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Article Open Access

miR-650 promotes non-small cell lung cancer cell proliferation and invasion by targeting ING4 through Wnt-1/β-catenin pathway

  • Authors:
    • Xiangqin Tang
    • Yanjun Ding
    • Xiaoqing Wang
    • Xiuzhen Wang
    • Lin Zhao
    • Hongmei Bi
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China, Department of General Surgery, People's Hospital of Chiping, Chiping, Shandong 252100, P.R. China, First Ward, Department of Neurology, The Affiliated Central Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China, Department of Clinical Nutrition, People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Respiratory Medicine, People's Hospital of Rizhao, Rizhao, Shandong 276826, P.R. China, Department of Respiratory Medicine, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China
    Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4621-4628
    |
    Published online on: September 4, 2019
       https://doi.org/10.3892/ol.2019.10805
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Abstract

Non-small cell lung cancer (NSCLC) is the most frequent cancer worldwide with a poor 5-year survival. miR-650 acts as an oncogene and regulates tumor progress in various cancers. Molecular mechanisms of miR-650 in NSCLC cell proliferation and invasion was studied. The mRNA levels of miR-650 and special genes were calculated using RT-qPCR. MTT and transwell assays were applied to measure the proliferative and invasive ability. Kaplan-Meier method was used to assess the survival of NSCLC patients. miR-650 was upregulated in NSCLC and upregulation of miR-650 was associated with a poor overall survival of NSCLC, while the results of ING4 demonstrated the opposite results. miR-650 promoted proliferation and invasion through Wnt-1/β‑catenin pathway by targeting inhibitor of growth 4 (ING4) in A549 cells. ING4 was a direct target gene of miR-650 and the expression of ING4 was mediated by exogenous altering the expression of miR-650. Remarkably, alterations of ING4 expression eliminated the functions of miR-650 on the proliferation and metastasis of NSCLC. miR-650 enhanced A549 cell proliferation and invasion through Wnt-1/β-catenin pathway by directly targeting the 3'-UTR of ING4 mRNA. The newly identified miR-650/ING4 axis provides a novel insight into the pathogenesis of NSCLC.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Heist RS and Engelman JA: SnapShot: non-small cell lung cancer. Cancer Cell. 21:448.e22012. View Article : Google Scholar : PubMed/NCBI

3 

Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Garzon R, Calin GA and Croce CM: MicroRNAs in cancer. Annu Rev Med. 60:167–179. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Feng L, Xie Y, Zhang H and Wu Y: Down-regulation of NDRG2 gene expression in human colorectal cancer involves promoter methylation and microRNA-650. Biochem Biophys Res Commun. 406:534–538. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Yang YQ, Tian T, Zhu HY, Liang JH, Wu W, Wu JZ, Xia Y, Wang L, Fan L, Li JY, et al: NDRG2 mRNA levels and miR-28-5p and miR-650 activity in chronic lymphocytic leukemia. BMC Cancer. 18:10092018. View Article : Google Scholar : PubMed/NCBI

8 

Yun JH, Moon S, Lee HS, Hwang MY, Kim YJ, Yu HY, Kim Y, Han BG, Kim BJ and Kim JM: MicroRNA-650 in a copy number-variable region regulates the production of interleukin 6 in human osteosarcoma cells. Oncol Lett. 10:2603–2609. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Sun B, Pu B, Chu D, Chu X, Li W and Wei D: MicroRNA-650 expression in glioma is associated with prognosis of patients. J Neurooncol. 115:375–380. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Mraz M, Dolezalova D, Plevova K, Stano Kozubik K, Mayerova V, Cerna K, Musilova K, Tichy B, Pavlova S, Borsky M, et al: MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia. Blood. 119:2110–2113. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Jin P, Chen H, Xie J, Zhou C and Zhu X: Essential role of microRNA-650 in the regulation of B-cell CLL/lymphoma 11B gene expression following transplantation: A novel mechanism behind the acute rejection of renal allografts. Int J Mol Med. 40:1840–1850. 2017.PubMed/NCBI

