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Article

MLKL is a potential prognostic marker in gastric cancer

  • Authors:
    • Wei Sun
    • Wenyan Yu
    • Lili Shen
    • Tieao Huang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Xiangcheng People's Hospital, Suzhou, Jiangsu 215131, P.R. China, Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Oncology, Haimen People's Hospital, Haimen, Jiangsu 226100, P.R. China
  • Pages: 3830-3836
    |
    Published online on: July 29, 2019
       https://doi.org/10.3892/ol.2019.10687
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Abstract

The mixed lineage kinase domain‑like protein (MLKL), which is a major mediator of the necroptosis pathway, is involved in a certain cancers. The present study aimed to explore the expression patterns and exact role of MLKL in gastric cancer (GC) tumorigenesis and progression. In Cancer Cell Line Encyclopedia analysis, the MLKL mRNA expression levels in GC cell lines were not higher compared with that in other cancer cell lines. The results of the present study demonstrated that MLKL expression was decreased in gastric cancer tissues compared with that in normal tissues. In the Kaplan‑Meier Plotter database survival analyses, decreased MLKL expression was associated with poor overall survival and first progression in patients with gastric cancer. In Oncomine gene co‑expression analysis, MLKL expression was significantly associated with fatty acid 2‑hydroxylase (FA2H) expression, which also exhibited similar effects on the prognosis of patients with GC in the survival analysis. This result suggested that FA2H may be a downstream molecule of MLKL. The results of the present study indicated that MLKL may be a novel prognostic biomarker for patients with GC.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 69:7–34. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Moore MA, Eser S, Igisinov N, Igisinov S, Mohagheghi MA, Mousavi-Jarrahi A, Ozentürk G, Soipova M, Tuncer M and Sobue T: Cancer epidemiology and control in North-Western and Central Asia-past, present and future. Asian Pac J Cancer Prev. 11 (Suppl 2):S17–S32. 2010.

3 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Apicella M, Corso S and Giordano S: Targeted therapies for gastric cancer: Failures and hopes from clinical trials. Oncotarget. 8:57654–57669. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X and Wang X: Mixed lineage kinase domain-like proteinmediates necrosis signaling downstream of RIP3 kinase. Cell. 148:213–227. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Zhao J, Jitkaew S, Cai Z, Choksi S, Li Q, Luo J and Liu ZG: Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. Proc Natl Acad Sci USA. 109:5322–5327. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Vanlangenakker N, Vanden Berghe T and Vandenabeele P: Many stimuli pull the necrotic trigger, an overview. Cell Death Differ. 19:75–86. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Tenev T, Bianchi K, Darding M, Broemer M, Langlais C, Wallberg F, Zachariou A, Lopez J, MacFarlane M, Cain K and Meier P: The ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell. 43:432–448. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Coupienne I, Fettweis G and Piette J: RIP3 expression induces a death profile change in U2OS osteosarcoma cells after 5-ALA-PDT. Lasers Surg Med. 43:557–564. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Chu WM: Tumor necrosis factor. Cancer Lett. 328:222–225. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Zong WX and Thompson CB: Necrotic death as a cell fate. Genes Dev. 20:1–15. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Zhou Z, Han V and Han J: New components of the necroptotic pathway. Protein Cell. 3:811–817. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, Guan A, Hesley JA, Miller SC, Cromwell EF, Solow-Cordero DE, et al: A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Mol Cell. 35:228–239. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Ruan J, Mei L, Zhu Q, Shi G and Wang H: Mixed lineage kinase domain-like protein is a prognostic biomarker for cervical squamous cell cancer. Int J Clin Exp Pathol. 8:150352015.PubMed/NCBI

15 

He L, Peng K, Liu Y, Xiong J and Zhu FF: Low expression of mixed lineage kinase domain-like protein is associated with poor prognosis in ovarian cancer patients. Onco Targets Ther. 6:1539–1543. 2013.PubMed/NCBI

16 

Colbert LE, Fisher SB, Hardy CW, Hall WA, Saka B, Shelton JW, Petrova AV, Warren MD, Pantazides BG, Gandhi K, et al: Pronecrotic mixed lineage kinase domain-like protein expression is a prognostic biomarker in patients with early-stage resected pancreatic adenocarcinoma. Cancer. 119:3148–3155. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Li X, Guo J, Ding AP, Qi WW, Zhang PH, Lv J, Qiu WS and Sun ZQ: Association of mixed lineage kinase domain-like protein expression with prognosis in patients with colon cancer. Technol Cancer Res Treat. 16:428–434. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Ajani JA In H and Sano T: Stomach. AJCC Cancer Staging Manual. Amin MB. 8th. Springer-Verlag; New York, NY: 2016

