Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November-2019 Volume 18 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2019 Volume 18 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Knockdown of neuron‑specific enolase suppresses the proliferation and migration of NCI‑H209 cells

  • Authors:
    • Xia Liu
    • Shousheng Liu
    • Juan Fu
    • Jinsheng Huang
    • Chengyin Weng
    • Xisheng Fang
    • Mingmei Guan
    • Yong Wu
    • Lin Yang
    • Guolong Liu
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, P.R. China, State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China, Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4809-4815
    |
    Published online on: September 4, 2019
       https://doi.org/10.3892/ol.2019.10797
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Neuron‑specific enolase (NSE) is generally considered as a marker for diagnosis and evaluation of the response to therapy in small cell lung cancer (SCLC). However, the role of NSE in the progression of SCLC remains to be elucidated. In the present study, the functions of NSE in SCLC, in addition to the potential mechanisms, were investigated using a loss‑of‑function approach with NSE‑targeting small interfering (si)RNA. The knockdown of NSE markedly decreased the proliferation of NCI‑H209 cells, as indicated by MTT assay (P<0.05). Furthermore, the silencing of NSE resulted in the formation of smaller and fewer colonies compared with that in the control group (P<0.001). Flow cytometric analysis indicated that the silencing of NSE resulted in a decreased S‑phase population among NCI‑H209 cells (P<0.05). Transwell assay demonstrated that the silencing of NSE suppressed the migration of NCI‑H209 cells (P<0.001). NCI‑H209 cells transfected with NSE siRNA‑1 or negative control were collected and the protein levels of metastasis‑associated genes were detected using western blot analysis. The results indicated that the knockdown of NSE led to downregulation of the pro‑metastatic gene vascular endothelial growth factor (VEGF; P<0.05) and the upregulation of metastasis suppressor genes NM23 and E‑cadherin (P<0.05). Taken together, the results of the present study demonstrated that the silencing of NSE suppressed the migration, proliferation and colony formation ability of SCLC cells and decreased the S‑phase population. In addition, the knockdown of NSE resulted in the upregulation of E‑cadherin and NM23 and the downregulation of VEGF. Collectively, these results indicated that intracellular NSE may have an important role in the progression of SCLC.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Wistuba II, Gazdar AF and Minna JD: Molecular genetics of small cell lung carcinoma. Semin Oncol 28 (2 Suppl 4). S3–S13. 2001.

3 

van Meerbeeck JP, Fennell DA and De Ruysscher DK: Small- cell lung cancer. Lancet. 378:1741–1755. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Pelayo Alvarez M, Westeel V, Cortés-Jofré M and Bonfill Cosp X: Chemotherapy versus best supportive care for extensive small cell lung cancer. Cochrane Database Syst Rev. CD0019902013.PubMed/NCBI

5 

Shirasawa M, Fukui T, Kusuhara S, Hiyoshi Y, Ishihara M, Kasajima M, Nakahara Y, Otani S, Igawa S, Yokoba M, et al: Prognostic significance of the 8th edition of the TNM classification for patients with extensive disease small cell lung cancer. Cancer Manag Res. 10:6039–6047. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Qiu G, DU X, Zhou X, Bao W, Chen L, Chen J, Ji Y and Wang S: Prophylactic cranial irradiation in 399 patients with limited-stage small cell lung cancer. Oncol Lett. 11:2654–2660. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Chan BA and Coward JI: Chemotherapy advances in small-cell lung cancer. J Thorac Dis. 5 (Suppl 5):S565–S578. 2013.PubMed/NCBI

8 

Oze I, Ito H, Nishino Y, Hattori M, Nakayama T, Miyashiro I, Matsuo K and Ito Y: Trends in small-cell lung cancer survival in 1993–2006 based on population-based cancer registry data in Japan. J Epidemiol. Nov 17–2018.(Epub ahead of print). doi: 10.2188/jea.JE20180112.

9 

Harmsma M, Schutte B and Ramaekers FC: Serum markers in small cell lung cancer: Opportunities for improvement. Biochim Biophys Acta. 1836:255–272. 2013.PubMed/NCBI

10 

Bremnes RM, Sundstrom S, Aasebø U, Kaasa S, Hatlevoll R and Aamdal S; Norweigian Lung Cancer StudyGroup, : The value of prognostic factors in small cell lung cancer: Results from a randomised multicenter study with minimum 5 year follow-up. Lung Cancer. 39:303–313. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Ono A, Naito T, Ito I, Watanabe R, Shukuya T, Kenmotsu H, Tsuya A, Nakamura Y, Murakami H, Kaira K, et al: Correlations between serial pro-gastrin-releasing peptide and neuron-specific enolase levels, and the radiological response to treatment and survival of patients with small-cell lung cancer. Lung Cancer. 76:439–444. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Zhao WX and Luo JF: Serum neuron-specific enolase levels were associated with the prognosis of small cell lung cancer: A meta-analysis. Tumour Biol. 34:3245–3248. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Sharma RA, Wotherspoon AC, Cook G, Morgan GJ and Huddart RA: Neuron-specific enolase expression in multiple myeloma. Lancet OncoL. 7:9602006. View Article : Google Scholar : PubMed/NCBI

