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High gene expression levels of VEGFA and CXCL8 in the peritumoral brain zone are associated with the recurrence of glioblastoma: A bioinformatics analysis

  • Authors:
    • Xiaobin Luo
    • Shangyi Xu
    • Yali Zhong
    • Tianqi Tu
    • Youlin Xu
    • Xianglong Li
    • Bin Wang
    • Fubing Yang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China, School of Nursing, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou 550000, P.R. China
    Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6171-6179
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    Published online on: October 14, 2019
       https://doi.org/10.3892/ol.2019.10988
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Abstract

The present study aimed to identify differentially regulated genes between the peritumoral brain zone (PBZ) and tumor core (TC) of glioblastoma (GBM), to elucidate the underlying molecular mechanisms and provide a target for the treatment of tumors. The GSE13276 and GSE116520 datasets were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) for the PBZ and TC were obtained using the GEO2R tool. The bioinformatics and evolutionary genomics online tool Venn was used to identify common DEGs between the two datasets. The Database for Annotation, Visualization, and Integrated Discovery online tool was used to analyze enriched pathways of the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) databases. The Search Tool for the Retrieval of Interacting Genes/Proteins online tool was used to construct a protein‑protein interaction (PPI) network of DEGs. Hub genes were identified using Cytohubba, a plug‑in for Cytoscape. The Gene Expression Profiling Interactive Analysis (GEPIA) database was utilized to perform survival analysis. In total, 75 DEGs, including 12 upregulated and 63 downregulated genes, were identified. In the GO term analysis, these DEGs were mainly enriched in ‘regulation of angiogenesis’ and ‘central nervous system development’. Furthermore, in the KEGG pathway analysis, the DEGs were mainly enriched in ‘bladder cancer’ and ‘endocytosis’. When filtering the results of the PPI network analysis using Cytohubba, a total of 10 hub genes, including proteolipid protein 1, myelin associated oligodendrocyte basic protein, contactin 2, myelin oligodendrocyte glycoprotein, myelin basic protein, myelin associated glycoprotein, SRY‑box transcription factor 10, C‑X‑C motif chemokine ligand 8 (CXCL8), vascular endothelial growth factor A (VEGFA) and plasmolipin, were identified. These hub genes were further subjected to GO term and KEGG pathway analysis, and were revealed to be enriched in ‘central nervous system development’, ‘bladder cancer’ and ‘rheumatoid arthritis’. These hub genes were used to perform survival analysis using the GEPIA database, and it was determined that VEGFA and CXCL8 were significantly associated with a reduction in the overall survival of patients with GBM. In conclusion, the results suggest that the recurrence of GBM is associated with high gene expression levels VEGFA and CXCL8, and the development of the central nervous system.
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1 

Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P and Ellison DW: The 2016 World Health Organization Classification of tumors of the central nervous system: A summary. Acta Neuropathol. 131:803–820. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Mangiola A, Saulnier N, De Bonis P, Orteschi D, Sica G, Lama G, Pettorini BL, Sabatino G, Zollino M, Lauriola L, et al: Gene expression profile of glioblastoma peritumoral tissue: An ex vivo study. PLoS One. 8:e571452013. View Article : Google Scholar : PubMed/NCBI

3 

Jayamanne D, Wheeler H, Cook R, Teo C, Brazier D, Schembri G, Kastelan M, Guo L and Back MF: Survival improvements with adjuvant therapy in patients with glioblastoma. ANZ J Surg. 88:196–201. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Lassman AB, van den Bent MJ, Gan HK, Reardon DA, Kumthekar P, Butowski N, Lwin Z, Mikkelsen T, Nabors LB, Papadopoulos KP, et al: Safety and efficacy of depatuxizumab mafodotin + temozolomide in patients with EGFR-amplified, recurrent glioblastoma: Results from an international phase I multicenter trial. Neuro Oncol. 21:106–114. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Franceschi E, Minichillo S and Brandes AA: Pharmacotherapy of glioblastoma: Established treatments and emerging concepts. CNS Drugs. 31:675–684. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Mangiola A, de Bonis P, Maira G, Balducci M, Sica G, Lama G, Lauriola L and Anile C: Invasive tumor cells and prognosis in a selected population of patients with glioblastoma multiforme. Cancer. 113:841–846. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Long H, Liang C, Zhang X, Fang L, Wang G, Qi S, Huo H and Song Y: Prediction and analysis of key genes in glioblastoma based on bioinformatics. Biomed Res Int. 2017:76531012017. View Article : Google Scholar : PubMed/NCBI

