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Review Open Access

Prospective applications of microRNAs in oral cancer (Review)

  • Authors:
    • Chuan Fang
    • Yadong Li
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China
    Copyright: © Fang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3974-3984
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    Published online on: August 16, 2019
       https://doi.org/10.3892/ol.2019.10751
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Abstract

MicroRNAs (miRNAs) are non‑coding RNA molecules that are generally encoded by endogenous genes and exert suppressive effects on post‑transcriptional regulation of their target genes by translation repression or degradation of mRNA. This subsequently mediates activation or blocking of downstream signaling pathways associated with oral malignancies. Aberrant levels of certain miRNAs have been identified in cell experiments, clinical carcinomatous specimens, saliva, serum or plasma samples of patients with oral malignancies. miRNAs are associated with multiple aspects of oral cancer, including tumor growth, cellular proliferation, apoptosis, migration, invasion, metastasis, glycometabolism, radiosensitivity and chemosensitivity. miRNAs have the potential to be used in clinical applications as minimally invasive or non‑invasive tools for early diagnosis and prognosis by the detection of serum, plasma and saliva levels, and may provide a new ancillary or additional reference index of traditional pathological grading and clinical staging. Furthermore, miRNAs may be used as prognostic biomarkers or targets for novel therapies for oral cancer.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Montero PH and Patel SG: Cancer of the oral cavity. Surg Oncol Clin N Am. 24:491–508. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Zhong LP, Zhang CP, Ren GX, Guo W, William WN Jr, Sun J, Zhu HG, Tu WY, Li J, Cai YL, et al: Randomized phase III trial of induction chemotherapy with docetaxel, cisplatin, and fluorouracil followed by surgery versus up-front surgery in locally advanced resectable oral squamous cell carcinoma. J Clin Oncol. 31:744–751. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Sadighi S, Keyhani A, Harirchi I, Garajei A, Aghili M, Kazemian A, Motiee Langroudi M, Zendehdel K and Nikparto N: Neoadjuvant chemotherapy for locally advanced squamous carcinoma of oral cavity: A pilot study. Acta Med Iran. 53:380–386. 2015.PubMed/NCBI

6 

Bossi P, Lo Vullo S, Guzzo M, Mariani L, Granata R, Orlandi E, Locati L, Scaramellini G, Fallai C and Licitra L: Preoperative chemotherapy in advanced resectable OCSCC: Long-term results of a randomized phase III trial. Ann Oncol. 25:462–466. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Valdez JA and Brennan MT: Impact of oral cancer on quality of life. Dent Clin North Am. 62:143–154. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Rupaimoole R and Slack FJ: MicroRNA therapeutics: Towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 16:203–222. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Anastasiadou E, Jacob LS and Slack FJ: Non-coding RNA networks in cancer. Nat Rev Cancer. 18:5–18. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Chen Y, Cao XY, Li YN, Qiu YY, Li YN, Li W and Wang H: Reversal of cisplatin resistance by microRNA-139-5p-independent RNF2 downregulation and MAPK inhibition in ovarian cancer. Am J Physiol Cell Physiol. 315:C225–C235. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Gong R, Lv X and Liu F: MiRNA-17 encoded by the miR-17-92 cluster increases the potential for steatosis in hepatoma cells by targeting CYP7A1. Cell Mol Biol Lett. 23:162018. View Article : Google Scholar : PubMed/NCBI

12 

Ruhl R, Rana S, Kelley K, Espinosa-Diez C, Hudson C, Lanciault C, Thomas CR Jr, Liana Tsikitis V and Anand S: MicroRNA-451a regulates colorectal cancer proliferation in response to radiation. BMC Cancer. 18:5172018. View Article : Google Scholar : PubMed/NCBI

13 

Yang Y, Sun Y, Wang H, Li H, Zhang M, Zhou L, Meng X, Wu Y, Liu P, Liu X, et al: MicroRNA-221 induces autophagy through suppressing HDAC6 expression and promoting apoptosis in pancreatic cancer. Oncol Lett. 16:7295–7301. 2018.PubMed/NCBI

14 

Anastasiadou E, Stroopinsky D, Alimperti S, Jiao AL, Pyzer AR, Cippitelli C, Pepe G, Severa M, Rosenblatt J, Etna MP, et al: Epstein-Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas. Leukemia. 33:132–147. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Anastasiadou E, Faggioni A, Trivedi P and Slack FJ: The nefarious nexus of noncoding RNAs in cancer. Int J Mol Sci. 19:20722018. View Article : Google Scholar

