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Inhibition of long non‑coding RNA‑AWPPH decreases osteosarcoma cell proliferation, migration and invasion

  • Authors:
    • Wenbin Ding
    • Dajiang Wu
    • Fang Ji
    • Hao Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Traumatic Orthopedics, Changhai Hospital, Shanghai 200433, P.R. China
    Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5055-5062
    |
    Published online on: September 20, 2019
       https://doi.org/10.3892/ol.2019.10898
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Abstract

Long non‑coding RNAs (lncRNAs) serve a crucial role in various types of cancer. The lncRNA AWPPH has been reported to promote hepatocellular carcinoma and bladder cancer progression. However, to the best of our knowledge, the biological roles of AWPPH in osteosarcoma (OS) remain unclear. In the present study, the levels of AWPPH in OS tissues and cell lines were determined by reverse transcription‑quantitative polymerase chain reaction. An MTT assay was used to detect OS cell proliferation. The levels of proteins associated with the PI3K/Akt signaling pathway and apoptosis were determined by western blotting. Wound‑healing and Transwell assays were conducted to determine cell migration and invasion, respectively. The results demonstrated that AWPPH was highly expressed in OS tissues and cells. Functional analyses revealed that AWPPH depletion significantly inhibited OS cell proliferation and migration, and promoted OS cell apoptosis. Furthermore, AWPPH downregulation significantly inhibited the PI3K/AKT pathway. The present study demonstrated that AWPPH was highly expressed in OS, and that AWPPH promoted OS cell proliferation and migration, and inhibited OS cell apoptosis, which may be mediated by PI3K/AKT pathway activation.
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1 

Rothermundt C, Seddon BM, Dileo P, Strauss SJ, Coleman J, Briggs TW, Haile SR and Whelan JS: Follow-up practices for high-grade extremity Osteosarcoma. BMC Cancer. 16:3012016. View Article : Google Scholar : PubMed/NCBI

2 

Kager L, Zoubek A, Pötschger U, Kastner U, Flege S, Kempf-Bielack B, Branscheid D, Kotz R, Salzer-Kuntschik M, Winkelmann W, et al: Primary metastatic osteosarcoma: Presentation and outcome of patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol. 21:2011–2018. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Anderson ME: Update on survival in osteosarcoma. Orthop Clin North Am. 47:283–292. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Senerchia AA, Macedo CR, Ferman S, Scopinaro M, Cacciavillano W, Boldrini E, Lins de Moraes VL, Rey G, de Oliveira CT, Castillo L, et al: Results of a randomized, prospective clinical trial evaluating metronomic chemotherapy in nonmetastatic patients with high-grade, operable osteosarcomas of the extremities: A report from the Latin American Group of Osteosarcoma Treatment. Cancer. 123:1003–1010. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Chung SW, Han I, Oh JH, Shin SH, Cho HS and Kim HS: Prognostic effect of erroneous surgical procedures in patients with osteosarcoma: Evaluation using propensity score matching. J Bone Joint Surg Am. 96:e602014. View Article : Google Scholar : PubMed/NCBI

6 

Cheng C, Chen ZQ and Shi XT: MicroRNA-320 inhibits osteosarcoma cells proliferation by directly targeting fatty acid synthase. Tumour Biol. 35:4177–4183. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Li E, Zhang J, Yuan T and Ma B: MiR-145 inhibits osteosarcoma cells proliferation and invasion by targeting ROCK1. Tumour Biol. 35:7645–7650. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Rinn JL and Chang HY: Genome regulation by long noncoding RNAs. Annu Rev Biochem. 81:145–166. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Ponjavic J, Ponting CP and Lunter G: Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs. Genome Res. 17:556–565. 2007. View Article : Google Scholar : PubMed/NCBI

10 

ENCODE Project Consortium, ; Birney E, Stamatoyannopoulos JA, Dutta A, Guigó R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, et al: Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 447:799–816. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Hirano T, Yoshikawa R, Harada H, Harada Y, Ishida A and Yamazaki T: Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression. Mol Cancer. 14:902015. View Article : Google Scholar : PubMed/NCBI

12 

Chen F, Mo J and Zhang L: Long noncoding RNA BCAR4 promotes osteosarcoma progression through activating GLI2-dependent gene transcription. Tumour Biol. 37:13403–13412. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Raveh E, Matouk IJ, Gilon M and Hochberg A: The H19 Long non-coding RNA in cancer initiation, progression and metastasis-a proposed unifying theory. Mol Cancer. 14:1842015. View Article : Google Scholar : PubMed/NCBI

