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Bioinformatics analysis identifies hub genes and pathways in nasopharyngeal carcinoma

  • Authors:
    • Kang Liu
    • Min Kang
    • Ziyan Zhou
    • Wen Qin
    • Rensheng Wang
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Guangxi, Nanning 530021, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3637-3645
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    Published online on: August 2, 2019
       https://doi.org/10.3892/ol.2019.10707
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Abstract

The aim of the present study was to identify genes associated with and the underlying mechanisms in nasopharyngeal carcinoma (NPC) using microarray data. GSE12452 and GSE34573 gene expression profiles were obtained from the Gene Expression Omnibus (GEO) database. GEO2R was utilized to obtain differentially expressed genes (DEGs). In addition, the Database for Annotation, Visualization and Integrated Discovery was used to perform pathway enrichment analyses for DEGs using the Gene Ontology (GO) annotation along with the Kyoto Encyclopedia of Genes and Genomes (KEGG). Furthermore, Cytoscape was used to perform module analysis of the protein‑protein interaction (PPI) network and pathways of the hub genes were studied. A total of 298 genes were ascertained as DEGs in the two datasets. To functionally categorize these DEGs, we obtained 82 supplemented GO terms along with 7 KEGG pathways. Subsequently, a PPI network consisting of 10 hub genes with high degrees of interaction was constructed. These hub genes included cyclin‑dependent kinase (CDK) 1, structural maintenance of chromosomes (SMC) 4, kinetochore‑associated (KNTC) 1, kinesin family member (KIF) 23, aurora kinase A (AURKA), ATAD (ATPase family AAA domain containing) 2, NDC80 kinetochore complex component, enhancer of zeste 2 polycomb repressive complex 2 subunit, BUB1 mitotic checkpoint serine/threonine kinase and protein regulator of cytokinesis 1. CDK1, SMC4, KNTC1, KIF23, AURKA and ATAD2 presented with high areas under the curve in receiver operator curves, suggesting that these genes may be diagnostic markers for nasopharyngeal carcinoma. In conclusion, it was proposed that CDK1, SMC4, KNTC1, KIF23, AURKA and ATAD2 may be involved in the tumorigenesis of NPC. Furthermore, they may be utilized as molecular biomarkers in early diagnosis of NPC.
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1 

Lam KO, Lee AW, Choi CW, Sze HC, Zietman AL, Hopkins KI and Rosenblatt E: Global pattern of nasopharyngeal cancer: Correlation of outcome with access to radiation therapy. Int J Radiat Oncol Biol Phys. 94:1106–1112. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Peng H, Chen L, Zhang J, Li WF, Mao YP, Zhang Y, Liu LZ, Tian L, Lin AH, Sun Y and Ma J: Induction chemotherapy improved Long-term outcomes of patients with locoregionally advanced nasopharyngeal carcinoma: A propensity matched analysis of 5-year survival outcomes in the Era of intensity-modulated radiotherapy. J Cancer. 8:371–377. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Tan WL, Tan EH, Lim DW, Ng QS, Tan DS, Jain A and Ang MK: Advances in systemic treatment for nasopharyngeal carcinoma. Chin Clin Oncol. 5:212016. View Article : Google Scholar : PubMed/NCBI

4 

Kang M, Zhou P, Liao X, Xu M and Wang R: Prognostic value of masticatory muscle involvement in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy. Oral Oncol. 75:100–105. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Ren XY, Zhou GQ, Jiang W, Sun Y, Xu YF, Li YQ, Tang XR, Wen X, He QM, Yang XJ, et al: Low SFRP1 expression correlates with poor prognosis and promotes cell invasion by activating the Wnt/β-catenin signaling pathway in NPC. Cancer Prev Res (Phila). 8:968–977. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Tao Q and Chan AT: Nasopharyngeal carcinoma: Molecular pathogenesis and therapeutic developments. Expert Rev Mol Med. 9:1–24. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Sun R, Zhang Q, Guo L, Chen MY, Sun Y, Cao B and Sun J: HGF stimulates proliferation through the HGF/c-Met pathway in nasopharyngeal carcinoma cells. Oncol Lett. 3:1124–1128. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Low SY, Tan BS, Choo HL, Tiong KH, Khoo AS and Leong CO: Suppression of BCL-2 synergizes cisplatin sensitivity in nasopharyngeal carcinoma cells. Cancer Lett. 314:166–175. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Lakhanpal M, Singh LC, Rahman T, Sharma J, Singh MM, Kataki AC, Verma S, Chauhan PS, Singh YM, Wajid S, et al: Contribution of susceptibility locus at HLA class I region and environmental factors to occurrence of nasopharyngeal cancer in Northeast India. Tumour Biol. 36:3061–3073. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Cao Y, Miao XP, Huang MY, Deng L, Hu LF, Ernberg I, Zeng YX, Lin DX and Shao JY: Polymorphisms of XRCC1 genes and risk of nasopharyngeal carcinoma in the Cantonese population. BMC Cancer. 6:1672006. View Article : Google Scholar : PubMed/NCBI