16 

Lu L, Xue X, Lan J, Gao Y, Xiong Z, Zhang H, Jiang W, Song W and Zhi Q: MicroRNA-29a upregulates MMP2 in oral squamous cell carcinoma to promote cancer invasion and anti-apoptosis. Biomed Pharmacother. 68:13–19. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Xu Q, Sun Q, Zhang J, Yu J, Chen W and Zhang Z: Downregulation of miR-153 contributes to epithelial-mesenchymal transition and tumor metastasis in human epithelial cancer. Carcinogenesis. 34:539–549. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Arantes LMRB, De Carvalho AC, Melendez ME and Lopes Carvalho A: Serum, plasma and saliva biomarkers for head and neck cancer. Expert Rev Mol Diagn. 18:85–112. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Chai L, Yuan Y, Chen C, Zhou J and Wu Y: The role of long non-coding RNA ANRIL in the carcinogenesis of oral cancer by targeting miR-125a. Biomed Pharmacother. 103:38–45. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Ha M and Kim VN: Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol. 15:509–524. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, Lee J, Provost P, Rådmark O, Kim S and Kim VN: The nuclear RNase III Drosha initiates microRNA processing. Nature. 425:415–419. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Chendrimada TP, Gregory RI, Kumaraswamy E, Norman J, Cooch N, Nishikura K and Shiekhattar R: TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature. 436:740–744. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Yeom KH, Lee Y, Han J, Suh MR and Kim VN: Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing. Nucleic Acids Res. 34:4622–4629. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Chen HC, Tseng YK, Chi CC, Chen YH, Yang CM, Huang SJ, Lee YC, Liou HH, Tsai KW and Ger LP: Genetic variants in microRNA-146a (C>G) and microRNA-1269b (G>C) are associated with the decreased risk of oral premalignant lesions, oral cancer, and pharyngeal cancer. Arch Oral Biol. 72:21–32. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Philipone E, Yoon AJ, Wang S, Shen J, Ko YC, Sink JM, Rockafellow A, Shammay NA and Santella RM: MicroRNAs-208b-3p, 204–5p, 129-2-3p and 3065-5p as predictive markers of oral leukoplakia that progress to cancer. Am J Cancer Res. 6:1537–1546. 2016.PubMed/NCBI

26 

Aghbari SMH, Gaafar SM, Shaker OG, Ashiry SE and Zayed SO: Evaluating the accuracy of microRNA-27b and microRNA-137 as biomarkers of activity and potential malignant transformation in oral lichen planus patients. Arch Dermatol Res. 310:209–220. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Harrandah AM, Fitzpatrick SG, Smith MH, Wang D, Cohen DM and Chan EK: MicroRNA-375 as a biomarker for malignant transformation in oral lesions. Oral Surg Oral Med Oral Pathol Oral Radiol. 122:743–752.e1. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Liu CJ, Lin SC, Yang CC, Cheng HW and Chang KW: Exploiting salivary miR-31 as a clinical biomarker of oral squamous cell carcinoma. Head Neck. 34:219–214. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Zahran F, Ghalwash D, Shaker O, Al-Johani K and Scully C: Salivary microRNAs in oral cancer. Oral Dis. 21:739–747. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Ries J, Baran C, Wehrhan F, Weber M, Neukam FW, Krautheim-Zenk A and Nkenke E: Prognostic significance of altered miRNA expression in whole blood of OSCC patients. Oncol Rep. 37:3467–3474. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Wang T, Ren Y, Liu R, Ma J, Shi Y, Zhang L and Bu R: MiR-195-5p suppresses the proliferation, migration, and invasion of oral squamous cell carcinoma by targeting TRIM14. Biomed Res Int. 2017:73781482017. View Article : Google Scholar : PubMed/NCBI

32 

Zhang B, Li Y, Hou D, Shi Q, Yang S and Li Q: MicroRNA-375 inhibits growth and enhances radiosensitivity in oral squamous cell carcinoma by targeting insulin like growth factor 1 receptor. Cell Physiol Biochem. 42:2105–2117. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Xu P, Li Y, Yang S, Yang H, Tang J and Li M: Micro-ribonucleic acid 143 (MiR-143) inhibits oral squamous cell carcinoma (OSCC) cell migration and invasion by downregulation of phospho-c-Met through targeting CD44 v3. Oral Surg Oral Med Oral Pathol Oral Radiol. 120:43–51. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Cao J, Guo T, Dong Q, Zhang J and Li Y: MiR-26b is downregulated in human tongue squamous cell carcinoma and regulates cell proliferation and metastasis through a COX-2-dependent mechanism. Oncol Rep. 33:974–980. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Baba O, Hasegawa S, Nagai H, Uchida F, Yamatoji M, Kanno NI, Yamagata K, Sakai S, Yanagawa T and Bukawa H: MicroRNA-155-5p is associated with oral squamous cell carcinoma metastasis and poor prognosis. J Oral Pathol Med. 45:248–255. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Xu H, Yang Y, Zhao H, Yang X, Luo Y, Ren Y, Liu W and Li N: Serum miR-483-5p: A novel diagnostic and prognostic biomarker for patients with oral squamous cell carcinoma. Tumour Biol. 37:447–453. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Hung KF, Liu CJ, Chiu PC, Lin JS, Chang KW, Shih WY, Kao SY and Tu HF: MicroRNA-31 upregulation predicts increased risk of progression of oral potentially malignant disorder. Oral Oncol. 53:42–47. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Lu MY, Yu CC, Chen PY, Hsieh PL, Peng CY, Liao YW, Yu CH and Lin KH: MiR-200c inhibits the arecoline-associated myofibroblastic transdifferentiation in buccal mucosal fibroblasts. J Formos Med Assoc. 117:791–797. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Brito JA, Gomes CC, Guimarães AL, Campos K and Gomez RS: Relationship between microRNA expression levels and histopathological features of dysplasia in oral leukoplakia. J Oral Pathol Med. 43:211–216. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Nylander E, Ebrahimi M, Wahlin YB, Boldrup L and Nylander K: Changes in miRNA expression in sera and correlation to duration of disease in patients with multifocal mucosal lichen planus. J Oral Pathol Med. 41:86–89. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Ren W, Wang X, Gao L, Li S, Yan X, Zhang J, Huang C, Zhang Y and Zhi K: MiR-21 modulates chemosensitivity of tongue squamous cell carcinoma cells to cisplatin by targeting PDCD4. Mol Cell Biochem. 390:253–262. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Arnaoutakis D, Bishop J, Westra W and Califano JA: Recurrence patterns and management of oral cavity premalignant lesions. Oral Oncol. 49:814–817. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Mortazavi H, Baharvand M and Mehdipour M: Oral potentially malignant disorders: An overview of more than 20 entities. J Dent Res Dent Clin Dent Prospects. 8:6–14. 2014.PubMed/NCBI

