Prognostic value of nuclear FBI‑1 in patients with rectal cancer with or without preoperative radiotherapy

Wang,Chao‑Jie; Chao,Chu‑Rui; Liu,Hui‑Min; Zhu,Yan‑Yan; Adell,Gunnar; Jarlsfelt,Ingvar; Zhang,Hong; Sun,Xiao‑Feng

doi:10.3892/ol.2019.10890

Prognostic value of nuclear FBI‑1 in patients with rectal cancer with or without preoperative radiotherapy

Authors:
- Chao‑Jie Wang
- Chu‑Rui Chao
- Hui‑Min Liu
- Yan‑Yan Zhu
- Gunnar Adell
- Ingvar Jarlsfelt
- Hong Zhang
- Xiao‑Feng Sun
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Affiliations: Department of Oncology, Henan Provincial People's Hospital & People's Hospital of Henan University, Zhengzhou, Henan 450003, P.R. China, Department of Oncology, Linköping University, Linköping SE‑58183, Sweden, Department of Pathology, Ryhov Hospital, Jönköping SE‑55111, Sweden, Department of Medical Sciences, Örebro University, Örebro SE‑70182, Sweden
Published online on: September 19, 2019 https://doi.org/10.3892/ol.2019.10890
Pages: 5301-5309
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Factor that binds to the inducer of short transcripts of the human immunodeficiency virus‑1 (FBI‑1) represents as a crucial gene regulator in colorectal cancer; however, the correlation between FBI‑1 and preoperative radiotherapy (RT) in rectal cancer (RC) has not yet been reported. The aim was to detect FBI‑1 expression in patients with RC with or without RT, by immunohistochemistry and quantitative polymerase chain reaction, and to analyze its association with clinicopathological features and response to RT. The results from immunohistochemistry analysis (n=139) and reverse transcription‑quantitative polymerase chain reaction (n=55) demonstrated that FBI‑1 was overexpressed in patients with RC, whether they had received preoperative RT or not. Subsequently, the association between FBI‑1 expression, and the clinicopathological features and response to RT in patients with RC was analyzed. Cytoplasmic FBI‑1 was upregulated in non‑RT (n=77) and RT (n=62) groups (17.7 vs. 74.0%, P<0.001; 41.1 vs. 69.4%, P=0.002, respectively) of patients with RC compared with normal mucosa. However, nuclear FBI‑1 was downregulated (75.8 vs. 22.1%, P<0.001; 83.9 vs. 35.5%, P<0.001, respectively) in both groups. RT had no significant effect on FBI‑1 expression in RC tissues. Furthermore, nuclear FBI‑1 was positively associated with tumor‑node‑metastasis stage and distant recurrence (P=0.003 and P=0.010, respectively). In patients with stage I, II or III RC, higher nuclear FBI‑1 expression was associated with poorer disease‑free survival [hazard ratio (HR)=1.934, 95% confidence interval (CI): 1.055‑3.579, P=0.033] and overall survival (HR=2.174, 95% CI: 1.102‑4.290, P=0.025), independently of sex, age, growth pattern, differentiation and RT. In addition, FBI‑1 was positively correlated with numerous biological factors, including p73 [Spearman's correlation coefficient (rs)=0.332, P=0.007], lysyl oxidase (rs=0.234, P=0.043), Wrap53 (rs=‑0.425, P=0.0002) and peroxisome proliferator‑activated receptor δ (rs=‑0.294, P=0.026). In conclusion, the present study demonstrated that nuclear FBI‑1 was an independent prognostic factor in patients with RC and correlated with numerous biological factors, which indicated that it may have multiple roles in RC.

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