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Long non‑coding RNA XIST predicting advanced clinical parameters in cancer: A Meta‑Analysis and case series study in a single institution (Review)

  • Authors:
    • Changkai Deng
    • Xianliang Hu
    • Ke Wu
    • Juan Tan
    • Chao Yang
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    Affiliations: Department of Pediatric Surgery, Chengdu Women's and Children's Central Hospital of Chongqing Medical University, Chengdu, Sichuan 610069, P.R. China, Department of Pharmacology, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing 400014, P.R. China, Outpatient Department, The Children's Hospital of Chongqing Medical University, Chongqing 401122, P.R. China, Department of Pediatric Surgical Oncology, The Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China
    Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2192-2202
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    Published online on: July 9, 2019
       https://doi.org/10.3892/ol.2019.10592
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Abstract

Dysregulated expression of long non‑coding RNA X‑inactive specific transcript (lncRNA‑XIST) has been indicated in various cancer types. In the present study, a meta‑analysis was conducted to evaluate the potential role of lncRNA‑XIST in predicting the clinicopathological parameters of patients with cancer. Eligible studies were obtained through a systematic search of PubMed, Web of Science, Embase and the Cochrane Library, of articles published prior to January 2019. The combined odds ratio and 95% confidence interval were calculated to determine the association between lncRNA‑XIST expression and patient outcome. In addition, 45 pairs of osteosarcoma (OS) tissues and adjacent healthy tissues from a single institution were analyzed for the expression of lncRNA‑XIST, and its association with clinicopathological features; ultimately, a total of 1,869 cancer patients from 25 studies were assessed. The results demonstrated that high expression levels of lncRNA‑XIST were significantly associated with lymphatic metastasis, larger tumor size, advanced cancer stage and distant metastasis. However, sex was not associated with lncRNA‑XIST expression level. In the OS patient cohort, it was demonstrated that lncRNA‑XIST was highly expressed in OS tissues, which negatively correlated with patient prognosis. The present study indicated that lncRNA‑XIST may serve as a potential biomarker for advanced clinical parameters in human cancer.
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View References

1 

Torre LA, Siegel RL, Ward EM and Jemal A: Global cancer incidence and mortality rates and trends-an update. Cancer Epidemiol Biomarkers Prev. 25:16–27. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Cui Z, Chen Y, Xiao Z, Hu M, Lin Y, Chen Y and Zheng Y: Long noncoding RNAs as auxiliary biomarkers for gastric cancer screening: A pooled analysis of individual studies. Oncotarget. 7:25791–800. 2016.PubMed/NCBI

3 

ENCODE Project Consortium, Birney E, Stamatoyannopoulos JA, Dutta A, Guigó R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, et al: Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 447:799–816. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Kapranov P, Willingham AT and Gingeras TR: Genome-wide transcription and the implications for genomic organization. Nat Rev Genet. 8:413–423. 2007. View Article : Google Scholar : PubMed/NCBI

5 

ENCODE Project Consortium: An integrated encyclopedia of DNA elements in the human genome. Nature. 489:57–74. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Sana J, Faltejskova P, Svoboda M and Slaby O: Novel classes of non-coding RNAs and cancer. J Transl Med. 10:1032012. View Article : Google Scholar : PubMed/NCBI

7 

Tsai MC, Spitale RC and Chang HY: Long intergenic noncoding RNAs: New links in cancer progression. Cancer Res. 71:3–7. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Blythe AJ, Fox AH and Bond CS: The ins and outs of lncRNA structure: How, why and what comes next. Biochim Biophys Acta. 1859:46–58. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Tseng YY, Moriarity BS, Gong W, Akiyama R, Tiwari A, Kawakami H, Ronning P, Reuland B, Guenther K, Beadnell TC, et al: PVT1 dependence in cancer with MYC copy-number increase. Nature. 512:82–86. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Huang J, Zhou N, Watabe K, Lu Z, Wu F, Xu M and Mo YY: Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1). Cell Death Dis. 5:e10082014. View Article : Google Scholar : PubMed/NCBI

11 

Brown CJ, Ballabio A, Rupert JL, Lafreniere RG, Grompe M, Tonlorenzi R and Willard HF: A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome. Nature. 349:38–44. 1991. View Article : Google Scholar : PubMed/NCBI

12 

Song H, He P, Shao T, Li Y, Li J and Zhang Y: Long non-coding RNA XIST functions as an oncogene in human colorectal cancer by targeting miR-132-3p. J BUON. 22:696–703. 2017.PubMed/NCBI