44 

Wu X, Gong Z, Sun L, Ma L and Wang Q: MicroRNA-802 plays a tumour suppressive role in tongue squamous cell carcinoma through directly targeting MAP2K4. Cell Prolif. Mar 20–2017.(Epub ahead of print). doi: 10.1111/cpr.12336. View Article : Google Scholar

45 

Sun L, Liang J, Wang Q, Li Z, Du Y and Xu X: MicroRNA-137 suppresses tongue squamous carcinoma cell proliferation, migration and invasion. Cell Prolif. 49:628–635. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Wang X, Li F and Zhou X: MiR-204-5p regulates cell proliferation and metastasis through inhibiting CXCR4 expression in OSCC. Biomed Pharmacother. 82:202–207. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Supic G, Zeljic K, Rankov AD, Kozomara R, Nikolic A, Radojkovic D and Magic Z: MiR-183 and miR-21 expression as biomarkers of progression and survival in tongue carcinoma patients. Clin Oral Investig. 22:401–409. 2018. View Article : Google Scholar : PubMed/NCBI

48 

Weng J, Zhang H, Wang C, Liang J, Chen G, Li W, Tang H and Hou J: MiR-373-3p targets DKK1 to promote EMT-induced metastasis via the Wnt/β-catenin pathway in tongue squamous cell carcinoma. Biomed Res Int. 2017:60109262017. View Article : Google Scholar : PubMed/NCBI

49 

Fu S, Chen HH, Cheng P, Zhang CB and Wu Y: MiR-155 regulates oral squamous cell carcinoma Tca8113 cell proliferation, cycle, and apoptosis via regulating p27Kip1. Eur Rev Med Pharmacol Sci. 21:937–944. 2017.PubMed/NCBI

50 

Wang J, Wang W, Li J, Wu L, Song M and Meng Q: MiR-182 activates the Ras-MEK-ERK pathway in human oral cavity squamous cell carcinoma by suppressing RASA1 and SPRED1. Onco Targets Ther. 10:667–679. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Zhao J, Hu C, Chi J, Li J, Peng C, Yun X, Li D, Yu Y, Li Y, Gao M and Zheng X: MiR-24 promotes the proliferation, migration and invasion in human tongue squamous cell carcinoma by targeting FBXW7. Oncol Rep. 36:1143–1149. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Liu MD, Wu H, Wang S, Pang P, Jin S, Sun CF and Liu FY: MiR-1275 promotes cell migration, invasion and proliferation in squamous cell carcinoma of head and neck via up-regulating IGF-1R and CCR7. Gene. 646:1–7. 2018. View Article : Google Scholar : PubMed/NCBI

53 

El-Hefnawy T, Raja S, Kelly L, Bigbee WL, Kirkwood JM, Luketich JD and Godfrey TE: Characterization of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics. Clin Chem. 50:564–573. 2014. View Article : Google Scholar

54 

Park NJ, Li Y, Yu T, Brinkman BM and Wong DT: Characterization of RNA in saliva. Clin Chem. 52:988–994. 2006. View Article : Google Scholar : PubMed/NCBI

55 

Tsui NB, Ng EK and Lo YM: Stability of endogenous and added RNA in blood specimens, serum, and plasma. Clin Chem. 48:1647–1653. 2002.PubMed/NCBI

56 

Park NJ, Zhou H, Elashoff D, Henson BS, Kastratovic DA, Abemayor E and Wong DT: Salivary microRNA: Discovery, characterization, and clinical utility for oral cancer detection. Clin Cancer Res. 15:5473–5477. 2009. View Article : Google Scholar : PubMed/NCBI

57 

Yeh LY, Liu CJ, Wong YK, Chang C, Lin SC and Chang KW: MiR-372 inhibits p62 in head and neck squamous cell carcinoma in vitro and in vivo. Oncotarget. 6:6062–6075. 2015. View Article : Google Scholar : PubMed/NCBI