12 

Ningning S, Libo S, Chuanbin W, Haijiang S and Qing Z: MiR-650 regulates the proliferation, migration and invasion of human oral cancer by targeting growth factor independent 1 (Gfi1). Biochimie. 156:69–78. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Yuan C, Xu L, Du P and Pang J: miRNA-650 exerts anti-leukemia activity by inhibiting cell proliferation through Gfi1 targeting. Tumori. 104:369–374. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Guérillon C, Bigot N and Pedeux R: The ING tumor suppressor genes: Status in human tumors. Cancer Lett. 345:1–16. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Doyon Y, Cayrou C, Ullah M, Landry AJ, Côté V, Selleck W, Lane WS, Tan S, Yang XJ and Côté J: ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell. 21:51–64. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Nagashima M, Shiseki M, Pedeux RM, Okamura S, Kitahama-Shiseki M, Miura K, Yokota J and Harris CC: A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis. Oncogene. 22:343–350. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Cui S, Gao Y, Zhang K, Chen J, Wang R and Chen L: The emerging role of inhibitor of growth 4 as a tumor suppressor in multiple human cancers. Cell Physiol Biochem. 36:409–422. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Gunduz M, Nagatsuka H, Demircan K, Gunduz E, Cengiz B, Ouchida M, Tsujigiwa H, Yamachika E, Fukushima K, Beder L, et al: Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas. Gene. 356:109–117. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Wu Y, Mou X, Wang S, Liu XE and Sun X: ING4 expressing oncolytic vaccinia virus promotes anti-tumor efficiency and synergizes with gemcitabine in pancreatic cancer. Oncotarget. 8:82728–82739. 2017.PubMed/NCBI

20 

Keenen MM and Kim S: Tumor suppressor ING4 inhibits estrogen receptor activity in breast cancer cells. Breast Cancer (Dove Med Press). 8:211–221. 2016.PubMed/NCBI

21 

Ren Y, Zhao S, Chen H, Fu YM and Zhao B: Association between the expression of inhibitor of growth family member 4 and the progression of clear cell renal carcinoma. Oncol Lett. 14:2453–2457. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Chen Y, Fu R, Xu M, Huang Y, Sun G and Xu L: N-methyl-N-nitro-N-nitrosoguanidine-mediated ING4 downregulation contributed to the angiogenesis of transformed human gastric epithelial cells. Life Sci. 199:179–187. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Cai L, Li H, Chen C, Cheng X, Wang Y, Liu J, Wang Y and Hao L: Role of inhibitor of growth 4 in the suppression of human melanoma cells through the Fas/FasL-mediated apoptosis pathway. Int J Mol Med. 41:1055–1061. 2018.PubMed/NCBI

24 

Chen Y, Huang Y, Hou P, Zhang Z, Zhang Y, Wang W, Sun G, Xu L, Zhou J, Bai J, et al: ING4 suppresses tumor angiogenesis and functions as a prognostic marker in human colorectal cancer. Oncotarget. 7:79017–79031. 2016.PubMed/NCBI

25 

Pan X, Wang R, Bian H, De W, Zhang P, Wei C and Wang Z: Overexpression of inhibitor of growth 4 enhances radiosensitivity in non-small cell lung cancer cell line SPC-A1. Technol Cancer Res Treat. 16:533–545. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Ettinger DS, Akerley W, Borghaei H, Chang AC, Cheney RT, Chirieac LR, D'Amico TA, Demmy TL, Govindan R, Grannis FW Jr, et al National comprehensive cancer network, : Non-small cell lung cancer, version 2.2013. J Natl Compr Canc Netw. 11:645–653, quiz 653. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Huang JY, Cui SY, Chen YT, Song HZ, Huang GC, Feng B, Sun M, De W, Wang R and Chen LB: MicroRNA-650 was a prognostic factor in human lung adenocarcinoma and confers the docetaxel chemoresistance of lung adenocarcinoma cells via regulating Bcl-2/Bax expression. PLoS One. 8:e726152013. View Article : Google Scholar : PubMed/NCBI

29 

You Q, Li H, Liu Y, Xu Y, Miao S, Yao G, Xue Y, Geng J, Jin X and Meng H: MicroRNA-650 targets inhibitor of growth 4 to promote colorectal cancer progression via mitogen activated protein kinase signaling. Oncol Lett. 16:2326–2334. 2018.PubMed/NCBI

30 

Zeng ZL, Li FJ, Gao F, Sun DS and Yao L: Upregulation of miR-650 is correlated with down-regulation of ING4 and progression of hepatocellular carcinoma. J Surg Oncol. 107:105–110. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Xu X, Chen H, Zhang Q, Xu J, Shi Q and Wang M: MiR-650 inhibits proliferation, migration and invasion of rheumatoid arthritis synovial fibroblasts by targeting AKT2. Biomed Pharmacother. 88:535–541. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Zhou C, Cui F, Li J, Wang D, Wei Y, Wu Y, Wang J, Zhu H and Wang S: MiR-650 represses high-risk non-metastatic colorectal cancer progression via inhibition of AKT2/GSK3β/E-cadherin pathway. Oncotarget. 8:49534–49547. 2017.PubMed/NCBI

