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Review Open Access

Mitochondrial oncobioenergetics of prostate tumorigenesis (Review)

  • Authors:
    • Praveen Kumar Vayalil
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    Affiliations: Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Copyright: © Vayalil et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4367-4376
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    Published online on: August 27, 2019
       https://doi.org/10.3892/ol.2019.10785
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Abstract

Mitochondria are emerging as key players in the tumorigenic process of cells by maintaining the biosynthetic and energetic capabilities of cancer cells. It is now evident that mitochondria are involved in the malignant transformation, cell proliferation, aggression and metastatic behavior of prostate cancer (PC). Recent comprehensive analysis of the mitochondrial oncobioenergetic (MOB) profile of PC cells using microplate‑based high resolution respirometry has clearly demonstrated that characteristic MOB alterations occur at different stages of PC development. Additionally, studies have reported that modification of the MOB profile significantly inhibits the growth of malignant cells. This observation suggests that dynamic alterations in the MOB function are a critical component in the development of malignant disease of the prostate. Therefore, quantification of MOB function may be a good marker for the prediction of tumor stage. Future studies may develop novel approaches to measure oncobioenergetics of tumors with minimal invasive procedures effectively in men to determine the general prostate health and tumor staging, and to predict whether a tumor will proceed to malignancy in patients. Additionally, since PC is a slow growing tumor, modulating the MOB profile at specific stages of tumor development may be a novel approach to treat or prevent PC.
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Copy and paste a formatted citation
Spandidos Publications style
Vayalil PK: Mitochondrial oncobioenergetics of prostate tumorigenesis (Review). Oncol Lett 18: 4367-4376, 2019.
APA
Vayalil, P.K. (2019). Mitochondrial oncobioenergetics of prostate tumorigenesis (Review). Oncology Letters, 18, 4367-4376. https://doi.org/10.3892/ol.2019.10785
MLA
Vayalil, P. K."Mitochondrial oncobioenergetics of prostate tumorigenesis (Review)". Oncology Letters 18.5 (2019): 4367-4376.
Chicago
Vayalil, P. K."Mitochondrial oncobioenergetics of prostate tumorigenesis (Review)". Oncology Letters 18, no. 5 (2019): 4367-4376. https://doi.org/10.3892/ol.2019.10785
Copy and paste a formatted citation
x
Spandidos Publications style
Vayalil PK: Mitochondrial oncobioenergetics of prostate tumorigenesis (Review). Oncol Lett 18: 4367-4376, 2019.
APA
Vayalil, P.K. (2019). Mitochondrial oncobioenergetics of prostate tumorigenesis (Review). Oncology Letters, 18, 4367-4376. https://doi.org/10.3892/ol.2019.10785
MLA
Vayalil, P. K."Mitochondrial oncobioenergetics of prostate tumorigenesis (Review)". Oncology Letters 18.5 (2019): 4367-4376.
Chicago
Vayalil, P. K."Mitochondrial oncobioenergetics of prostate tumorigenesis (Review)". Oncology Letters 18, no. 5 (2019): 4367-4376. https://doi.org/10.3892/ol.2019.10785
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