58 

Sun L, Liu L, Fu H, Wang Q and Shi Y: Association of decreased expression of serum miR-9 with poor prognosis of oral squamous cell carcinoma patients. Med Sci Monit. 22:289–294. 2016. View Article : Google Scholar : PubMed/NCBI

59 

Yang CC, Hung PS, Wang PW, Liu CJ, Chu TH, Cheng HW and Lin SC: miR-181 as a putative biomarker for lymph-node metastasis of oral squamous cell carcinoma. J Oral Pathol Med. 40:397–404. 2011. View Article : Google Scholar : PubMed/NCBI

60 

Wong TS, Liu XB, Wong BY, Ng RW, Yuen AP and Wei WI: Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue. Clin Cancer Res. 14:2588–2592. 2018. View Article : Google Scholar

61 

Lu YC, Chen YJ, Wang HM, Tsai CY, Chen WH, Huang YC, Fan KH, Tsai CN, Huang SF, Kang CJ, et al: Oncogenic function and early detection potential of miRNA-10b in oral cancer as identified by microRNA profiling. Cancer Prev Res (Phila). 5:665–674. 2012. View Article : Google Scholar : PubMed/NCBI

62 

Kao YY, Tu HF, Kao SY, Chang KW and Lin SC: The increase of oncogenic miRNA expression in tongue carcinogenesis of a mouse model. Oral Oncol. 51:1103–1112. 2015. View Article : Google Scholar : PubMed/NCBI

63 

Liu CJ, Tsai MM, Tu HF, Lui MT, Cheng HW and Lin SC: MiR-196a overexpression and miR-196a2 gene polymorphism are prognostic predictors of oral carcinomas. Ann Surg Oncol. 20 (Suppl 3):S406–S414. 2013. View Article : Google Scholar : PubMed/NCBI

64 

Lin SC, Liu CJ, Lin JA, Chiang WF, Hung PS and Chang KW: MiR-24 up-regulation in oral carcinoma: Positive association from clinical and in vitro analysis. Oral Oncol. 46:204–208. 2010. View Article : Google Scholar : PubMed/NCBI

65 

Lu YC, Chang JT, Huang YC, Huang CC, Chen WH, Lee LY, Huang BS, Chen YJ, Li HF and Cheng AJ: Combined determination of circulating miR-196a and miR-196b levels produces high sensitivity and specificity for early detection of oral cancer. Clin Biochem. 48:115–121. 2015. View Article : Google Scholar : PubMed/NCBI

66 

Liu CJ, Lin JS, Cheng HW, Hsu YH, Cheng CY and Lin SC: Plasma miR-187* is a potential biomarker for oral carcinoma. Clin Oral Investig. 21:1131–1138. 2017. View Article : Google Scholar : PubMed/NCBI

67 

Lo WY, Wang HJ, Chiu CW and Chen SF: MiR-27b-regulated TCTP as a novel plasma biomarker for oral cancer: From quantitative proteomics to post-transcriptional study. J Proteomics. 77:154–166. 2012. View Article : Google Scholar : PubMed/NCBI

68 

Ries J, Vairaktaris E, Kintopp R, Baran C, Neukam FW and Nkenke E: Alterations in miRNA expression patterns in whole blood of OSCC patients. In Vivo. 28:851–861. 2014.PubMed/NCBI

69 

Shin JA, Li C, Choi ES, Cho SD and Cho NP: High expression of microRNA-127 is involved in cell cycle arrest in MC-3 mucoepidermoid carcinoma cells. Mol Med Rep. 7:708–712. 2013. View Article : Google Scholar : PubMed/NCBI

70 

Binmadi NO, Basile JR, Perez P, Gallo A, Tandon M, Elias W, Jang SI and Alevizos I: miRNA expression profile of mucoepidermoid carcinoma. Oral Dis. 24:537–543. 2018. View Article : Google Scholar : PubMed/NCBI

71 

Ramer N, Wu H, Sabo E, Ramer Y, Emanuel P, Orta L and Burstein DE: Prognostic value of quantitative p63 immunostaining in adenoid cystic carcinoma of salivary gland assessed by computerized image analysis. Cancer. 116:77–83. 2010.PubMed/NCBI

72 

Wang Y, Zhang CY, Xia RH, Han J, Sun B, Sun SY and Li J: The MYB/miR-130a/NDRG2 axis modulates tumor proliferation and metastatic potential in salivary adenoid cystic carcinoma. Cell Death Dis. 9:9172018. View Article : Google Scholar : PubMed/NCBI

73 

Chen W, Zhao X, Dong Z, Cao G and Zhang S: Identification of microRNA profiles in salivary adenoid cystic carcinoma cells during metastatic progression. Oncol Lett. 7:2029–2034. 2014. View Article : Google Scholar : PubMed/NCBI

