Open Access

CAR‑T 19 combined with reduced‑dose PD‑1 blockade therapy for treatment of refractory follicular lymphoma: A case report

  • Authors:
    • Jia Wang
    • Qi Deng
    • Yan‑Yu Jiang
    • Rui Zhang
    • Hai‑Bo Zhu
    • Juan‑Xia Meng
    • Yu‑Ming Li
  • View Affiliations

  • Published online on: August 27, 2019     https://doi.org/10.3892/ol.2019.10783
  • Pages: 4415-4420
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Anti‑CD19 chimeric antigen receptor T cell (CAR‑T) therapy has changed the typical outcomes of relapsed/refractory B‑cell leukemia and lymphoma. However, treatment effectiveness for patients with relapsed/refractory B‑cell non‑Hodgkin lymphoma has been less satisfactory compared with patients with B‑cell acute lymphoblastic leukemia. The present study described a case of refractory follicular lymphoma. A high expression of programmed cell death 1 (PD‑1) was measured on CD3+ T cells (80.90%) in peripheral blood samples obtained from the patient enrolled in this study, indicating that treatment with autologous CAR‑T 19 cell therapy may not be successful. Therefore, a therapy regimen consisting of CAR‑T 19 cells in combination with a reduced dose of nivolumab (1.5 mg/kg) for PD‑1 blockade was used. A low dose of PD‑1 blockade therapy was used to reduce the adverse effects associated with the combination of a PD‑1 inhibitor and CAR‑T 19 cells. This salvage therapy resulted in remission that lasted for >10 months.
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November-2019
Volume 18 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang J, Deng Q, Jiang YY, Zhang R, Zhu HB, Meng JX and Li YM: CAR‑T 19 combined with reduced‑dose PD‑1 blockade therapy for treatment of refractory follicular lymphoma: A case report. Oncol Lett 18: 4415-4420, 2019
APA
Wang, J., Deng, Q., Jiang, Y., Zhang, R., Zhu, H., Meng, J., & Li, Y. (2019). CAR‑T 19 combined with reduced‑dose PD‑1 blockade therapy for treatment of refractory follicular lymphoma: A case report. Oncology Letters, 18, 4415-4420. https://doi.org/10.3892/ol.2019.10783
MLA
Wang, J., Deng, Q., Jiang, Y., Zhang, R., Zhu, H., Meng, J., Li, Y."CAR‑T 19 combined with reduced‑dose PD‑1 blockade therapy for treatment of refractory follicular lymphoma: A case report". Oncology Letters 18.5 (2019): 4415-4420.
Chicago
Wang, J., Deng, Q., Jiang, Y., Zhang, R., Zhu, H., Meng, J., Li, Y."CAR‑T 19 combined with reduced‑dose PD‑1 blockade therapy for treatment of refractory follicular lymphoma: A case report". Oncology Letters 18, no. 5 (2019): 4415-4420. https://doi.org/10.3892/ol.2019.10783