11 

Vercauteren SM, Sung S, Starczynowski DT, Lam WL, Bruyere H, Horsman DE, Tsang P, Leitch H and Karsan A: Array comparative genomic hybridization of peripheral blood granulocytes of patients with myelodysplastic syndrome detects karyotypic abnormalities. Am J Clin Pathol. 134:119–126. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Zhang W, Guo Z, Wang W, Sun Y, Zhang C, Wang X, Zhang L and Wang C: Application of single nucleotide polymorphism microarray and fluorescence in situ hybridization analysis for the prenatal diagnosis of a case with Pallister-Killian syndrome. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 35:232–235. 2018.(In Chinese). PubMed/NCBI

13 

Liu K, Kang M, Li J, Qin W and Wang R: Prognostic value of the mRNA expression of members of the HSP90 family in non-small cell lung cancer. Exp Ther Med. 17:2657–2665. 2019.PubMed/NCBI

14 

Chen F, Shen C, Wang X, Wang H, Liu Y, Yu C, Lv J, He J and Wen Z: Identification of genes and pathways in nasopharyngeal carcinoma by bioinformatics analysis. Oncotarget. 8:63738–63749. 2017.PubMed/NCBI

15 

Meng C, Shen X and Jiang W: Potential biomarkers of HCC based on gene expression and DNA methylation profiles. Oncol Lett. 16:3183–3192. 2018.PubMed/NCBI

16 

Dodd LE, Sengupta S, Chen IH, den Boon JA, Cheng YJ, Westra W, Newton MA, Mittl BF, McShane L, Chen CJ, et al: Genes involved in DNA repair and nitrosamine metabolism and those located on chromosome 14q32 are dysregulated in nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 15:2216–2225. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Hu C, Wei W, Chen X, Woodman CB, Yao Y, Nicholls JM, Joab I, Sihota SK, Shao JY, Derkaoui KD, et al: A global view of the oncogenic landscape in nasopharyngeal carcinoma: An integrated analysis at the genetic and expression levels. PLoS One. 7:e410552012. View Article : Google Scholar : PubMed/NCBI

18 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al: NCBI GEO: Archive for functional genomics data sets-update. Nucleic Acids Res. 41(Database Issue): D991–D995. 2013.PubMed/NCBI

19 

Gene Ontology Consortium: The gene ontology (GO) project in 2006. Nucleic Acids Res. 34(Database Issue): D322–D326. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Kanehisa M, Sato Y, Kawashima M, Furumichi M and Tanabe M: KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res. 44:D457–D462. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic acids Res. 43(Database Issue): D447–D452. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Su G, Morris JH, Demchak B and Bader GD: Biological network exploration with Cytoscape 3. Curr Protoc Bioinformatics. 47:8.13.11–24. 2014. View Article : Google Scholar

23 

Zhai X, Yang Y, Wan J, Zhu R and Wu Y: Inhibition of LDH-A by oxamate induces G2/M arrest, apoptosis and increases radiosensitivity in nasopharyngeal carcinoma cells. Oncol Rep. 30:2983–2991. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Cao SM, Simons MJ and Qian CN: The prevalence and prevention of nasopharyngeal carcinoma in China. Chin J Cancer. 30:114–119. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Wei KR, Zheng RS, Zhang SW, Liang ZH, Li ZM and Chen WQ: Nasopharyngeal carcinoma incidence and mortality in China, 2013. Chin J Cancer. 36:902017. View Article : Google Scholar : PubMed/NCBI

