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Screening and authentication of molecular markers in malignant glioblastoma based on gene expression profiles

  • Authors:
    • Yang‑Fan Zou
    • Ling‑Bing Meng
    • Zhao‑Kai He
    • Chen‑Hao Hu
    • Meng‑Jie Shan
    • Deng‑Yuan Wang
    • Xin Yu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Chinese People's Liberation Army General Hospital‑Sixth Medical Center, Beijing 100037, P.R. China, Department of Neurology, Beijing Hospital, National Center of Gerontology, Beijing 100730, P.R. China, State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102200, P.R. China, Graduate School, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China
    Copyright: © Zou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4593-4604
    |
    Published online on: September 4, 2019
       https://doi.org/10.3892/ol.2019.10804
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Abstract

Glioblastoma (GBM) is a malignant tumor of the central nervous system with high mortality rates. Gene expression profiling may determine the chemosensitivity of GBMs. However, the molecular mechanisms underlying GBM remain to be determined. To screen the novel key genes in its occurrence and development, two glioma databases, GSE122498 and GSE104291, were analyzed in the present study. Bioinformatics analyses were performed using the Database for Annotation, Visualization and Integrated Discovery, the Search Tool for the Retrieval of Interacting Genes, Cytoscape, cBioPortal, and Gene Expression Profiling Interactive Analysis softwares. Patients with recurrent GBM showed worse overall survival rate. Overall, 341 differentially expressed genes (DEGs) were authenticated based on two microarray datasets, which were primarily enriched in ‘cell division’, ‘mitotic nuclear division’, ‘DNA replication’, ‘nucleoplasm’, ‘cytosol, nucleus’, ‘protein binding’, ‘ATP binding’, ‘protein C‑terminus binding’, ‘the cell cycle’, ‘DNA replication’, ‘oocyte meiosis’ and ‘valine’. The protein‑protein interaction network was composed of 1,799 edges and 237 nodes. Its significant module had 10 hub genes, and CDK1, BUB1B, NDC80, NCAPG, BUB1, CCNB1, TOP2A, DLGAP5, ASPM and MELK were significantly associated with carcinogenesis and the development of GBM. The present study indicated that the DEGs and hub genes, identified based on bioinformatics analyses, had significant diagnostic value for patients with GBM.
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1 

Laug D, Glasgow SM and Deneen B: A glial blueprint for gliomagenesis. Nat Rev Neurosci. 19:393–403. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Amirian ES, Armstrong GN, Zhou R, Lau CC, Claus EB, Barnholtz-Sloan JS, Il'yasova D, Schildkraut J, Ali-Osman F, Sadetzki S, et al: The Glioma international case-control study: A report from the genetic epidemiology of glioma international consortium. Am J Epidemiol. 183:85–91. 2016.PubMed/NCBI

3 

Benenemissi IH, Sifi K, Sahli LK, Semmam O, Abadi N and Satta D: Angiotensin-converting enzyme insertion/deletion gene polymorphisms and the risk of glioma in an Algerian population. Pan Afr Med J. 32:1972019. View Article : Google Scholar : PubMed/NCBI

4 

Hempel JM, Schittenhelm J, Bisdas S, Brendle C, Bender B, Bier G, Skardelly M, Tabatabai G, Castaneda Vega S, Ernemann U and Klose U: In vivo assessment of tumor heterogeneity in WHO 2016 glioma grades using diffusion kurtosis imaging: Diagnostic performance and improvement of feasibility in routine clinical practice. J Neuroradiol. 45:32–40. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Cancer Genome Atlas Research Networ, ; Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR, Cooper LA, Rheinbay E, Miller CR, Vitucci M, et al: Comprehensive, integrative genomic analysis of diffuse Lower-Grade gliomas. N Engl J Med. 372:2481–2498. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Schmid RS, Simon JM, Vitucci M, McNeill RS, Bash RE, Werneke AM, Huey L, White KK, Ewend MG, Wu J and Miller CR: Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide. Neuro Oncol. 18:962–973. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Fischer U, Struss AK, Hemmer D, Michel A, Henn W, Steudel WI and Meese E: PHF3 expression is frequently reduced in glioma. Cytogenet Cell Genet. 94:131–136. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Lewis PW, Muller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, Garcia BA, Muir TW, Becher OJ and Allis CD: Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science. 340:857–861. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Schwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, Jacob K, Sturm D, Fontebasso AM, Quang DA, Tönjes M, et al: Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature. 482:226–231. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Ceccon G, Werner JM, Dunkl V, Tscherpel C, Stoffels G, Brunn A, Deckert M, Fink GR and Galldiks N: Dabrafenib treatment in a patient with an Epithelioid Glioblastoma and BRAF V600E Mutation. Int J Mol Sci. 19:E10902018. View Article : Google Scholar : PubMed/NCBI

