Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2019 Volume 18 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2019 Volume 18 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Sex‑biased differences in the correlation between epithelial‑to‑mesenchymal transition‑associated genes in cancer cell lines

  • Authors:
    • Sun Young Kim
    • Seungeun Lee
    • Eunhye Lee
    • Hyesol Lim
    • Ji Yoon Shin
    • Joohee Jung
    • Sang Geon Kim
    • Aree Moon
  • View Affiliations / Copyright

    Affiliations: Department of Chemistry, College of Natural Sciences, Duksung Women's University, Seoul 01369, Republic of Korea, Duksung Innovative Drug Center, College of Pharmacy, Duksung Women's University, Seoul 01369, Republic of Korea, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea
  • Pages: 6852-6868
    |
    Published online on: October 29, 2019
       https://doi.org/10.3892/ol.2019.11016
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

There is a wide disparity in the incidence, malignancy and mortality of different types of cancer between each sex. The sex‑specificity of cancer seems to be dependent on the type of cancer. Cancer incidence and mortality have been demonstrated as sex‑specific in a number of different types of cancer, such as liver cancer, whereas sex‑specificity is not noticeable in certain other types of cancer, including colon and lung cancer. The present study aimed to elucidate the molecular basis for sex‑biased gene expression in cancer. The mRNA expression of the epithelial‑to‑mesenchymal transition‑associated genes was investigated, including E‑cadherin (also termed CDH1), vimentin (VIM), discoidin domain receptor 1 (DDR1) and zinc finger E‑box binding homeobox 1 (ZEB1) in female‑ and male‑derived cancer cell lines by reverse transcription (RT)‑PCR and the Broad‑Novartis Cancer Cell Line Encyclopedia (CCLE) database analysis. A negative correlation was observed between DDR1 and ZEB1 only in the female‑derived cancer cell lines via RT‑PCR analysis. A negative correlation between DDR1 index (defined by the logarithmic value of DDR1 divided by ZEB1, based on the mRNA data from the RT‑PCR analysis) and an invasive phenotype was observed in cancer cell lines in a sex‑specific manner. Analysis of the CCLE database demonstrated that DDR1 and ZEB1, which are already known to be sex‑biased, were negatively correlated in female‑derived liver cancer cell lines, but not in male‑derived liver cancer cell lines. In contrast, cell lines of colon and lung cancer did not reveal any sex‑dependent difference in the correlation between DDR1 and ZEB1. Kaplan‑Meier survival curves using the transcriptomic datasets such as Gene Expression Omnibus, European Genome‑phenome Archiva and The Cancer Genome Atlas databases suggested a sex‑biased difference in the correlation between DDR1 expression pattern and overall survival in patients with liver cancer. The results of the present study indicate that sex factors may affect the regulation of gene expression, contributing to the sex‑biased progression of the different types of cancer, particularly liver cancer. Overall, these findings suggest that analyses of the correlation between DDR1 and ZEB1 may prove useful when investigating sex‑biased cancers.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Zahm SH and Fraumeni JF Jr: Racial, ethnic, and gender variations in cancer risk: Considerations for future epidemiologic research. Environ Health Perspect. 103 (Suppl 8):283–286. 1995. View Article : Google Scholar : PubMed/NCBI

2 

Kirsch-Volders M, Bonassi S, Herceg Z, Hirvonen A, Möller L and Phillips DH: Gender-related differences in response to mutagens and carcinogens. Mutagenesis. 25:213–221. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Dorak MT and Karpuzoglu E: Gender differences in cancer susceptibility: An inadequately addressed issue. Front Genet. 3:2682012. View Article : Google Scholar : PubMed/NCBI

4 

Siegel RL, Miller KD and Jemal A: Cancer Statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Bosch FX, Ribes J, Díaz M and Cléries R: Primary liver cancer: Worldwide incidence and trends. Gastroenterology. 127:S5–S16. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Oh CM, Cho H, Won YJ, Kong HJ, Roh YH, Jeong KH and Jung KW: Nationwide trends in the incidence of melanoma and non-melanoma skin cancers from 1999 to 2014 in South Korea. Cancer Res Treat. 50:729–737. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Jung KW, Won YJ, Kong HJ and Lee ES: Prediction of cancer incidence and mortality in Korea, 2018. Cancer Res Treat. 50:317–323. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Ryerson AB, Eheman CR, Altekruse SF, Ward JW, Jemal A, Sherman RL, Henley SJ, Holtzman D, Lake A, Noone AM, et al: Annual Report to the Nation on the Status of Cancer, 1975–2012, featuring the increasing incidence of liver cancer. Cancer. 122:1312–1337. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Gao RN, Neutel CI and Wai E: Gender differences in colorectal cancer incidence, mortality, hospitalizations and surgical procedures in Canada. J Public Health (Oxf). 30:194–201. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Thun MJ, Hannan LM, Adams-Campbell LL, Boffetta P, Buring JE, Feskanich D, Flanders WD, Jee SH, Katanoda K, Kolonel LN, et al: Lung cancer occurrence in never-smokers: An analysis of 13 cohorts and 22 cancer registry studies. PLoS Med. 5:e1852008. View Article : Google Scholar : PubMed/NCBI

