Multi‑pathway integrated adjustment mechanism of licorice flavonoids presenting anti‑inflammatory activity

  • Authors:
    • Xiaomeng Yu
    • Yongrui Bao
    • Xiansheng Meng
    • Shuai Wang
    • Tianjiao Li
    • Xin Chang
    • Weifeng Xu
    • Guanlin Yang
    • Tao Bo
  • View Affiliations

  • Published online on: September 4, 2019     https://doi.org/10.3892/ol.2019.10793
  • Pages: 4956-4963
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Glycyrrhiza, commonly known as licorice, is a herbal medicine that has been used for thousands of years. Licorice contains multiple flavonoids, which possess a variety of biological activities. On the basis of the anti‑inflammatory effects of licorice flavonoids, the potential mechanism of action was investigated via a plasma metabolomics approach. A total of 9 differential endogenous metabolites associated with the therapeutic effect of licorice flavonoids were identified, including linoleic acid, sphingosine, tryptophanamide, corticosterone and leukotriene B4. Besides classical arachidonic acid metabolism, metabolism of sphingolipids, tryptophan and fatty acids, phospholipids synthesis, and other pathways were also involved. The multi‑pathway integrated adjustment mechanism of licorice flavonoid action may reduce side effects in patients, along with any anti‑inflammatory functions, which provides a foundation for identifying and developing novel, high‑potential natural drugs with fewer side effects for clinical application.
View Figures
View References

Related Articles

Journal Cover

November-2019
Volume 18 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yu X, Bao Y, Meng X, Wang S, Li T, Chang X, Xu W, Yang G and Bo T: Multi‑pathway integrated adjustment mechanism of licorice flavonoids presenting anti‑inflammatory activity. Oncol Lett 18: 4956-4963, 2019.
APA
Yu, X., Bao, Y., Meng, X., Wang, S., Li, T., Chang, X. ... Bo, T. (2019). Multi‑pathway integrated adjustment mechanism of licorice flavonoids presenting anti‑inflammatory activity. Oncology Letters, 18, 4956-4963. https://doi.org/10.3892/ol.2019.10793
MLA
Yu, X., Bao, Y., Meng, X., Wang, S., Li, T., Chang, X., Xu, W., Yang, G., Bo, T."Multi‑pathway integrated adjustment mechanism of licorice flavonoids presenting anti‑inflammatory activity". Oncology Letters 18.5 (2019): 4956-4963.
Chicago
Yu, X., Bao, Y., Meng, X., Wang, S., Li, T., Chang, X., Xu, W., Yang, G., Bo, T."Multi‑pathway integrated adjustment mechanism of licorice flavonoids presenting anti‑inflammatory activity". Oncology Letters 18, no. 5 (2019): 4956-4963. https://doi.org/10.3892/ol.2019.10793