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Long non‑coding RNA zinc finger antisense 1 functions as an oncogene in acute promyelocytic leukemia cells

  • Authors:
    • Lifang Su
    • Hongwei Kong
    • Fenzhi Wu
    • Hongjiao Lv
    • Wenping Wu
    • Gang Wang
    • Xuefen Yan
    • Jiaheng Wang
    • Qiang Fang
  • View Affiliations / Copyright

    Affiliations: School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China, Department of Hematopathology, Quzhou People's Hospital, Quzhou, Zhejiang 324000, P.R. China, Intensive Care Unit, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
    Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6331-6338
    |
    Published online on: October 29, 2019
       https://doi.org/10.3892/ol.2019.11014
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Abstract

Despite progress in the diagnosis and treatment of acute promyelocytic leukemia (APL), its prognosis remains poor. Multiple studies have shown that long non‑coding RNAs (lncRNAs) are involved in carcinogenesis and metastasis. The present study assessed the function of the lncRNA zinc finger antisense 1 (ZFAS1) in APL. In a cohort of 33 patients, ZFAS1 was significantly overexpressed compared with the level in healthy controls. To investigate the specific mechanisms of this upregulation, in vitro studies showed that silencing of ZFAS1 by small interfering RNA significantly inhibited cell proliferation in APL cells. Moreover, downregulation of ZFAS1 increased cellular apoptosis, decreased expression of B‑cell lymphoma‑2 and of induced myeloid leukemia cell differentiation protein Mcl‑1, increased the expression of apoptosis regulator BAX and promoted the release of cytochrome c and Diablo homolog mitochondrial into the cytoplasm. In conclusion, these data indicate that ZFAS1 may serve as an oncogene in APL and may thus be a useful target for future clinical management.
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1 

He Y, Meng XM, Huang C, Wu BM, Zhang L, Lv XW and Li J: Long noncoding RNAs: Novel insights into hepatocelluar carcinoma. Cancer Lett. 344:20–27. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Testa U and Lo-Coco F: Prognostic factors in acute promyelocytic leukemia: Strategies to define high-risk patients. Ann Hematol. 95:673–680. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Wilusz JE, Sunwoo H and Spector DL: Long noncoding RNAs: Functional surprises from the RNA world. Genes Dev. 23:1494–1504. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Gutschner T and Diederichs S: The hallmarks of cancer: A long non-coding RNA point of view. RNA Biol. 9:703–719. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, et al: The transcriptional landscape of the mammalian genome. Science. 309:1559–1563. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Mercer TR, Dinger ME and Mattick JS: Long non-coding RNAs: Insights into functions. Nat Rev Genet. 10:155–159. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, Tanaka F, Shibata K, Suzuki A, Komune S, et al: Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res. 71:6320–6326. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Mourtada-Maarabouni M, Pickard MR, Hedge VL, Farzaneh F and Williams GT: GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer. Oncogene. 28:195–208. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Benetatos L, Vartholomatos G and Hatzimichael E: MEG3 imprinted gene contribution in tumorigenesis. Int J Cancer. 129:773–779. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Gutschner T, Hämmerle M, Eissmann M, Hsu J, Kim Y, Hung G, Revenko A, Arun G, Stentrup M, Gross M, et al: The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res. 73:1180–1189. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Svoboda M, Slyskova J, Schneiderova M, Makovicky P, Bielik L, Levy M, Lipska L, Hemmelova B, Kala Z, Protivankova M, et al: HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients. Carcinogenesis. 35:1510–1515. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Askarian-Amiri ME, Crawford J, French JD, Smart CE, Smith MA, Clark MB, Ru K, Mercer TR, Thompson ER, Lakhani SR, et al: SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer. RNA. 17:878–891. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Li T, Xie J, Shen C, Cheng D, Shi Y, Wu Z, Deng X, Chen H, Shen B, Peng C, et al: Amplification of long noncoding RNA ZFAS1 promotes metastasis in hepatocellular carcinoma. Cancer Res. 75:3181–3191. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Thorenoor N, Faltejskova-Vychytilova P, Hombach S, Mlcochova J, Kretz M, Svoboda M and Slaby O: Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer. Oncotarget. 7:622–637. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Zeng C, Xu Y, Xu L, Yu X, Cheng J, Yang L, Chen S and Li Y: Inhibition of long non-coding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leukemia cells. BMC Cancer. 14:6932014. View Article : Google Scholar : PubMed/NCBI

16 

Zeng C, Yu X, Lai J, Yang L, Chen S and Li Y: Overexpression of the long non-coding RNA PVT1 is correlated with leukemic cell proliferation in acute promyelocytic leukemia. J Hematol Oncol. 8:1262015. View Article : Google Scholar : PubMed/NCBI

17 

English D and Andersen BR: Single-step separation of red blood cells. Granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-Hypaque. J Immunol Methods. 5:249–252. 1974. View Article : Google Scholar : PubMed/NCBI

18 

Fuss IJ, Kanof ME, Smith PD and Zola H: Isolation of whole mononuclear cells from peripheral blood and cord blood. Curr Protoc Immunol Chapter. 7:Unit 7.1. 2009.

