10526
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Abstract

Correlation between phosphatase and tensin homolog deleted on chromosome ten (PTEN) gene polymorphism and oral squamous cell carcinoma (OSCC) was investigated. A total of 33 OSCC patients were studied and 33 healthy individuals were included as the control group. Correlation between PTEN gene and OSCC was explored via quantitative polymerase chain reaction (qPCR), immuno­histochemistry and western blot analysis. The PTEN gene polymorphism was detected via PCR‑restriction fragment length polymorphism (PCR‑RFLP), and its correlation with OSCC was explored. The immunohistochemical assay showed that the PTEN protein expression level significantly declined in OSCC patients (2.37±1.01 µg/l) compared with that in healthy subjects (3.09±0.95 µg/l). There was no significant difference in the rs2943773 genotype between control and experimental group (χ2=0.863, P=0.712), but there was a significant difference in the rs9651495 genotype between the two groups (P<0.05). The C/C genotype frequency of rs9651495 in OSCC patients (50.15%) was significantly higher than that in healthy subjects (23.71%) (P<0.05). The C/T genotype frequency of rs9651495 had no significant difference between the two groups (18.52 vs. 19.01%) (P>0.05). The T/T genotype frequency of rs9651495 in OSCC patients (31.33%) was obviously lower than that in healthy subjects (57.19%) (P<0.05). According to statistics, the PTEN protein expression level in patients with C/C genotype was remarkably lower than that in patients with other genotypes. There is a correlation between PTEN gene polymorphism and OSCC. Thereby, the higher C/C genotype frequency corresponds to the lower PTEN protein expression level, thus inducing OSCC.
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1 

Siegel R, Ward E, Brawley O and Jemal A: Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 61:212–236. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Tsai LL, Yu CC, Chang YC, Yu CH and Chou MY: Markedly increased Oct4 and Nanog expression correlates with cisplatin resistance in oral squamous cell carcinoma. J Oral Pathol Med. 40:621–628. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Bhaijee F, Pepper DJ, Pitman KT and Bell D: Cancer stem cells in head and neck squamous cell carcinoma: A review of current knowledge and future applications. Head Neck. 34:894–899. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Sayed SI, Dwivedi RC, Katna R, Garg A, Pathak KA, Nutting CM, Rhys-Evans P, Harrington KJ and Kazi R: Implications of understanding cancer stem cell (CSC) biology in head and neck squamous cell cancer. Oral Oncol. 47:237–243. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Wu SJ, Huang SY, Lin CT, Lin YJ, Chang CJ and Tien HF: The incidence of chronic lymphocytic leukemia in Taiwan, 1986–2005: A distinct increasing trend with birth-cohort effect. Blood. 116:4430–4435. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Sun C and Li J: Expression of MiRNA-137 in oral squamous cell carcinoma and its clinical significance. J BUON. 23:167–172. 2018.PubMed/NCBI

7 

Wiestner A: Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia. Blood. 120:4684–4691. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Albers AE, Chen C, Köberle B, Qian X, Klussmann JP, Wollenberg B and Kaufmann AM: Stem cells in squamous head and neck cancer. Crit Rev Oncol Hematol. 81:224–240. 2012. View Article : Google Scholar : PubMed/NCBI

