Q-PTP is an optimized technology of 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser in the laser therapy of melasma: A prospective split-face study

Guo,Xiaorui; Cai,Xiaojian; Jin,Yudan; Zhang,Taohua; Wang,Bulin; Li,Qin

doi:10.3892/ol.2019.10743

Q-PTP is an optimized technology of 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser in the laser therapy of melasma: A prospective split-face study

Authors:
- Xiaorui Guo
- Xiaojian Cai
- Yudan Jin
- Taohua Zhang
- Bulin Wang
- Qin Li
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Affiliations: Plastic Surgery, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Laser Cosmetics and Plastic Surgery, Zhongshan Second People's Hospital, Zhongshan, Guangdong 528400, P.R. China
Published online on: August 14, 2019 https://doi.org/10.3892/ol.2019.10743
Pages: 4136-4143
Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Quickly-pulse-to-pulse (Q-PTP) is the latest dual pulse mode Q-switched neodymium-doped yttrium aluminum garnet [QS Nd:YAG (QSNY)] laser technology that improves efficacy and minimizes side effects. In this study, the safety, efficacy, and advantages of Q-PTP and single-pulse laser mode of 1064-nm QSNY in the treatment of melasma were compared. Twelve healthy women were enrolled in this split-face study. Q-PTP and single-pulse laser mode of 1064-nm QSNY were applied to the treatment side and the control side, respectively. Physician's global assessment, patients' self-assessment and the modified melasma area and severity index (mMASI) scores were used to quantify pigmentation changes. Side effects were recorded. Mean mMASI scores were decreased significantly at the 4th and 12th-week follow‑up visit compared to the baseline. Melasma lesion clearance was more than 50% in 58% of patients compared with the baseline. However, both sides of the same patient showed similar therapeutic effect. Minor pain experience and slighter skin erythema reaction were reported in Q-PTP laser mode treatment side compared with the control. No serious complications were found in any of the patients. Q-PTP laser mode of 1064-nm QSNY is an optimal laser therapy in the treatment of melasma with greater safety and superiority.

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