13 

Hu Y, Deng C, Zhang H, Zhang J, Peng B and Hu C: Long non-coding RNA XIST promotes cell growth and metastasis through regulating miR-139-5p mediated Wnt/β-catenin signaling pathway in bladder cancer. Oncotarget. 8:94554–94568. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Ma L, Zhou Y, Luo X, Gao H, Deng X and Jiang Y: Long non-coding RNA XIST promotes cell growth and invasion through regulating miR-497/MACC1 axis in gastric cancer. Oncotarget. 8:4125–4135. 2017.PubMed/NCBI

15 

Song P, Ye LF, Zhang C, Peng T and Zhou XH: Long non-coding RNA XIST exerts oncogenic functions in human nasopharyngeal carcinoma by targeting miR-34a-5p. Gene. 592:8–14. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Yang C, Wu K, Wang S and Wei G: Long non-coding RNA XIST promotes osteosarcoma progression by targeting YAP via miR-195-5p. J Cell Biochem. 119:5646–5656. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Huang YS, Chang CC, Lee SS, Jou YS and Shih HM: Xist reduction in breast cancer upregulates AKT phosphorylation via HDAC3-mediated repression of PHLPP1 expression. Oncotarget. 7:43256–43266. 2016.PubMed/NCBI

18 

Du Y, Weng XD, Wang L, Liu XH, Zhu HC, Guo J, Ning JZ and Xiao CC: LncRNA XIST acts as a tumor suppressor in prostate cancer through sponging miR-23a to modulate RKIP expression. Oncotarget. 8:94358–94370. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Kobayashi R, Miyagawa R, Yamashita H, Morikawa T, Okuma K, Fukayama M, Ohtomo K and Nakagawa K: Increased expression of long non-coding RNA XIST predicts favorable prognosis of cervical squamous cell carcinoma subsequent to definitive chemoradiation therapy. Oncol Lett. 12:3066–3074. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Hu S, Chang J, Li Y, Wang W, Guo M, Zou EC, Wang Y and Yang Y: Long non-coding RNA XIST as a potential prognostic biomarker in human cancers: A meta-analysis. Oncotarget. 9:13911–13919. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Mao H, Wang K, Feng Y, Zhang J, Pan L, Zhan Y, Sheng H and Luo G. Prognostic role of long non-coding RNA XIST expression in patients with solid tumors: A meta-analysis. Cancer Cell Int. 18:342018. View Article : Google Scholar : PubMed/NCBI

22 

Liu X, Ming X, Jing W, Luo P, Li N, Zhu M, Yu M, Liang C and Tu J: Long non-coding RNA XIST predicts worse prognosis in digestive system tumors: A systemic review and meta-analysis. Biosci Rep. 38:BSR201801692018. View Article : Google Scholar : PubMed/NCBI

23 

Sun K, Jia Z, Duan R, Yan Z, Jin Z, Yan L, Li Q and Yang J: Long non-coding RNA XIST regulates miR-106b-5p/P21 axis to suppress tumor progression in renal cell carcinoma. Biochem Biophys Res Commun. 510:416–420. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Zhang R and Xia T: Long non-coding RNA XIST regulates PDCD4 expression by interacting with miR-21-5p and inhibits osteosarcoma cell growth and metastasis. Int J Oncol. 51:1460–1470. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA and Thacker SB: Meta-analysis of observational studies in epidemiology: A proposal for reporting. Meta-analysis of Observational Studies in Epidemiology (MOOSE) group. JAMA. 283:2008–2012. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Enneking WF: A system of staging musculoskeletal neoplasms. Clin Orthop Relat Res. 9–24. 1986.PubMed/NCBI

27 

Zhang Q, Wang J, Deng F, Yan Z, Xia Y, Wang Z, Ye J, Deng Y, Zhang Z, Qiao M, et al: TqPCR: A touchdown qPCR assay with significantly improved detection sensitivity and amplification efficiency of SYBR green qPCR. PLoS One. 10:e01326662015. View Article : Google Scholar : PubMed/NCBI

28 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Higgins JP and Thompson SG: Quantifying heterogeneity in a meta-analysis. Stat Med. 21:1539–1558. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Bowden J, Tierney JF, Copas AJ and Burdett S: Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Q statistics. BMC Med Res Methodol. 11:412011. View Article : Google Scholar : PubMed/NCBI

31 

Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M and Tugwell P: The Newcastle–Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.aspJune 15–2019

32 

Tantai J, Hu D, Yang Y and Geng J: Combined identification of long non-coding RNA XIST and HIF1A-AS1 in serum as an effective screening for non-small cell lung cancer. Int J Clin Exp Pathol. 8:7887–7895. 2015.PubMed/NCBI

