Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2019 Volume 18 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2019 Volume 18 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Identification of key pathways and genes in colorectal cancer to predict the prognosis based on mRNA interaction network

  • Authors:
    • Hengzhou Zhu
    • Yi Ji
    • Wenting Li
    • Mianhua Wu
  • View Affiliations / Copyright

    Affiliations: First Clinical Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210000, P.R. China, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Institute of Oncology, The First Clinical Medical College, Nanjing, Jiangsu 210000, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3778-3786
    |
    Published online on: August 1, 2019
       https://doi.org/10.3892/ol.2019.10698
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to identify key genes in colorectal cancer (CRC) that could be used to reliably diagnose this disease and to explore the potential underlying mechanisms in silico. The gene expression profiles of primary human cancer datasets GSE21510 and GSE32323 were downloaded from the Gene Expression Omnibus database. The limma R software package was used to identify differentially expressed (DE) genes. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed on DE genes using the Database for Annotation, Visualization and Integrated Discovery. The Search Tool for the Retrieval of Interacting Genes/Proteins database was used to construct a protein‑protein interaction (PPI) network of the DE genes. Survival rate was analyzed and visualized using The Cancer Genome Atlas (TCGA). A total of 1,126 genes were significantly DE in the present study. All DE genes were enriched in KEGG pathways including ‘cell cycle’, ‘mineral absorption’, ‘pancreatic secretion’, ‘pathways in cancer’, ‘metabolic pathways’, ‘aldosterone‑regulated sodium reabsorption’ and ‘Wnt signaling pathway’. A total of 5 hub genes enriched in cell cycle and tumor‑associated pathways, including E2F2, SKP2, MYC, CDKN1A and CDKN2B, were significantly DE and validated between tumor and normal tissues. CDKN1A and CDKN2B were identified within the PPI network using the Molecular Complex Detection algorithm. Survival and content distribution analyses of 362 clinical samples from TCGA revealed that CDKN1A effectively predicted the prognosis of patients. The present study identified key genes and potential signaling pathways involved in CRC. These findings may provide new insights for survival assessment during the clinical diagnosis of CRC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Hodson L, Skeaff CM and Fielding BA: Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. Prog Lipid Res. 47:348–380. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Yang C, Zhang J, Ding M, Xu K, Li L, Mao L and Zheng J: Ki67 targeted strategies for cancer therapy. Clin Transl Oncol. 20:570–575. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Li J, Zhang Z, Chen F, Hu T, Peng W, Gu Q and Sun Y: The diverse oncogenic and tumor suppressor roles of microRNA-105 in cancer. Front Oncol. 9:5182019. View Article : Google Scholar : PubMed/NCBI

4 

Dong P, Xiong Y, Yue J, Hanley SJB, Kobayashi N, Todo Y and Watari H: Long Non-coding RNA NEAT1: A novel target for diagnosis and therapy in human tumors. Front Genet. 9:4712018. View Article : Google Scholar : PubMed/NCBI

5 

Panoutsopoulou K, Avgeris M and Scorilas A: miRNA and long non-coding RNA: Molecular function and clinical value in breast and ovarian cancers. Expert Rev Mol Diagn. 18:963–979. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global patterns and trends in colorectal cancer incidence and mortality. Gut. 66:683–691. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Song N, Kim K, Shin A, Park JW, Chang HJ, Shi J, Cai Q, Kim DY, Zheng W and Oh JH: Colorectal cancer susceptibility loci and influence on survival. Genes Chromosomes Cancer. 57:630–637. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Lech G, Słotwiński R, Słodkowski M and Krasnodębski IW: Colorectal cancer tumour markers and biomarkers: Recent therapeutic advances. World J Gastroenterol. 22:1745–1755. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Puccini A, Berger MD, Zhang W and Lenz HJ: What we know about stage II and III colon cancer: It's still not enough. Target Oncol. 12:265–275. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Lan J, Sun L, Xu F, Liu L, Hu F, Song D, Hou Z, Wu W, Luo X, Wang J, et al: M2 macrophage-derived exosomes promote cell migration and invasion in colon cancer. Cancer Res. 79:146–158. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Tsukamoto S, Ishikawa T, Iida S, Ishiguro M, Mogushi K, Mizushima H, Uetake H, Tanaka H and Sugihara K: Clinical significance of osteoprotegerin expression in human colorectal cancer. Clin Cancer Res. 17:2444–2450. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Khamas A, Ishikawa T, Shimokawa K, Mogushi K, Iida S, Ishiguro M, Mizushima H, Tanaka H, Uetake H and Sugihara K: Screening for epigenetically masked genes in colorectal cancer Using 5-Aza-2′-deoxycytidine, microarray and gene expression profile. Cancer Genomics Proteomics. 9:67–75. 2012.PubMed/NCBI

14 

R Core Team. R, . A language and environment for statistical computing. R Foundation for Statistical Computing. (Vienna, Austria). 2012.