74 

Andreasen S, Tan Q, Agander TK, Hansen TVO, Steiner P, Bjørndal K, Høgdall E, Larsen SR, Erentaite D, Olsen CH, et al: MicroRNA dysregulation in adenoid cystic carcinoma of the salivary gland in relation to prognosis and gene fusion status: A cohort study. Virchows Arch. 473:329–340. 2018. View Article : Google Scholar : PubMed/NCBI

75 

Wang C, Li T, Yan F, Cai W, Zheng J, Jiang X and Sun J: Effect of simvastatin and microRNA-21 inhibitor on metastasis and progression of human salivary adenoid cystic carcinoma. Biomed Pharmacother. 105:1054–1061. 2018. View Article : Google Scholar : PubMed/NCBI

76 

Yang X, Ruan H, Hu X, Cao A and Song L: miR-381-3p suppresses the proliferation of oral squamous cell carcinoma cells by directly targeting FGFR2. Am J Cancer Res. 7:913–922. 2017.PubMed/NCBI

77 

Thiery JP, Acloque H, Huang RY and Nieto MA: Epithelial-mesenchymal transitions in development and disease. Cell. 139:871–890. 2009. View Article : Google Scholar : PubMed/NCBI

78 

Wong TS, Gao W and Chan JY: Transcription regulation of E-cadherin by zinc finger E-box binding homeobox proteins in solid tumors. Biomed Res Int. 2014:9215642014. View Article : Google Scholar : PubMed/NCBI

79 

Hashiguchi Y, Kawano S, Goto Y, Yasuda K, Kaneko N, Sakamoto T, Matsubara R, Jinno T, Maruse Y, Tanaka H, et al: Tumor-suppressive roles of ΔNp63β-miR-205 axis in epithelial-mesenchymal transition of oral squamous cell carcinoma via targeting ZEB1 and ZEB2. J Cell Physiol. 233:6565–6577. 2018. View Article : Google Scholar : PubMed/NCBI

80 

Shi W, Yang J, Li S, Shan X, Liu X, Hua H, Zhao C, Feng Z, Cai Z, Zhang L, et al: Potential involvement of miR-375 in the premalignant progression of oral squamous cell carcinoma mediated via transcription factor KLF5. Oncotarget. 6:40172–40185. 2015. View Article : Google Scholar : PubMed/NCBI

81 

Wu Y, Sun X, Song B, Qiu X and Zhao J: MiR-375/SLC7A11 axis regulates oral squamous cell carcinoma proliferation and invasion. Cancer Med. 6:1686–1697. 2017. View Article : Google Scholar : PubMed/NCBI

82 

Ji M, Wang W, Yan W, Chen D, Ding X and Wang A: Dysregulation of AKT1, a miR-138 target gene, is involved in the migration and invasion of tongue squamous cell carcinoma. J Oral Pathol Med. 46:731–737. 2017. View Article : Google Scholar : PubMed/NCBI

83 

Xu R, Zeng G, Gao J, Ren Y, Zhao Z, Zhang J, Tao H and Li D: miR-138 suppresses the proliferation of oral squamous cell carcinoma cells by targeting Yes-associated protein 1. Oncol Rep. 34:2171–2178. 2015. View Article : Google Scholar : PubMed/NCBI

84 

Kim JS, Choi DW, Kim CS, Yu SK, Kim HJ, Go DS, Lee SA, Moon SM, Kim SG, Chun HS, et al: MicroRNA-203 induces apoptosis by targeting Bmi-1 in YD-38 oral cancer cells. Anticancer Res. 38:3477–3485. 2018. View Article : Google Scholar : PubMed/NCBI

85 

Lim HS, Kim CS, Kim JS, Yu SK, Go DS, Lee SA, Moon SM, Chun HS, Kim S and Kim DK: Suppression of oral carcinoma oncogenic activity by microRNA-203 via down-regulation of SEMA6A. Anticancer Res. 37:5425–5433. 2017.PubMed/NCBI

86 

Lin J, Lin Y, Fan L, Kuang W, Zheng L, Wu J, Shang P, Wang Q and Tan J: miR-203 inhibits cell proliferation and promotes cisplatin induced cell death in tongue squamous cancer. Biochem Biophys Res Commun. 473:382–387. 2016. View Article : Google Scholar : PubMed/NCBI

87 

Xie NN, Liu ZX, Wu C, Wang PL, Song GT and Chen Z: MicroRNA-200c suppresses tumor metastasis in oral squamous carcinoma by inhibiting epithelial-mesenchymal transition. Eur Rev Med Pharmacol Sci. 22:3415–3422. 2018.PubMed/NCBI

88 

Zhao L, Ren Y, Tang H, Wang W, He Q, Sun J, Zhou X and Wang A: Deregulation of the miR-222-ABCG2 regulatory module in tongue squamous cell carcinoma contributes to chemoresistance and enhanced migratory/invasive potential. Oncotarget. 6:44538–44550. 2015. View Article : Google Scholar : PubMed/NCBI

89 

Wang X, Guo H, Yao B and Helms J: miR-15b inhibits cancer-initiating cell phenotypes and chemoresistance of cisplatin by targeting TRIM14 in oral tongue squamous cell cancer. Oncol Rep. 37:2720–2726. 2017. View Article : Google Scholar : PubMed/NCBI

