Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2019 Volume 18 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2019 Volume 18 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Nomogram for predicting the survival of patients with malignant melanoma: A population analysis

  • Authors:
    • Jin Yang
    • Zhenyu Pan
    • Quan Zhou
    • Qingqing Liu
    • Fanfan Zhao
    • Xiaojie Feng
    • Jun Lyu
  • View Affiliations / Copyright

    Affiliations: Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Science and Education, The First People's Hospital of Changde City, Changde, Hunan 415003, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3591-3598
    |
    Published online on: August 6, 2019
       https://doi.org/10.3892/ol.2019.10720
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the current study was to develop and validate a nomogram based on a large population to estimate the 3‑ and 5‑year survival rates of patients with malignant melanoma (MM). Patients were selected from the Surveillance, Epidemiology and End Results database and randomly divided into the training and validation cohorts. A nomogram was developed, and was used to assess the accuracy of the model. Independent prognostic factors associated with overall survival (OS) rate were identified through multivariate analysis, and were included in the internal validation of the nomogram. The nomogram provided high C‑indexes for the training cohort [area under the time‑dependent receiver operating characteristic curve (AUC) of 0.877 for 3‑year OS rate and 0.872 for 5‑year OS rate] and the validation cohort (AUC of 0.880 for 3‑year OS rate and 0.874 for 5‑year OS rate), indicating that the model had good discrimination ability. Calibration plots showed that the predicted 3‑ and 5‑year OS rates probabilities for the training and validation groups were almost identical to the actual observations. The 3‑ and 5‑year decision curves indicated net benefits for both the training and validation cohorts. The nomogram may aid clinicians to provide more accurate prognosis prediction in patient consultations and more personalized postoperative management plans.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Bhandaru M, Ardekani GS, Zhang G, Martinka M, McElwee KJ, Li G and Rotte A: A combination of p300 and Braf expression in the diagnosis and prognosis of melanoma. BMC Cancer. 14:3982014. View Article : Google Scholar : PubMed/NCBI

2 

Berrocal A, Cabañas L, Espinosa E, Fernández-de-Misa R, Martín-Algarra S, Martínez-Cedres JC, Ríos-Buceta L and Rodríguez-Peralto JL: Melanoma: Diagnosis, staging, and treatment. consensus group recommendations. Adv Ther. 31:945–960. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Mishra H, Mishra PK, Ekielski A, Jaggi M, Iqbal Z and Talegaonkar S: Melanoma treatment: From conventional to nanotechnology. J Cancer Res Clin Oncol. 144:2283–2302. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Zhang M and Zhang N: Clinical and prognostic factors in 98 patients with malignant melanoma in China. J Int Med Res. 45:1369–1377. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Wan X, Zhu Y, Zhang L and Hou W: Gefitinib inhibits malignant melanoma cells through the VEGF/AKT signaling pathway. Mol Med Rep. 17:7351–7355. 2018.PubMed/NCBI

6 

Kang X, Zeng Y, Liang J, Li J, Ren D, Chai L, Sun Z, Yu S, Wu X, Han W and Wang W: Aberrations and clinical significance of BRAF in malignant melanoma. Medicine. 97:e95092018. View Article : Google Scholar : PubMed/NCBI

7 

You H, Yang J, Liu Q, Tang L, Bu Q, Pan Z and Lyu J: The impact of the lymph node density on overall survival in patients with Wilms' tumor: A SEER analysis. Cancer Manag Res. 10:671–677. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Duggan MA, Anderson WF, Altekruse S, Penberthy L and Sherman ME: The surveillance, epidemiology, and end results (SEER) program and pathology. Am J Surg Pathol. 40:e94–e102. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Healy MA, Morris AM, Abrahamse P, Ward KC, Kato I and Veenstra CM: The accuracy of chemotherapy ascertainment among colorectal cancer patients in the surveillance, epidemiology, and end results registry program. BMC Cancer. 18:4812018. View Article : Google Scholar : PubMed/NCBI

10 

Cao J, Yuan P, Wang L, Wang Y, Ma H, Yuan X, Lv W and Hu J: Clinical nomogram for predicting survival of esophageal cancer patients after esophagectomy. Sci Rep. 6:266842016. View Article : Google Scholar : PubMed/NCBI

11 

Sun W, Jiang YZ, Liu YR, Ma D and Shao ZM: Nomograms to estimate long-term overall survival and breast cancer-specific survival of patients with luminal breast cancer. Oncotarget. 7:20496–20506. 2016.PubMed/NCBI

