Exosome complex genes mediate RNA degradation and predict survival in mantle cell lymphoma

Zhang,Weilong; Zhu,Junyong; He,Xue; Liu,Xiaoni; Li,Jinhang; Li,Wei; Yang,Ping; Wang,Jing; Hu,Kai; Zhang,Xiuru; Li,Xiru; Jing,Hongmei

doi:10.3892/ol.2019.10850

Exosome complex genes mediate RNA degradation and predict survival in mantle cell lymphoma

Authors:
- Weilong Zhang
- Junyong Zhu
- Xue He
- Xiaoni Liu
- Jinhang Li
- Wei Li
- Ping Yang
- Jing Wang
- Kai Hu
- Xiuru Zhang
- Xiru Li
- Hongmei Jing
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Affiliations: Department of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing 100191, P.R. China, Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China, Department of Pathology, Beijing Tiantan Hospital Affiliated with Capital Medical University, Beijing 100050, P.R. China, Department of Respiratory Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Guangdong 341000, P.R. China, Department of Pathology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China
Published online on: September 11, 2019 https://doi.org/10.3892/ol.2019.10850
Pages: 5119-5128
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Exosome complex (EXOSC) genes, which encode a multi‑protein intracellular complex, mediate the degradation of various types of RNA molecules. EXOSCs, also known as polymyositis/scleroderma complexes, exist in eukaryotic cells and archaea, and primarily mediate 3' to 5'mRNA degradation. However, how EXOSC genes are implicated in processes of B‑cell immune‑associated pathways and B‑cell tumorigenesis remains unclear. The present bioinformatics study indicated that 6 of 10 EXOSC genes, particularly the EXO.index, were able to predict the survival of patients with mantle cell lymphoma (MCL), by analyzing gene expression profiles of 123 patients with MCL from the Gene Expression Omnibus database. The results suggested that EXOSC gene expression may be a molecular marker for MCL. Compared with the whole transcript profile, patients with MCL with a high EXO.index exhibited poorer survival and decreased RNA levels, which was also verified in a second dataset. The EXOSC genes may be associated with DNA repair and B‑cell activation pathways, which may be the cause of poorer survival of patients with MCL.

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