90 

Li X, Fan Q, Li J, Song J and Gu Y: MiR-124 down-regulation is critical for cancer associated fibroblasts-enhanced tumor growth of oral carcinoma. Exp Cell Res. 351:100–108. 2017. View Article : Google Scholar : PubMed/NCBI

91 

Lin XJ, He CL, Sun T, Duan XJ, Sun Y and Xiong SJ: Hsa-miR-485-5p reverses epithelial to mesenchymal transition and promotes cisplatin-induced cell death by targeting PAK1 in oral tongue squamous cell carcinoma. Int J Mol Med. 40:83–89. 2017. View Article : Google Scholar : PubMed/NCBI

92 

Lin Z, Sun L, Chen W, Liu B, Wang Y, Fan S, Li Y and Li J: miR-639 regulates transforming growth factor beta-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting FOXC1. Cancer Sci. 105:1288–1298. 2014. View Article : Google Scholar : PubMed/NCBI

93 

Liu B, Chen W, Cao G, Dong Z, Xu J, Luo T and Zhang S: MicroRNA-27b inhibits cell proliferation in oral squamous cell carcinoma by targeting FZD7 and Wnt signaling pathway. Arch Oral Biol. 83:92–96. 2017. View Article : Google Scholar : PubMed/NCBI

94 

Min A, Zhu C, Peng S, Shuai C, Sun L, Han Y, Qian Y, Gao S and Su T: Downregulation of MicroRNA-148a in cancer-associated fibroblasts from oral cancer promotes cancer cell migration and invasion by targeting Wnt10b. J Biochem Mol Toxicol. 30:186–191. 2016. View Article : Google Scholar : PubMed/NCBI

95 

Nagai H, Hasegawa S, Uchida F, Terabe T, Ishibashi Kanno N, Kato K, Yamagata K, Sakai S, Kawashiri S, Sato H, et al: MicroRNA-205-5p suppresses the invasiveness of oral squamous cell carcinoma by inhibiting TIMP2 expression. Int J Oncol. 52:841–850. 2018.PubMed/NCBI

96 

Qiao B, Cai JH, King-Yin Lam A and He BX: MicroRNA-542-3p inhibits oral squamous cell carcinoma progression by inhibiting ILK/TGF-β1/Smad2/3 signaling. Oncotarget. 8:70761–70776. 2017. View Article : Google Scholar : PubMed/NCBI

97 

Qiu K, Huang Z, Huang Z, He Z and You S: miR-22 regulates cell invasion, migration and proliferation in vitro through inhibiting CD147 expression in tongue squamous cell carcinoma. Arch Oral Biol. 66:92–97. 2016. View Article : Google Scholar : PubMed/NCBI

98 

Rastogi B, Kumar A, Raut SK, Panda NK, Rattan V, Joshi N and Khullar M: Downregulation of miR-377 promotes oral squamous cell carcinoma growth and migration by targeting HDAC9. Cancer Invest. 35:152–162. 2017. View Article : Google Scholar : PubMed/NCBI

99 

Ruan P, Tao Z and Tan A: Low expression of miR-30a-5p induced the proliferation and invasion of oral cancer via promoting the expression of FAP. Biosci Rep. 38:BSR201710272018. View Article : Google Scholar : PubMed/NCBI

100 

Sakha S, Muramatsu T, Ueda K and Inazawa J: Exosomal microRNA miR-1246 induces cell motility and invasion through the regulation of DENND2D in oral squamous cell carcinoma. Sci Rep. 6:387502014. View Article : Google Scholar

101 

Shang A, Lu WY, Yang M, Zhou C, Zhang H, Cai ZX, Wang WW, Wang WX and Wu GQ: miR-9 induces cell arrest and apoptosis of oral squamous cell carcinoma via CDK 4/6 pathway. Artif Cells Nanomed Biotechnol. 46:1754–1762. 2018.PubMed/NCBI

102 

Shi Z, Johnson JJ, Jiang R, Liu Y and Stack MS: Decrease of miR-146a is associated with the aggressiveness of human oral squamous cell carcinoma. Arch Oral Biol. 60:1416–1427. 2015. View Article : Google Scholar : PubMed/NCBI

103 

Wang L and Liu H: microRNA-188 is downregulated in oral squamous cell carcinoma and inhibits proliferation and invasion by targeting SIX1. Tumour Biol. 37:4105–4113. 2016. View Article : Google Scholar : PubMed/NCBI

104 

Wang K, Jin J, Ma T and Zhai H: MiR-139-5p inhibits the tumorigenesis and progression of oral squamous carcinoma cells by targeting HOXA9. J Cell Mol Med. 21:3730–3740. 2017. View Article : Google Scholar : PubMed/NCBI

105 

Wang K, Jin J, Ma T and Zhai H: MiR-376c-3p regulates the proliferation, invasion, migration, cell cycle and apoptosis of human oral squamous cancer cells by suppressing HOXB7. Biomed Pharmacother. 91:517–525. 2017. View Article : Google Scholar : PubMed/NCBI