11 

Wang Z, Bao Z, Yan W, You G, Wang Y, Li X and Zhang W: Isocitrate dehydrogenase 1 (IDH1) mutation-specific microRNA signature predicts favorable prognosis in glioblastoma patients with IDH1 wild type. J Exp Clin Cancer Res. 32:592013. View Article : Google Scholar : PubMed/NCBI

12 

Srinivasan S, Patric IR and Somasundaram K: A ten-microRNA expression signature predicts survival in glioblastoma. PLoS One. 6:e174382011. View Article : Google Scholar : PubMed/NCBI

13 

Wang W, Zhang L, Wang Z, Yang F, Wang H, Liang T, Wu F, Lan Q, Wang J and Zhao J: A three-gene signature for prognosis in patients with MGMT promoter-methylated glioblastoma. Oncotarget. 7:69991–69999. 2016.PubMed/NCBI

14 

Karsy M, Guan J, Cohen AL, Jensen RL and Colman H: New molecular considerations for glioma: IDH, ATRX, BRAF, TERT, H3 K27M. Curr Neurol Neurosci Rep. 17:192017. View Article : Google Scholar : PubMed/NCBI

15 

Solanki C, Sadana D, Arimappamagan A, Rao KV, Rajeswaran J, Subbakrishna DK, Santosh V and Pandey P: Impairments in quality of life and cognitive functions in long-term survivors of glioblastoma. J Neurosci Rural Pract. 8:228–235. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Arimappamagan A, Somasundaram K, Thennarasu K, Peddagangannagari S, Srinivasan H, Shailaja BC, Samuel C, Patric IR, Shukla S, Thota B, et al: A fourteen gene GBM prognostic signature identifies association of immune response pathway and mesenchymal subtype with high risk group. PLoS One. 8:e620422013. View Article : Google Scholar : PubMed/NCBI

17 

Vastrad B, Vastrad C, Godavarthi A and Chandrashekar R: Molecular mechanisms underlying gliomas and glioblastoma pathogenesis revealed by bioinformatics analysis of microarray data. Med Oncol. 34:1822017. View Article : Google Scholar : PubMed/NCBI

18 

Zhong S, Wu B, Dong X, Han Y, Jiang S, Zhang Y, Bai Y, Luo SX, Chen Y, Zhang H and Zhao G: Identification of driver genes and key pathways of glioblastoma shows JNJ-7706621 as a novel antiglioblastoma drug. World Neurosurg. 109:e329–e342. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Aldape K, Zadeh G, Mansouri S, Reifenberger G and von Deimling A: Glioblastoma: Pathology, molecular mechanisms and markers. Acta Neuropathol. 129:829–848. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Poon CC, Sarkar S, Yong VW and Kelly JJP: Glioblastoma-associated microglia and macrophages: Targets for therapies to improve prognosis. Brain. 140:1548–1560. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Kim SM, Kwon IJ, Myoung H, Lee JH and Lee SK: Identification of human papillomavirus (HPV) subtype in oral cancer patients through microarray technology. Eur Arch Otorhinolaryngol. 275:535–543. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Cheng Y, Ping J and Chen J: Identification of potential gene network associated with HCV-Related hepatocellular carcinoma using microarray analysis. Pathol Oncol Res. 24:507–514. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Edgar R, Domrachev M and Lash AE: Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30:207–210. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Hilf N, Kuttruff-Coqui S, Frenzel K, Bukur V, Stevanovic S, Gouttefangeas C, Platten M, Tabatabai G, Dutoit V, van der Burg SH, et al: Actively personalized vaccination trial for newly diagnosed glioblastoma. Nature. 565:240–245. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Bady P, Diserens AC, Castella V, Kalt S, Heinimann K, Hamou MF, Delorenzi M and Hegi ME: DNA fingerprinting of glioma cell lines and considerations on similarity measurements. Neuro Oncol. 14:701–711. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al: NCBI GEO: Archive for functional genomics data sets-update. Nucleic Acids Res 41 (Database Issue). D991–D995. 2013.

27 

Solari A and Goeman JJ: Minimally adaptive BH: A tiny but uniform improvement of the procedure of Benjamini and Hochberg. Biom J. 59:776–780. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Huang DW, Sherman BT, Tan Q, Collins JR, Alvord WG, Roayaei J, Stephens R, Baseler MW, Lane HC and Lempicki RA: The DAVID gene functional classification tool: A novel biological module-centric algorithm to functionally analyze large gene lists. Genome Biol. 8:R1832007. View Article : Google Scholar : PubMed/NCBI