26 

Brown NR, Korolchuk S, Martin MP, Stanley WA, Moukhametzianov R, Noble MEM and Endicott JA: CDK1 structures reveal conserved and unique features of the essential cell cycle CDK. Nat Commun. 6:67692015. View Article : Google Scholar : PubMed/NCBI

27 

Chua MLK, Wee JTS, Hui EP and Chan ATC: Nasopharyngeal carcinoma. Lancet. 387:1012–1024. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Johnson N, Li YC, Walton ZE, Cheng KA, Li D, Rodig SJ, Moreau LA, Unitt C, Bronson RT, Thomas HD, et al: Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. Nat Med. 17:875–882. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Kang J, Sergio CM, Sutherland RL and Musgrove EA: Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells. BMC Cancer. 14:322014. View Article : Google Scholar : PubMed/NCBI

30 

Wei-Shan H, Amit VC and Clarke DJ: Cell cycle regulation of condensin Smc4. Oncotarget. 10:263–276. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Zhou B, Yuan T, Liu M, Liu H, Xie J, Shen Y and Chen P: Overexpression of the structural maintenance of chromosome 4 protein is associated with tumor de-differentiation, advanced stage and vascular invasion of primary liver cancer. Oncol Rep. 28:1263–1268. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Feng XD, Song Q, Li CW, Chen J, Tang HM, Peng ZH and Wang XC: Structural maintenance of chromosomes 4 is a predictor of survival and a novel therapeutic target in colorectal cancer. Asian Pac J Cancer Prev. 15:9459–9465. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Morozumi Y, Boussouar F, Tan M, Chaikuad A, Jamshidikia M, Colak G, He H, Nie L, Petosa C, de Dieuleveult M, et al: Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells. J Mol Cell Biol. 8:349–362. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Caron C, Lestrat C, Marsal S, Escoffier E, Curtet S, Virolle V, Barbry P, Debernardi A, Brambilla C, Brambilla E, et al: Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers. Oncogene. 29:5171–5181. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Wu G, Liu H, He H, Wang Y, Lu X, Yu Y, Xia S, Meng X and Liu Y: miR-372 down-regulates the oncogene ATAD2 to influence hepatocellular carcinoma proliferation and metastasis. BMC Cancer. 14:1072014. View Article : Google Scholar : PubMed/NCBI

36 

Wan WN, Zhang YX, Wang XM, Liu YJ, Zhang YQ, Que YH and Zhao WJ: ATAD2 is highly expressed in ovarian carcinomas and indicates poor prognosis. Asian Pac J Cancer Prev. 15:2777–2783. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Takahashi S, Fusaki N, Ohta S, Iwahori Y, Iizuka Y, Inagawa K, Kawakami Y, Yoshida K and Toda M: Downregulation of KIF23 suppresses glioma proliferation. J Neurooncol. 106:519–529. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Fischer M, Grundke I, Sohr S, Quaas M, Hoffmann S, Knörck A, Gumhold C and Rother K: p53 and cell cycle dependent transcription of kinesin family member 23 (KIF23) is controlled via a CHR promoter element bound by DREAM and MMB complexes. PLoS One. 8:e631872013. View Article : Google Scholar : PubMed/NCBI

39 

Zhou H, Kuang J, Zhong L, Kuo WL, Gray JW, Sahin A, Brinkley BR and Sen S: Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet. 20:189–193. 1998. View Article : Google Scholar : PubMed/NCBI

40 

Katayama H, Sasai K, Kawai H, Yuan ZM, Bondaruk J, Suzuki F, Fujii S, Arlinghaus RB, Czerniak BA and Sen S: Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat Genet. 36:55–62. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Li J, Hong MJ, Chow JP, Man WY, Mak JP, Ma HT and Poon RY: Co-inhibition of polo-like kinase 1 and Aurora kinases promotes mitotic catastrophe. Oncotarget. 6:9327–9340. 2015.PubMed/NCBI