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Lanotte M, Martin-Thouvenin V, Najman S, Balerini P, Valensi F and Berger R: NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood. 77:1080–1086. 1991. View Article : Google Scholar : PubMed/NCBI

21 

Dimberg A and Oberg F: Retinoic acid-induced cell cycle arrest of human myeloid cell lines. Leuk Lymphoma. 44:1641–1650. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Dimberg A, Bahram F, Karlberg I, Larsson LG, Nilsson K and Oberg F: Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E and posttranscriptional up-regulation of p27(Kip1). Blood. 99:2199–2206. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Galluzzi L, López-Soto A, Kumar S and Kroemer G: Caspases connect cell-death signaling to organismal homeostasis. Immunity. 44:221–231. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Adams J and Nassiri M: Acute promyelocytic leukemia: A review and discussion of variant translocations. Arch Pathol Lab Med. 139:1308–1313. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Nie F, Yu X, Huang M, Wang Y, Xie M, Ma H, Wang Z, De W and Sun M: Long noncoding RNA ZFAS1 promotes gastric cancer cells proliferation by epigenetically repressing KLF2 and NKD2 expression. Oncotarget. 8:38227–38238. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Yu R, Yu BX, Chen JF, Lv XY, Yan ZJ, Chen Y and Ma Q: Anti-tumor effects of Atractylenolide I on bladder cancer cells. J Exp Clin Cancer Res. 35:402016. View Article : Google Scholar : PubMed/NCBI

27 

Delbridge AR and Strasser A: The BCL-2 protein family, BH3-mimetics and cancer therapy. Cell Death Differ. 22:1071–1080. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Martinou JC and Youle RJ: Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell. 21:92–101. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Gross A, McDonnell JM and Korsmeyer SJ: BCL-2 family members and the mitochondria in apoptosis. Genes Dev. 13:1899–1911. 1999. View Article : Google Scholar : PubMed/NCBI

30 

Peng W, Wu J and Feng J: Long noncoding RNA HULC predicts poor clinical outcome and represents pro-oncogenic activity in diffuse large B-cell lymphoma. Biomed Pharmacother. 79:188–193. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Zhu H, Li X, Song Y, Zhang P, Xiao Y and Xing Y: Long non-coding RNA ANRIL is up-regulated in bladder cancer and regulates bladder cancer cell proliferation and apoptosis through the intrinsic pathway. Biochem Biophys Res Commun. 467:223–228. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Su L, Kong H, Wu F, Lv H, Wu W, Wang G, Yan X, Wang J and Fang Q: Long non‑coding RNA zinc finger antisense 1 functions as an oncogene in acute promyelocytic leukemia cells. Oncol Lett 18: 6331-6338, 2019.
APA
Su, L., Kong, H., Wu, F., Lv, H., Wu, W., Wang, G. ... Fang, Q. (2019). Long non‑coding RNA zinc finger antisense 1 functions as an oncogene in acute promyelocytic leukemia cells. Oncology Letters, 18, 6331-6338. https://doi.org/10.3892/ol.2019.11014
MLA
Su, L., Kong, H., Wu, F., Lv, H., Wu, W., Wang, G., Yan, X., Wang, J., Fang, Q."Long non‑coding RNA zinc finger antisense 1 functions as an oncogene in acute promyelocytic leukemia cells". Oncology Letters 18.6 (2019): 6331-6338.
Chicago
Su, L., Kong, H., Wu, F., Lv, H., Wu, W., Wang, G., Yan, X., Wang, J., Fang, Q."Long non‑coding RNA zinc finger antisense 1 functions as an oncogene in acute promyelocytic leukemia cells". Oncology Letters 18, no. 6 (2019): 6331-6338. https://doi.org/10.3892/ol.2019.11014
Copy and paste a formatted citation
x
Spandidos Publications style
Su L, Kong H, Wu F, Lv H, Wu W, Wang G, Yan X, Wang J and Fang Q: Long non‑coding RNA zinc finger antisense 1 functions as an oncogene in acute promyelocytic leukemia cells. Oncol Lett 18: 6331-6338, 2019.
APA
Su, L., Kong, H., Wu, F., Lv, H., Wu, W., Wang, G. ... Fang, Q. (2019). Long non‑coding RNA zinc finger antisense 1 functions as an oncogene in acute promyelocytic leukemia cells. Oncology Letters, 18, 6331-6338. https://doi.org/10.3892/ol.2019.11014
MLA
Su, L., Kong, H., Wu, F., Lv, H., Wu, W., Wang, G., Yan, X., Wang, J., Fang, Q."Long non‑coding RNA zinc finger antisense 1 functions as an oncogene in acute promyelocytic leukemia cells". Oncology Letters 18.6 (2019): 6331-6338.
Chicago
Su, L., Kong, H., Wu, F., Lv, H., Wu, W., Wang, G., Yan, X., Wang, J., Fang, Q."Long non‑coding RNA zinc finger antisense 1 functions as an oncogene in acute promyelocytic leukemia cells". Oncology Letters 18, no. 6 (2019): 6331-6338. https://doi.org/10.3892/ol.2019.11014
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