12 

Abu-Rustum NR, Zhou Q, Gomez JD, Alektiar KM, Hensley ML, Soslow RA, Levine DA, Chi DS, Barakat RR and Iasonos A: A nomogram for predicting overall survival of women with endometrial cancer following primary therapy: Toward improving individualized cancer care. Gynecol Oncol. 116:399–403. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Iasonos A, Schrag D, Raj GV and Panageas KS: How to build and interpret a nomogram for cancer prognosis. J Clin Oncol. 26:1364–1370. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Weiser MR, Landmann RG, Kattan MW, Gonen M, Shia J, Chou J, Paty PB, Guillem JG, Temple LK, Schrag D, et al: Individualized prediction of colon cancer recurrence using a nomogram. J Clin Oncol. 26:380–385. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Ohori Tatsuo Gondo, Riu Hamada M, Gondo T and Hamada R: Nomogram as predictive model in clinical practice. Gan To Kagaku Ryoho. 6:901–906. 2009.(In Japanese).

16 

Han DS, Suh YS, Kong SH, Lee HJ, Choi Y, Aikou S, Sano T, Park BJ, Kim WH and Yang HK: Nomogram predicting long-term survival after d2 gastrectomy for gastric cancer. J Clin Oncol. 30:3834–3840. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Albert JM, Liu DD, Shen Y, Pan IW, Shih YC, Hoffman KE, Buchholz TA, Giordano SH and Smith BD: Nomogram to predict the benefit of radiation for older patients with breast cancer treated with conservative surgery. J Clin Oncol. 30:2837–2843. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Wang Y, Li J, Xia Y, Gong R, Wang K, Yan Z, Wan X, Liu G, Wu D, Shi L, et al: Prognostic nomogram for intrahepatic cholangiocarcinoma after partial hepatectomy. J Clin Oncol. 31:1188–1195. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Mariani P, Dureau S, Savignoni A, Rouic LL, Levy-Gabriel C, Piperno-Neumann S, Rodrigues MJ, Desjardins L, Cassoux N and Servois V: Development of a prognostic nomogram for liver metastasis of uveal melanoma patients selected by liver MRI. Cancers (Basel). 11(pii): E8632019. View Article : Google Scholar : PubMed/NCBI

20 

Woods JF, De Marchi JA, Lowery AJ and Hill AD: Validation of a nomogram predicting sentinel lymph node status in melanoma in an Irish population. Ir J Med Sci. 184:769–773. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Yang J, Pan Z, Zhao F, Feng X, Liu Q, Li Y and Lyu J: A nomogram for predicting survival in patients with nodular melanoma: A population-based study. Medicine (Baltimore). 98:e160592019. View Article : Google Scholar : PubMed/NCBI

22 

Kavuluru R, Hands I, Durbin EB and Witt L: Automatic extraction of ICD-O-3 primary sites from cancer pathology reports. AMIA Jt Summits Transl Sci Proc 2013. 112–116. 2013.

23 

Harrell FE Jr, Lee KL and Mark DB: Multivariable prognostic models: Issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med. 15:361–387. 1996. View Article : Google Scholar : PubMed/NCBI

24 

Hu Y, You S, Yang Z and Cheng S: Nomogram predicting survival of hepatocellular carcinoma with portal vein tumour thrombus after curative resection. ANZ J Surg. 89:E20–E25. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Vickers AJ and Elkin EB: Decision curve analysis: A novel method for evaluating prediction models. Med Decis Making. 26:565–574. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Rousson V and Zumbrunn T: Decision curve analysis revisited: Overall net benefit, relationships to ROC curve analysis, and application to case-control studies. BMC Med Inform Decis Mak. 11:452011. View Article : Google Scholar : PubMed/NCBI

27 

Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, Meyer L, Gress DM, Byrd DR and Winchester DP: The eighth edition AJCC cancer staging manual: Continuing to build a bridge from a population-based to a more ‘personalized’ approach to cancer staging. CA Cancer J Clin. 67:93–99. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Mou K, Ding M, Han D, Zhou Y, Mu X, Liu W and Wang L: miR-590-5p inhibits tumor growth in malignant melanoma by suppressing YAP1 expression. Oncol Rep. 40:2056–2066. 2018.PubMed/NCBI

29 

Shen W, Sakamoto N and Yang L: Melanoma-specific mortality and competing mortality in patients with non-metastatic malignant melanoma: A population-based analysis. BMC Cancer. 16:4132016. View Article : Google Scholar : PubMed/NCBI

30 

Xu XL, Cheng H, Tang MS, Zhang HL, Wu RY, Yu Y, Li X, Wang XM, Mai J, Yang CL, et al: A novel nomogram based on LODDS to predict the prognosis of epithelial ovarian cancer. Oncotarget. 8:8120–8130. 2017.PubMed/NCBI

