Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2019 Volume 18 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2019 Volume 18 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Deregulation of folate pathway gene expression correlates with poor prognosis in acute leukemia

  • Authors:
    • Jorge Organista‑Nava
    • Yazmín Gómez‑Gómez
    • Oscar del Moral‑Hernandez
    • Berenice Illades‑Aguiar
    • Jazmin Gómez‑Santamaria
    • Ana Bertha Rivera‑Ramírez
    • Mónica Virginia Saavedra‑Herrera
    • Marco Antonio Jimenez‑López
    • Marco Antonio Leyva‑Vázquez
  • View Affiliations / Copyright

    Affiliations: Laboratorio de Biomedicina Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero 39090, México, Laboratorio de Virología, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero 39090, México, Instituto Estatal de Cancerologia, ‘Dr. Arturo Beltrán Ortega’, Acapulco, Guerrero 39570, México
    Copyright: © Organista‑Nava et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3115-3127
    |
    Published online on: July 22, 2019
       https://doi.org/10.3892/ol.2019.10650
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study analyzed the mRNA expression levels of genes involved in the transport and metabolism of methotrexate (MTX) (RFC1, ABCC1, ABCB1, GGH, FPGS, ATIC, TS, MTHFR, MTRR, MS and MTHFD1) in patients with acute leukemia (AL). The expression levels of the examined genes were analyzed by reverse transcription quantitative polymerase chain reaction (RT‑qPCR) in patients with AL (ALL:50/AML:19) and 66 healthy individuals. The mRNA expression levels of RFC1, MS, MTRR, MTHFR and ABCB1 were decreased (P<0.05), while those of GGH, FPGS, TS and MTHFD1 (P<0.05) were overexpressed in patients with AL. Patients with high mRNA levels of GGH (OR=4.28, 95% CI=1.29‑14.14), TS (OR=7.14, 95% CI 1.84‑27.81), MTHFR (OR=4.81, 95% CI=1.31‑17.64), ABCB1 (OR=4.61, 95% CI=1.33‑15.97) and ABCC1 (OR=5.50, 95% CI=1.12‑27.06) had a higher chance of relapse. Interestingly, high mRNA levels of RFC1 are a protective factor in the risk of AL relapse (OR=0.22, 95% 0.06‑0.80). The results of the present study indicated that deregulation of folate pathway gene expression is associated with poor prognosis in AL and that the expression levels of these markers could serve as novel molecular targets for the treatment of patients with AL.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Bekker-Méndez VC, Miranda-Peralta E, Núñez-Enríquez JC, Olarte-Carrillo I, Guerra-Castillo FX, Pompa-Mera EN, Ocaña-Mondragón A, Rangel-López A, Bernáldez-Ríos R, Medina-Sanson A, et al: Prevalence of gene rearrangements in mexican children with acute lymphoblastic Leukemia: A population study-report from the mexican interinstitutional group for the identification of the causes of childhood leukemia. Biomed Res Int. 2014:2105602014. View Article : Google Scholar : PubMed/NCBI

2 

Mejía-Aranguré JM, Pérez-Saldivar MaL, Pelayo-Camacho R, et al: Childhood acute leukemias in Hispanic population: Differences by age peak and immunophenotype. Novel Aspects in Acute Lymphoblastic Leukemia. Rijeka: InTech; Croatia: pp. 322011

3 

Leukemia in Childers. American Cancer Society, 2019, . https://www.cancer.org/cancer/leukemia-in-children.htmlMarch 10–2019

4 

Stanulla M and Schrappe M: Treatment of childhood acute lymphoblastic leukemia. Semin Hematol. 46:52–63. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Pui CH, Robison LL and Look AT: Acute lymphoblastic leukaemia. Lancet. 371:1030–1043. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Hider SL, Bruce IN and Thomson W: The pharmacogenetics of methotrexate. Rheumatology (Oxford). 46:1520–1524. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Assaraf YG: Molecular basis of antifolate resistance. Cancer Metastasis Rev. 26:153–181. 2007. View Article : Google Scholar : PubMed/NCBI

