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Upregulation of SPDEF is associated with poor prognosis in prostate cancer

  • Authors:
    • Jan Meiners
    • Katharina Schulz
    • Katharina Möller
    • Doris Höflmayer
    • Christoph Burdelski
    • Claudia Hube‑Magg
    • Ronald Simon
    • Cosima Göbel
    • Andrea Hinsch
    • Viktor Reiswich
    • Sören Weidemann
    • Jacob R. Izbicki
    • Guido Sauter
    • Frank Jacobsen
    • Christina Möller‑Koop
    • Tim Mandelkow
    • Niclas C. Blessin
    • Florian Lutz
    • Florian Viehweger
    • Maximillian Lennartz
    • Christoph Fraune
    • Hans Heinzer
    • Sarah Minner
    • Sarah Bonk
    • Hartwig Huland
    • Markus Graefen
    • Thorsten Schlomm
    • Franziska Büscheck
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, University Medical Center Hamburg‑Eppendorf, D‑20246 Hamburg, Germany, General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg‑Eppendorf, D‑20246 Hamburg, Germany, Prostate Cancer Center, Martini‑Clinic, University Medical Center Hamburg‑Eppendorf, D‑20246 Hamburg, Germany, Department of Urology, Section for Translational Prostate Cancer Research, University Medical Center Hamburg‑Eppendorf, D‑20246 Hamburg, Germany
    Copyright: © Meiners et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5107-5118
    |
    Published online on: September 19, 2019
       https://doi.org/10.3892/ol.2019.10885
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Abstract

SAM pointed domain‑containing Ets transcription factor (SPDEF), a member of the ETS transcription factor family, has been associated with prostate cancer development; however, its role in tumour development and progression is controversial. In the present study, SPDEF expression was analysed on a tissue microarray with >12,000 prostate cancer samples. SPDEF expression levels were higher in most prostate cancer samples than in normal prostate epithelium, suggesting SPDEF was upregulated in cancer. Nuclear SPDEF expression was identified in 80% of prostate cancer samples, and considered weak in 26.4%, moderate in 40.1% and strong in 13.5% of cases. SPDEF positivity was significantly associated with tumour stage, Gleason grade, lymph node metastasis and PSA recurrence (all P<0.0001). SPDEF overexpression was more common in ERG positive (94%) than in ERG negative cancer (69%; P<0.0001). Elevated SPDEF expression predicted poor prognosis independent from established prognostic parameters, including Gleason grade, pT, pN, serum PSA level and nodal status (P<0.01). In summary, SPDEF overexpression was associated with aggressive behaviour, particularly in ERG negative prostate cancer, and may have potential for clinical application.
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Copy and paste a formatted citation
Spandidos Publications style
Meiners J, Schulz K, Möller K, Höflmayer D, Burdelski C, Hube‑Magg C, Simon R, Göbel C, Hinsch A, Reiswich V, Reiswich V, et al: Upregulation of SPDEF is associated with poor prognosis in prostate cancer. Oncol Lett 18: 5107-5118, 2019.
APA
Meiners, J., Schulz, K., Möller, K., Höflmayer, D., Burdelski, C., Hube‑Magg, C. ... Büscheck, F. (2019). Upregulation of SPDEF is associated with poor prognosis in prostate cancer. Oncology Letters, 18, 5107-5118. https://doi.org/10.3892/ol.2019.10885
MLA
Meiners, J., Schulz, K., Möller, K., Höflmayer, D., Burdelski, C., Hube‑Magg, C., Simon, R., Göbel, C., Hinsch, A., Reiswich, V., Weidemann, S., Izbicki, J. R., Sauter, G., Jacobsen, F., Möller‑Koop, C., Mandelkow, T., Blessin, N. C., Lutz, F., Viehweger, F., Lennartz, M., Fraune, C., Heinzer, H., Minner, S., Bonk, S., Huland, H., Graefen, M., Schlomm, T., Büscheck, F."Upregulation of SPDEF is associated with poor prognosis in prostate cancer". Oncology Letters 18.5 (2019): 5107-5118.
Chicago
Meiners, J., Schulz, K., Möller, K., Höflmayer, D., Burdelski, C., Hube‑Magg, C., Simon, R., Göbel, C., Hinsch, A., Reiswich, V., Weidemann, S., Izbicki, J. R., Sauter, G., Jacobsen, F., Möller‑Koop, C., Mandelkow, T., Blessin, N. C., Lutz, F., Viehweger, F., Lennartz, M., Fraune, C., Heinzer, H., Minner, S., Bonk, S., Huland, H., Graefen, M., Schlomm, T., Büscheck, F."Upregulation of SPDEF is associated with poor prognosis in prostate cancer". Oncology Letters 18, no. 5 (2019): 5107-5118. https://doi.org/10.3892/ol.2019.10885
Copy and paste a formatted citation
x
Spandidos Publications style
Meiners J, Schulz K, Möller K, Höflmayer D, Burdelski C, Hube‑Magg C, Simon R, Göbel C, Hinsch A, Reiswich V, Reiswich V, et al: Upregulation of SPDEF is associated with poor prognosis in prostate cancer. Oncol Lett 18: 5107-5118, 2019.
APA
Meiners, J., Schulz, K., Möller, K., Höflmayer, D., Burdelski, C., Hube‑Magg, C. ... Büscheck, F. (2019). Upregulation of SPDEF is associated with poor prognosis in prostate cancer. Oncology Letters, 18, 5107-5118. https://doi.org/10.3892/ol.2019.10885
MLA
Meiners, J., Schulz, K., Möller, K., Höflmayer, D., Burdelski, C., Hube‑Magg, C., Simon, R., Göbel, C., Hinsch, A., Reiswich, V., Weidemann, S., Izbicki, J. R., Sauter, G., Jacobsen, F., Möller‑Koop, C., Mandelkow, T., Blessin, N. C., Lutz, F., Viehweger, F., Lennartz, M., Fraune, C., Heinzer, H., Minner, S., Bonk, S., Huland, H., Graefen, M., Schlomm, T., Büscheck, F."Upregulation of SPDEF is associated with poor prognosis in prostate cancer". Oncology Letters 18.5 (2019): 5107-5118.
Chicago
Meiners, J., Schulz, K., Möller, K., Höflmayer, D., Burdelski, C., Hube‑Magg, C., Simon, R., Göbel, C., Hinsch, A., Reiswich, V., Weidemann, S., Izbicki, J. R., Sauter, G., Jacobsen, F., Möller‑Koop, C., Mandelkow, T., Blessin, N. C., Lutz, F., Viehweger, F., Lennartz, M., Fraune, C., Heinzer, H., Minner, S., Bonk, S., Huland, H., Graefen, M., Schlomm, T., Büscheck, F."Upregulation of SPDEF is associated with poor prognosis in prostate cancer". Oncology Letters 18, no. 5 (2019): 5107-5118. https://doi.org/10.3892/ol.2019.10885
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