33 

Li S, Fan T, Liu H, Chen J, Qin C and Ren X: Tumor suppressor ING4 overexpression contributes to proliferation and invasion inhibition in gastric carcinoma by suppressing the NF-κB signaling pathway. Mol Biol Rep. 40:5723–5732. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Yuan S, Jin J, Shi J and Hou Y: Inhibitor of growth-4 is a potential target for cancer therapy. Tumour Biol. 37:4275–4279. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Ma Y, Cheng X, Wang F, Pan J, Liu J, Chen H, Wang Y and Cai L: ING4 inhibits proliferation and induces apoptosis in human melanoma A375 cells via the Fas/caspase-8 apoptosis pathway. Dermatology. 232:265–272. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Qu H, Yin H, Yan S, Tao M, Xie Y and Chen W: Inhibitor of growth 4 suppresses colorectal cancer growth and invasion by inducing G1 arrest, inhibiting tumor angiogenesis and reversing epithelial-mesenchymal transition. Oncol Rep. 35:2927–2935. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Li M, Zhu Y, Zhang H, Li L, He P, Xia H, Zhang Y and Mao C: Delivery of inhibitor of growth 4 (ING4) gene significantly inhibits proliferation and invasion and promotes apoptosis of human osteosarcoma cells. Sci Rep. 4:73802014. View Article : Google Scholar : PubMed/NCBI

38 

Hu X, Feng Y, Sun L, Qu L and Sun C: Roles of microRNA-330 and its target gene ING4 in the development of aggressive phenotype in hepatocellular carcinoma cells. Dig Dis Sci. 62:715–722. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Li S, Zeng A, Hu Q, Yan W, Liu Y and You Y: miR-423-5p contributes to a malignant phenotype and temozolomide chemoresistance in glioblastomas. Neuro Oncol. 19:55–65. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Yan A, Yang C, Chen Z, Li C and Cai L: MiR-761 promotes progression and metastasis of non-small cell lung cancer by targeting ING4 and TIMP2. Cell Physiol Biochem. 37:55–66. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tang X, Ding Y, Wang X, Wang X, Zhao L and Bi H: miR-650 promotes non-small cell lung cancer cell proliferation and invasion by targeting ING4 through Wnt-1/β-catenin pathway . Oncol Lett 18: 4621-4628, 2019.
APA
Tang, X., Ding, Y., Wang, X., Wang, X., Zhao, L., & Bi, H. (2019). miR-650 promotes non-small cell lung cancer cell proliferation and invasion by targeting ING4 through Wnt-1/β-catenin pathway . Oncology Letters, 18, 4621-4628. https://doi.org/10.3892/ol.2019.10805
MLA
Tang, X., Ding, Y., Wang, X., Wang, X., Zhao, L., Bi, H."miR-650 promotes non-small cell lung cancer cell proliferation and invasion by targeting ING4 through Wnt-1/β-catenin pathway ". Oncology Letters 18.5 (2019): 4621-4628.
Chicago
Tang, X., Ding, Y., Wang, X., Wang, X., Zhao, L., Bi, H."miR-650 promotes non-small cell lung cancer cell proliferation and invasion by targeting ING4 through Wnt-1/β-catenin pathway ". Oncology Letters 18, no. 5 (2019): 4621-4628. https://doi.org/10.3892/ol.2019.10805
Copy and paste a formatted citation
x
Spandidos Publications style
Tang X, Ding Y, Wang X, Wang X, Zhao L and Bi H: miR-650 promotes non-small cell lung cancer cell proliferation and invasion by targeting ING4 through Wnt-1/β-catenin pathway . Oncol Lett 18: 4621-4628, 2019.
APA
Tang, X., Ding, Y., Wang, X., Wang, X., Zhao, L., & Bi, H. (2019). miR-650 promotes non-small cell lung cancer cell proliferation and invasion by targeting ING4 through Wnt-1/β-catenin pathway . Oncology Letters, 18, 4621-4628. https://doi.org/10.3892/ol.2019.10805
MLA
Tang, X., Ding, Y., Wang, X., Wang, X., Zhao, L., Bi, H."miR-650 promotes non-small cell lung cancer cell proliferation and invasion by targeting ING4 through Wnt-1/β-catenin pathway ". Oncology Letters 18.5 (2019): 4621-4628.
Chicago
Tang, X., Ding, Y., Wang, X., Wang, X., Zhao, L., Bi, H."miR-650 promotes non-small cell lung cancer cell proliferation and invasion by targeting ING4 through Wnt-1/β-catenin pathway ". Oncology Letters 18, no. 5 (2019): 4621-4628. https://doi.org/10.3892/ol.2019.10805
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