8 

de Beaumais TA and Jacqz-Aigrain E: Intracellular disposition of methotrexate in acute lymphoblastic leukemia in children. Curr Drug Metab. 13:822–834. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Gonen N and Assaraf YG: Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance. Drug Resist Updat. 15:183–210. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Wojtuszkiewicz A, Peters GJ, Woerden NL, Dubbelman B, Escherich G, Schmiegelow K, Sonneveld E, Pieters R, van de Ven PM, Jansen G, et al: Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia. J Hematol Oncol. 8:612015. View Article : Google Scholar : PubMed/NCBI

11 

Rothem L, Aronheim A and Assaraf YG: Alterations in the expression of transcription factors and the reduced folate carrier as a novel mechanism of antifolate resistance in human leukemia cells. J Biol Chem. 278:8935–8941. 2003. View Article : Google Scholar : PubMed/NCBI

12 

de Jonge R, Hooijberg JH, van Zelst BD, Jansen G, van Zantwijk CH, Kaspers GJ, Peters GJ, Ravindranath Y, Pieters R and Lindemans J: Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia. Blood. 106:717–720. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Gómez-Gómez Y, Organista-Nava J, Saavedra-Herrera MV, Rivera-Ramírez AB, Terán-Porcayo MA, Del Carmen Alarcón-Romero L, Illades-Aguiar B and Leyva-Vázquez MA: Survival and risk of relapse of acute lymphoblastic leukemia in a Mexican population is affected by dihydrofolate reductase gene polymorphisms. Exp Ther Med. 3:665–672. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Organista-Nava J, Gómez-Gómez Y, Illades-Aguiar B, Del Carmen Alarcón-Romero L, Saavedra-Herrera MV, Rivera-Ramírez AB, Garzón-Barrientos VH and Leyva-Vázquez MA: High miR-24 expression is associated with risk of relapse and poor survival in acute leukemia. Oncol Rep. 33:1639–1649. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Reiter A, Schrappe M, Ludwig WD, Hiddemann W, Sauter S, Henze G, Zimmermann M, Lampert F, Havers W, Niethammer D, et al: Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86. Blood. 84:3122–3133. 1994.PubMed/NCBI

16 

Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:156–159. 1987. View Article : Google Scholar : PubMed/NCBI

17 

Abdel-Haleem AM, El-Zeiry MI, Mahran LG, Abou-Aisha K, Rady MH, Rohde J, Mostageer M and Spahn-Langguth H: Expression of RFC/SLC19A1 is associated with tumor type in bladder cancer patients. PLoS One. 6:e218202011. View Article : Google Scholar : PubMed/NCBI

18 

Obata T, Tanaka M, Suzuki Y and Sasaki T: The role of thymidylate synthase in pemetrexed-resistant malignant pleural mesothelioma cells. J Cancer Therapy. 4:82013. View Article : Google Scholar

19 

Ogawa M, Watanabe M, Mitsuyama Y, Anan T, Ohkuma M, Kobayashi T, Eto K and Yanaga K: Thymidine phosphorylase mRNA expression may be a predictor of response to post-operative adjuvant chemotherapy with S-1 in patients with stage III colorectal cancer. Oncol Lett. 8:2463–2468. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Seitz U, Wagner M, Neumaier B, Wawra E, Glatting G, Leder G, Schmid RM and Reske SN: Evaluation of pyrimidine metabolising enzymes and in vitro uptake of 3′-[18F]fluoro-3′-deoxythymidine [(18F)FLT] in pancreatic cancer cell lines. Eur J Nucl Med Mol Imaging. 29:1174–1181. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Malek RL, Irby RB, Guo QM, Lee K, Wong S, He M, Tsai J, Frank B, Liu ET, Quackenbush J, et al: Identification of Src transformation fingerprint in human colon cancer. Oncogene. 21:7256–7265. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Liu R, Yin L and Pu Y: Association between gene expression of metabolizing enzymes and esophageal squamous cell carcinomas in china. Genet Test Mol Biomarkers. 16:1211–1217. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Kawakami K, Ooyama A, Ruszkiewicz A, Jin M, Watanabe G, Moore J, Oka T, Iacopetta B and Minamoto T: Low expression of gamma-glutamyl hydrolase mRNA in primary colorectal cancer with the CpG island methylator phenotype. Br J Cancer. 98:1555–1561. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Zhao JY, Yang XY, Gong XH, Gu ZY, Duan WY, Wang J, Ye ZZ, Shen HB, Shi KH, Hou J, et al: Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the han chinese population clinical perspective. Circulation. 125:482–490. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Huang T, Wahlqvist ML and Li D: Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism. Nutr J. 11:62012. View Article : Google Scholar : PubMed/NCBI

