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Review Open Access

Soft tissue sarcomas of the upper extremities: Maximizing treatment opportunities and outcomes (Review)

  • Authors:
    • Jose Duran‑Moreno
    • Vasileios Kontogeorgakos
    • Anna Koumarianou
  • View Affiliations / Copyright

    Affiliations: Hematology Oncology Unit, Fourth Department of Internal Medicine, National and Kapodistrian University of Athens, School of Medicine, ‘Attikon’ University General Hospital, Athens 12462, Greece, Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, ‘Attikon’ University General Hospital, Athens 12462, Greece
    Copyright: © Duran‑Moreno et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2179-2191
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    Published online on: July 5, 2019
       https://doi.org/10.3892/ol.2019.10575
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Abstract

Soft tissue sarcomas (STS) are rare tumors; they do not even equate to 1% of all malignant tumor cases. One‑fifth of all STS occur in the upper extremities, where epithelioid sarcoma, synovial sarcoma, clear cell sarcoma and malignant fibrohistiocytoma are the most frequent subtypes. Surgical resection is the cornerstone of treatment. However, accomplishment of optimal oncological and functional results of STS of the upper extremities may represent a challenge for hand surgeons, due to the complex anatomy. In several cases, preoperative therapies are needed to facilitate tumor resection and improve the oncological outcome. Oligometastatic disease may also be a challenging scenario as curative strategies can be applied. Radiotherapy and chemotherapy are commonly used for this purpose albeit with conflicting evidence. Novel drug combinations have also been approved in the metastatic setting, further improving the quality of life and survival of eligible patients. Thus, prior to any approach, every case should be individually discussed in sarcoma centers with specialized multidisciplinary tumor boards. The aim of the present review was to gather the multidisciplinary experiences of the available therapeutic strategies for STS of the upper extremities.
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Copy and paste a formatted citation
Spandidos Publications style
Duran‑Moreno J, Kontogeorgakos V and Koumarianou A: Soft tissue sarcomas of the upper extremities: Maximizing treatment opportunities and outcomes (Review). Oncol Lett 18: 2179-2191, 2019.
APA
Duran‑Moreno, J., Kontogeorgakos, V., & Koumarianou, A. (2019). Soft tissue sarcomas of the upper extremities: Maximizing treatment opportunities and outcomes (Review). Oncology Letters, 18, 2179-2191. https://doi.org/10.3892/ol.2019.10575
MLA
Duran‑Moreno, J., Kontogeorgakos, V., Koumarianou, A."Soft tissue sarcomas of the upper extremities: Maximizing treatment opportunities and outcomes (Review)". Oncology Letters 18.3 (2019): 2179-2191.
Chicago
Duran‑Moreno, J., Kontogeorgakos, V., Koumarianou, A."Soft tissue sarcomas of the upper extremities: Maximizing treatment opportunities and outcomes (Review)". Oncology Letters 18, no. 3 (2019): 2179-2191. https://doi.org/10.3892/ol.2019.10575
Copy and paste a formatted citation
x
Spandidos Publications style
Duran‑Moreno J, Kontogeorgakos V and Koumarianou A: Soft tissue sarcomas of the upper extremities: Maximizing treatment opportunities and outcomes (Review). Oncol Lett 18: 2179-2191, 2019.
APA
Duran‑Moreno, J., Kontogeorgakos, V., & Koumarianou, A. (2019). Soft tissue sarcomas of the upper extremities: Maximizing treatment opportunities and outcomes (Review). Oncology Letters, 18, 2179-2191. https://doi.org/10.3892/ol.2019.10575
MLA
Duran‑Moreno, J., Kontogeorgakos, V., Koumarianou, A."Soft tissue sarcomas of the upper extremities: Maximizing treatment opportunities and outcomes (Review)". Oncology Letters 18.3 (2019): 2179-2191.
Chicago
Duran‑Moreno, J., Kontogeorgakos, V., Koumarianou, A."Soft tissue sarcomas of the upper extremities: Maximizing treatment opportunities and outcomes (Review)". Oncology Letters 18, no. 3 (2019): 2179-2191. https://doi.org/10.3892/ol.2019.10575
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