42 

Ertych N, Stolz A, Stenzinger A, Weichert W, Kaulfuß S, Burfeind P, Aigner A, Wordeman L and Bastians H: Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells. Nat Cell Biol. 16:779–791. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Katsha A, Soutto M, Sehdev V, Peng D, Washington MK, Piazuelo MB, Tantawy MN, Manning HC, Lu P, Shyr Y, et al: Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia. Gastroenterology. 145:1312–1322.e1-e8. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Wang XX, Liu R, Jin SQ, Fan FY and Zhan QM: Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell carcinoma cell line. Cell Res. 16:356–366. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Dutta-Simmons J, Zhang Y, Gorgun G, Gatt M, Mani M, Hideshima T, Takada K, Carlson NE, Carrasco DE, Tai YT, et al: Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression. Blood. 114:2699–2708. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Li JJ, Weroha SJ, Lingle WL, Papa D, Salisbury JL and Li SA: Estrogen mediates Aurora-A overexpression, centrosome amplification, chromosomal instability, and breast cancer in female ACI rats. Proc Natl Acad Sci USA. 101:18123–18128. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Zou Z, Yuan Z, Zhang Q, Long Z, Chen J, Tang Z, Zhu Y, Chen S, Xu J, Yan M, et al: Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells. Autophagy. 8:1798–1810. 2012. View Article : Google Scholar : PubMed/NCBI

48 

Park HS, Park WS, Bondaruk J, Tanaka N, Katayama H, Lee S, Spiess PE, Steinberg JR, Wang Z, Katz RL, et al: Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detection. J Natl Cancer Inst. 100:1401–1411. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Sarfraz S, Hamid S, Ali S, Jafri W and Siddiqui AA: Modulations of cell cycle checkpoints during HCV associated disease. BMC Infect Dis. 9:1252009. View Article : Google Scholar : PubMed/NCBI

50 

Kops GJ, Kim Y, Weaver BA, Mao Y, McLeod I, Yates JR III, Tagaya M and Cleveland DW: ZW10 links mitotic checkpoint signaling to the structural kinetochore. J Cell Biol. 169:49–60. 2005. View Article : Google Scholar : PubMed/NCBI

51 

Zhang X, Xiao D, Wang Z, Zou Y, Huang L, Lin W, Deng Q, Pan H, Zhou J, Liang C and He J: MicroRNA-26a/b regulate DNA replication licensing, tumorigenesis, and prognosis by targeting CDC6 in lung cancer. Mol Cancer Res. 12:1535–1546. 2014. View Article : Google Scholar : PubMed/NCBI

52 

Wang H, Bierie B, Li AG, Pathania S, Toomire K, Dimitrov SD, Liu B, Gelman R, Giobbie-Hurder A, Feunteun J, et al: BRCA1/FANCD2/BRG1-Driven DNA repair stabilizes the differentiation state of human mammary epithelial cells. Mol Cell. 63:277–292. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Lu JH, Liao WT, Lee CH, Chang KL, Ke HL and Yu HS: ΔNp63 promotes abnormal epidermal proliferation in arsenical skin cancers. Toxicol In Vitro. 53:57–66. 2018. View Article : Google Scholar : PubMed/NCBI

54 

Wu Z, Wang S, Jiang F, Li Q, Wang C, Wang H, Zhang W, Xue P and Wang SL: Mass spectrometric detection combined with bioinformatic analysis identified possible protein markers and key pathways associated with bladder cancer. Gene. 626:407–413. 2017. View Article : Google Scholar : PubMed/NCBI

55 

Zhang HJ, Tao J, Sheng L, Hu X, Rong RM, Xu M and Zhu TY: Twist2 promotes kidney cancer cell proliferation and invasion by regulating ITGA6 and CD44 expression in the ECM-receptor interaction pathway. Onco Targets Ther. 9:1801–1812. 2016.PubMed/NCBI

56 

Xu M, Bower KA, Chen G, Shi X, Dong Z, Ke Z and Luo J: Ethanol enhances the interaction of breast cancer cells over-expressing ErbB2 with fibronectin. Alcohol Clin Exp Res. 34:751–760. 2010. View Article : Google Scholar : PubMed/NCBI

57 

Ni Z and Yi J: Oxymatrine induces nasopharyngeal cancer cell death through inhibition of PI3K/AKT and NF-κB pathways. Mol Med Rep. 16:9701–9706. 2017. View Article : Google Scholar : PubMed/NCBI

