Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2019 Volume 18 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2019 Volume 18 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Icotinib and pemetrexed in treatment of lung adenocarcinoma and the effects on prognostic survival rate of patients

  • Authors:
    • Xueheng Zhou
    • Defeng Hua
    • Chengpeng Gao
    • Yixiang Zhang
    • Lijie Qiu
    • Leqiang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Affiliated Hospital of Weifang Medical University, Weifang, Shandong 261031, P.R. China, Department of Neurology, Weifang Brain Hospital, Weifang, Shandong 261000, P.R. China, Department of Respiratory Medicine, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4153-4159
    |
    Published online on: August 16, 2019
       https://doi.org/10.3892/ol.2019.10763
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Efficacy comparison of icotinib and pemetrexed in the treatment of lung adenocarcinoma and the effects on the prognostic survival rate of patients were investigated. A retrospective analysis was performed in 132 lung adenocarcinoma patients who were treated in the Affiliated Hospital of Weifang Medical University from July 2010 to July 2015. Among them, 69 patients were treated with icotinib (icotinib group), and 63 patients were treated with pemetrexed (pemetrexed group). In the icotinib group, 125 mg icotinib was orally administered continuously, 3 times a day, until progressive disease or intolerable adverse reactions occurred. In the pemetrexed group, 500 mg/m2 pemetrexed was intravenously dripped for a total of 4 cycles, 21 days for 1 cycle, until progressive disease or intolerable adverse reactions occurred. The efficacy, toxic and side effects, and survival rate of the two groups were evaluated. There was a statistically significant difference in toxic and side effects between the two groups of drugs after the treatment of lung adenocarcinoma (P<0.05). The median survival time of patients was 16 months in the icotinib group and 10 months in the pemetrexed group, with a statistically significant difference (P<0.05). The 1‑year survival rate was higher in the icotinib group than that in the pemetrexed group (P<0.05). There was no difference in 2‑ and 3‑year survival rates between the two groups (P>0.05). In conclusion, the clinical efficacy of icotinib is similar to that of pemetrexed in the treatment of lung adenocarcinoma, but icotinib has less adverse reactions, with better improvement in disease control.
View Figures

Figure 1

View References

1 

Black CN, Bot M, Scheffer PG, Cuijpers P and Penninx BW: Is depression associated with increased oxidative stress? A systematic review and meta-analysis. Psychoneuro-endocrinology. 51:164–175. 2015. View Article : Google Scholar

2 

National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health: The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General. Centers for Disease Control and Prevention (US); Atlanta, GA: 2014

3 

Thomas PA, Berbis J, Baste JM, Le Pimpec-Barthes F, Tronc F, Falcoz PE, Dahan M and Loundou A; EPITHOR group, : Pneumonectomy for lung cancer: Contemporary national early morbidity and mortality outcomes. J Thorac Cardiovasc Surg. 149:73–82. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Zeng Y, Zhu J, Shen D, Qin H, Lei Z, Li W, Liu Z and Huang JA: MicroRNA-205 targets SMAD4 in non-small cell lung cancer and promotes lung cancer cell growth in vitro and in vivo. Oncotarget. 8:30817–30829. 2017.PubMed/NCBI

5 

Girard N, Corral J, Cortinovis D and Heigener DF: Second-line treatment selection in patients with non-small-cell lung cancer of adenocarcinoma histology: Findings from a European survey of treating physicians. Clin Lung Cancer. 18:e89–e97. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Meaney CL, Zingone A, Brown D, Yu Y, Cao L and Ryan BM: Identification of serum inflammatory markers as classifiers of lung cancer mortality for stage I adenocarcinoma. Oncotarget. 8:40946–40957. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Wagland R, Brindle L, Ewings S, James E, Moore M, Rivas C, Esqueda AI and Corner J: Promoting help-seeking in response to symptoms amongst primary care patients at high risk of lung cancer: A mixed method study. PLoS One. 11:e01656772016. View Article : Google Scholar : PubMed/NCBI