31 

Cai BB, Shi KQ, Li P, Chen BC, Shi L, Johnson PJ, Lai P, Toyoda H and Zhou MT: A nomogram integrating hepatic reserve and tumor characteristics for hepatocellular carcinoma following curative liver resection. Clin Chim Acta. 485:187–194. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Zhang W, Hong HJ and Chen YL: Establishment of a gallbladder cancer-specific survival model to predict prognosis in non-metastatic gallbladder cancer patients after surgical resection. Dig Dis Sci. 63:2251–2258. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Pietrantonio F, Barretta F, Fanotto V, Park SH, Morano F, Fucà G, Niger M, Prisciandaro M, Silvestris N, Bergamo F, et al: Estimating survival probabilities of advanced gastric cancer patients in the second-line setting: The gastric life nomogram. Oncology. 95:344–352. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Ribero S, Stucci LS, Marra E, Marconcini R, Spagnolo F, Orgiano L, Picasso V, Queirolo P, Palmieri G, Quaglino P and Bataille V: Effect of age on melanoma risk, prognosis and treatment response. Acta Derm Venereol. 98:624–629. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Reyes Ortiz CA, Freeman JL, Kuo YF and Goodwin JS: The influence of marital status on stage at diagnosis and survival of older persons with melanoma. J Gerontol A Biol Sci Med Sci. 62:892–898. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Jiang AJ, Rambhatla PV and Eide MJ: A systematic review of socioeconomic and lifestyle factors and melanoma. Br J Derm. 74:885–915. 2014.

37 

McLaughlin JM, Fisher JL and Paskett ED: Marital status and stage at diagnosis of cutaneous melanoma: Results from the surveillance epidemiology and end results (SEER) program, 1973–2006. Cancer. 117:1984–1993. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Arce PM, Camilon PR, Stokes WA, Nguyen SA and Lentsch EJ: Is sex an independent prognostic factor in cutaneous head and neck melanoma? Laryngoscope. 124:1363–1367. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Vaithinathan AG and Asokan V: Public health and precision medicine share a goal. J Evid Based Med. 10:76–80. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang J, Pan Z, Zhou Q, Liu Q, Zhao F, Feng X and Lyu J: Nomogram for predicting the survival of patients with malignant melanoma: A population analysis. Oncol Lett 18: 3591-3598, 2019.
APA
Yang, J., Pan, Z., Zhou, Q., Liu, Q., Zhao, F., Feng, X., & Lyu, J. (2019). Nomogram for predicting the survival of patients with malignant melanoma: A population analysis. Oncology Letters, 18, 3591-3598. https://doi.org/10.3892/ol.2019.10720
MLA
Yang, J., Pan, Z., Zhou, Q., Liu, Q., Zhao, F., Feng, X., Lyu, J."Nomogram for predicting the survival of patients with malignant melanoma: A population analysis". Oncology Letters 18.4 (2019): 3591-3598.
Chicago
Yang, J., Pan, Z., Zhou, Q., Liu, Q., Zhao, F., Feng, X., Lyu, J."Nomogram for predicting the survival of patients with malignant melanoma: A population analysis". Oncology Letters 18, no. 4 (2019): 3591-3598. https://doi.org/10.3892/ol.2019.10720
Copy and paste a formatted citation
x
Spandidos Publications style
Yang J, Pan Z, Zhou Q, Liu Q, Zhao F, Feng X and Lyu J: Nomogram for predicting the survival of patients with malignant melanoma: A population analysis. Oncol Lett 18: 3591-3598, 2019.
APA
Yang, J., Pan, Z., Zhou, Q., Liu, Q., Zhao, F., Feng, X., & Lyu, J. (2019). Nomogram for predicting the survival of patients with malignant melanoma: A population analysis. Oncology Letters, 18, 3591-3598. https://doi.org/10.3892/ol.2019.10720
MLA
Yang, J., Pan, Z., Zhou, Q., Liu, Q., Zhao, F., Feng, X., Lyu, J."Nomogram for predicting the survival of patients with malignant melanoma: A population analysis". Oncology Letters 18.4 (2019): 3591-3598.
Chicago
Yang, J., Pan, Z., Zhou, Q., Liu, Q., Zhao, F., Feng, X., Lyu, J."Nomogram for predicting the survival of patients with malignant melanoma: A population analysis". Oncology Letters 18, no. 4 (2019): 3591-3598. https://doi.org/10.3892/ol.2019.10720
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team