58 

Liu X, Takano C, Shimizu T, Yokobe S, Abe-Kanoh N, Zhu B, Nakamura T, Munemasa S, Murata Y and Nakamura Y: Inhibition of phosphatidylinositide 3-kinase ameliorates antiproliferation by benzyl isothiocyanate in human colon cancer cells. Biochem Biophys Res Commun. 491:209–216. 2017. View Article : Google Scholar : PubMed/NCBI

59 

Kaushik S, Shyam H, Sharma R and Balapure AK: Dietary isoflavone daidzein synergizes centchroman action via induction of apoptosis and inhibition of PI3K/Akt pathway in MCF-7/MDA MB-231 human breast cancer cells. Phytomedicine. 40:116–124. 2018. View Article : Google Scholar : PubMed/NCBI

60 

Huang Y, Hua K, Zhou X, Jin H, Chen X, Lu X, Yu Y, Zha X and Feng Y: Activation of the PI3K/AKT pathway mediates FSH-stimulated VEGF expression in ovarian serous cystadenocarcinoma. Cell Res. 18:780–791. 2008. View Article : Google Scholar : PubMed/NCBI

61 

Chen X, Yan CC, Zhang X and You ZH: Long non-coding RNAs and complex diseases: From experimental results to computational models. Brief Bioinform. 18:558–576. 2017.PubMed/NCBI

62 

Chen X and Yan GY: Novel human lncRNA-disease association inference based on lncRNA expression profiles. Bioinformatics. 29:2617–2624. 2013. View Article : Google Scholar : PubMed/NCBI

63 

Chen X and Huang L: LRSSLMDA: Laplacian regularized sparse subspace learning for MiRNA-disease association prediction. PLoS Comput Biol. 13:e10059122017. View Article : Google Scholar : PubMed/NCBI

64 

Chen X, Xie D, Wang L, Zhao Q, You ZH and Liu H: BNPMDA: Bipartite Network projection for MiRNA-disease association prediction. Bioinformatics. 34:3178–3186. 2018. View Article : Google Scholar : PubMed/NCBI

65 

Chen X, Wang L, Qu J, Guan NN and Li JQ: Predicting miRNA-disease association based on inductive matrix completion. Bioinformatics. 34:4256–4265. 2018.PubMed/NCBI

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Spandidos Publications style
Liu K, Kang M, Zhou Z, Qin W and Wang R: Bioinformatics analysis identifies hub genes and pathways in nasopharyngeal carcinoma. Oncol Lett 18: 3637-3645, 2019.
APA
Liu, K., Kang, M., Zhou, Z., Qin, W., & Wang, R. (2019). Bioinformatics analysis identifies hub genes and pathways in nasopharyngeal carcinoma. Oncology Letters, 18, 3637-3645. https://doi.org/10.3892/ol.2019.10707
MLA
Liu, K., Kang, M., Zhou, Z., Qin, W., Wang, R."Bioinformatics analysis identifies hub genes and pathways in nasopharyngeal carcinoma". Oncology Letters 18.4 (2019): 3637-3645.
Chicago
Liu, K., Kang, M., Zhou, Z., Qin, W., Wang, R."Bioinformatics analysis identifies hub genes and pathways in nasopharyngeal carcinoma". Oncology Letters 18, no. 4 (2019): 3637-3645. https://doi.org/10.3892/ol.2019.10707
Copy and paste a formatted citation
x
Spandidos Publications style
Liu K, Kang M, Zhou Z, Qin W and Wang R: Bioinformatics analysis identifies hub genes and pathways in nasopharyngeal carcinoma. Oncol Lett 18: 3637-3645, 2019.
APA
Liu, K., Kang, M., Zhou, Z., Qin, W., & Wang, R. (2019). Bioinformatics analysis identifies hub genes and pathways in nasopharyngeal carcinoma. Oncology Letters, 18, 3637-3645. https://doi.org/10.3892/ol.2019.10707
MLA
Liu, K., Kang, M., Zhou, Z., Qin, W., Wang, R."Bioinformatics analysis identifies hub genes and pathways in nasopharyngeal carcinoma". Oncology Letters 18.4 (2019): 3637-3645.
Chicago
Liu, K., Kang, M., Zhou, Z., Qin, W., Wang, R."Bioinformatics analysis identifies hub genes and pathways in nasopharyngeal carcinoma". Oncology Letters 18, no. 4 (2019): 3637-3645. https://doi.org/10.3892/ol.2019.10707
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