14 

Huang L, Zhou JG, Yao WX, Tian X, Lv SP, Zhang TY, Jin SH, Bai YJ and Ma H: Systematic review and meta-analysis of the efficacy of serum neuron-specific enolase for early small cell lung cancer screening. Oncotarget. 8:64358–64372. 2017.PubMed/NCBI

15 

Molina R, Auge JM, Escudero JM, Marrades R, Viñolas N, Carcereny E, Ramirez J and Filella X: Mucins CA 125, CA 19.9, CA 15.3 and TAG-72.3 as tumor markers in patients with lung cancer: Comparison with CYFRA 21-1, CEA, SCC and NSE. Tumour Biol. 29:371–380. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Liu S, Guo H, Kong L, Li H, Zhang Y, Zhu H and Yu J: The prognostic factors in the elderly patients with small cell lung cancer: A retrospective analysis from a single cancer institute. Int J Clin Exp Pathol. 8:11033–11041. 2015.PubMed/NCBI

17 

Buil-Bruna N, López-Picazo JM, Moreno-Jiménez M, Martín-Algarra S, Ribba B and Trocóniz IF: A population pharmacodynamic model for lactate dehydrogenase and neuron specific enolase to predict tumor progression in small cell lung cancer patients. AAPS J. 16:609–619. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Fizazi K, Cojean I, Pignon JP, Rixe O, Gatineau M, Hadef S, Arriagada R, Baldeyrou P, Comoy E and Le Chevalier T: Normal serum neuron specific enolase (NSE) value after the first cycle of chemotherapy: An early predictor of complete response and survival in patients with small cell lung carcinoma. Cancer. 82:1049–1055. 1998. View Article : Google Scholar : PubMed/NCBI

19 

Liu X, Zhang W, Yin W, Xiao Y, Zhou C, Hu Y and Geng S: The prognostic value of the serum neuron specific enolase and lactate dehydrogenase in small cell lung cancer patients receiving first-line platinum-based chemotherapy. Medicine (Baltimore). 96:e82582017. View Article : Google Scholar : PubMed/NCBI

20 

Liu S, Cai X, Xia L, Jiang C, Chen P, Wang X, Zhang B and Zhao HY: Chloroquine exerts antitumor effects on NB4 acute promyelocytic leukemia cells and functions synergistically with arsenic trioxide. Oncol Lett. 15:2024–2030. 2018.PubMed/NCBI

21 

Liu X, Lv XB, Wang XP, Sang Y, Xu S, Hu K, Wu M, Liang Y, Liu P, Tang J, et al: MiR-138 suppressed nasopharyngeal carcinoma growth and tumorigenesis by targeting the CCND1 oncogene. Cell Cycle. 11:2495–2506. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Lv XB, Jiao Y, Qing Y, Hu H, Cui X, Lin T, Song E and Yu F: miR-124 suppresses multiple steps of breast cancer metastasis by targeting a cohort of pro-metastatic genes in vitro. CHIN J CANCER. 30:821–830. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Yan HJ, Tan Y and Gu W: Neuron specific enolase and prognosis of non-small cell lung cancer: A systematic review and meta-analysis. J BUON. 19:153–156. 2014.PubMed/NCBI

24 

Proshchina AE, Krivova YS, Barabanov VM and Saveliev SV: Ontogeny of neuro-insular complexes and islets innervation in the human pancreas. Front Endocrinol (Lausanne). 5:572014. View Article : Google Scholar : PubMed/NCBI

25 

Tang D, Wang M, Sui A, Wang Y, Yang R, Wang Z, Zhao Y, Jiao W and Shen Y: Prospective validation of quantitative NSE mRNA in pleural fluid of non-small cell lung cancer patients. Med Oncol. 30:6992013. View Article : Google Scholar : PubMed/NCBI

26 

Jang SM, Kim JW, Kim CH, Kim D, Rhee S and Choi KH: p19(ras) Represses proliferation of non-small cell lung cancer possibly through interaction with Neuron-Specific Enolase (NSE). Cancer Lett. 289:91–98. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Gronowitz JS, Bergström R, Nôu E, Påhlman S, Brodin O, Nilsson S and Källander CF: Clinical and serologic markers of stage and prognosis in small cell lung cancer. A multivariate analysis. Cancer. 66:722–732. 1990. View Article : Google Scholar : PubMed/NCBI