8 

Sha F, Zhuang S, Zhou L, Zhang L, Yang Y, Zhang S, Jiang Y, Qiu G, Chen C, Zheng J, et al: Biomarkers for cancer-related fatigue and adverse reactions to chemotherapy in lung cancer patients. Mol Clin Oncol. 3:163–166. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Shaw AT, Kim DW, Nakagawa K, Seto T, Crinó L, Ahn MJ, De Pas T, Besse B, Solomon BJ, Blackhall F, et al: Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 368:2385–2394. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Yao S, Zhi X, Wang R, Qian K, Hu M and Zhang Y: Retrospective study of adjuvant icotinib in postoperative lung cancer patients harboring epidermal growth factor receptor mutations. Thorac Cancer. 7:543–548. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Chen YT, Feng B and Chen LB: Update of research on drug resistance in small cell lung cancer chemotherapy. Asian Pac J Cancer Prev. 13:3577–3581. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Liew SC: Folic acid and diseases - supplement it or not? Rev Assoc Med Bras 1992. 62:90–100. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Li B, Li MY, Sun LL, Wang J, Zheng YQ and Hao J: Impact of anticancer drugs price cut on physician's prescription choices on first-line chemotherapy regimens and health expenditure for advanced non-small cell lung cancer in China. J Thorac Dis. 8:2832–2842. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Mok TS, Wu YL, Ahn MJ, Garassino MC, Kim HR, Ramalingam SS, Shepherd FA, He Y, Akamatsu H, Theelen WS, et al AURA3 Investigators, : Osimertinib or platinum-pemetrexed in EGFR T790M-positive lung cancer. N Engl J Med. 376:629–640. 2017. View Article : Google Scholar : PubMed/NCBI

15 

de Kock I, Mirhosseini M, Lau F, Thai V, Downing M, Quan H, Lesperance M and Yang J: Conversion of Karnofsky Performance Status (KPS) and Eastern Cooperative Oncology Group Performance Status (ECOG) to Palliative Performance Scale (PPS), and the interchangeability of PPS and KPS in prognostic tools. J Palliat Care. 29:163–169. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Guenther LM, Rowe RG, Acharya PT, Swenson DW, Meyer SC, Clinton CM, Guo D, Sridharan M, London WB, Grier HE, et al: Response Evaluation Criteria in Solid Tumors (RECIST) following neoadjuvant chemotherapy in osteosarcoma. Pediatr Blood Cancer. 65:652018. View Article : Google Scholar

17 

Luo Y, Li J, Wang Y, Hao X and Qu F: Nimotuzumab combined with chemotherapy as second- or later-line in the treatment of advanced lung squamous cell carcinoma. Zhongguo Fei Ai Za Zhi. 19:665–669. 2016.(In Chinese). PubMed/NCBI

18 

Fritz I and Olsson H: Lung cancer in young women in southern Sweden: A descriptive study. Clin Respir J. 12:1565–1571. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Murphy RA, Mourtzakis M, Chu QS, Baracos VE, Reiman T and Mazurak VC: Supplementation with fish oil increases first-line chemotherapy efficacy in patients with advanced nonsmall cell lung cancer. Cancer. 117:3774–3780. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Kanesvaran R, Roy Chowdhury A and Krishna L: Practice pearls in the management of lung cancer in the elderly. J Geriatr Oncol. 7:362–367. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Gutschner T, Hämmerle M, Eissmann M, Hsu J, Kim Y, Hung G, Revenko A, Arun G, Stentrup M, Gross M, et al: The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res. 73:1180–1189. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Zhou L, He J, Xiong W, Liu Y, Xiang J, Yu Q, Liang M, Zhou X, Ding Z, Huang M, et al: Impact of whole brain radiation therapy on CSF penetration ability of Icotinib in EGFR-mutated non-small cell lung cancer patients with brain metastases: Results of phase I dose-escalation study. Lung Cancer. 96:93–100. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Song Z, Su H and Zhang Y: Patients with ROS1 rearrangement-positive non-small-cell lung cancer benefit from pemetrexed-based chemotherapy. Cancer Med. 5:2688–2693. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Scheinpflug K, Menzel C, Koch A, Kahl C and Achenbach HJ: Toxic epidermal necrolysis related to cisplatin and pemetrexed for metastatic non-small cell lung cancer. Onkologie. 35:600–603. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Ping W, Gao Y, Fan X, Li W, Deng Y and Fu X: MiR-181a contributes gefitinib resistance in non-small cell lung cancer cells by targeting GAS7. Biochem Biophys Res Commun. 495:2482–2489. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Ding T, Zhou F, Chen X, Zhang S, Liu Y, Sun H, Ren S, Li X, Zhao C, Wang H, et al: Continuation of gefitinib plus chemotherapy prolongs progression-free survival in advanced non-small cell lung cancer patients who get acquired resistance to gefitinib without T790M mutations. J Thorac Dis. 9:2923–2934. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Liu Y, Zhang Y, Feng G, Niu Q, Xu S, Yan Y, Li S and Jing M: Comparison of effectiveness and adverse effects of gefitinib, erlotinib and icotinib among patients with non-small cell lung cancer: A network meta-analysis. Exp Ther Med. 14:4017–4032. 2017.PubMed/NCBI

