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Article

HDGF and PRKCA upregulation is associated with a poor prognosis in patients with lung adenocarcinoma

  • Authors:
    • Honghong Jiang
    • Qiaofen Fu
    • Xin Song
    • Chunlei Ge
    • Ruilei Li
    • Zhen Li
    • Baozhen Zeng
    • Chunyan Li
    • Ying Wang
    • Yuanbo Xue
    • Rongcheng Luo
    • Weiyi Fang
  • View Affiliations / Copyright

    Affiliations: Cancer Centre, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510315, P.R. China, Department of Cancer Biotherapy Centre, Third Affiliated Hospital of Kunming Medical University (Tumour Hospital of Yunnan Province), Kunming, Yunnan 510118, P.R. China
  • Pages: 4936-4946
    |
    Published online on: September 5, 2019
       https://doi.org/10.3892/ol.2019.10812
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Abstract

Lung adenocarcinoma is the most common histologic subtype of lung cancer. The aim of the present study was to assess the expression of hepatoma‑derived growth factor (HDGF) and protein kinase Cα (PRKCA) in lung adenocarcinoma (LADC), and to determine the association between the combined expression of these two proteins and clinicopathological characteristics of patients with LADC. The expression of HDGF and PRKCA mRNA was assessed by GEO database analysis, and HDGF and PRKCA protein levels were examined by immunohistochemistry using a tissue microarray. High HDGF and PRKCA expression was observed in LADC tissue compared to normal samples, and increased HDGF and PRKCA expression was associated with AJCC clinical stage, tumor classification, node classification, and lymph node metastasis. GEO database analysis revealed no significant differences between HDGF mRNA and PRKCA mRNA in LADC tissue. However, high PRKCA protein expression was associated with high HDGF protein expression, and patients with high HDGF and PRKCA expression exhibited poorer overall survival rates than patients with low expression levels of the two proteins. The results of the present study suggest that upregulation of both HDGF and PRKCA may be an unfavourable factor for lung adenocarcinoma progression.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

2 

McIntyre A and Ganti AK: Lung cancer-a global perspective. J Surg Oncol. 115:550–554. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Glatzer M, Elicin O, Ramella S, Nestle U and Putora PM: Radio(chemo)therapy in locally advanced nonsmall cell lung cancer. Eur Respir Rev. 25:65–70. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Patel MI, Cheng I and Gomez SL: US lung cancer trends by histologic type. Cancer. 121:1150–1152. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Zhang L, Li M, Wu N and Chen Y: Time trends in epidemiologic characteristics and imaging features of lung adenocarcinoma: A population study of 21,113 cases in China. PLoS One. 10:e01367272015. View Article : Google Scholar : PubMed/NCBI

6 

Ettinger DS, Wood DE, Aisner DL, Akerley W, Bauman J, Chirieac LR, D'Amico TA, DeCamp MM, Dilling TJ, Dobelbower M, et al: Non-small cell lung cancer, version 5.2017, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 15:504–535. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Jung CY and Antonia SJ: Tumor immunology and immune checkpoint inhibitors in non-small cell lung cancer. Tuberc Respir Dis (Seoul). 81:29–41. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Rabbani M, Kanevsky J, Kafi K, Chandelier F and Giles FJ: Role of artificial intelligence in the care of patients with nonsmall cell lung cancer. Eur J Clin Invest. 482018.doi: 10.1111/eci.12901.

9 

Walter AO, Sjin RT, Haringsma HJ, Ohashi K, Sun J, Lee K, Dubrovskiy A, Labenski M, Zhu Z, Wang Z, et al: Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC. Cancer Discov. 3:1404–1415. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Passiglia F, Listí A, Castiglia M, Perez A, Rizzo S, Bazan V and Russo A: EGFR inhibition in NSCLC: New findings.. and opened questions? Crit Rev Oncol Hematol. 112:126–135. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Fu Q, Song X, Liu Z, Deng X, Luo R, Ge C, Li R, Li Z, Zhao M, Chen Y, et al: miRomics and proteomics reveal a miR-296-3p/PRKCA/FAK/Ras/c-Myc feedback loop modulated by HDGF/DDX5/β-catenin complex in lung adenocarcinoma. Clin Cancer Res. 23:6336–6350. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Nakamura H, Kambe H, Egawa T, Kimura Y, Ito H, Hayashi E, Yamamoto H, Sato J and Kishimoto S: Partial purification and characterization of human hepatoma-derived growth factor. Clin Chim Acta. 183:273–284. 1989. View Article : Google Scholar : PubMed/NCBI