33 

Fang J, Sun CC and Gong C: Long noncoding RNA XIST acts as an oncogene in non-small cell lung cancer by epigenetically repressing KLF2 expression. Biochem Biophys Res Commun. 478:811–817. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Chen DL, Ju HQ, Lu YX, Chen LZ, Zeng ZL, Zhang DS, Luo HY, Wang F, Qiu MZ, Wang DS, et al: Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression. J Exp Clin Cancer Res. 35:1422016. View Article : Google Scholar : PubMed/NCBI

35 

Li GL, Wu YX, Li YM and Li J: High expression of long non-coding RNA XIST in osteosarcoma is associated with cell proliferation and poor prognosis. Eur Rev Med Pharmacol Sci. 21:2829–2834. 2017.PubMed/NCBI

36 

Chen DL, Chen LZ, Lu YX, Zhang DS, Zeng ZL, Pan ZZ, Huang P, Wang FH, Li YH, Ju HQ and Xu RH: Long noncoding RNA XIST expedites metastasis and modulates epithelial-mesenchymal transition in colorectal cancer. Cell Death Dis. 8:e30112017. View Article : Google Scholar : PubMed/NCBI

37 

Wei W, Liu Y, Lu Y, Yang B and Tang L: LncRNA XIST promotes pancreatic cancer proliferation through miR-133a/EGFR. J Cell Biochem. 118:3349–3358. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Du P, Zhao H, Peng R, Liu Q, Yuan J, Peng G and Liao Y: LncRNA-XIST interacts with miR-29c to modulate the chemoresistance of glioma cell to TMZ through DNA mismatch repair pathway. Biosci Rep. 37:BSR201706962017. View Article : Google Scholar : PubMed/NCBI

39 

Wang Z, Yuan J, Li L, Yang Y, Xu X and Wang Y: Long non-coding RNA XIST exerts oncogenic functions in human glioma by targeting miR-137. Am J Transl Res. 9:1845–1855. 2017.PubMed/NCBI

40 

Mo Y, Lu Y, Wang P, Huang S, He L, Li D, Li F, Huang J, Lin X, Li X, et al: Long non-coding RNA XIST promotes cell growth by regulating miR-139-5p/PDK1/AKT axis in hepatocellular carcinoma. Tumour Biol. 39:10104283176909992017. View Article : Google Scholar : PubMed/NCBI

41 

Sun G, Wang C and Zhang H: Long non-coding RNA XIST promotes cervical cancer cell epithelial-mesenchymal transition through the Wnt/β-catenin pathway. Int J Clin Exp Pathol. 10:2333–2339. 2017.

42 

Xiong Y, Wang L, Li Y, Chen M, He W and Qi L: The long non-coding RNA XIST interacted with MiR-124 to modulate bladder cancer growth, invasion and migration by targeting androgen receptor (AR). Cell Physiol Biochem. 43:405–418. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Sun W, Zu Y, Fu X and Deng Y: Knockdown of lncRNA-XIST enhances the chemosensitivity of NSCLC cells via suppression of autophagy. Oncol Rep. 38:3347–3354. 2017.PubMed/NCBI

44 

Wu X, Dinglin X, Wang X, Luo W, Shen Q, Li Y, Gu L, Zhou Q, Zhu H, Li Y, et al: Long noncoding RNA XIST promotes malignancies of esophageal squamous cell carcinoma via regulation of miR-101/EZH2. Oncotarget. 8:76015–76028. 2017.PubMed/NCBI

45 

Kong Q, Zhang S, Liang C, Zhang Y, Kong Q, Chen S, Qin J and Jin Y: LncRNA XIST functions as a molecular sponge of miR-194-5p to regulate MAPK1 expression in hepatocellular carcinoma cell. J Cell Biochem. 119:4458–4468. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Yi SZ, Zhang W, Zhou QY and Cheng GR: lncRNA XIST promotes aggressive tumor phenotype and is associated with poor prognosis in esophageal squamous cell carcinoma. Int J Clin Exp Med. 11:8317–8323. 2018.