26 

Yoshida M, Suzuki T, Komiya T, Hatashita E, Nishio K, Kazuhiko N and Fukuoka M: Induction of MRP5 and SMRP mRNA by adriamycin exposure and its overexpression in human lung cancer cells resistant to adriamycin. Int J Cancer. 94:432–437. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Ramos-Nino ME, Scapoli L, Martinelli M, Land S and Mossman BT: Microarray analysis and RNA silencing link fra-1 to cd44 and c-met expression in mesothelioma. Cancer Res. 63:3539–3545. 2003.PubMed/NCBI

28 

Nolan T, Hands RE and Bustin SA: Quantification of mRNA using real-time RT-PCR. Nat Protoc. 1:1559–1582. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Dulucq S, St-Onge G, Gagné V, Ansari M, Sinnett D, Labuda D, Moghrabi A and Krajinovic M: DNA variants in the dihydrofolate reductase gene and outcome in childhood ALL. Blood. 111:3692–3700. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Obuchi W, Ohtsuki S, Uchida Y, Ohmine K, Yamori T and Terasaki T: Identification of transporters associated with etoposide sensitivity of stomach cancer cell lines and methotrexate sensitivity of breast cancer cell lines by quantitative targeted absolute proteomics. Mol Pharmacol. 83:490–500. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Galbiatti ALS, Castro R, Caldas HC, Padovani JA, Pavarino ÉC and Goloni-Bertollo EM: Alterations in the expression pattern of MTHFR, DHFR, TYMS, and SLC19A1 genes after treatment of laryngeal cancer cells with high and low doses of methotrexate. Tumor Biol. 34:3765–3771. 2013. View Article : Google Scholar

32 

Li WW, Waltham M, Tong W, Schweitzer BI and Bertino JR: Increased Activity of γ-Glutamyl Hydrolase in Human Sarcoma Cell Lines: A Novel Mechanism of Intrinsic Resistance to Methotrexate (MTX). Chemistry and Biology of Pteridines and Folates. Ayling JE, Nair MG and Baugh CM: Springer US; Boston, MA: pp. 635–638. 1993, View Article : Google Scholar

33 

Kim SE, Cole PD, Cho RC, Ly A, Ishiguro L, Sohn KJ, Croxford R, Kamen BA and Kim YI: γ-Glutamyl hydrolase modulation and folate influence chemosensitivity of cancer cells to 5-fluorouracil and methotrexate. Br J Cancer. 109:2175–2188. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Shubbar E, Helou K, Kovács A, Nemes S, Hajizadeh S, Enerbäck C and Einbeigi Z: High levels of γ-glutamyl hydrolase (GGH) are associated with poor prognosis and unfavorable clinical outcomes in invasive breast cancer. BMC Cancer. 13:472013. View Article : Google Scholar : PubMed/NCBI

35 

Melling N, Rashed M, Schroeder C, Hube-Magg C, Kluth M, Lang D, Simon R, Möller-Koop C, Steurer S, Sauter G, et al: High-level γ-glutamyl-hydrolase (GGH) expression is linked to poor prognosis in ERG negative prostate cancer. Int J Mol Sci. 18:E2862017. View Article : Google Scholar : PubMed/NCBI

36 

Galpin AJ, Schuetz JD, Masson E, Yanishevski Y, Synold TW, Barredo JC, Pui CH, Relling MV and Evans WE: Differences in folylpolyglutamate synthetase and dihydrofolate reductase expression in human B-Lineage versus T-lineage leukemic lymphoblasts: Mechanisms for lineage differences in methotrexate polyglutamylation and cytotoxicity. Mol Pharmacol. 52:155–163. 1997. View Article : Google Scholar : PubMed/NCBI