14 

Modali SD, Parekh VI, Kebebew E and Agarwal SK: Epigenetic regulation of the lncRNA MEG3 and its target c-MET in pancreatic neuroendocrine tumors. Mol Endocrinol. 29:224–237. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Wu XS, Wang F, Li HF, Hu YP, Jiang L, Zhang F, Li ML, Wang XA, Jin YP, Zhang YJ, et al: LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis. EMBO Rep. 18:1837–1853. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Xiao J, Lv Y, Jin F, Liu Y, Ma Y, Xiong Y, Liu L, Zhang S, Sun Y, Tipoe GL, et al: LncRNA HANR promotes tumorigenesis and increase of chemoresistance in hepatocellular carcinoma. Cell Physiol Biochem. 43:1926–1938. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Hu X, Feng Y, Zhang D, Zhao SD, Hu Z, Greshock J, Zhang Y, Yang L, Zhong X, Wang LP, et al: A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer. Cancer Cell. 26:344–357. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Schmitt AM and Chang HY: Long noncoding RNAs in cancer pathways. Cancer Cell. 29:452–463. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Peng W, Si S, Zhang Q, Li C, Zhao F, Wang F, Yu J and Ma R: Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression. J Exp Clin Cancer Res. 34:792015. View Article : Google Scholar : PubMed/NCBI

20 

Sun L, Yang C, Xu J, Feng Y, Wang L and Cui T: Long noncoding RNA EWSAT1 promotes osteosarcoma cell growth and metastasis through suppression of MEG3 expression. DNA Cell Biol. 35:812–818. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Li Z, Yu X and Shen J: Long non-coding RNAs: Emerging players in osteosarcoma. Tumour Biol. 37:2811–2816. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Cui X, Jing X, Long C, Tian J and Zhu J: Long noncoding RNA MEG3, a potential novel biomarker to predict the clinical outcome of cancer patients: A meta-analysis. Oncotarget. 8:19049–19056. 2017.PubMed/NCBI

23 

Ying L, Huang Y, Chen H, Wang Y, Xia L, Chen Y, Liu Y and Qiu F: Downregulated MEG3 activates autophagy and increases cell proliferation in bladder cancer. Mol Biosyst. 9:407–411. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Qin R, Chen Z, Ding Y, Hao J, Hu J and Guo F: Long noncoding RNA MEG3 inhibits the proliferation of cervical carcinoma cells through the induction of cell cycle arrest and apoptosis. Neoplasma. 60:486–492. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Chang L, Wang G, Jia T, Zhang L, Li Y, Han Y, Zhang K, Lin G, Zhang R, Li J and Wang L: Armored long non-coding RNA MEG3 targeting EGFR based on recombinant MS2 bacteriophage virus-like particles against hepatocellular carcinoma. Oncotarget. 7:23988–24004. 2016.PubMed/NCBI

26 

Cao X, Zhuang S, Hu Y, Xi L, Deng L, Sheng H and Shen W: Associations between polymorphisms of long noncoding RNA MEG3 and risk of colorectal cancer in Chinese. Oncotarget. 7:19054–19059. 2016.PubMed/NCBI

27 

Zhu F, Zhang X, Yu Q, Han G, Diao F, Wu C and Zhang Y: LncRNA AWPPH inhibits SMAD4 via EZH2 to regulate bladder cancer progression. J Cell Biochem. 119:4496–4505. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Yu G, Wang W, Deng J and Dong S: LncRNA AWPPH promotes the proliferation, migration and invasion of ovarian carcinoma cells via activation of the Wnt/β-catenin signaling pathway. Mol Med Rep. 19:3615–3621. 2019.PubMed/NCBI

29 

Zhao X, Liu Y and Yu S: Long noncoding RNA AWPPH promotes hepatocellular carcinoma progression through YBX1 and serves as a prognostic biomarker. Biochim Biophys Acta Mol Basis Dis. 1863:1805–1816. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Guo D, Li Q, Lv Q, Wei Q, Cao S and Gu J: MiR-27a targets sFRP1 in hFOB cells to regulate proliferation, apoptosis and differentiation. PLoS One. 9:e913542014. View Article : Google Scholar : PubMed/NCBI

31 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Bielack S, Carrle D and Casali PG; ESMO Guidelines Working Group, : Osteosarcoma: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol. 20 (Suppl 4):S137–S139. 2009. View Article : Google Scholar

33 

Zhang J, Lan Q and Lin J: Identification of key gene modules for human osteosarcoma by co-expression analysis. World J Surg Oncol. 16:892018. View Article : Google Scholar : PubMed/NCBI

