Open Access

Prospective comparison of the value of CRASH and CARG toxicity scores in predicting chemotherapy toxicity in geriatric oncology

  • Authors:
    • Jun Zhang
    • Xin Liao
    • Jin Feng
    • Tiejun Yin
    • Yajun Liang
  • View Affiliations

  • Published online on: September 10, 2019     https://doi.org/10.3892/ol.2019.10840
  • Pages: 4947-4955
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Predicting the risk of severe adverse reactions to chemotherapy is of great clinical significance for proper selection of effective and safe treatment for elderly cancer patients. The present study aimed to verify and compare the value of two evaluation models of chemotherapy risk prediction for elderly cancer patients through prospective analysis. The two evaluation models assessed were the Chemotherapy Risk Assessment Scale for High‑Age Patients (CRASH) and Cancer Aging Research Group (CARG) toxicity scores. Elderly patients aged ≥70 with cancer were recruited at two participating hospitals in China and completed an assessment prior to starting chemotherapy. CRASH and CARG toxicity scores of each participant were calculated. Chemotherapy‑related toxicity was recorded through each cycle of chemotherapy. A total of 106 participants were recruited between September 2015 and August 2018. The CRASH and CARG toxicity scores were positively correlated (r=0.689; P<0.01). Of the participants, 54 (50.9%) participants underwent a grade 3‑5 chemotherapy‑related toxicity and 21 (19.8%) experienced grade 3‑5 nonhematological toxicity in the process of treatment. CRASH and CARG toxicity scores predicted severe chemotherapy‑related toxicity and had a high discriminatory value based on receiver operating characteristic curve analysis (area under the curve of 0.772 and 0.760, respectively; P<0.001). The results of the present study indicate that the CRASH and CARG toxicity scores are helpful tools for the prediction of severe chemotherapy‑related toxicity, and are recommended for routine oncology practice.
View Figures
View References

Related Articles

Journal Cover

November-2019
Volume 18 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Liao X, Feng J, Yin T and Liang Y: Prospective comparison of the value of CRASH and CARG toxicity scores in predicting chemotherapy toxicity in geriatric oncology. Oncol Lett 18: 4947-4955, 2019
APA
Zhang, J., Liao, X., Feng, J., Yin, T., & Liang, Y. (2019). Prospective comparison of the value of CRASH and CARG toxicity scores in predicting chemotherapy toxicity in geriatric oncology. Oncology Letters, 18, 4947-4955. https://doi.org/10.3892/ol.2019.10840
MLA
Zhang, J., Liao, X., Feng, J., Yin, T., Liang, Y."Prospective comparison of the value of CRASH and CARG toxicity scores in predicting chemotherapy toxicity in geriatric oncology". Oncology Letters 18.5 (2019): 4947-4955.
Chicago
Zhang, J., Liao, X., Feng, J., Yin, T., Liang, Y."Prospective comparison of the value of CRASH and CARG toxicity scores in predicting chemotherapy toxicity in geriatric oncology". Oncology Letters 18, no. 5 (2019): 4947-4955. https://doi.org/10.3892/ol.2019.10840