37 

Chen J, Wang Q, Yin FQ, Zhang W, Yan LH and Li L: MTRR silencing inhibits growth and cisplatin resistance of ovarian carcinoma via inducing apoptosis and reducing autophagy. Am J Transl Res. 7:1510–1527. 2015.PubMed/NCBI

38 

Kotsopoulos J, Hecht JL, Marotti JD, Kelemen LE and Tworoger SS: Relationship between dietary and supplemental intake of folate, methionine, vitamin B(6) and folate receptor α expression in ovarian tumors. Int J Cancer. 126:2191–2198. 2010.PubMed/NCBI

39 

López-Cortés A, Echeverría C, Oña-Cisneros F, Sánchez ME, Herrera C, Cabrera-Andrade A, Rosales F, Ortiz M and Paz-Y-Miño C: Breast cancer risk associated with gene expression and genotype polymorphisms of the folate-metabolizing MTHFR gene: A case-control study in a high altitude Ecuadorian mestizo population. Tumor Biol. 36:6451–6461. 2015. View Article : Google Scholar

40 

Leclerc D, Campeau E, Goyette P, Adjalla CE, Christensen B, Ross M, Eydoux P, Rosenblatt DS, Rozen R and Gravel RA: Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders. Hum Mol Genet. 5:1867–1874. 1996. View Article : Google Scholar : PubMed/NCBI

41 

Wu LL and Wu JT: Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker. Clin Chim Acta. 322:21–28. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Li Y and Tollefsbol TO: Impact on DNA methylation in cancer prevention and therapy by bioactive dietary components. Curr Med Chem. 17:2141–2151. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Wajed SA, Laird PW and DeMeester TR: DNA methylation: An alternative pathway to cancer. Ann Surg. 234:10–20. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Zhang W, Braun A, Bauman Z, Olteanu H, Madzelan P and Banerjee R: Expression profiling of homocysteine junction enzymes in the NCI60 panel of human cancer cell lines. Cancer Res. 65:1554–1560. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Bahari G, Hashemi M, Naderi M and Taheri M: Association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and susceptibility to childhood acute lymphoblastic leukemia in an iranian population. Int J Hematol Oncol Stem Cell Res. 10:130–137. 2016.PubMed/NCBI

46 

Erčulj N, Kotnik BF, Debeljak M, Jazbec J and Dolžan V: Influence of folate pathway polymorphisms on high-dose methotrexate-related toxicity and survival in childhood acute lymphoblastic leukemia. Leuk Lymphoma. 53:1096–1104. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Shan F, Liu YL, Wang Q and Shi YL: Thymidylate synthase predicts poor response to pemetrexed chemotherapy in patients with advanced breast cancer. Oncol Lett. 16:3274–3280. 2018.PubMed/NCBI

48 

Yu Z, Sun J, Zhen J, Zhang Q and Yang Q: Thymidylate synthase predicts for clinical outcome in invasive breast cancer. Histol Histopathol. 20:871–878. 2005.PubMed/NCBI

49 

Kaira K, Okumura T, Ohde Y, Takahashi T, Murakami H, Kondo H, Nakajima T and Yamamoto N: Prognostic significance of thymidylate synthase expression in the adjuvant chemotherapy after resection for pulmonary metastases from colorectal cancer. Anticancer Res. 31:2763–2771. 2011.PubMed/NCBI

50 

Vrana D, Hlavac V, Brynychova V, Vaclavikova R, Neoral C, Vrba J, Aujesky R, Matzenauer M, Melichar B and Soucek P: ABC transporters and their role in the neoadjuvant treatment of esophageal cancer. Int J Mol Sci. 19:E8682018. View Article : Google Scholar : PubMed/NCBI

51 

Robey RW, Pluchino KM, Hall MD, Fojo AT, Bates SE and Gottesman MM: Revisiting the role of ABC transporters in multidrug-resistant cancer. Nat Rev Cancer. 18:452–464. 2018. View Article : Google Scholar : PubMed/NCBI

52 

Ho MM, Hogge DE and Ling V: MDR1 and BCRP1 expression in leukemic progenitors correlates with chemotherapy response in acute myeloid leukemia. Exp Hematol. 36:433–442. 2008. View Article : Google Scholar : PubMed/NCBI

