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Article Open Access

Downregulation of thymopoietin by miR‑139‑5p suppresses cell proliferation and induces cell cycle arrest/apoptosis in pancreatic ductal adenocarcinoma

Retraction in: /10.3892/ol.2024.14623
  • Authors:
    • Huadong Zhou
    • Linfei Zhang
    • Huahua Tu
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Pancreatic Surgery, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3443-3452
    |
    Published online on: July 29, 2019
       https://doi.org/10.3892/ol.2019.10679
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Abstract

MicroRNAs (miRNAs) serve a pivotal role in tumor development and progression, in which miRNA (miR)‑139‑5p functions as a tumor suppressor. However, the functions and mechanisms of miR‑139‑5p in pancreatic ductal adenocarcinoma (PDAC) remain unclear. In the present study, it was found that miR‑139‑5p was markedly decreased in PDAC tissues and cell lines. Noticeably, thymopoietin (TMPO) was predicted and confirmed as a direct target of miR‑139‑5p using a luciferase reporter system. The expression level of miR‑139‑5p was inversely associated with the expression of TMPO in PDAC specimens. A series of gain‑of‑function assays elucidated that the overexpression of miR‑139‑5p suppressed cell proliferation, and induced cell cycle arrest and cell apoptosis, determined with a Cell Counting Kit‑8, colony formation assays and flow cytometry, respectively. Furthermore, the re‑expression of TMPO eliminated the effects of miR‑139‑5p on cell proliferation, cell cycle progression and apoptosis. In summary, these findings demonstrated that miR‑139‑5p may be a tumor suppressor in PDAC, which may be useful in developing promising therapies for PDAC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou H, Zhang L and Tu H: Downregulation of thymopoietin by miR‑139‑5p suppresses cell proliferation and induces cell cycle arrest/apoptosis in pancreatic ductal adenocarcinoma Retraction in /10.3892/ol.2024.14623. Oncol Lett 18: 3443-3452, 2019.
APA
Zhou, H., Zhang, L., & Tu, H. (2019). Downregulation of thymopoietin by miR‑139‑5p suppresses cell proliferation and induces cell cycle arrest/apoptosis in pancreatic ductal adenocarcinoma Retraction in /10.3892/ol.2024.14623. Oncology Letters, 18, 3443-3452. https://doi.org/10.3892/ol.2019.10679
MLA
Zhou, H., Zhang, L., Tu, H."Downregulation of thymopoietin by miR‑139‑5p suppresses cell proliferation and induces cell cycle arrest/apoptosis in pancreatic ductal adenocarcinoma Retraction in /10.3892/ol.2024.14623". Oncology Letters 18.4 (2019): 3443-3452.
Chicago
Zhou, H., Zhang, L., Tu, H."Downregulation of thymopoietin by miR‑139‑5p suppresses cell proliferation and induces cell cycle arrest/apoptosis in pancreatic ductal adenocarcinoma Retraction in /10.3892/ol.2024.14623". Oncology Letters 18, no. 4 (2019): 3443-3452. https://doi.org/10.3892/ol.2019.10679
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou H, Zhang L and Tu H: Downregulation of thymopoietin by miR‑139‑5p suppresses cell proliferation and induces cell cycle arrest/apoptosis in pancreatic ductal adenocarcinoma Retraction in /10.3892/ol.2024.14623. Oncol Lett 18: 3443-3452, 2019.
APA
Zhou, H., Zhang, L., & Tu, H. (2019). Downregulation of thymopoietin by miR‑139‑5p suppresses cell proliferation and induces cell cycle arrest/apoptosis in pancreatic ductal adenocarcinoma Retraction in /10.3892/ol.2024.14623. Oncology Letters, 18, 3443-3452. https://doi.org/10.3892/ol.2019.10679
MLA
Zhou, H., Zhang, L., Tu, H."Downregulation of thymopoietin by miR‑139‑5p suppresses cell proliferation and induces cell cycle arrest/apoptosis in pancreatic ductal adenocarcinoma Retraction in /10.3892/ol.2024.14623". Oncology Letters 18.4 (2019): 3443-3452.
Chicago
Zhou, H., Zhang, L., Tu, H."Downregulation of thymopoietin by miR‑139‑5p suppresses cell proliferation and induces cell cycle arrest/apoptosis in pancreatic ductal adenocarcinoma Retraction in /10.3892/ol.2024.14623". Oncology Letters 18, no. 4 (2019): 3443-3452. https://doi.org/10.3892/ol.2019.10679
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