8 

Ruiz-Ontañon P, Orgaz JL, Aldaz B, Elosegui-Artola A, Martino J, Berciano MT, Montero JA, Grande L, Nogueira L, Diaz-Moralli S, et al: Cellular plasticity confers migratory and invasive advantages to a population of glioblastoma-initiating cells that infiltrate peritumoral tissue. Stem Cells. 31:1075–1085. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Van Meter T, Dumur C, Hafez N, Garrett C, Fillmore H and Broaddus WC: Microarray analysis of MRI-defined tissue samples in glioblastoma reveals differences in regional expression of therapeutic targets. Diagn Mol Pathol. 15:195–205. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Lama G, Mangiola A, Anile C, Sabatino G, De Bonis P, Lauriola L, Giannitelli C, La Torre G, Jhanwar-Uniyal M, Sica G and Maira G: Activated ERK1/2 expression in glioblastoma multiforme and in peritumor tissue. Int J Oncol. 30:1333–1342. 2007.PubMed/NCBI

11 

Kruthika BS, Jain R, Arivazhagan A, Bharath RD, Yasha TC, Kondaiah P and Santosh V: Transcriptome profiling reveals PDZ binding kinase as a novel biomarker in peritumoral brain zone of glioblastoma. J Neurooncol. 141:315–325. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Huang DW, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Huang DW, Sherman BT and Lempicki RA: Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37:1–13. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork P, et al: STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 47:D607–D613. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45:W98–W102. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Rickman DS, Tyagi R, Zhu XX, Bobek MP, Song S, Blaivas M, Misek DE, Israel MA, Kurnit DM, Ross DA, et al: The gene for the axonal cell adhesion molecule TAX-1 is amplified and aberrantly expressed in malignant gliomas. Cancer Res. 61:2162–2168. 2001.PubMed/NCBI

18 

Eckerich C, Zapf S, Ulbricht U, Müller S, Fillbrandt R, Westphal M and Lamszus K: Contactin is expressed in human astrocytic gliomas and mediates repulsive effects. Glia. 53:1–12. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Solly SK, Daubas P, Monge M, Dautigny A and Zalc B: Functional analysis of the mouse myelin/oligodendrocyte glycoprotein gene promoter in the oligodendroglial CG4 cell line. J Neurochem. 68:1705–1711. 1997. View Article : Google Scholar : PubMed/NCBI

20 

Nakagawa H, Yamada M, Kanayama T, Tsuruzono K, Miyawaki Y, Tokiyoshi K, Hagiwara Y and Hayakawa T: Myelin basic protein in the cerebrospinal fluid of patients with brain tumors. Neurosurgery. 34:825–833. 1994. View Article : Google Scholar : PubMed/NCBI

21 

Serão NV, Delfino KR, Southey BR, Beever JE and Rodriguez-Zas SL: Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival. BMC Med Genomics. 4:492011. View Article : Google Scholar : PubMed/NCBI

22 

Kong J, Cooper LA, Wang F, Gao J, Teodoro G, Scarpace L, Mikkelsen T, Schniederjan MJ, Moreno CS, Saltz JH and Brat DJ: Machine-based morphologic analysis of glioblastoma using whole-slide pathology images uncovers clinically relevant molecular correlates. PLoS One. 8:e810492013. View Article : Google Scholar : PubMed/NCBI

23 

Ljubimova JY, Wilson SE, Petrovic LM, Ehrenman K, Ljubimov AV, Demetriou AA, Geller SA and Black KL: Novel human malignancy-associated gene (MAG) expressed in various tumors and in some tumor preexisting conditions. Cancer Res. 58:4475–4479. 1998.PubMed/NCBI

24 

Reis ST, Leite KR, Piovesan LF, Pontes-Junior J, Viana NI, Abe DK, Crippa A, Moura CM, Adonias SP, Srougi M and Dall'Oglio MF: Increased expression of MMP-9 and IL-8 are correlated with poor prognosis of Bladder Cancer. BMC Urol. 12:182012. View Article : Google Scholar : PubMed/NCBI

25 

Pathak JL, Bakker AD, Verschueren P, Lems WF, Luyten FP, Klein-Nulend J and Bravenboer N: CXCL8 and CCL20 enhance osteoclastogenesis via modulation of cytokine production by human primary osteoblasts. PLoS One. 10:e01310412015. View Article : Google Scholar : PubMed/NCBI

