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Long non‑coding RNA mortal obligate RNA transcript suppresses tumor cell proliferation in prostate carcinoma by inhibiting glucose uptake

  • Authors:
    • Zhenfeng Shi
    • Feng Guo
    • Deyong Jia
    • Jinxing Huang
    • Jie Chen
    • Min Sun
    • Feibo Qi
    • Chengyuan Liang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The People's Hospital of Xinjiang Uyghur Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region 830002, P.R. China, Department of Urology, University of Washington, Seattle, WA 98109, USA, Department of Urology, The People's Hospital of Shache County, Kashi, Xinjiang Uygur Autonomous Region 844700, P.R. China, Department of Radiography, The People's Hospital of Xinjiang Uyghur Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region 830002, P.R. China, Department of Pharmacy, Shaanxi University of Science and Technology, Xi'an, Shaanxi 710021, P.R. China
    Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3787-3791
    |
    Published online on: August 5, 2019
       https://doi.org/10.3892/ol.2019.10711
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Abstract

A previous study reported the decreased expression of long non‑coding RNA mortal obligate RNA transcript (lncRNA MORT) in 16 types of cancer, while the functionality of lncRNA MORT in cancer biology remains unknown. Therefore, the present study was conducted to characterize the functionality of lncRNA MORT in prostate carcinoma, a common cancer type worldwide. lncRNA MORT expression level was downregulated in tumor tissues compared with that in the adjacent healthy tissues of patients with prostate carcinoma. Expression of lncRNA MORT in tumor tissues was influenced by tumor size, but not by tumor metastasis. Overexpression of lncRNA MORT inhibited glucose uptake and glucose transporter 1 (GLUT‑1) expression in prostate carcinoma cell lines; GLUT‑1 overexpression upregulated glucose uptake and attenuated the effects of lncRNA MORT overexpression on glucose uptake, but did not significantly affect the expression of lncRNA MORT. Overexpression of lncRNA MORT inhibited, while GLUT‑1 overexpression promoted the proliferation of prostate carcinoma cells. In addition, GLUT‑1 overexpression attenuated the effects of lncRNA MORT on cell proliferation. Therefore, lncRNA MORT may inhibit cancer cell proliferation in prostate carcinoma by preventing glucose uptake.
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Copy and paste a formatted citation
Spandidos Publications style
Shi Z, Guo F, Jia D, Huang J, Chen J, Sun M, Qi F and Liang C: Long non‑coding RNA mortal obligate RNA transcript suppresses tumor cell proliferation in prostate carcinoma by inhibiting glucose uptake. Oncol Lett 18: 3787-3791, 2019.
APA
Shi, Z., Guo, F., Jia, D., Huang, J., Chen, J., Sun, M. ... Liang, C. (2019). Long non‑coding RNA mortal obligate RNA transcript suppresses tumor cell proliferation in prostate carcinoma by inhibiting glucose uptake. Oncology Letters, 18, 3787-3791. https://doi.org/10.3892/ol.2019.10711
MLA
Shi, Z., Guo, F., Jia, D., Huang, J., Chen, J., Sun, M., Qi, F., Liang, C."Long non‑coding RNA mortal obligate RNA transcript suppresses tumor cell proliferation in prostate carcinoma by inhibiting glucose uptake". Oncology Letters 18.4 (2019): 3787-3791.
Chicago
Shi, Z., Guo, F., Jia, D., Huang, J., Chen, J., Sun, M., Qi, F., Liang, C."Long non‑coding RNA mortal obligate RNA transcript suppresses tumor cell proliferation in prostate carcinoma by inhibiting glucose uptake". Oncology Letters 18, no. 4 (2019): 3787-3791. https://doi.org/10.3892/ol.2019.10711
Copy and paste a formatted citation
x
Spandidos Publications style
Shi Z, Guo F, Jia D, Huang J, Chen J, Sun M, Qi F and Liang C: Long non‑coding RNA mortal obligate RNA transcript suppresses tumor cell proliferation in prostate carcinoma by inhibiting glucose uptake. Oncol Lett 18: 3787-3791, 2019.
APA
Shi, Z., Guo, F., Jia, D., Huang, J., Chen, J., Sun, M. ... Liang, C. (2019). Long non‑coding RNA mortal obligate RNA transcript suppresses tumor cell proliferation in prostate carcinoma by inhibiting glucose uptake. Oncology Letters, 18, 3787-3791. https://doi.org/10.3892/ol.2019.10711
MLA
Shi, Z., Guo, F., Jia, D., Huang, J., Chen, J., Sun, M., Qi, F., Liang, C."Long non‑coding RNA mortal obligate RNA transcript suppresses tumor cell proliferation in prostate carcinoma by inhibiting glucose uptake". Oncology Letters 18.4 (2019): 3787-3791.
Chicago
Shi, Z., Guo, F., Jia, D., Huang, J., Chen, J., Sun, M., Qi, F., Liang, C."Long non‑coding RNA mortal obligate RNA transcript suppresses tumor cell proliferation in prostate carcinoma by inhibiting glucose uptake". Oncology Letters 18, no. 4 (2019): 3787-3791. https://doi.org/10.3892/ol.2019.10711
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