15 

RStudio Team. RStudio, . Integrated development for R. RStudio, Inc. (Boston, MA). 2015.

16 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W and Smyth GK: Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43:e472015. View Article : Google Scholar : PubMed/NCBI

17 

Krüger T: Editorial change at statistical applications in genetics and molecular biology. Stat Appl Genet Mol. 17(pii)2018.doi: 10.1515/sagmb-2018-0046.

18 

Yu G, Wang L, Han Y and He Q: clusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–287. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43((Database Issue)): D447–D452. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Henson DE, Hueman MT, Chen D, Patel JA, Wang H and Schwartz AM: The anatomy of the TNM for colon cancer. J Gastrointest Oncol. 8:12–19. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45:W98–W102. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Zhao X, Ponomaryov T, Ornell KJ, Zhou P, Dabral SK, Pak E, Li W, Atwood SX, Whitson RJ, Chang AL, et al: RAS/MAPK activation drives resistance to Smo inhibition, metastasis, and tumor evolution in Shh pathway-dependent tumors. Cancer Res. 75:3623–3635. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Ma D, Chen X, Zhang PY, Zhang H, Wei LJ, Hu S, Tang JZ, Zhou MT, Xie C, Ou R, et al: Upregulation of the ALDOA/DNA-PK/p53 pathway by dietary restriction suppresses tumor growth. Oncogene. 37:1041–1048. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Duchartre Y, Kim Y and Kahn M: The Wnt signaling pathway in cancer. Crit Rev Oncol Hematol. 99:141–149. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Kalkat M, Resetca D, Lourenco C, Chan P, Wei Y, Shiah Y, Vitkin N, Tong Y, Sunnerhagen M, Done SJ, et al: MYC protein interactome profiling reveals functionally distinct regions that cooperate to drive tumorigenesis. Mol Cell. 72:836–848.e7. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Stine ZE, Walton ZE, Altman BJ, Hsieh AL and Dang CV: MYC, metabolism, and cancer. Cancer Discov. 5:1024–1039. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Zhou J, Cheng M, Wu M, Boriboun C, Jujo K, Xu S, Zhao TC, Tang Y, Kishore R and Qin G: Contrasting roles of E2F2 and E2F3 in endothelial cell growth and ischemic angiogenesis. J Mol Cell Cardiol. 60:68–71. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Gao Y, Feng B, Lu L, Han S, Chu X, Chen L and Wang R: MiRNAs and E2F3: A complex network of reciprocal regulations in human cancers. Oncotarget. 8:60624–60639. 2017.PubMed/NCBI

29 

Lee SW, Li CF, Jin G, Cai Z, Han F, Chan CH, Yang WL, Li BK, Rezaeian AH, Li HY, et al: Skp2-dependent ubiquitination and activation of LKB1 is essential for cancer cell survival under energy stress. Mol Cell. 57:1022–1033. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Yao R, Han D, Sun X, Xie Y, Wu Q, Fu C, Yao Y, Li H, Li Z and Xu K: Scriptaid inhibits cell survival, cell cycle, and promotes apoptosis in multiple myeloma via epigenetic regulation of p21. Exp Hematol. 60:63–72. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Wall SJ, Zhong Z and DeClerck YA: The Cyclin-dependent kinase inhibitors p15INK4B and p21CIP are critical regulators of fibrillar collagen-induced tumor cell cycle arrest. J Biol Chem. 282:24471–24476. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Ansems M, Søndergaard JN, Sieuwerts AM, Looman MW, Smid M, de Graaf AM, de Weerd V, Zuidscherwoude M, Foekens JA, Martens JW and Adema GJ: DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells. Breast Cancer Res Treat. 149:693–703. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Wang D, Han S, Peng R, Jiao C, Wang X, Yang X, Yang R and Li X: Depletion of histone demethylase KDM5B inhibits cell proliferation of hepatocellular carcinoma by regulation of cell cycle checkpoint proteins p15 and p27. J Exp Clin Cancer Res. 35:372016. View Article : Google Scholar : PubMed/NCBI

