Open Access

Diagnostic and prognostic value of the BEX family in lung adenocarcinoma

  • Authors:
    • Zhong‑Hao Zhang
    • Zhi‑Yu Luan
    • Fei Han
    • Hong‑Qiang Chen
    • Wen‑Bin Liu
    • Jin‑Yi Liu
    • Jia Cao
  • View Affiliations

  • Published online on: September 20, 2019     https://doi.org/10.3892/ol.2019.10905
  • Pages: 5523-5533
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Previous studies have demonstrated that members of the brain‑expressed X‑linked (BEX) family participate in a wide range of biological functions in normal and tumor tissues. However, their role and clinical significance in lung adenocarcinoma (LUAD) remains unclear. The present study investigated The Cancer Genome Atlas data and revealed that the BEX family was downregulated in LUAD tissues compared with adjacent non‑cancerous tissues. Additionally, analysis of LUAD cohorts from the Oncomine database revealed similar results. Furthermore, the expression of BEX members was significantly decreased in several LUAD cell lines compared with normal lung epithelial cells in vitro. The aforementioned data mining and in vitro results suggested that the BEX family may be involved in the development of LUAD. Furthermore, receiver operating characteristic curve analysis revealed that BEX members exhibited high sensitivity and specificity for the diagnosis of patients with LUAD. The low expression levels of BEX1, BEX4 and BEX5 were associated with certain pathologic features, particularly in advanced LUAD. Survival analysis demonstrated that BEX members, particularly BEX4, were involved in the prognosis of patients with LUAD at early and late clinical stages. The results obtained in the current study suggested that BEX members may serve as potential tumor biomarkers for the diagnosis and prognosis of patients with LUAD.
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November-2019
Volume 18 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang ZH, Luan ZY, Han F, Chen HQ, Liu WB, Liu JY and Cao J: Diagnostic and prognostic value of the BEX family in lung adenocarcinoma. Oncol Lett 18: 5523-5533, 2019
APA
Zhang, Z., Luan, Z., Han, F., Chen, H., Liu, W., Liu, J., & Cao, J. (2019). Diagnostic and prognostic value of the BEX family in lung adenocarcinoma. Oncology Letters, 18, 5523-5533. https://doi.org/10.3892/ol.2019.10905
MLA
Zhang, Z., Luan, Z., Han, F., Chen, H., Liu, W., Liu, J., Cao, J."Diagnostic and prognostic value of the BEX family in lung adenocarcinoma". Oncology Letters 18.5 (2019): 5523-5533.
Chicago
Zhang, Z., Luan, Z., Han, F., Chen, H., Liu, W., Liu, J., Cao, J."Diagnostic and prognostic value of the BEX family in lung adenocarcinoma". Oncology Letters 18, no. 5 (2019): 5523-5533. https://doi.org/10.3892/ol.2019.10905