Open Access

Mitochondrial oncobioenergetics of prostate tumorigenesis (Review)

  • Authors:
    • Praveen Kumar Vayalil
  • View Affiliations

  • Published online on: August 27, 2019     https://doi.org/10.3892/ol.2019.10785
  • Pages: 4367-4376
  • Copyright: © Vayalil . This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Mitochondria are emerging as key players in the tumorigenic process of cells by maintaining the biosynthetic and energetic capabilities of cancer cells. It is now evident that mitochondria are involved in the malignant transformation, cell proliferation, aggression and metastatic behavior of prostate cancer (PC). Recent comprehensive analysis of the mitochondrial oncobioenergetic (MOB) profile of PC cells using microplate‑based high resolution respirometry has clearly demonstrated that characteristic MOB alterations occur at different stages of PC development. Additionally, studies have reported that modification of the MOB profile significantly inhibits the growth of malignant cells. This observation suggests that dynamic alterations in the MOB function are a critical component in the development of malignant disease of the prostate. Therefore, quantification of MOB function may be a good marker for the prediction of tumor stage. Future studies may develop novel approaches to measure oncobioenergetics of tumors with minimal invasive procedures effectively in men to determine the general prostate health and tumor staging, and to predict whether a tumor will proceed to malignancy in patients. Additionally, since PC is a slow growing tumor, modulating the MOB profile at specific stages of tumor development may be a novel approach to treat or prevent PC.
View Figures
View References

Related Articles

Journal Cover

November-2019
Volume 18 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Vayalil PK: Mitochondrial oncobioenergetics of prostate tumorigenesis (Review). Oncol Lett 18: 4367-4376, 2019
APA
Vayalil, P.K. (2019). Mitochondrial oncobioenergetics of prostate tumorigenesis (Review). Oncology Letters, 18, 4367-4376. https://doi.org/10.3892/ol.2019.10785
MLA
Vayalil, P. K."Mitochondrial oncobioenergetics of prostate tumorigenesis (Review)". Oncology Letters 18.5 (2019): 4367-4376.
Chicago
Vayalil, P. K."Mitochondrial oncobioenergetics of prostate tumorigenesis (Review)". Oncology Letters 18, no. 5 (2019): 4367-4376. https://doi.org/10.3892/ol.2019.10785