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Article

Upregulation of lncRNA GATA6‑AS suppresses the migration and invasion of cervical squamous cell carcinoma by downregulating MTK‑1

  • Authors:
    • Lan Chen
    • Xuming Wang
    • Limian Song
    • Dujuan Yao
    • Qianqian Tang
    • Jun Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China
  • Pages: 2605-2611
    |
    Published online on: July 4, 2019
       https://doi.org/10.3892/ol.2019.10554
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Abstract

The diagnosis and treatment of cervical squamous cell carcinoma is challenged by difficulties in the determination of tumor invasion. GATA binding protein 6 antisense (GATA6‑AS) is a recently identified long non‑coding RNA that exhibits critical functions in the growth of endothelial cells; however, to the best of our knowledge, its involvement in other physiological and pathological processes is unknown. By reverse transcription‑quantitative polymerase chain reaction, the present study examined the expression of GATA6‑AS in tumor tissues and adjacent healthy tissues, and the serum from patients with cervical squamous cell carcinoma and healthy controls. The diagnostic and prognostic potentials of GATA6‑AS for cervical squamous cell carcinoma were analyzed by receiver operating characteristic curve analysis and survival curve analysis, respectively. Associations between the serum levels of GATA6‑AS and clinical characteristics of patients with cervical squamous cell carcinoma were analyzed by a χ2 test. A GATA6‑AS overexpression vector was transfected into cervical squamous cell carcinoma cells, and the effects on cell migration and invasion were investigated by Transwell migration and invasion assays, respectively. The expression of mitogen‑activated protein kinase kinase 4 (MTK‑1) following transfection with the GATA6‑AS overexpression vector was detected by western blot analysis. It was identified that the expression levels of GATA6‑AS were lower in tumor tissues compared with healthy tissues. In addition, serum levels of GATA6‑AS were higher in patients compared with healthy controls. The serum levels of GATA6‑AS were associated with tumor metastasis, and may serve as a potential diagnostic and prognostic marker for cervical squamous cell carcinoma. Furthermore, GATA6‑AS overexpression inhibited cancer cell migration and invasion. The expression levels of MTK‑1 were also reduced following GATA6‑AS overexpression. Therefore, the present study proposed that downregulated GATA6‑AS expression was associated with tumor metastasis in cervical squamous cell carcinoma, and that GATA6‑AS expression may inhibit cancer cell migration and invasion by downregulating MTK‑1.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Yang PM, Chou CJ, Tseng SH and Hung CF: Bioinformatics and in vitro experimental analyses identify the selective therapeutic potential of interferon gamma and apigenin against cervical squamous cell carcinoma and adenocarcinoma. Oncotarget. 8:46145–46162. 2017.PubMed/NCBI

3 

Crosbie EJ, Einstein MH, Franceschi S and Kitchener HC: Human papillomavirus and cervical cancer. Lancet. 382:889–899. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Burd EM: Human papillomavirus and cervical cancer. Clin Microbiol Rev. 16:1–17. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Hildesheim A, Gonzalez P, Kreimer AR, Wacholder S, Schussler J, Rodriguez AC, Porras C, Schiffman M, Sidawy M, Schiller JT, et al: Impact of human papillomavirus (HPV) 16 and 18 vaccination on prevalent infections and rates of cervical lesions after excisional treatment. Am J Obstet Gynecol. 215:212.e1–212.e15. 2016. View Article : Google Scholar

6 

Rodríguez-Carunchio L, Soveral I, Steenbergen RD, Torné A, Martinez S, Fusté P, Pahisa J, Marimon L, Ordi J and del Pino M: HPV-negative carcinoma of the uterine cervix: A distinct type of cervical cancer with poor prognosis. BJOG. 122:119–127. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Yang M and Huang CZ: Mitogen-activated protein kinase signaling pathway and invasion and metastasis of gastric cancer. World J Gastroenterol. 21:11673–11679. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Peng S, Geng J, Sun R, Tian Z and Wei H: Polyinosinic-polycytidylic acid liposome induces human hepatoma cells apoptosis which correlates to the up-regulation of RIG-I like receptors. Cancer Sci. 100:529–536. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Fredholm S, Litvinov IV, Mongan NP, Schiele S, Willerslev-Olsen A, Petersen DL, Krejsgaard T, Sibbesen N, Nastasi C, Bonefeld CM, et al: The expression of IL-21 is promoted by MEKK4 in malignant t cells and associated with increased progression risk in cutaneous T-cell lymphoma. J Invest Dermatol. 136:866–869. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Tasharrofi B and Ghafouri-Fard S: Long non-coding RNAs as regulators of the mitogen-activated protein kinase (MAPK) pathway in cancer. Klin Onkol. 31:95–102. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Neumann P, Jaé N, Knau A, Glaser SF, Fouani Y, Rossbach O, Krüger M, John D, Bindereif A, Grote P, et al: The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2. Nat Commun. 9:2372018. View Article : Google Scholar : PubMed/NCBI