106 

Wang Q, Lv L, Li Y and Ji H: MicroRNA-655 suppresses cell proliferation and invasion in oral squamous cell carcinoma by directly targeting metadherin and regulating the PTEN/AKT pathway. Mol Med Rep. 18:3106–3114. 2018.PubMed/NCBI

107 

Wang Z, Yan J, Zou T and Gao H: MicroRNA-1294 inhibited oral squamous cell carcinoma growth by targeting c-Myc. Oncol Lett. 16:2243–2250. 2018.PubMed/NCBI

108 

Weng JH, Yu CC, Lee YC, Lin CW, Chang WW and Kuo YL: miR-494-3p induces cellular senescence and enhances radiosensitivity in human oral squamous carcinoma cells. Int J Mol Sci. 17(pii): E10922016. View Article : Google Scholar : PubMed/NCBI

109 

Xu P, Li Y, Zhang H, Li M and Zhu H: MicroRNA-340 mediates metabolic shift in oral squamous cell carcinoma by targeting glucose transporter-1. J Oral Maxillofac Surg. 74:844–850. 2016. View Article : Google Scholar : PubMed/NCBI

110 

Zeng G, Xun W, Wei K, Yang Y and Shen H: MicroRNA-27a-3p regulates epithelial to mesenchymal transition via targeting YAP1 in oral squamous cell carcinoma cells. Oncol Rep. 36:1475–1482. 2016. View Article : Google Scholar : PubMed/NCBI

111 

Li X, He J, Shao M, Cui B, Peng F, Li J, Ran Y, Jin D, Kong J, Chang J, et al: Downregulation of miR-218-5p promotes invasion of oral squamous cell carcinoma cells via activation of CD44-ROCK signaling. Biomed Pharmacother. 106:646–654. 2018. View Article : Google Scholar : PubMed/NCBI

112 

Zhuang Z, Hu F, Hu J, Wang C, Hou J, Yu Z, Wang TT, Liu X and Huang H: MicroRNA-218 promotes cisplatin resistance in oral cancer via the PPP2R5A/Wnt signaling pathway. Oncol Rep. 38:2051–2061. 2017. View Article : Google Scholar : PubMed/NCBI

113 

Jiang F, Zhao W, Zhou L, Liu Z, Li W and Yu D: MiR-222 targeted PUMA to improve sensitization of UM1 cells to cisplatin. Int J Mol Sci. 15:22128–22141. 2014. View Article : Google Scholar : PubMed/NCBI

114 

Du L, Ma S, Wen X, Chai J and Zhou D: Oral squamous cell carcinoma cells are resistant to doxorubicin through upregulation of miR-221. Mol Med Rep. 16:2659–2667. 2017. View Article : Google Scholar : PubMed/NCBI

115 

Zhou L, Jiang F, Chen X, Liu Z, Ouyang Y, Zhao W and Yu D: Downregulation of miR-221/222 by a microRNA sponge promotes apoptosis in oral squamous cell carcinoma cells through upregulation of PTEN. Oncol Lett. 12:4419–4426. 2016. View Article : Google Scholar : PubMed/NCBI

116 

Zheng X, Li J, Peng C, Zhao J, Chi J, Meng X, Yun X, Li D, Yun Y, Gao M and Li Y: MicroRNA-24 induces cisplatin resistance by targeting PTEN in human tongue squamous cell carcinoma. Oral Oncol. 51:998–1003. 2015. View Article : Google Scholar : PubMed/NCBI

117 

Cheng CM, Shiah SG, Huang CC, Hsiao JR and Chang JY: Up-regulation of miR-455-5p by the TGF-β-SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B. J Pathol. 240:38–49. 2016. View Article : Google Scholar : PubMed/NCBI

118 

Guo Y, Ren MS, Shang C, Zhu L and Zhong M: MTSS1 gene regulated by miR-96 inhibits cell proliferation and metastasis in tongue squamous cellular carcinoma Tca8113 cell line. Int J Clin Exp Med. 8:15441–15449. 2015.PubMed/NCBI

119 

Hu J, Xu JF and Ge WL: MiR-497 enhances metastasis of oral squamous cell carcinoma through SMAD7 suppression. Am J Transl Res. 8:3023–3031. 2016.PubMed/NCBI

120 

Kawakubo-Yasukochi T, Morioka M, Hazekawa M, Yasukochi A, Nishinakagawa T, Ono K, Kawano S, Nakamura S and Nakashima M: MiR-200c-3p spreads invasive capacity in human oral squamous cell carcinoma microenvironment. Mol Carcinog. 57:295–302. 2018. View Article : Google Scholar : PubMed/NCBI

121 

Li N, Nan CC, Zhong XY, Weng JQ, Fan HD, Sun HP, Tang S, Shi L and Huang SX: miR-182-5p promotes growth in oral squamous cell carcinoma by inhibiting CAMK2N1. Cell Physiol Biochem. 49:1329–1341. 2018. View Article : Google Scholar : PubMed/NCBI