13 

Bao CH, Liu K, Wang XT, Ma W, Wang JB, Wang C, Jia YB, Wang NN, Tan BX, Song QX and Cheng YF: Prognostic role of hepatoma-derived growth factor in solid tumors of Eastern Asia: A systematic review and meta-analysis. Asian Pac J Cancer Prev. 16:1803–1811. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Zhao J, Ma MZ, Ren H, Liu Z, Edelman MJ, Pan H and Mao L: Anti-HDGF targets cancer and cancer stromal stem cells resistant to chemotherapy. Clin Cancer Res. 19:3567–3576. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Baier G: The PKC gene module: Molecular biosystematics to resolve its T cell functions. Immunol Rev. 192:64–79. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Guo Y, Bao Y, Ma M, Zhang S, Zhang Y, Yuan M, Liu B, Yang Y, Cui W, Ansong E, et al: Clinical significance of the correlation between PLCE 1 and PRKCA in esophageal inflammation and esophageal carcinoma. Oncotarget. 8:33285–33299. 2017.PubMed/NCBI

17 

Paraboschi EM, Rimoldi V, Soldá G, Tabaglio T, Dall'Osso C, Saba E, Vigliano M, Salviati A, Leone M, Benedetti MD, et al: Functional variations modulating PRKCA expression and alternative splicing predispose to multiple sclerosis. Hum Mol Genet. 23:6746–6761. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Rosenberg S, Simeonova I, Bielle F, Verreault M, Bance B, Le Roux I, Daniau M, Nadaradjane A, Gleize V, Paris S, et al: A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas. Nat Commun. 9:23712018. View Article : Google Scholar : PubMed/NCBI

19 

Edge SB, Byrd DR, Compton CC, et al: AJCC 7th Edition Cancer Staging Manual. 2010. https://cancerstaging.org/references-tools/deskreferences/Pages/default.aspx22–10. 2015

20 

Liu Z, Li L, Yang Z, Luo W, Li X, Yang H, Yao K, Wu B and Fang W: Increased expression of MMP9 is correlated with poor prognosis of nasopharyngeal carcinoma. BMC Cancer. 10:2702010. View Article : Google Scholar : PubMed/NCBI

21 

Tu L, Liu Z, He X, He Y, Yang H, Jiang Q, Xie S, Xiao G, Li X, Yao K and Fang W: Over-expression of eukaryotic translation initiation factor 4 gamma 1 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma. Mol Cancer. 9:782010. View Article : Google Scholar : PubMed/NCBI

22 

Xu H, Jin X, Yuan Y, Deng P, Jiang L, Zeng X, Li XS, Wang ZY and Chen QM: Prognostic value rom integrative analysis of transcription factors c-Jun and Fra-1 in oral squamous cell carcinoma: A multicenter cohort study. Sci Rep. 7:75222017. View Article : Google Scholar : PubMed/NCBI

23 

Philipsen S: Expression data for early stage NSCLC. 2010. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE1918810–06. 2017

24 

Cai S, Cai J, Jiang WG and Ye L: Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review). Int J Mol Med. 40:965–971. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Bica-Pop C, Cojocneanu-Petric R, Magdo L, Raduly L, Gulei D and Berindan-Neagoe I: Overview upon miR-21 in lung cancer: Focus on NSCLC. Cell Mol Life Sci. 75:3539–3551. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Jing P, Zhao N, Xie N, Ye M, Zhang Y, Zhang Z, Li M, Lai X, Zhang J and Gu Z: miR-24-3p/FGFR3 Signaling as a novel axis is involved in epithelial-mesenchymal transition and regulates lung adenocarcinoma progression. J Immunol Res. 2018:28341092018. View Article : Google Scholar : PubMed/NCBI

27 

Li W, Qiu T, Guo L, Ling Y, Gao Y, Ying J and He J: Primary and acquired EGFR T790M-mutant NSCLC patients identified by routine mutation testing show different characteristics but may both respond to osimertinib treatment. Cancer Lett. 423:9–15. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Lin L, Zhao J, Hu J, Zou G, Huang F, Han J, He Y and Cao X: Current smoking has a detrimental effect on survival for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) negative advanced non-squamous Non-small cell lung cancer (NSCLC) patients treated with pemetrexed continuation maintenance. J Cancer. 9:2140–2146. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Su C, Cheng X, Li Y, Han Y, Song X, Yu D, Cao X and Liu Z: MiR-21 improves invasion and migration of drug-resistant lung adenocarcinoma cancer cell and transformation of EMT through targeting HBP1. Cancer Med. 7:2485–2503. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Nakamura H, Izumoto Y, Kambe H, Kuroda T, Mori T, Kawamura K, Yamamoto H and Kishimoto T: Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. Its homology with high mobility group-1 protein. J Biol Chem. 269:25143–25149. 1994.PubMed/NCBI

31 

Enomoto H, Nakamura H, Liu W and Nishiguchi S: Hepatoma-derived growth factor: Its possible involvement in the progression of hepatocellular carcinoma. Int J Mol Sci. 16:14086–14097. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Li M, Shen J, Wu X, Zhang B, Zhang R, Weng H, Ding Q, Tan Z, Gao G, Mu J, et al: Downregulated expression of hepatoma- derived growth factor (HDGF) reduces gallbladder cancer cell proliferation and invasion. Med Oncol. 30:5872013. View Article : Google Scholar : PubMed/NCBI