9 

White AC, Tran K, Khuu J, Dang C, Cui Y, Binder SW and Lowry WE: Defining the origins of Ras/p53-mediated squamous cell carcinoma. Proc Natl Acad Sci USA. 108:7425–7430. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Lapouge G, Youssef KK, Vokaer B, Achouri Y, Michaux C, Sotiropoulou PA and Blanpain C: Identifying the cellular origin of squamous skin tumors. Proc Natl Acad Sci USA. 108:7431–7436. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Livak KJ and Scmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Van Keymeulen A and Blanpain C: Tracing epithelial stem cells during development, homeostasis, and repair. J Cell Biol. 197:575–584. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Zou ZJ, Zhang R, Fan L, Wang L, Fang C, Zhang LN, Yang S, Li YY, Li JY and Xu W: Low expression level of phosphatase and tensin homolog deleted on chromosome ten predicts poor prognosis in chronic lymphocytic leukemia. Leuk Lymphoma. 54:1159–1164. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Zhu DX, Zhu W, Fang C, Fan L, Zou ZJ, Wang YH, Liu P, Hong M, Miao KR, Liu P, et al: miR-181a/b significantly enhances drug sensitivity in chronic lymphocytic leukemia cells via targeting multiple anti-apoptosis genes. Carcinogenesis. 33:1294–1301. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Doupé DP, Klein AM, Simons BD and Jones PH: The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate. Dev Cell. 18:317–323. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Hoellenriegel J, Meadows SA, Sivina M, Wierda WG, Kantarjian H, Keating MJ, Giese N, O'Brien S, Yu A, Miller LL, et al: The phosphoinositide 3′-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood. 118:3603–3612. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Fabbri M, Bottoni A, Shimizu M, Spizzo R, Nicoloso MS, Rossi S, Barbarotto E, Cimmino A, Adair B, Wojcik SE, et al: Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. JAMA. 305:59–67. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Jotta PY, Ganazza MA, Silva A, Viana MB, da Silva MJ, Zambaldi LJ, Barata JT, Brandalise SR and Yunes JA: Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemia. Leukemia. 24:239–242. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Jjingo D, Conley AB, Yi SV, Lunyak VV and Jordan IK: On the presence and role of human gene-body DNA methylation. Oncotarget. 3:462–474. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Khan H, Vale C, Bhagat T and Verma A: Role of DNA methylation in the pathogenesis and treatment of myelodysplastic syndromes. Semin Hematol. 50:16–37. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu M, Song H, Xing Z, Lu G, Li J and Chen D: Correlation between PTEN gene polymorphism and oral squamous cell carcinoma. Oncol Lett 18: 1755-1760, 2019.
APA
Liu, M., Song, H., Xing, Z., Lu, G., Li, J., & Chen, D. (2019). Correlation between PTEN gene polymorphism and oral squamous cell carcinoma. Oncology Letters, 18, 1755-1760. https://doi.org/10.3892/ol.2019.10526
MLA
Liu, M., Song, H., Xing, Z., Lu, G., Li, J., Chen, D."Correlation between PTEN gene polymorphism and oral squamous cell carcinoma". Oncology Letters 18.2 (2019): 1755-1760.
Chicago
Liu, M., Song, H., Xing, Z., Lu, G., Li, J., Chen, D."Correlation between PTEN gene polymorphism and oral squamous cell carcinoma". Oncology Letters 18, no. 2 (2019): 1755-1760. https://doi.org/10.3892/ol.2019.10526
Copy and paste a formatted citation
x
Spandidos Publications style
Liu M, Song H, Xing Z, Lu G, Li J and Chen D: Correlation between PTEN gene polymorphism and oral squamous cell carcinoma. Oncol Lett 18: 1755-1760, 2019.
APA
Liu, M., Song, H., Xing, Z., Lu, G., Li, J., & Chen, D. (2019). Correlation between PTEN gene polymorphism and oral squamous cell carcinoma. Oncology Letters, 18, 1755-1760. https://doi.org/10.3892/ol.2019.10526
MLA
Liu, M., Song, H., Xing, Z., Lu, G., Li, J., Chen, D."Correlation between PTEN gene polymorphism and oral squamous cell carcinoma". Oncology Letters 18.2 (2019): 1755-1760.
Chicago
Liu, M., Song, H., Xing, Z., Lu, G., Li, J., Chen, D."Correlation between PTEN gene polymorphism and oral squamous cell carcinoma". Oncology Letters 18, no. 2 (2019): 1755-1760. https://doi.org/10.3892/ol.2019.10526
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