122 

Lin SC, Kao SY, Chang JC, Liu YC, Yu EH, Tseng SH, Liu CJ and Chang KW: Up-regulation of miR-187 modulates the advances of oral carcinoma by targeting BARX2 tumor suppressor. Oncotarget. 7:61355–61365. 2016.PubMed/NCBI

123 

Liu Z, Diep C, Mao T, Huang L, Merrill R, Zhang Z and Peng Y: MicroRNA-92b promotes tumor growth and activation of NF-κB signaling via regulation of NLK in oral squamous cell carcinoma. Oncol Rep. 34:2961–2968. 2015. View Article : Google Scholar : PubMed/NCBI

124 

Lu M, Wang C, Chen W, Mao C and Wang J: miR-654-5p targets GRAP to promote proliferation, metastasis, and chemoresistance of oral squamous cell carcinoma through Ras/MAPK signaling. DNA Cell Biol. 37:381–388. 2018. View Article : Google Scholar : PubMed/NCBI

125 

Peng SY, Tu HF, Yang CC, Wu CH, Liu CJ, Chang KW and Lin SC: MiR-134 targets PDCD7 to reduce E-cadherin expression and enhance oral cancer progression. Int J Cancer. 143:2892–2904. 2018. View Article : Google Scholar : PubMed/NCBI

126 

Qiao B, He BX, Cai JH, Tao Q and King-Yin Lam A: microRNA-27a-3p modulates the Wnt/β-Catenin signaling pathway to promote epithelial-mesenchymal transition in oral squamous carcinoma stem cells by targeting SFRP1. Sci Rep. 7:446882017. View Article : Google Scholar : PubMed/NCBI

127 

Zhao J, Chi J, Gao M, Zhi J, Li Y and Zheng X: Loss of PTEN expression is associated with high microRNA-24 level and poor prognosis in patients with tongue squamous cell carcinoma. J Oral Maxillofac Surg. 75:1449.e1–1449.e8. 2017. View Article : Google Scholar

128 

Zheng G, Li N, Jia X, Peng C, Luo L, Deng Y, Yin J, Song Y, Liu H, Lu M, et al: MYCN-mediated miR-21 overexpression enhances chemo-resistance via targeting CADM1 in tongue cancer. J Mol Med (Berl). 94:1129–1141. 2016. View Article : Google Scholar : PubMed/NCBI

129 

Chen YF, Yang CC, Kao SY, Liu CJ, Lin SC and Chang KW: MicroRNA-211 enhances the oncogenicity of carcinogen-induced oral carcinoma by repressing TCF12 and increasing antioxidant activity. Cancer Res. 76:4872–4886. 2016. View Article : Google Scholar : PubMed/NCBI

130 

Chen YH, Song Y, Yu YL, Cheng W and Tong X: MiRNA-10a promotes cancer cell proliferation in oral squamous cell carcinoma by upregulating GLUT1 and promoting glucose metabolism. Oncol Lett. 17:5441–5446. 2019.PubMed/NCBI

131 

Cao ZH, Cheng JL, Zhang Y, Bo CX and Li YL: MicroRNA-375 inhibits oral squamous cell carcinoma cell migration and invasion by targeting platelet derived growth factor A. Mol Med Rep. 15:922–928. 2017. View Article : Google Scholar : PubMed/NCBI

132 

Du Y, Li Y, Lv H, Zhou S, Sun Z and Wang M: miR-98 suppresses tumor cell growth and metastasis by targeting IGF1R in oral squamous cell carcinoma. Int J Clin Exp Pathol. 8:12252–12259. 2015.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fang C and Li Y: Prospective applications of microRNAs in oral cancer (Review). Oncol Lett 18: 3974-3984, 2019.
APA
Fang, C., & Li, Y. (2019). Prospective applications of microRNAs in oral cancer (Review). Oncology Letters, 18, 3974-3984. https://doi.org/10.3892/ol.2019.10751
MLA
Fang, C., Li, Y."Prospective applications of microRNAs in oral cancer (Review)". Oncology Letters 18.4 (2019): 3974-3984.
Chicago
Fang, C., Li, Y."Prospective applications of microRNAs in oral cancer (Review)". Oncology Letters 18, no. 4 (2019): 3974-3984. https://doi.org/10.3892/ol.2019.10751
Copy and paste a formatted citation
x
Spandidos Publications style
Fang C and Li Y: Prospective applications of microRNAs in oral cancer (Review). Oncol Lett 18: 3974-3984, 2019.
APA
Fang, C., & Li, Y. (2019). Prospective applications of microRNAs in oral cancer (Review). Oncology Letters, 18, 3974-3984. https://doi.org/10.3892/ol.2019.10751
MLA
Fang, C., Li, Y."Prospective applications of microRNAs in oral cancer (Review)". Oncology Letters 18.4 (2019): 3974-3984.
Chicago
Fang, C., Li, Y."Prospective applications of microRNAs in oral cancer (Review)". Oncology Letters 18, no. 4 (2019): 3974-3984. https://doi.org/10.3892/ol.2019.10751
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