47 

Liang S, Gong X, Zhang G, Huang G, Lu Y and Li Y: The lncRNA XIST interacts with miR-140/miR-124/iASPP axis to promote pancreatic carcinoma growth. Oncotarget. 8:113701–113718. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Sun N, Zhang G and Liu Y: Long non-coding RNA XIST sponges miR-34a to promotes colon cancer progression via Wnt/β-catenin signaling pathway. Gene. 665:141–148. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Liu H, Deng H, Zhao Y, Li C and Liang Y: LncRNA XIST/miR-34a axis modulates the cell proliferation and tumor growth of thyroid cancer through MET-PI3K-AKT signaling. J Exp Clin Cancer Res. 37:2792018. View Article : Google Scholar : PubMed/NCBI

50 

Hu C, Liu S, Han M, Wang Y and Xu C: Knockdown of lncRNA XIST inhibits retinoblastoma progression by modulating the miR-124/STAT3 axis. Biomed Pharmacother. 107:547–554. 2018. View Article : Google Scholar : PubMed/NCBI

51 

Zhu H, Zheng T, Yu J, Zhou L and Wang L: LncRNA XIST accelerates cervical cancer progression via upregulating Fus through competitively binding with miR-200a. Biomed Pharmacother. 105:789–797. 2018. View Article : Google Scholar : PubMed/NCBI

52 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Yarmishyn AA and Kurochkin IV: Long noncoding RNAs: A potential novel class of cancer biomarkers. Front Genet. 6:1452015. View Article : Google Scholar : PubMed/NCBI

54 

Mercer TR, Dinger ME and Mattick JS: Long non-coding RNAs: Insights into functions. Nat Rev Genet. 10:155–159. 2009. View Article : Google Scholar : PubMed/NCBI

55 

Cui X, Jing X, Long C, Tian J and Zhu J: Long noncoding RNA MEG3, a potential novel biomarker to predict the clinical outcome of cancer patients: A meta-analysis. Oncotarget. 8:19049–19056. 2017.PubMed/NCBI

56 

Fan YH, Fang H, Ji CX, Xie H, Xiao B and Zhu XG: Long noncoding RNA CCAT2 can predict metastasis and poor prognosis: A meta-analysis. Clin Chim Acta. 466:120–126. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Zhang S, Chen S, Yang G, Gu F, Li M, Zhong B, Hu J, Hoffman A and Chen M: Long noncoding RNA HOTAIR as an independent prognostic marker in cancer: A meta-analysis. PLoS One. 9:e1055382014. View Article : Google Scholar : PubMed/NCBI

58 

Zhu J, Kong F, Xing L, Jin Z and Li Z: Prognostic and clinicopathological value of long noncoding RNA XIST in cancer. Clin Chim Acta. 479:43–47. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Deng C, Hu X, Wu K, Tan J and Yang C: Long non‑coding RNA XIST predicting advanced clinical parameters in cancer: A Meta‑Analysis and case series study in a single institution (Review). Oncol Lett 18: 2192-2202, 2019.
APA
Deng, C., Hu, X., Wu, K., Tan, J., & Yang, C. (2019). Long non‑coding RNA XIST predicting advanced clinical parameters in cancer: A Meta‑Analysis and case series study in a single institution (Review). Oncology Letters, 18, 2192-2202. https://doi.org/10.3892/ol.2019.10592
MLA
Deng, C., Hu, X., Wu, K., Tan, J., Yang, C."Long non‑coding RNA XIST predicting advanced clinical parameters in cancer: A Meta‑Analysis and case series study in a single institution (Review)". Oncology Letters 18.3 (2019): 2192-2202.
Chicago
Deng, C., Hu, X., Wu, K., Tan, J., Yang, C."Long non‑coding RNA XIST predicting advanced clinical parameters in cancer: A Meta‑Analysis and case series study in a single institution (Review)". Oncology Letters 18, no. 3 (2019): 2192-2202. https://doi.org/10.3892/ol.2019.10592
Copy and paste a formatted citation
x
Spandidos Publications style
Deng C, Hu X, Wu K, Tan J and Yang C: Long non‑coding RNA XIST predicting advanced clinical parameters in cancer: A Meta‑Analysis and case series study in a single institution (Review). Oncol Lett 18: 2192-2202, 2019.
APA
Deng, C., Hu, X., Wu, K., Tan, J., & Yang, C. (2019). Long non‑coding RNA XIST predicting advanced clinical parameters in cancer: A Meta‑Analysis and case series study in a single institution (Review). Oncology Letters, 18, 2192-2202. https://doi.org/10.3892/ol.2019.10592
MLA
Deng, C., Hu, X., Wu, K., Tan, J., Yang, C."Long non‑coding RNA XIST predicting advanced clinical parameters in cancer: A Meta‑Analysis and case series study in a single institution (Review)". Oncology Letters 18.3 (2019): 2192-2202.
Chicago
Deng, C., Hu, X., Wu, K., Tan, J., Yang, C."Long non‑coding RNA XIST predicting advanced clinical parameters in cancer: A Meta‑Analysis and case series study in a single institution (Review)". Oncology Letters 18, no. 3 (2019): 2192-2202. https://doi.org/10.3892/ol.2019.10592
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