29 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Kanehisa M: The KEGG database. Novartis Found Symp. 247:91–103, 119-128, 244–252. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43:D447–D452. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Smoot ME, Ono K, Ruscheinski J, Wang PL and Ideker T: Cytoscape 2.8: New features for data integration and network visualization. Bioinformatics. 27:431–432. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Bader GD and Hogue CW: An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 4:22003. View Article : Google Scholar : PubMed/NCBI

34 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Maere S, Heymans K and Kuiper M: BiNGO: A Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks. Bioinformatics. 21:3448–3449. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Bian EB, Li J, Xie YS, Zong G, Li J and Zhao B: LncRNAs: New players in gliomas, with special emphasis on the interaction of lncRNAs With EZH2. J Cell Physiol. 230:496–503. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, et al: The epidemiology of glioma in adults: A ‘state of the science’ review. Neuro Oncol. 16:896–913. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Perry JR, Laperriere N, O'Callaghan CJ, Brandes AA, Menten J, Phillips C, Fay M, Nishikawa R, Cairncross JG, Roa W, et al: Short-course radiation plus Temozolomide in elderly patients with Glioblastoma. N Engl J Med. 376:1027–1037. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Peñaranda Fajardo NM, Meijer C and Kruyt FA: The endoplasmic reticulum stress/unfolded protein response in gliomagenesis, tumor progression and as a therapeutic target in glioblastoma. Biochem Pharmacol. 118:1–8. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Sacristan MP, Ovejero S and Bueno A: Human Cdc14A becomes a cell cycle gene in controlling Cdk1 activity at the G2/M transition. Cell Cycle. 10:387–391. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Glousker G, Touzot F, Revy P, Tzfati Y and Savage SA: Unraveling the pathogenesis of Hoyeraal-Hreidarsson syndrome, a complex telomere biology disorder. Br J Haematol. 170:457–471. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Rooj AK, Mineo M and Godlewski J: MicroRNA and extracellular vesicles in glioblastoma: Small but powerful. Brain Tumor Pathol. 33:77–88. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Liau BB, Sievers C, Donohue LK, Gillespie SM, Flavahan WA, Miller TE, Venteicher AS, Hebert CH, Carey CD, Rodig SJ, et al: Adaptive chromatin remodeling drives glioblastoma stem cell plasticity and drug tolerance. Cell Stem Cell. 20:233–246.e7. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Yamashita T, Nishimura K, Saiki R, Okudaira H, Tome M, Higashi K, Nakamura M, Terui Y, Fujiwara K, Kashiwagi K and Igarashi K: Role of polyamines at the G1/S boundary and G2/M phase of the cell cycle. Int J Biochem Cell Biol. 45:1042–1050. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Castedo M, Perfettini JL, Roumier T, Yakushijin K, Horne D, Medema R and Kroemer G: The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe. Oncogene. 23:4353–4361. 2004. View Article : Google Scholar : PubMed/NCBI

46 

Wada S, Yue L and Furuta I: Prognostic significance of p34cdc2 expression in tongue squamous cell carcinoma. Oral Oncol. 40:164–169. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Zhang R, Loganathan S, Humphreys I and Srivastava SK: Benzyl isothiocyanate-induced DNA damage causes G2/M cell cycle arrest and apoptosis in human pancreatic cancer cells. J Nutr. 136:2728–2734. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Soria JC, Jang SJ, Khuri FR, Hassan K, Liu D, Hong WK and Mao L: Overexpression of cyclin B1 in early-stage non-small cell lung cancer and its clinical implication. Cancer Res. 60:4000–4004. 2000.PubMed/NCBI

49 

Girke P and Seufert W: Compositional reorganization of the nucleolus in budding yeast mitosis. Mol Biol Cell. 30:591–606. 2019. View Article : Google Scholar : PubMed/NCBI

50 

Guerrero PA, Tchaicha JH, Chen Z, Morales JE, McCarty N, Wang Q, Sulman EP, Fuller G, Lang FF, Rao G and McCarty JH: Glioblastoma stem cells exploit the αvβ8 integrin-TGFβ1 signaling axis to drive tumor initiation and progression. Oncogene. 36:6568–6580. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Shing JC, Choi JW, Chapman R, Schroeder MA, Sarkaria JN, Fauq A and Bram RJ: A novel synthetic 1,3-phenyl bis-thiourea compound targets microtubule polymerization to cause cancer cell death. Cancer Biol Ther. 15:895–905. 2014. View Article : Google Scholar : PubMed/NCBI

52 

Nagarajan P, Curry JL, Ning J, Piao J, Torres-Cabala CA, Aung PP, Ivan D, Ross MI, Levenback CF, Frumovitz M, et al: Tumor thickness and mitotic rate robustly predict melanoma-specific survival in patients with primary vulvar melanoma: A retrospective review of 100 cases. Clin Cancer Res. 23:2093–2104. 2017. View Article : Google Scholar : PubMed/NCBI