28 

Lee JK, Hahn S, Kim DW, Suh KJ, Keam B, Kim TM, Lee SH and Heo DS: Epidermal growth factor receptor tyrosine kinase inhibitors vs conventional chemotherapy in non-small cell lung cancer harboring wild-type epidermal growth factor receptor: A meta-analysis. JAMA. 311:1430–1437. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Fennell DA, Gaudino G, O'Byrne KJ, Mutti L and van Meerbeeck J: Advances in the systemic therapy of malignant pleural mesothelioma. Nat Clin Pract Oncol. 5:136–147. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Chen M, Cao H, Ji Y, Mao Y, Shen S and Li X: Association between the ALK Gene Status and the efficacy of first-line pemetrexed chemotherapy in patients with advanced lung adenocarcinoma. Zhongguo Fei Ai Za Zhi. 20:732–736. 2017.(In Chinese). PubMed/NCBI

31 

Shi Y, Zhang L, Liu X, Zhou C, Zhang L, Zhang S, Wang D, Li Q, Qin S, Hu C, et al: Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): A randomised, double-blind phase 3 non-inferiority trial. Lancet Oncol. 14:953–961. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhou X, Hua D, Gao C, Zhang Y, Qiu L and Wang L: Icotinib and pemetrexed in treatment of lung adenocarcinoma and the effects on prognostic survival rate of patients. Oncol Lett 18: 4153-4159, 2019.
APA
Zhou, X., Hua, D., Gao, C., Zhang, Y., Qiu, L., & Wang, L. (2019). Icotinib and pemetrexed in treatment of lung adenocarcinoma and the effects on prognostic survival rate of patients. Oncology Letters, 18, 4153-4159. https://doi.org/10.3892/ol.2019.10763
MLA
Zhou, X., Hua, D., Gao, C., Zhang, Y., Qiu, L., Wang, L."Icotinib and pemetrexed in treatment of lung adenocarcinoma and the effects on prognostic survival rate of patients". Oncology Letters 18.4 (2019): 4153-4159.
Chicago
Zhou, X., Hua, D., Gao, C., Zhang, Y., Qiu, L., Wang, L."Icotinib and pemetrexed in treatment of lung adenocarcinoma and the effects on prognostic survival rate of patients". Oncology Letters 18, no. 4 (2019): 4153-4159. https://doi.org/10.3892/ol.2019.10763
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou X, Hua D, Gao C, Zhang Y, Qiu L and Wang L: Icotinib and pemetrexed in treatment of lung adenocarcinoma and the effects on prognostic survival rate of patients. Oncol Lett 18: 4153-4159, 2019.
APA
Zhou, X., Hua, D., Gao, C., Zhang, Y., Qiu, L., & Wang, L. (2019). Icotinib and pemetrexed in treatment of lung adenocarcinoma and the effects on prognostic survival rate of patients. Oncology Letters, 18, 4153-4159. https://doi.org/10.3892/ol.2019.10763
MLA
Zhou, X., Hua, D., Gao, C., Zhang, Y., Qiu, L., Wang, L."Icotinib and pemetrexed in treatment of lung adenocarcinoma and the effects on prognostic survival rate of patients". Oncology Letters 18.4 (2019): 4153-4159.
Chicago
Zhou, X., Hua, D., Gao, C., Zhang, Y., Qiu, L., Wang, L."Icotinib and pemetrexed in treatment of lung adenocarcinoma and the effects on prognostic survival rate of patients". Oncology Letters 18, no. 4 (2019): 4153-4159. https://doi.org/10.3892/ol.2019.10763
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team