53 

Eadie LN, Dang P, Saunders VA, Yeung DT, Osborn MP, Grigg AP, Hughes TP and White DL: The clinical significance of ABCB1 overexpression in predicting outcome of CML patients undergoing first-line imatinib treatment. Leukemia. 31:752016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Organista‑Nava J, Gómez‑Gómez Y, del Moral‑Hernandez O, Illades‑Aguiar B, Gómez‑Santamaria J, Rivera‑Ramírez AB, Saavedra‑Herrera MV, Jimenez‑López MA and Leyva‑Vázquez MA: Deregulation of folate pathway gene expression correlates with poor prognosis in acute leukemia. Oncol Lett 18: 3115-3127, 2019.
APA
Organista‑Nava, J., Gómez‑Gómez, Y., del Moral‑Hernandez, O., Illades‑Aguiar, B., Gómez‑Santamaria, J., Rivera‑Ramírez, A.B. ... Leyva‑Vázquez, M.A. (2019). Deregulation of folate pathway gene expression correlates with poor prognosis in acute leukemia. Oncology Letters, 18, 3115-3127. https://doi.org/10.3892/ol.2019.10650
MLA
Organista‑Nava, J., Gómez‑Gómez, Y., del Moral‑Hernandez, O., Illades‑Aguiar, B., Gómez‑Santamaria, J., Rivera‑Ramírez, A. B., Saavedra‑Herrera, M. V., Jimenez‑López, M. A., Leyva‑Vázquez, M. A."Deregulation of folate pathway gene expression correlates with poor prognosis in acute leukemia". Oncology Letters 18.3 (2019): 3115-3127.
Chicago
Organista‑Nava, J., Gómez‑Gómez, Y., del Moral‑Hernandez, O., Illades‑Aguiar, B., Gómez‑Santamaria, J., Rivera‑Ramírez, A. B., Saavedra‑Herrera, M. V., Jimenez‑López, M. A., Leyva‑Vázquez, M. A."Deregulation of folate pathway gene expression correlates with poor prognosis in acute leukemia". Oncology Letters 18, no. 3 (2019): 3115-3127. https://doi.org/10.3892/ol.2019.10650
Copy and paste a formatted citation
x
Spandidos Publications style
Organista‑Nava J, Gómez‑Gómez Y, del Moral‑Hernandez O, Illades‑Aguiar B, Gómez‑Santamaria J, Rivera‑Ramírez AB, Saavedra‑Herrera MV, Jimenez‑López MA and Leyva‑Vázquez MA: Deregulation of folate pathway gene expression correlates with poor prognosis in acute leukemia. Oncol Lett 18: 3115-3127, 2019.
APA
Organista‑Nava, J., Gómez‑Gómez, Y., del Moral‑Hernandez, O., Illades‑Aguiar, B., Gómez‑Santamaria, J., Rivera‑Ramírez, A.B. ... Leyva‑Vázquez, M.A. (2019). Deregulation of folate pathway gene expression correlates with poor prognosis in acute leukemia. Oncology Letters, 18, 3115-3127. https://doi.org/10.3892/ol.2019.10650
MLA
Organista‑Nava, J., Gómez‑Gómez, Y., del Moral‑Hernandez, O., Illades‑Aguiar, B., Gómez‑Santamaria, J., Rivera‑Ramírez, A. B., Saavedra‑Herrera, M. V., Jimenez‑López, M. A., Leyva‑Vázquez, M. A."Deregulation of folate pathway gene expression correlates with poor prognosis in acute leukemia". Oncology Letters 18.3 (2019): 3115-3127.
Chicago
Organista‑Nava, J., Gómez‑Gómez, Y., del Moral‑Hernandez, O., Illades‑Aguiar, B., Gómez‑Santamaria, J., Rivera‑Ramírez, A. B., Saavedra‑Herrera, M. V., Jimenez‑López, M. A., Leyva‑Vázquez, M. A."Deregulation of folate pathway gene expression correlates with poor prognosis in acute leukemia". Oncology Letters 18, no. 3 (2019): 3115-3127. https://doi.org/10.3892/ol.2019.10650
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team