Open Access

Preoperative color Doppler ultrasonography predicts early recurrence in AFP‑positive hepatocellular carcinoma

  • Authors:
    • Miao Chen
    • Duo Wang
    • Yuan Zhao
    • Dan‑Mei Lu
    • Hong‑Xue Li
    • Jun‑Jie Liu
    • Hang Li
  • View Affiliations

  • Published online on: September 9, 2019     https://doi.org/10.3892/ol.2019.10825
  • Pages: 4703-4711
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to evaluate the hepatic hemodynamics of patients with α‑fetoprotein (AFP)‑positive hepatocellular carcinoma (HCC) and early recurrence (ER), as determined by color Doppler ultrasound. Screening with color Doppler ultrasound was performed in 150 patients with AFP‑positive HCC, yielding 43 cases with postoperative ER. In addition, 35 healthy controls were enrolled in the study for comparison of the blood flow parameters between the healthy control and the HCC groups. Receiver operating characteristic curve analysis was performed to evaluate the predicted effect of Doppler for the ER of HCC. The average mean flow velocity of portal vein in patients with HCC (14.686±5.873 cm/s) was significantly lower in the HCC group compared with the healthy control group (17.631±3.569 cm/s; P=0.005). Additionally, the preoperative portal vein diameter in the HCC group was significantly higher compared with that in the healthy control group (P=0.001). Regarding the effect of surgery, the portal vein diameter was significantly increased in the patients postoperatively compared with preoperatively (P=0.003), while the pulsation and resistance indexes exhibited a decreasing trend in the postoperative group (P=0.001 and P=0.003, respectively). Notably, patients with HCC and ER presented with a higher resistance index (1.163±0.342) compared with the ER‑free group (1.023±0.176; P=0.004). Furthermore, a significant difference in hepatic artery pulsation index was also observed between the ER group (0.673±0.075) and the ER‑free group (0.624±0.056; P=0.018), indicating that an increased hepatic artery pulsation index may significantly predict the ER of HCC. In addition, areas under the curve of 0.683 and 0.700, respectively, suggested that the hepatic artery resistance and pulsation indexes may be used to diagnose ER in HCC (P=0.009 and P=0.004, respectively). Taken together, Doppler ultrasound provides a reliable and accurate quantification of hepatic hemodynamics for detecting ER in HCC with a good diagnostic accuracy.
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November-2019
Volume 18 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Chen M, Wang D, Zhao Y, Lu DM, Li HX, Liu JJ and Li H: Preoperative color Doppler ultrasonography predicts early recurrence in AFP‑positive hepatocellular carcinoma. Oncol Lett 18: 4703-4711, 2019.
APA
Chen, M., Wang, D., Zhao, Y., Lu, D., Li, H., Liu, J., & Li, H. (2019). Preoperative color Doppler ultrasonography predicts early recurrence in AFP‑positive hepatocellular carcinoma. Oncology Letters, 18, 4703-4711. https://doi.org/10.3892/ol.2019.10825
MLA
Chen, M., Wang, D., Zhao, Y., Lu, D., Li, H., Liu, J., Li, H."Preoperative color Doppler ultrasonography predicts early recurrence in AFP‑positive hepatocellular carcinoma". Oncology Letters 18.5 (2019): 4703-4711.
Chicago
Chen, M., Wang, D., Zhao, Y., Lu, D., Li, H., Liu, J., Li, H."Preoperative color Doppler ultrasonography predicts early recurrence in AFP‑positive hepatocellular carcinoma". Oncology Letters 18, no. 5 (2019): 4703-4711. https://doi.org/10.3892/ol.2019.10825