28 

Jett JR, Schild SE, Kesler KA and Kalemkerian GP: Treatment of small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 143 (Suppl 5):e400S–e419S. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Lurje G, Zhang W, Schultheis AM, Yang D, Groshen S, Hendifar AE, Husain H, Gordon MA, Nagashima F, Chang HM and Lenz HJ: Polymorphisms in VEGF and IL-8 predict tumor recurrence in stage III colon cancer. Ann Oncol. 19:1734–1741. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Ustuner Z, Saip P, Yasasever V, Vural B, Yazar A, Bal C, Ozturk B, Ozbek U and Topuz E: Prognostic and predictive value of vascular endothelial growth factor and its soluble receptors, VEGFR-1 and VEGFR-2 levels in the sera of small cell lung cancer patients. Med Oncol. 25:394–399. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Berx G and van Roy F: Involvement of members of the cadherin superfamily in cancer. Cold Spring Harb Perspect Biol. 1:a31292009. View Article : Google Scholar

33 

Li LI, Lv Y, Zhang Y, He L and Zhang H: Expression and clinical significance of Oct-4 and E-cad in non-small-cell lung cancer. Oncol Lett. 11:234–236. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Carotenuto M, de Antonellis P, Chiarolla CM, Attanasio C, Damiani V, Boffa I, Aiese N, Pedone E, Accordi B, Basso G, et al: A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction. Naunyn Schmiedebergs Arch Pharmacol. 388:257–269. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Esposito S, Russo MV, Airoldi I, Tupone MG, Sorrentino C, Barbarito G, Di Meo S and Di Carlo E: SNAI2/Slug gene is silenced in prostate cancer and regulates neuroendocrine differentiation, metastasis-suppressor and pluripotency gene expression. Oncotarget. 6:17121–17134. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Huang CS, Shih MK, Chuang CH and Hu ML: Lycopene inhibits cell migration and invasion and upregulates Nm23-H1 in a highly invasive hepatocarcinoma, SK-Hep-1 cells. J Nutr. 135:2119–2123. 2005. View Article : Google Scholar : PubMed/NCBI

37 

Kim YI, Park S, Jeoung DI and Lee H: Point mutations affecting the oligomeric structure of Nm23-H1 abrogates its inhibitory activity on colonization and invasion of prostate cancer cells. Biochem Biophys Res Commun. 307:281–289. 2003. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu X, Liu S, Fu J, Huang J, Weng C, Fang X, Guan M, Wu Y, Yang L, Liu G, Liu G, et al: Knockdown of neuron‑specific enolase suppresses the proliferation and migration of NCI‑H209 cells. Oncol Lett 18: 4809-4815, 2019.
APA
Liu, X., Liu, S., Fu, J., Huang, J., Weng, C., Fang, X. ... Liu, G. (2019). Knockdown of neuron‑specific enolase suppresses the proliferation and migration of NCI‑H209 cells. Oncology Letters, 18, 4809-4815. https://doi.org/10.3892/ol.2019.10797
MLA
Liu, X., Liu, S., Fu, J., Huang, J., Weng, C., Fang, X., Guan, M., Wu, Y., Yang, L., Liu, G."Knockdown of neuron‑specific enolase suppresses the proliferation and migration of NCI‑H209 cells". Oncology Letters 18.5 (2019): 4809-4815.
Chicago
Liu, X., Liu, S., Fu, J., Huang, J., Weng, C., Fang, X., Guan, M., Wu, Y., Yang, L., Liu, G."Knockdown of neuron‑specific enolase suppresses the proliferation and migration of NCI‑H209 cells". Oncology Letters 18, no. 5 (2019): 4809-4815. https://doi.org/10.3892/ol.2019.10797
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Liu S, Fu J, Huang J, Weng C, Fang X, Guan M, Wu Y, Yang L, Liu G, Liu G, et al: Knockdown of neuron‑specific enolase suppresses the proliferation and migration of NCI‑H209 cells. Oncol Lett 18: 4809-4815, 2019.
APA
Liu, X., Liu, S., Fu, J., Huang, J., Weng, C., Fang, X. ... Liu, G. (2019). Knockdown of neuron‑specific enolase suppresses the proliferation and migration of NCI‑H209 cells. Oncology Letters, 18, 4809-4815. https://doi.org/10.3892/ol.2019.10797
MLA
Liu, X., Liu, S., Fu, J., Huang, J., Weng, C., Fang, X., Guan, M., Wu, Y., Yang, L., Liu, G."Knockdown of neuron‑specific enolase suppresses the proliferation and migration of NCI‑H209 cells". Oncology Letters 18.5 (2019): 4809-4815.
Chicago
Liu, X., Liu, S., Fu, J., Huang, J., Weng, C., Fang, X., Guan, M., Wu, Y., Yang, L., Liu, G."Knockdown of neuron‑specific enolase suppresses the proliferation and migration of NCI‑H209 cells". Oncology Letters 18, no. 5 (2019): 4809-4815. https://doi.org/10.3892/ol.2019.10797
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team