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Granular cell tumors overexpress TFE3 without gene rearrangement: Evaluation of immunohistochemistry and break‑apart FISH in 45 cases

  • Authors:
    • Yang Liu
    • Qin Zheng
    • Chen Wang
    • Jinping Wang
    • Jian Ming
    • Yong Zhang
    • Xiaoman Li
    • William Chi‑Shing Cho
    • Liang Wang
    • Qing‑Chang Li
    • Xue‑Shan Qiu
    • En‑Hua Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Pathology, The 202nd Hospital of Chinese PLA, Shenyang, Liaoning 110003, P.R. China, Department of Pathology, Cancer Hospital of China Medical University, Shenyang, Liaoning 110042, P.R. China, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong SAR, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6355-6360
    |
    Published online on: October 17, 2019
       https://doi.org/10.3892/ol.2019.10995
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Abstract

Transcription factor E3 (TFE3) is a useful marker for tumors with Xp11.2 translocation, including alveolar soft part sarcoma and renal cell carcinoma. Recently, TFE3 overexpression was also found in granular cell tumors (GrCTs). However, the case cohorts of these two studies were limited to only 11 and 6 cases. Whether aberrant TFE3 expression is a common feature of Asian patients with GrCT requires further investigation. In the present study, immunohistochemical staining and TFE3 break‑apart fluorescence in situ hybridization (FISH) assay were performed in 45 samples of GrCTs obtained from Chinese patients recruited from three medical centers in northeast China. Diffusive and marked nuclear staining for TFE3 was identified in 11/45 (24%) cases, which was lower than previously reported. Focal or weak TFE3 staining was identified in 13/45 (29%) cases. The remaining 21 cases were negative stained. In addition, GrCTs in subcutaneous tissue exhibited a relatively higher ratio (8/45, 18%) for TFE3 expression, compared with those in other sites. Furthermore, according to FISH data, no rearrangement or amplification of TFE3 was identified in these cases, whether they were positively or negatively stained for TFE3. The results from the present study demonstrated that part of patients GrCTs exhibited TFE3 overexpression, which suggested that this may not be derived from gene rearrangement.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Zheng Q, Wang C, Wang J, Ming J, Zhang Y, Li X, Cho WC, Wang L, Li QC, Li QC, et al: Granular cell tumors overexpress TFE3 without gene rearrangement: Evaluation of immunohistochemistry and break‑apart FISH in 45 cases. Oncol Lett 18: 6355-6360, 2019.
APA
Liu, Y., Zheng, Q., Wang, C., Wang, J., Ming, J., Zhang, Y. ... Wang, E. (2019). Granular cell tumors overexpress TFE3 without gene rearrangement: Evaluation of immunohistochemistry and break‑apart FISH in 45 cases. Oncology Letters, 18, 6355-6360. https://doi.org/10.3892/ol.2019.10995
MLA
Liu, Y., Zheng, Q., Wang, C., Wang, J., Ming, J., Zhang, Y., Li, X., Cho, W. C., Wang, L., Li, Q., Qiu, X., Wang, E."Granular cell tumors overexpress TFE3 without gene rearrangement: Evaluation of immunohistochemistry and break‑apart FISH in 45 cases". Oncology Letters 18.6 (2019): 6355-6360.
Chicago
Liu, Y., Zheng, Q., Wang, C., Wang, J., Ming, J., Zhang, Y., Li, X., Cho, W. C., Wang, L., Li, Q., Qiu, X., Wang, E."Granular cell tumors overexpress TFE3 without gene rearrangement: Evaluation of immunohistochemistry and break‑apart FISH in 45 cases". Oncology Letters 18, no. 6 (2019): 6355-6360. https://doi.org/10.3892/ol.2019.10995
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Zheng Q, Wang C, Wang J, Ming J, Zhang Y, Li X, Cho WC, Wang L, Li QC, Li QC, et al: Granular cell tumors overexpress TFE3 without gene rearrangement: Evaluation of immunohistochemistry and break‑apart FISH in 45 cases. Oncol Lett 18: 6355-6360, 2019.
APA
Liu, Y., Zheng, Q., Wang, C., Wang, J., Ming, J., Zhang, Y. ... Wang, E. (2019). Granular cell tumors overexpress TFE3 without gene rearrangement: Evaluation of immunohistochemistry and break‑apart FISH in 45 cases. Oncology Letters, 18, 6355-6360. https://doi.org/10.3892/ol.2019.10995
MLA
Liu, Y., Zheng, Q., Wang, C., Wang, J., Ming, J., Zhang, Y., Li, X., Cho, W. C., Wang, L., Li, Q., Qiu, X., Wang, E."Granular cell tumors overexpress TFE3 without gene rearrangement: Evaluation of immunohistochemistry and break‑apart FISH in 45 cases". Oncology Letters 18.6 (2019): 6355-6360.
Chicago
Liu, Y., Zheng, Q., Wang, C., Wang, J., Ming, J., Zhang, Y., Li, X., Cho, W. C., Wang, L., Li, Q., Qiu, X., Wang, E."Granular cell tumors overexpress TFE3 without gene rearrangement: Evaluation of immunohistochemistry and break‑apart FISH in 45 cases". Oncology Letters 18, no. 6 (2019): 6355-6360. https://doi.org/10.3892/ol.2019.10995
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