Open Access

Long non‑coding RNA zinc finger antisense 1 functions as an oncogene in acute promyelocytic leukemia cells

  • Authors:
    • Lifang Su
    • Hongwei Kong
    • Fenzhi Wu
    • Hongjiao Lv
    • Wenping Wu
    • Gang Wang
    • Xuefen Yan
    • Jiaheng Wang
    • Qiang Fang
  • View Affiliations

  • Published online on: October 29, 2019     https://doi.org/10.3892/ol.2019.11014
  • Pages: 6331-6338
  • Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Despite progress in the diagnosis and treatment of acute promyelocytic leukemia (APL), its prognosis remains poor. Multiple studies have shown that long non‑coding RNAs (lncRNAs) are involved in carcinogenesis and metastasis. The present study assessed the function of the lncRNA zinc finger antisense 1 (ZFAS1) in APL. In a cohort of 33 patients, ZFAS1 was significantly overexpressed compared with the level in healthy controls. To investigate the specific mechanisms of this upregulation, in vitro studies showed that silencing of ZFAS1 by small interfering RNA significantly inhibited cell proliferation in APL cells. Moreover, downregulation of ZFAS1 increased cellular apoptosis, decreased expression of B‑cell lymphoma‑2 and of induced myeloid leukemia cell differentiation protein Mcl‑1, increased the expression of apoptosis regulator BAX and promoted the release of cytochrome c and Diablo homolog mitochondrial into the cytoplasm. In conclusion, these data indicate that ZFAS1 may serve as an oncogene in APL and may thus be a useful target for future clinical management.
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December-2019
Volume 18 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Su L, Kong H, Wu F, Lv H, Wu W, Wang G, Yan X, Wang J and Fang Q: Long non‑coding RNA zinc finger antisense 1 functions as an oncogene in acute promyelocytic leukemia cells. Oncol Lett 18: 6331-6338, 2019
APA
Su, L., Kong, H., Wu, F., Lv, H., Wu, W., Wang, G. ... Fang, Q. (2019). Long non‑coding RNA zinc finger antisense 1 functions as an oncogene in acute promyelocytic leukemia cells. Oncology Letters, 18, 6331-6338. https://doi.org/10.3892/ol.2019.11014
MLA
Su, L., Kong, H., Wu, F., Lv, H., Wu, W., Wang, G., Yan, X., Wang, J., Fang, Q."Long non‑coding RNA zinc finger antisense 1 functions as an oncogene in acute promyelocytic leukemia cells". Oncology Letters 18.6 (2019): 6331-6338.
Chicago
Su, L., Kong, H., Wu, F., Lv, H., Wu, W., Wang, G., Yan, X., Wang, J., Fang, Q."Long non‑coding RNA zinc finger antisense 1 functions as an oncogene in acute promyelocytic leukemia cells". Oncology Letters 18, no. 6 (2019): 6331-6338. https://doi.org/10.3892/ol.2019.11014