Long non‑coding RNA DRHC inhibits the proliferation of cancer cells in triple negative breast cancer by downregulating long non‑coding RNA HOTAIR

Yu,Fusheng; Wang,Lei; Zhang,Bowen

doi:10.3892/ol.2019.10683

October-2019 Volume 18 Issue 4

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October-2019 Volume 18 Issue 4

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Article

Long non‑coding RNA DRHC inhibits the proliferation of cancer cells in triple negative breast cancer by downregulating long non‑coding RNA HOTAIR

Authors:
- Fusheng Yu
- Lei Wang
- Bowen Zhang
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Affiliations: Department of Oncology, Heilongjiang Farms and Land General Hospital, Haerbin, Heilongjiang 150088, P.R. China, Department of Pharmacy Intravenous Admixture Services, Heilongjiang Farms and Land General Hospital, Haerbin, Heilongjiang 150088, P.R. China
Pages: 3817-3822
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Published online on: July 29, 2019

https://doi.org/10.3892/ol.2019.10683
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Abstract

Long non‑coding RNA (lncRNA) downregulated in hepatocellular carcinoma (DRHC) is a tumor suppressor in liver cancer. However, the role of this lncRNA in breast cancer has not been investigated. The present study revealed that lncRNA DRHC was downregulated and lncRNA Hox transcript antisense RNA (HOTAIR) was upregulated in tumor tissues compared with adjacent healthy tissues in patients with triple negative breast cancer (TNBC). Expression levels of lncRNA DRHC and lncRNA HOTAIR were negatively correlated in tumor tissues but not in adjacent healthy tissues. The lncRNA DRHC expression level was correlated with tumor size but not tumor metastasis. In vitro overexpression of lncRNA DRHC in TNBC cell lines resulted in decreased expression of lncRNA HOTAIR; however, lncRNA HOTAIR overexpression did not affect the expression level of lncRNA DRHC. Overexpression of lncRNA DRHC inhibited, while overexpression of lncRNA HOTAIR promoted the proliferation of the TNBC cell lines. In addition, lncRNA HOTAIR overexpression attenuated the inhibitory effects of lncRNA DRHC overexpression on cancer cell proliferation. The results obtained in the current study suggested that lncRNA DRHC may inhibit the proliferation of TNBC cells by downregulating the expression of lncRNA HOTAIR.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Long non‑coding RNA DRHC inhibits the proliferation of cancer cells in triple negative breast cancer by downregulating long non‑coding RNA HOTAIR

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