53 

Jun DY, Lee JY, Park HS, Lee YH and Kim YH: Tumor suppressor protein p53-mediated repression of human mitotic centromere-associated kinesin gene expression is exerted via down-regulation of Sp1 level. PLoS One. 12:e01896982017. View Article : Google Scholar : PubMed/NCBI

54 

Pinto M, Vieira J, Ribeiro FR, Soares MJ, Henrique R, Oliveira J, Jerónimo C and Teixeira MR: Overexpression of the mitotic checkpoint genes BUB1 and BUBR1 is associated with genomic complexity in clear cell kidney carcinomas. Cell Oncol. 30:389–395. 2008.PubMed/NCBI

55 

Myrie KA, Percy MJ, Azim JN, Neeley CK and Petty EM: Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines. Cancer Lett. 152:193–199. 2000. View Article : Google Scholar : PubMed/NCBI

56 

Scintu M, Vitale R, Prencipe M, Gallo AP, Bonghi L, Valori VM, Maiello E, Rinaldi M, Signori E, Rabitti C, et al: Genomic instability and increased expression of BUB1B and MAD2L1 genes in ductal breast carcinoma. Cancer Lett. 254:298–307. 2007. View Article : Google Scholar : PubMed/NCBI

57 

Herman JA, Toledo CM, Olson JM, DeLuca JG and Paddison PJ: Molecular pathways: Regulation and targeting of kinetochore-microtubule attachment in cancer. Clin Cancer Res. 21:233–239. 2015. View Article : Google Scholar : PubMed/NCBI

58 

DeLuca JG, Dong Y, Hergert P, Strauss J, Hickey JM, Salmon ED and McEwen BF: Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites. Mol Biol Cell. 16:519–531. 2005. View Article : Google Scholar : PubMed/NCBI

59 

Iemura K and Tanaka K: Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules. Nat Commun. 6:64472015. View Article : Google Scholar : PubMed/NCBI

60 

Shrestha RL and Draviam VM: Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK. Curr Biol. 23:1514–1526. 2013. View Article : Google Scholar : PubMed/NCBI

61 

Diaz-Rodriguez E, Sotillo R, Schvartzman JM and Benezra R: Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo. Proc Natl Acad Sci USA. 105:16719–16724. 2008. View Article : Google Scholar : PubMed/NCBI

62 

Sotillo R, Hernando E, Diaz-Rodriguez E, Teruya-Feldstein J, Cordón-Cardo C, Lowe SW and Benezra R: Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell. 11:9–23. 2007. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Zou YF, Meng LB, He ZK, Hu CH, Shan MJ, Wang DY and Yu X: Screening and authentication of molecular markers in malignant glioblastoma based on gene expression profiles. Oncol Lett 18: 4593-4604, 2019.
APA
Zou, Y., Meng, L., He, Z., Hu, C., Shan, M., Wang, D., & Yu, X. (2019). Screening and authentication of molecular markers in malignant glioblastoma based on gene expression profiles. Oncology Letters, 18, 4593-4604. https://doi.org/10.3892/ol.2019.10804
MLA
Zou, Y., Meng, L., He, Z., Hu, C., Shan, M., Wang, D., Yu, X."Screening and authentication of molecular markers in malignant glioblastoma based on gene expression profiles". Oncology Letters 18.5 (2019): 4593-4604.
Chicago
Zou, Y., Meng, L., He, Z., Hu, C., Shan, M., Wang, D., Yu, X."Screening and authentication of molecular markers in malignant glioblastoma based on gene expression profiles". Oncology Letters 18, no. 5 (2019): 4593-4604. https://doi.org/10.3892/ol.2019.10804
Copy and paste a formatted citation
x
Spandidos Publications style
Zou YF, Meng LB, He ZK, Hu CH, Shan MJ, Wang DY and Yu X: Screening and authentication of molecular markers in malignant glioblastoma based on gene expression profiles. Oncol Lett 18: 4593-4604, 2019.
APA
Zou, Y., Meng, L., He, Z., Hu, C., Shan, M., Wang, D., & Yu, X. (2019). Screening and authentication of molecular markers in malignant glioblastoma based on gene expression profiles. Oncology Letters, 18, 4593-4604. https://doi.org/10.3892/ol.2019.10804
MLA
Zou, Y., Meng, L., He, Z., Hu, C., Shan, M., Wang, D., Yu, X."Screening and authentication of molecular markers in malignant glioblastoma based on gene expression profiles". Oncology Letters 18.5 (2019): 4593-4604.
Chicago
Zou, Y., Meng, L., He, Z., Hu, C., Shan, M., Wang, D., Yu, X."Screening and authentication of molecular markers in malignant glioblastoma based on gene expression profiles". Oncology Letters 18, no. 5 (2019): 4593-4604. https://doi.org/10.3892/ol.2019.10804
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