33 

Wang L, Jiang Q, Hua S, Zhao M, Wu Q, Fu Q, Fang W and Guo S: High nuclear expression of HDGF correlates with disease progression and poor prognosis in human endometrial carcinoma. Dis Markers. 2014:2987952014. View Article : Google Scholar : PubMed/NCBI

34 

Liu Y, Sun J, Yang G, Liu Z, Guo S, Zhao R, Xu K, Wu X and Zhang Z: Downregulation of the expression of HDGF attenuates malignant biological behaviors of hilar cholangiocarcinoma cells. Mol Med Rep. 12:4713–4719. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Kim YD, Jeon JY, Woo HJ, Lee JC, Chung JH, Song SY, Yoon SK and Baek SH: Interleukin-1beta induces MUC2 gene expression and mucin secretion via activation of PKC-MEK/ERK, and PI3K in human airway epithelial cells. J Korean Med Sci. 17:765–771. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Lee HY, Crawley S, Hokari R, Kwon S and Kim YS: Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway. Int J Oncol. 36:941–953. 2010.PubMed/NCBI

37 

O'Brian C, Vogel VG, Singletary SE and Ward NE: Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue. Cancer Res. 49:3215–3217. 1989.PubMed/NCBI

38 

Kopp R, Noelke B, Sauter G, Schildberg FW, Paumgartner G and Pfeiffer A: Altered protein kinase C activity in biopsies of human colonic adenomas and carcinomas. Cancer Res. 51:205–210. 1991.PubMed/NCBI

39 

Wang C, Wang X, Liang H, Wang T, Yan X, Cao M, Wang N, Zhang S, Zen K, Zhang C and Chen X: miR-203 inhibits cell proliferation and migration of lung cancer cells by targeting PKCα. PLoS One. 8:e739852013. View Article : Google Scholar : PubMed/NCBI

40 

Lahn M, Sundell K and Köhler G: The role of protein kinase C-alpha in hematologic malignancies. Acta Haematol. 115:1–8. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Lahn M, Su C, Li S, Chedid M, Hanna KR, Graff JR, Sandusky GE, Ma D, Niyikiza C, Sundell KL, et al: Expression levels of protein kinase C-alpha in non-small-cell lung cancer. Clin Lung Cancer. 6:184–189. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang H, Fu Q, Song X, Ge C, Li R, Li Z, Zeng B, Li C, Wang Y, Xue Y, Xue Y, et al: HDGF and PRKCA upregulation is associated with a poor prognosis in patients with lung adenocarcinoma. Oncol Lett 18: 4936-4946, 2019.
APA
Jiang, H., Fu, Q., Song, X., Ge, C., Li, R., Li, Z. ... Fang, W. (2019). HDGF and PRKCA upregulation is associated with a poor prognosis in patients with lung adenocarcinoma. Oncology Letters, 18, 4936-4946. https://doi.org/10.3892/ol.2019.10812
MLA
Jiang, H., Fu, Q., Song, X., Ge, C., Li, R., Li, Z., Zeng, B., Li, C., Wang, Y., Xue, Y., Luo, R., Fang, W."HDGF and PRKCA upregulation is associated with a poor prognosis in patients with lung adenocarcinoma". Oncology Letters 18.5 (2019): 4936-4946.
Chicago
Jiang, H., Fu, Q., Song, X., Ge, C., Li, R., Li, Z., Zeng, B., Li, C., Wang, Y., Xue, Y., Luo, R., Fang, W."HDGF and PRKCA upregulation is associated with a poor prognosis in patients with lung adenocarcinoma". Oncology Letters 18, no. 5 (2019): 4936-4946. https://doi.org/10.3892/ol.2019.10812
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang H, Fu Q, Song X, Ge C, Li R, Li Z, Zeng B, Li C, Wang Y, Xue Y, Xue Y, et al: HDGF and PRKCA upregulation is associated with a poor prognosis in patients with lung adenocarcinoma. Oncol Lett 18: 4936-4946, 2019.
APA
Jiang, H., Fu, Q., Song, X., Ge, C., Li, R., Li, Z. ... Fang, W. (2019). HDGF and PRKCA upregulation is associated with a poor prognosis in patients with lung adenocarcinoma. Oncology Letters, 18, 4936-4946. https://doi.org/10.3892/ol.2019.10812
MLA
Jiang, H., Fu, Q., Song, X., Ge, C., Li, R., Li, Z., Zeng, B., Li, C., Wang, Y., Xue, Y., Luo, R., Fang, W."HDGF and PRKCA upregulation is associated with a poor prognosis in patients with lung adenocarcinoma". Oncology Letters 18.5 (2019): 4936-4946.
Chicago
Jiang, H., Fu, Q., Song, X., Ge, C., Li, R., Li, Z., Zeng, B., Li, C., Wang, Y., Xue, Y., Luo, R., Fang, W."HDGF and PRKCA upregulation is associated with a poor prognosis in patients with lung adenocarcinoma". Oncology Letters 18, no. 5 (2019): 4936-4946. https://doi.org/10.3892/ol.2019.10812
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