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Article

Overexpression levels of cripto‑1 predict poor prognosis in patients with prostate cancer following radical prostatectomy

  • Authors:
    • Yan Liu
    • Jianan Wang
    • Tong Yang
    • Ranlu Liu
    • Yong Xu
  • View Affiliations / Copyright

    Affiliations: Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China
  • Pages: 2584-2591
    |
    Published online on: July 4, 2019
       https://doi.org/10.3892/ol.2019.10555
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Abstract

Overexpression of cripto‑1 (CR‑1), an epidermal growth factor‑cripto‑1/FRL‑1/Cryptic family protein, has been reported in multiple types of malignancy. However, the clinical functions of CR‑1 in prostate cancer (PCa) remain largely unclear. The objective of the present study was to investigate the association between CR‑1 expression and the clinicopathological features and prognosis of PCa. CR‑1 expression was evaluated in 138 PCa tissues and 67 benign prostate hyperplasia (BPH) tissues using immunohistochemistry. The association between the clinicopathological features of patients with PCa and CR‑1 expression was analyzed using a χ2 test. Receiver operating characteristic (ROC) curve and Cox regression model were used to analyze the association between CR‑1 expression and biochemical recurrence (BCR)‑free survival. It was revealed that the protein expression of CR‑1 was markedly higher in PCa tissues than in BPH tissues. The mRNA expression of CR‑1 in PCa tissue and cells was also significantly higher than in BPH tissue and the normal RWPE‑1 prostate cell line (P<0.05). In addition, high CR‑1 expression was significantly associated with prostate‑specific antigen level (P=0.008), Gleason score (P=0.011) and lymph node metastasis (P=0.025) in patients with PCa. ROC curve indicated that patients with elevated expression of CR‑1 exhibited shorter BCR‑free survival (P<0.001). Furthermore, multivariate statistical analysis demonstrated that overexpression of CR‑1 may be a novel predictor for prognosis of patients with PCa. Accordingly, the present study considered CR‑1 to be a valuable predictor of poor prognosis and progression in PCa, and a potential therapeutic target for patients with PCa.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Wang J, Yang T, Liu R and Xu Y: Overexpression levels of cripto‑1 predict poor prognosis in patients with prostate cancer following radical prostatectomy. Oncol Lett 18: 2584-2591, 2019.
APA
Liu, Y., Wang, J., Yang, T., Liu, R., & Xu, Y. (2019). Overexpression levels of cripto‑1 predict poor prognosis in patients with prostate cancer following radical prostatectomy. Oncology Letters, 18, 2584-2591. https://doi.org/10.3892/ol.2019.10555
MLA
Liu, Y., Wang, J., Yang, T., Liu, R., Xu, Y."Overexpression levels of cripto‑1 predict poor prognosis in patients with prostate cancer following radical prostatectomy". Oncology Letters 18.3 (2019): 2584-2591.
Chicago
Liu, Y., Wang, J., Yang, T., Liu, R., Xu, Y."Overexpression levels of cripto‑1 predict poor prognosis in patients with prostate cancer following radical prostatectomy". Oncology Letters 18, no. 3 (2019): 2584-2591. https://doi.org/10.3892/ol.2019.10555
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Wang J, Yang T, Liu R and Xu Y: Overexpression levels of cripto‑1 predict poor prognosis in patients with prostate cancer following radical prostatectomy. Oncol Lett 18: 2584-2591, 2019.
APA
Liu, Y., Wang, J., Yang, T., Liu, R., & Xu, Y. (2019). Overexpression levels of cripto‑1 predict poor prognosis in patients with prostate cancer following radical prostatectomy. Oncology Letters, 18, 2584-2591. https://doi.org/10.3892/ol.2019.10555
MLA
Liu, Y., Wang, J., Yang, T., Liu, R., Xu, Y."Overexpression levels of cripto‑1 predict poor prognosis in patients with prostate cancer following radical prostatectomy". Oncology Letters 18.3 (2019): 2584-2591.
Chicago
Liu, Y., Wang, J., Yang, T., Liu, R., Xu, Y."Overexpression levels of cripto‑1 predict poor prognosis in patients with prostate cancer following radical prostatectomy". Oncology Letters 18, no. 3 (2019): 2584-2591. https://doi.org/10.3892/ol.2019.10555
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