12 

Sollome JJ, Thavathiru E, Camenisch TD and Vaillancourt RR: HER2/HER3 regulates extracellular acidification and cell migration through MTK1 (MEKK4). Cell Signal. 26:70–82. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Allison P, Espiritu D and Camenisch TD: BMP2 rescues deficient cell migration in Tgfbr3(−/-) epicardial cells and requires Src kinase. Cell Adh Migr. 10:259–268. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Du J, Zhou S, Wang L, Yu M and Mei L: Downregulation of ERBB3 decreases the proliferation, migration and invasion of cervical cancer cells though the interaction with MTK-1. Oncol Lett. 16:3453–3458. 2018.PubMed/NCBI

15 

Fatica A and Bozzoni I: Long non-coding RNAs: New players in cell differentiation and development. Nat Rev Genet. 15:7–21. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Sharma S and Munger K: Expression of the cervical carcinoma expressed PCNA regulatory (CCEPR) long noncoding RNA is driven by the human papillomavirus E6 protein and modulates cell proliferation independent of PCNA. Virology. 518:8–13. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Chen X, Liu L and Zhu W: Up-regulation of long non-coding RNA CCAT2 correlates with tumor metastasis and poor prognosis in cervical squamous cell cancer patients. Int J Clin Exp Pathol. 8:13261–13266. 2015.PubMed/NCBI

18 

Zhang J, Yao T, Wang Y, Yu J, Liu Y and Lin Z: Long noncoding RNA MEG3 is downregulated in cervical cancer and affects cell proliferation and apoptosis by regulating miR-21. Cancer Biol Ther. 17:104–113. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Nohata N, Abba MC and Gutkind JS: Unraveling the oral cancer lncRNAome: Identification of novel lncRNAs associated with malignant progression and HPV infection. Oral Oncol. 59:58–66. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Lutz AM, Willmann JK, Cochran FV, Ray P and Gambhir SS: Cancer screening: A mathematical model relating secreted blood biomarker levels to tumor sizes. PLoS Med. 5:e1702008. View Article : Google Scholar : PubMed/NCBI

21 

Grammatikakis I, Panda AC, Abdelmohsen K and Gorospe M: Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging. Aging (Albany NY). 6:992–1009. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Mayfield RD: Emerging roles for ncRNAs in alcohol use disorders. Alcohol. 60:31–39. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Wang J, Qiu M, Xu Y, Li M, Dong G, Mao Q, Yin R and Xu L: Long noncoding RNA CCAT2 correlates with smoking in esophageal squamous cell carcinoma. Tumour Biol. 36:5523–5528. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen L, Wang X, Song L, Yao D, Tang Q and Zhou J: Upregulation of lncRNA GATA6‑AS suppresses the migration and invasion of cervical squamous cell carcinoma by downregulating MTK‑1. Oncol Lett 18: 2605-2611, 2019.
APA
Chen, L., Wang, X., Song, L., Yao, D., Tang, Q., & Zhou, J. (2019). Upregulation of lncRNA GATA6‑AS suppresses the migration and invasion of cervical squamous cell carcinoma by downregulating MTK‑1. Oncology Letters, 18, 2605-2611. https://doi.org/10.3892/ol.2019.10554
MLA
Chen, L., Wang, X., Song, L., Yao, D., Tang, Q., Zhou, J."Upregulation of lncRNA GATA6‑AS suppresses the migration and invasion of cervical squamous cell carcinoma by downregulating MTK‑1". Oncology Letters 18.3 (2019): 2605-2611.
Chicago
Chen, L., Wang, X., Song, L., Yao, D., Tang, Q., Zhou, J."Upregulation of lncRNA GATA6‑AS suppresses the migration and invasion of cervical squamous cell carcinoma by downregulating MTK‑1". Oncology Letters 18, no. 3 (2019): 2605-2611. https://doi.org/10.3892/ol.2019.10554
Copy and paste a formatted citation
x
Spandidos Publications style
Chen L, Wang X, Song L, Yao D, Tang Q and Zhou J: Upregulation of lncRNA GATA6‑AS suppresses the migration and invasion of cervical squamous cell carcinoma by downregulating MTK‑1. Oncol Lett 18: 2605-2611, 2019.
APA
Chen, L., Wang, X., Song, L., Yao, D., Tang, Q., & Zhou, J. (2019). Upregulation of lncRNA GATA6‑AS suppresses the migration and invasion of cervical squamous cell carcinoma by downregulating MTK‑1. Oncology Letters, 18, 2605-2611. https://doi.org/10.3892/ol.2019.10554
MLA
Chen, L., Wang, X., Song, L., Yao, D., Tang, Q., Zhou, J."Upregulation of lncRNA GATA6‑AS suppresses the migration and invasion of cervical squamous cell carcinoma by downregulating MTK‑1". Oncology Letters 18.3 (2019): 2605-2611.
Chicago
Chen, L., Wang, X., Song, L., Yao, D., Tang, Q., Zhou, J."Upregulation of lncRNA GATA6‑AS suppresses the migration and invasion of cervical squamous cell carcinoma by downregulating MTK‑1". Oncology Letters 18, no. 3 (2019): 2605-2611. https://doi.org/10.3892/ol.2019.10554
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