Open Access

Overexpression of PSMA7 predicts poor prognosis in patients with gastric cancer

  • Authors:
    • Shujing Xia
    • Qi Tang
    • Xudong Wang
    • Lili Zhang
    • Lizhou Jia
    • Duo Wu
    • Pingxiang Xu
    • Xiumei Zhang
    • Genxiong Tang
    • Tingting Yang
    • Zhenqing Feng
    • Lungen Lu
  • View Affiliations

  • Published online on: September 19, 2019     https://doi.org/10.3892/ol.2019.10879
  • Pages: 5341-5349
  • Copyright: © Xia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Gastric cancer (GC) is the fourth most common tumor and the second most common cause of cancer‑associated mortality worldwide. Current tumor biomarkers for GC, such as serum carcinoembryonic antigen and carbohydrate antigen 19‑9, are not ideal due to their limited role as prognostic indicators for GC. Proteasome subunit α7 (PSMA7) is a multifunctional protein, which has been revealed to be involved in the development and progression of various types of malignancy. However, little is known about the role of PSMA7 in GC. In the present study, PSMA7 was identified to be overexpressed at the mRNA and protein levels in GC tissues, compared with in non‑tumor tissues, using reverse transcription‑quantitative PCR and immunohistochemistry. Furthermore, PSMA7 expression is associated with tumor invasion, lymph node metastasis, distant metastasis, and Tumor‑Node‑Metastasis stage. Univariate and multivariate Cox regression analysis identified that PSMA7 expression is an independent prognostic factor for poor survival. Kaplan‑Meier survival curves revealed that high PSMA7 expression is associated with a poor prognosis in patients with GC. Overall, the results of the present study suggested that PSMA7 may be a promising biomarker for the prognosis of GC, and may represent a new diagnostic marker and molecular therapeutic target for GC.
View Figures
View References

Related Articles

Journal Cover

November-2019
Volume 18 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xia S, Tang Q, Wang X, Zhang L, Jia L, Wu D, Xu P, Zhang X, Tang G, Yang T, Yang T, et al: Overexpression of PSMA7 predicts poor prognosis in patients with gastric cancer. Oncol Lett 18: 5341-5349, 2019
APA
Xia, S., Tang, Q., Wang, X., Zhang, L., Jia, L., Wu, D. ... Lu, L. (2019). Overexpression of PSMA7 predicts poor prognosis in patients with gastric cancer. Oncology Letters, 18, 5341-5349. https://doi.org/10.3892/ol.2019.10879
MLA
Xia, S., Tang, Q., Wang, X., Zhang, L., Jia, L., Wu, D., Xu, P., Zhang, X., Tang, G., Yang, T., Feng, Z., Lu, L."Overexpression of PSMA7 predicts poor prognosis in patients with gastric cancer". Oncology Letters 18.5 (2019): 5341-5349.
Chicago
Xia, S., Tang, Q., Wang, X., Zhang, L., Jia, L., Wu, D., Xu, P., Zhang, X., Tang, G., Yang, T., Feng, Z., Lu, L."Overexpression of PSMA7 predicts poor prognosis in patients with gastric cancer". Oncology Letters 18, no. 5 (2019): 5341-5349. https://doi.org/10.3892/ol.2019.10879