34 

Park J, Park M, Oh EH, Soung N, Lee SJ, Jung J, Lee O, Yun SJ, Kim W, Shin E and Kim EG: The p21-activated kinase 4-Slug transcription factor axis promotes epithelial-mesenchymal transition and worsens prognosis in prostate cancer. Oncogene. 37:5147–5159. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Dutto I, Tillhon M, Cazzalini O, Stivala LA and Prosperi E: Biology of the cell cycle inhibitor p21CDKN1A: Molecular mechanisms and relevance in chemical toxicology. Arch Toxicol. 89:155–178. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Basudan A, Priedigkeit N, Hartmaier RJ, Sokol ES, Bahreini A, Watters RJ, Boisen MM, Bhargava R, Weiss KR, Karsten MM, et al: Frequent ESR1 and CDK pathway copy number alterations in metastatic breast cancer. Mol Cancer Res. 17:457–468. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Li Z, Qiu R, Qiu X and Tian T: SNHG6 promotes tumor growth via repression of P21 in colorectal cancer. Cell Physiol Biochem. 49:463–478. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Zhang Z, Li J, Huang Y, Peng W, Qian W, Gu J, Wang Q, Hu T, Ji D, Ji B, et al: Upregulated miR-1258 regulates cell cycle and inhibits cell proliferation by directly targeting E2F8 in CRC. Cell Prolif. 51:e125052018. View Article : Google Scholar : PubMed/NCBI

39 

Chen Z, Hou R, Gao S, Song D and Feng Y: Baicalein inhibits proliferation activity of human colorectal cancer cells HCT116 through downregulation of Ezrin. Cell Physiol Biochem. 49:2035–2046. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Del CS, Sayagues JM, Bengoechea O, Anduaga MF, Alcazar JA, Gervas R, Garcia J, Orfao A, Bellvis LM, Sarasquete ME and Del Mar Abad M: Spatio-temporal tumor heterogeneity in metastatic CRC tumors: A mutational-based approach. Oncotarget. 9:34279–34288. 2018.PubMed/NCBI

41 

Xie XN, Yu J, Zhang LH, Luo ZY, Ouyang DS, Zheng LJ, Wang CY, Yang L, Chen L and Tan ZR: Relationship between polymorphisms of the lipid metabolism-related gene PLA2G16 and risk of colorectal cancer in the Chinese population. Funct Integr Genomic. 19:227–236. 2019. View Article : Google Scholar

42 

Yu C, Hong H, Lu J, Zhao X, Hu W, Zhang S, Zong Y, Mao Z, Li J, Wang M, et al: Prediction of target genes and pathways associated with cetuximab insensitivity in colorectal cancer. Technol Cancer Res Treat. 17:2018.doi: 10.1177/1533033818806905. View Article : Google Scholar

43 

Xue W, Li J, Wang F, Han P, Liu Y and Cui B: A long non-coding RNA expression signature to predict survival of patients with colon adenocarcinoma. Oncotarget. 8:101298–101308. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Lin Y, Wang X, Yu Y, Liu W, Xie F, Ouyang X and Huang Q: Expression and prognostic significance of cyclin-dependent kinase inhibitor 1A in patients with resected gastric adenocarcinoma. Oncol Lett. 14:7473–7482. 2017.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhu H, Ji Y, Li W and Wu M: Identification of key pathways and genes in colorectal cancer to predict the prognosis based on mRNA interaction network. Oncol Lett 18: 3778-3786, 2019.
APA
Zhu, H., Ji, Y., Li, W., & Wu, M. (2019). Identification of key pathways and genes in colorectal cancer to predict the prognosis based on mRNA interaction network. Oncology Letters, 18, 3778-3786. https://doi.org/10.3892/ol.2019.10698
MLA
Zhu, H., Ji, Y., Li, W., Wu, M."Identification of key pathways and genes in colorectal cancer to predict the prognosis based on mRNA interaction network". Oncology Letters 18.4 (2019): 3778-3786.
Chicago
Zhu, H., Ji, Y., Li, W., Wu, M."Identification of key pathways and genes in colorectal cancer to predict the prognosis based on mRNA interaction network". Oncology Letters 18, no. 4 (2019): 3778-3786. https://doi.org/10.3892/ol.2019.10698
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu H, Ji Y, Li W and Wu M: Identification of key pathways and genes in colorectal cancer to predict the prognosis based on mRNA interaction network. Oncol Lett 18: 3778-3786, 2019.
APA
Zhu, H., Ji, Y., Li, W., & Wu, M. (2019). Identification of key pathways and genes in colorectal cancer to predict the prognosis based on mRNA interaction network. Oncology Letters, 18, 3778-3786. https://doi.org/10.3892/ol.2019.10698
MLA
Zhu, H., Ji, Y., Li, W., Wu, M."Identification of key pathways and genes in colorectal cancer to predict the prognosis based on mRNA interaction network". Oncology Letters 18.4 (2019): 3778-3786.
Chicago
Zhu, H., Ji, Y., Li, W., Wu, M."Identification of key pathways and genes in colorectal cancer to predict the prognosis based on mRNA interaction network". Oncology Letters 18, no. 4 (2019): 3778-3786. https://doi.org/10.3892/ol.2019.10698
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team