26 

Kast RE: Glioblastoma invasion, cathepsin B, and the potential for both to be inhibited by auranofin, an old anti-rheumatoid arthritis drug. Cent Eur Neurosurg. 71:139–142. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Lanzardo S, Conti L, Brioschi C, Bartolomeo MP, Arosio D, Belvisi L, Manzoni L, Maiocchi A, Maisano F and Forni G: A new optical imaging probe targeting αVβ3 integrin in glioblastoma xenografts. Contrast Media Mol Imaging. 6:449–458. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Bergers G and Benjamin LE: Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 3:401–410. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Wu Y, Hooper AT, Zhong Z, Witte L, Bohlen P, Rafii S and Hicklin DJ: The vascular endothelial growth factor receptor (VEGFR-1) supports growth and survival of human breast carcinoma. Int J Cancer. 119:1519–1529. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Kane NM, Xiao Q, Baker AH, Luo Z, Xu Q and Emanueli C: Pluripotent stem cell differentiation into vascular cells: A novel technology with promises for vascular re(generation). Pharmacol Ther. 129:29–49. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Calvo CF, Fontaine RH, Soueid J, Tammela T, Makinen T, Alfaro-Cervello C, Bonnaud F, Miguez A, Benhaim L, Xu Y, et al: Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis. Genes Dev. 25:831–844. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Desbaillets I, Diserens AC, Tribolet N, Hamou MF and Van Meir EG: Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis. J Exp Med. 186:1201–1212. 1997. View Article : Google Scholar : PubMed/NCBI

33 

Wong ML, Prawira A, Kaye AH and Hovens CM: Tumour angiogenesis: Its mechanism and therapeutic implications in malignant gliomas. J Clin Neurosci. 16:1119–1130. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Gong J, Zhu S, Zhang Y and Wang J: Interplay of VEGFa and MMP2 regulates invasion of glioblastoma. Tumour Biol. 35:11879–11885. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Egorova AA, Maretina MA and Kiselev AV: VEGFA gene silencing in CXCR4-expressing cells via siRNA delivery by means of targeted peptide carrier. Methods Mol Biol. 1974:57–68. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Keunen O, Johansson M, Oudin A, Sanzey M, Rahim SA, Fack F, Thorsen F, Taxt T, Bartos M, Jirik R, et al: Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma. Proc Natl Acad Sci USA. 108:3749–3754. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Latzer P, Shchyglo O, Hartl T, Matschke V, Schlegel U, Manahan-Vaughan D and Theiss C: Blocking VEGF by bevacizumab compromises electrophysiological and morphological properties of hippocampal neurons. Front Cell Neurosci. 13:1132019. View Article : Google Scholar : PubMed/NCBI

38 

Koch A, Polverini P, Kunkel S, Harlow LA, DiPietro LA, Elner VM, Elner SG and Strieter RM: Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science. 258:1798–1801. 1992. View Article : Google Scholar : PubMed/NCBI

39 

Strieter RM, Kunkel SL, Elner VM, Martonyi CL, Koch AE, Polverini PJ and Elner SG: Interleukin-8. A corneal factor that induces neovascularization. Am J Pathol. 141:1279–1284. 1992.PubMed/NCBI

40 

Keane MP and Strieter RM: The role of CXC chemokines in the regulation of angiogenesis. Chem Immunol. 72:86–101. 1999. View Article : Google Scholar : PubMed/NCBI

41 

Tada M, Suzuki K, Yamakawa Y, Sawamura Y, Sakuma S, Abe H, van Meir E and de Tribolet N: Human glioblastoma cells produce 77 amino acid interleukin-8 (IL-8(77)). J Neurooncol. 16:25–34. 1993. View Article : Google Scholar : PubMed/NCBI

42 

Brat DJ, Bellail AC and Van Meir EG: The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol. 7:122–133. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Ahn SH, Park H, Ahn YH, Kim S, Cho MS, Kang JL and Choi YH: Necrotic cells influence migration and invasion of glioblastoma via NF-κB/AP-1-mediated IL-8 regulation. Sci Rep. 6:245522016. View Article : Google Scholar : PubMed/NCBI

44 

Sharma I, Singh A, Siraj F and Saxena S: IL-8/CXCR1/2 signalling promotes tumor cell proliferation, invasion and vascular mimicry in glioblastoma. J Biomed Sci. 25:622018. View Article : Google Scholar : PubMed/NCBI

45 

Infanger DW, Cho Y, Lopez BS, Mohanan S, Liu SC, Gursel D, Boockvar JA and Fischbach C: Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche. Cancer Res. 73:7079–7089. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Dwyer J, Hebda JK, Le Guelte A, Galan-Moya EM, Smith SS, Azzi S, Bidere N and Gavard J: Glioblastoma cell-secreted interleukin-8 induces brain endothelial cell permeability via CXCR2. PLoS One. 7:e455622012. View Article : Google Scholar : PubMed/NCBI