19 

Xue Y, Ma G, Gu D, Zhu L, Hua Q, Du M, Chu H, Tong N, Chen J, Zhang Z and Wang M: Genome-wide analysis of long noncoding RNA signature in human colorectal cancer. Gene. 556:227–234. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Ertao Z, Jianhui C, Kang W, Zhijun Y, Hui W, Chuangqi C, Changjiang Q, Sile C, Yulong H and Shirong C: Prognostic value of mixed lineage kinase domain-like protein expression in the survival of patients with gastric caner. Tumor Biol. 37:13679–13685. 2016. View Article : Google Scholar

22 

Vandenabeele P, Galluzzi L, Vanden Berghe T and Kroemer G: Molecular mechanisms of necroptosis: An ordered cellular explosion. Nat Rev Mol Cell Biol. 11:700–714. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Krysko O, Aaes TL, Kagan VE, D'Herde K, Bachert C, Leybaert L, Vandenabeele P and Krysko DV: Necroptotic cell death in anti-cancer therapy. Immunol Rev. 280:207–219. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Wang H, Sun L, Su L, Rizo J, Liu L, Wang LF, Wang FS and Wang X: Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Mol Cell. 54:133–146. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Dondelinger Y, Declercq W, Montessuit S, Roelandt R, Goncalves A, Bruggeman I, Hulpiau P, Weber K, Sehon CA, Marquis RW, et al: MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates. Cell Rep. 7:971–981. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Zhu Y, Cui H, Gan H, Xia Y, Wang L, Wang Y and Sun Y: Necroptosis mediated by receptor interaction protein kinase 1 and 3 aggravates chronic kidney injury of subtotal nephrectomised rats. Biochem Biophys Res Commun. 461:575–581. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Moriwaki K and Chan FK: RIP3: A molecular switch for necrosis and inflammation. Genes Dev. 27:1640–1649. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Pasparakis M and Vandenabeele P: Necroptosis and its role in inflammation. Nature. 517:311–320. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Alderson NL, Rembiesa BM, Walla MD, Bielawska A, Bielawski J and Hama H: The human FA2H gene encodes a fatty acid 2-hydroxylase. J Biol Chem. 279:48562–48568. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Alderson NL, Walla MD and Hama H: A novel method for the measurement of in vitro fatty acid 2-hydroxylase activity by gaschromatography-mass spectrometry. J Lipid Res. 46:1569–1575. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Herrero AB, Astudillo AM, Balboa MA, Cuevas C, Balsinde J and Moreno S: Levels of SCS7/FA2H-mediated fatty acid 2-hydroxylation determine the sensitivity of cells to antitumor PM02734. Cancer Res. 68:9779–9787. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Takeda S, Ikeda E, Su S, Harada M, Okazaki H, Yoshioka Y, Nishimura H, Ishii H, Kakizoe K, Taniguchi A, et al: Δ(9)-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: Possible involvement of induced levels of PPARα in MDA-MB-231 breast cancer cells. Toxicology. 326:18–24. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun W, Yu W, Shen L and Huang T: MLKL is a potential prognostic marker in gastric cancer. Oncol Lett 18: 3830-3836, 2019.
APA
Sun, W., Yu, W., Shen, L., & Huang, T. (2019). MLKL is a potential prognostic marker in gastric cancer. Oncology Letters, 18, 3830-3836. https://doi.org/10.3892/ol.2019.10687
MLA
Sun, W., Yu, W., Shen, L., Huang, T."MLKL is a potential prognostic marker in gastric cancer". Oncology Letters 18.4 (2019): 3830-3836.
Chicago
Sun, W., Yu, W., Shen, L., Huang, T."MLKL is a potential prognostic marker in gastric cancer". Oncology Letters 18, no. 4 (2019): 3830-3836. https://doi.org/10.3892/ol.2019.10687
Copy and paste a formatted citation
x
Spandidos Publications style
Sun W, Yu W, Shen L and Huang T: MLKL is a potential prognostic marker in gastric cancer. Oncol Lett 18: 3830-3836, 2019.
APA
Sun, W., Yu, W., Shen, L., & Huang, T. (2019). MLKL is a potential prognostic marker in gastric cancer. Oncology Letters, 18, 3830-3836. https://doi.org/10.3892/ol.2019.10687
MLA
Sun, W., Yu, W., Shen, L., Huang, T."MLKL is a potential prognostic marker in gastric cancer". Oncology Letters 18.4 (2019): 3830-3836.
Chicago
Sun, W., Yu, W., Shen, L., Huang, T."MLKL is a potential prognostic marker in gastric cancer". Oncology Letters 18, no. 4 (2019): 3830-3836. https://doi.org/10.3892/ol.2019.10687
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