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Identification of RAD54 homolog B as a promising therapeutic target for breast cancer

  • Authors:
    • Jing Feng
    • Juanjuan Hu
    • Ying Xia
  • View Affiliations / Copyright

    Affiliations: Institute of Chemical Component Analysis of Traditional Chinese Medicine, Chongqing Medical and Pharmaceutical College, Chongqing 401331, P.R. China
    Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5350-5362
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    Published online on: September 12, 2019
       https://doi.org/10.3892/ol.2019.10854
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Abstract

Breast cancer is a recognized threat to the health of women globally. Due to the lack of the knowledge about the molecular pathogenesis of breast cancer, therapeutic strategies remain inadequate, especially for aggressive breast cancer. In the present study, sequential bioinformatics analysis was performed using data from the GSE20711 dataset, and the results demonstrated that three genes may impact the survival of patients with breast cancer. One of these genes, RAD54 homolog B (RAD54B), may be a potential prognostic factor for breast cancer. A signature was established that could evaluate the overall survival for patients with breast cancer based on the risk score calculated from RAD54B expression and the Tumor‑Node‑Metastasis (TNM) stage [risk score=expRAD54B x 0.236 + TNM stage (I/II=0 or III/IV=1) x1.025]. In addition, based on the GSE85871 dataset and inhibitory assay, the study identified a natural compound, Japonicone A, which may reduce the proliferation of breast cancer cells by inhibiting the expression of RAD54B. Overall, the present study identified a novel candidate gene and a candidate compound as promising therapeutic targets for the treatment of breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Feng J, Hu J and Xia Y: Identification of RAD54 homolog B as a promising therapeutic target for breast cancer. Oncol Lett 18: 5350-5362, 2019.
APA
Feng, J., Hu, J., & Xia, Y. (2019). Identification of RAD54 homolog B as a promising therapeutic target for breast cancer. Oncology Letters, 18, 5350-5362. https://doi.org/10.3892/ol.2019.10854
MLA
Feng, J., Hu, J., Xia, Y."Identification of RAD54 homolog B as a promising therapeutic target for breast cancer". Oncology Letters 18.5 (2019): 5350-5362.
Chicago
Feng, J., Hu, J., Xia, Y."Identification of RAD54 homolog B as a promising therapeutic target for breast cancer". Oncology Letters 18, no. 5 (2019): 5350-5362. https://doi.org/10.3892/ol.2019.10854
Copy and paste a formatted citation
x
Spandidos Publications style
Feng J, Hu J and Xia Y: Identification of RAD54 homolog B as a promising therapeutic target for breast cancer. Oncol Lett 18: 5350-5362, 2019.
APA
Feng, J., Hu, J., & Xia, Y. (2019). Identification of RAD54 homolog B as a promising therapeutic target for breast cancer. Oncology Letters, 18, 5350-5362. https://doi.org/10.3892/ol.2019.10854
MLA
Feng, J., Hu, J., Xia, Y."Identification of RAD54 homolog B as a promising therapeutic target for breast cancer". Oncology Letters 18.5 (2019): 5350-5362.
Chicago
Feng, J., Hu, J., Xia, Y."Identification of RAD54 homolog B as a promising therapeutic target for breast cancer". Oncology Letters 18, no. 5 (2019): 5350-5362. https://doi.org/10.3892/ol.2019.10854
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