47 

Liu YS, Hsu JW, Lin HY, Lai SW, Huang BR, Tsai CF and Lu DY: Bradykinin B1 receptor contributes to interleukin-8 production and glioblastoma migration through interaction of STAT3 and SP-1. Neuropharmacology. 144:143–154. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Hasan T, Caragher SP, Shireman JM, Park CH, Atashi F, Baisiwala S, Lee G, Guo D, Wang JY, Dey M, et al: Interleukin-8/CXCR2 signaling regulates therapy-induced plasticity and enhances tumorigenicity in glioblastoma. Cell Death Dis. 10:2922019. View Article : Google Scholar : PubMed/NCBI

49 

Angara K, Borin TF, Rashid MH, Lebedyeva I, Ara R, Lin PC, Iskander A, Bollag RJ, Achyut BR and Arbab AS: CXCR2-expressing tumor cells drive vascular mimicry in antiangiogenic therapy-resistant glioblastoma. Neoplasia. 20:1070–1082. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Sun S, Wang Q, Giang A, Cheng C, Soo C, Wang CY, Liau LM and Chiu R: Knockdown of CypA inhibits interleukin-8 (IL-8) and IL-8-mediated proliferation and tumor growth of glioblastoma cells through down-regulated NF-κB. J Neurooncol. 101:1–14. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Folkman J: Tumor angiogenesis: Therapeutic implications. N Engl J Med. 285:1182–1186. 1971. View Article : Google Scholar : PubMed/NCBI

52 

Davis ME: Glioblastoma: Overview of disease and treatment. Clin J Oncol Nurs. 20 (Suppl 5):S2–S8. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Luo X, Xu S, Zhong Y, Tu T, Xu Y, Li X, Wang B and Yang F: High gene expression levels of VEGFA and CXCL8 in the peritumoral brain zone are associated with the recurrence of glioblastoma: A bioinformatics analysis. Oncol Lett 18: 6171-6179, 2019.
APA
Luo, X., Xu, S., Zhong, Y., Tu, T., Xu, Y., Li, X. ... Yang, F. (2019). High gene expression levels of VEGFA and CXCL8 in the peritumoral brain zone are associated with the recurrence of glioblastoma: A bioinformatics analysis. Oncology Letters, 18, 6171-6179. https://doi.org/10.3892/ol.2019.10988
MLA
Luo, X., Xu, S., Zhong, Y., Tu, T., Xu, Y., Li, X., Wang, B., Yang, F."High gene expression levels of VEGFA and CXCL8 in the peritumoral brain zone are associated with the recurrence of glioblastoma: A bioinformatics analysis". Oncology Letters 18.6 (2019): 6171-6179.
Chicago
Luo, X., Xu, S., Zhong, Y., Tu, T., Xu, Y., Li, X., Wang, B., Yang, F."High gene expression levels of VEGFA and CXCL8 in the peritumoral brain zone are associated with the recurrence of glioblastoma: A bioinformatics analysis". Oncology Letters 18, no. 6 (2019): 6171-6179. https://doi.org/10.3892/ol.2019.10988
Copy and paste a formatted citation
x
Spandidos Publications style
Luo X, Xu S, Zhong Y, Tu T, Xu Y, Li X, Wang B and Yang F: High gene expression levels of VEGFA and CXCL8 in the peritumoral brain zone are associated with the recurrence of glioblastoma: A bioinformatics analysis. Oncol Lett 18: 6171-6179, 2019.
APA
Luo, X., Xu, S., Zhong, Y., Tu, T., Xu, Y., Li, X. ... Yang, F. (2019). High gene expression levels of VEGFA and CXCL8 in the peritumoral brain zone are associated with the recurrence of glioblastoma: A bioinformatics analysis. Oncology Letters, 18, 6171-6179. https://doi.org/10.3892/ol.2019.10988
MLA
Luo, X., Xu, S., Zhong, Y., Tu, T., Xu, Y., Li, X., Wang, B., Yang, F."High gene expression levels of VEGFA and CXCL8 in the peritumoral brain zone are associated with the recurrence of glioblastoma: A bioinformatics analysis". Oncology Letters 18.6 (2019): 6171-6179.
Chicago
Luo, X., Xu, S., Zhong, Y., Tu, T., Xu, Y., Li, X., Wang, B., Yang, F."High gene expression levels of VEGFA and CXCL8 in the peritumoral brain zone are associated with the recurrence of glioblastoma: A bioinformatics analysis". Oncology Letters 18, no. 6 (2019): 6171-6179. https://doi.org/10.3892/ol.2019.10988
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