34 

Bassett AR, Akhtar A, Barlow DP, Bird AP, Brockdorff N, Duboule D, Ephrussi A, Ferguson-Smith AC, Gingeras TR, Haerty W, et al: Considerations when investigating lncRNA function in vivo. Elife. 3:e030582014. View Article : Google Scholar : PubMed/NCBI

35 

Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL, et al: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 464:1071–1076. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Danielsen SA, Eide PW, Nesbakken A, Guren T, Leithe E and Lothe RA: Portrait of the PI3K/AKT pathway in colorectal cancer. Biochim Biophys Acta. 1855:104–121. 2015.PubMed/NCBI

37 

Gardai SJ, Hildeman DA, Frankel SK, Whitlock BB, Frasch SC, Borregaard N, Marrack P, Bratton DL and Henson PM: Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biol Chem. 279:21085–21095. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Quan JH, Cha GH, Zhou W, Chu JQ, Nishikawa Y and Lee YH: Involvement of PI 3 kinase/Akt-dependent Bad phosphorylation in Toxoplasma gondii-mediated inhibition of host cell apoptosis. Exp Parasitol. 133:462–471. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S and Reed JC: Regulation of cell death protease caspase-9 by phosphorylation. Science. 282:1318–1321. 1998. View Article : Google Scholar : PubMed/NCBI

40 

Li C, Yu S, Wu S, Ni Y and Pan Z: MicroRNA-936 targets FGF2 to inhibit epithelial ovarian cancer aggressiveness by deactivating the PI3K/Akt pathway. Onco Targets Ther. 12:5311–5322. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Lee MS, Jeong MH, Lee HW, Han HJ, Ko A, Hewitt SM, Kim JH, Chun KH, Chung JY, Lee C, et al: PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis. Nat Commun. 6:77692015. View Article : Google Scholar : PubMed/NCBI

42 

Porta C, Paglino C and Mosca A: Targeting PI3K/Akt/mTOR signaling in cancer. Front Oncol. 4:642014. View Article : Google Scholar : PubMed/NCBI

43 

Hennessy BT, Smith DL, Ram PT, Lu Y and Mills GB: Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov. 4:988–1004. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Hu B, Lv X, Gao F, Chen S, Wang S, Qing X, Liu J, Wang B and Shao Z: Downregulation of DEPTOR inhibits the proliferation, migration, and survival of osteosarcoma through PI3K/Akt/mTOR pathway. Onco Targets Ther. 10:4379–4391. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ding W, Wu D, Ji F and Zhang H: Inhibition of long non‑coding RNA‑AWPPH decreases osteosarcoma cell proliferation, migration and invasion. Oncol Lett 18: 5055-5062, 2019.
APA
Ding, W., Wu, D., Ji, F., & Zhang, H. (2019). Inhibition of long non‑coding RNA‑AWPPH decreases osteosarcoma cell proliferation, migration and invasion. Oncology Letters, 18, 5055-5062. https://doi.org/10.3892/ol.2019.10898
MLA
Ding, W., Wu, D., Ji, F., Zhang, H."Inhibition of long non‑coding RNA‑AWPPH decreases osteosarcoma cell proliferation, migration and invasion". Oncology Letters 18.5 (2019): 5055-5062.
Chicago
Ding, W., Wu, D., Ji, F., Zhang, H."Inhibition of long non‑coding RNA‑AWPPH decreases osteosarcoma cell proliferation, migration and invasion". Oncology Letters 18, no. 5 (2019): 5055-5062. https://doi.org/10.3892/ol.2019.10898
Copy and paste a formatted citation
x
Spandidos Publications style
Ding W, Wu D, Ji F and Zhang H: Inhibition of long non‑coding RNA‑AWPPH decreases osteosarcoma cell proliferation, migration and invasion. Oncol Lett 18: 5055-5062, 2019.
APA
Ding, W., Wu, D., Ji, F., & Zhang, H. (2019). Inhibition of long non‑coding RNA‑AWPPH decreases osteosarcoma cell proliferation, migration and invasion. Oncology Letters, 18, 5055-5062. https://doi.org/10.3892/ol.2019.10898
MLA
Ding, W., Wu, D., Ji, F., Zhang, H."Inhibition of long non‑coding RNA‑AWPPH decreases osteosarcoma cell proliferation, migration and invasion". Oncology Letters 18.5 (2019): 5055-5062.
Chicago
Ding, W., Wu, D., Ji, F., Zhang, H."Inhibition of long non‑coding RNA‑AWPPH decreases osteosarcoma cell proliferation, migration and invasion". Oncology Letters 18, no. 5 (2019): 5055-5062. https://doi.org/10.3892/ol.2019.10898
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