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Case Report Open Access

Different responses to anti‑programmed cell death protein 1 (PD‑1) immunotherapy in a patient with Lynch syndrome and metachronous urothelial and colon cancer: A case report

  • Authors:
    • Yu Feng
    • Yufeng Cao
    • Mingming Yuan
    • Rongrong Chen
    • Xue Ji
    • Xingsheng Hu
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China, Department of Oncology, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250001, P.R. China, Department of R&D, Geneplus‑Beijing Institute, Beijing 102206, P.R. China
    Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5085-5090
    |
    Published online on: September 23, 2019
       https://doi.org/10.3892/ol.2019.10909
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Abstract

Lynch syndrome (LS), as a result of the germline mutations in DNA mismatch repair genes, is characterized by the increased risk of endometrium, colon, and urinary tract cancer. Individuals with this disorder may occasionally have multiple primary carcinomas. Regardless of tumor type, pembrolizumab was approved for the treatment of patients with unresectable or metastatic mismatch repair deficient tumors, which may be an optional therapeutic method for patients with LS with multiple primary carcinomas. This case study is of a MSH2‑deficient patient with LS with metachronous urothelial and colon cancer, who received pembrolizumab treatment for 8 months. The responses of the two primary sites to immunotherapy differed. Based on the changes of tumor markers and tumor size illustrated by imageological examinations, no response was observed in the sigmoid colon lesion, whereas an immune‑associated phenomenon known as pseudoprogression was detected in the ureteral lesion. Immunotherapy was innovatively applied to the patient with multiple primary carcinomas. This case proposes a novel concept in which immunotherapy may potentially control the cancer growth in patients with LS and multiple primary carcinomas. However, further large‑scale investigations are required. Furthermore, it raises a challenge to monitor the effectiveness of immunotherapy.
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Copy and paste a formatted citation
Spandidos Publications style
Feng Y, Cao Y, Yuan M, Chen R, Ji X and Hu X: Different responses to anti‑programmed cell death protein 1 (PD‑1) immunotherapy in a patient with Lynch syndrome and metachronous urothelial and colon cancer: A case report. Oncol Lett 18: 5085-5090, 2019.
APA
Feng, Y., Cao, Y., Yuan, M., Chen, R., Ji, X., & Hu, X. (2019). Different responses to anti‑programmed cell death protein 1 (PD‑1) immunotherapy in a patient with Lynch syndrome and metachronous urothelial and colon cancer: A case report. Oncology Letters, 18, 5085-5090. https://doi.org/10.3892/ol.2019.10909
MLA
Feng, Y., Cao, Y., Yuan, M., Chen, R., Ji, X., Hu, X."Different responses to anti‑programmed cell death protein 1 (PD‑1) immunotherapy in a patient with Lynch syndrome and metachronous urothelial and colon cancer: A case report". Oncology Letters 18.5 (2019): 5085-5090.
Chicago
Feng, Y., Cao, Y., Yuan, M., Chen, R., Ji, X., Hu, X."Different responses to anti‑programmed cell death protein 1 (PD‑1) immunotherapy in a patient with Lynch syndrome and metachronous urothelial and colon cancer: A case report". Oncology Letters 18, no. 5 (2019): 5085-5090. https://doi.org/10.3892/ol.2019.10909
Copy and paste a formatted citation
x
Spandidos Publications style
Feng Y, Cao Y, Yuan M, Chen R, Ji X and Hu X: Different responses to anti‑programmed cell death protein 1 (PD‑1) immunotherapy in a patient with Lynch syndrome and metachronous urothelial and colon cancer: A case report. Oncol Lett 18: 5085-5090, 2019.
APA
Feng, Y., Cao, Y., Yuan, M., Chen, R., Ji, X., & Hu, X. (2019). Different responses to anti‑programmed cell death protein 1 (PD‑1) immunotherapy in a patient with Lynch syndrome and metachronous urothelial and colon cancer: A case report. Oncology Letters, 18, 5085-5090. https://doi.org/10.3892/ol.2019.10909
MLA
Feng, Y., Cao, Y., Yuan, M., Chen, R., Ji, X., Hu, X."Different responses to anti‑programmed cell death protein 1 (PD‑1) immunotherapy in a patient with Lynch syndrome and metachronous urothelial and colon cancer: A case report". Oncology Letters 18.5 (2019): 5085-5090.
Chicago
Feng, Y., Cao, Y., Yuan, M., Chen, R., Ji, X., Hu, X."Different responses to anti‑programmed cell death protein 1 (PD‑1) immunotherapy in a patient with Lynch syndrome and metachronous urothelial and colon cancer: A case report". Oncology Letters 18, no. 5 (2019): 5085-5090. https://doi.org/10.3892/ol.2019.10909
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