12 

Cook MB, Dawsey SM, Freedman ND, Inskip PD, Wichner SM, Quraishi SM, Devesa SS and McGlynn KA: Sex disparities in cancer incidence by period and age. Cancer Epidemiol Biomarkers Prev. 18:1174–1182. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Klein SL: The effects of hormones on sex differences in infection: From genes to behavior. Neurosci Biobehav Rev. 24:627–638. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Yuan Y, Liu L, Chen H, Wang Y, Xu Y, Mao H, Li J, Mills GB, Shu Y, Li L and Liang H: Comprehensive characterization of molecular differences in cancer between male and female patients. Cancer Cell. 29:711–722. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Park MN, Park JH, Paik HY and Lee SK: Insufficient sex description of cells supplied by commercial vendors. Am J Physiol Cell Physiol. 308:C578–C580. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Becker JB, Arnold AP, Berkley KJ, Blaustein JD, Eckel LA, Hampson E, Herman JP, Marts S, Sadee W, Steiner M, et al: Strategies and methods for research on sex differences in brain and behavior. Endocrinology. 146:1650–1673. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Keitt SK, Fagan TF and Marts SA: Understanding sex differences in environmental health: A thought leaders' roundtable. Environ Health Perspect. 112:604–609. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Zucker I and Beery AK: Males still dominate animal studies. Nature. 465:6902010. View Article : Google Scholar : PubMed/NCBI

19 

Hay ED: An overview of epithelio-mesenchymal transformation. Acta Anat (Basel). 154:8–20. 1995. View Article : Google Scholar : PubMed/NCBI

20 

Kalluri R and Neilson EG: Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest. 112:1776–1784. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Kalluri R and Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest. 119:1420–1428. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Cano A, Pérez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, Portillo F and Nieto MA: The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol. 2:76–83. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Grooteclaes ML and Frisch SM: Evidence for a function of CtBP in epithelial gene regulation and anoikis. Oncogene. 19:3823–3828. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Comijn J, Berx G, Vermassen P, Verschueren K, van Grunsven L, Bruyneel E, Mareel M, Huylebroeck D and van Roy F: The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol Cell. 7:1267–1278. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Guaita S, Puig I, Franci C, Garrido M, Dominguez D, Battle E, Sancho E, Dedhar S, De Herreros AG and Baulida J: Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J Biol Chem. 277:39209–39216. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Hajra KM, Chen DY and Fearon ER: The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res. 62:1613–1618. 2002.PubMed/NCBI

27 

Gilles C and Thompson EW: The epithelial to mesenchymal transition and metastatic progression in carcinoma. Breast J. 2:83–96. 1996. View Article : Google Scholar

28 

Thompson EW, Newgreen DF and Tarin D: Carcinoma invasion and metastasis: A role for epithelial-mesenchymal transition? Cancer Res. 65:5991–5995, discusion 5995. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Fu HL, Valiathan RR, Arkwright R, Sohail A, Mihai C, Kumarasiri M, Mahasenan KV, Mobashery S, Huang P, Agarwal G and Fridman R: Discoidin domain receptors: Unique receptor tyrosine kinases in collagen-mediated signaling. J Biol Chem. 288:7430–7437. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Valiathan RR, Marco M, Leitinger B, Kleer CG and Fridman R: Discoidin domain receptor tyrosine kinases: New players in cancer progression. Cancer Metastasis Rev. 31:295–321. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Wang CZ, Yeh YC and Tang MJ: DDR1/E-cadherin complex regulates the activation of DDR1 and cell spreading. Am J Physiol Cell Physiol. 297:C419–C429. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Yeh YC, Wu CC, Wang YK and Tang MJ: DDR1 triggers epithelial cell differentiation by promoting cell adhesion through stabilization of E-cadherin. Mol Biol Cell. 22:940–953. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Chung VY, Tan TZ, Huang RL, Lai HC and Huang RY: Loss of discoidin domain receptor 1 (DDR1) via CpG methylation during EMT in epithelial ovarian cancer. Gene. 635:9–15. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Song J, Chen X, Bai J, Liu Q, Li H, Xie J, Jing H and Zheng J: Discoidin domain receptor 1 (DDR1), a promising biomarker, induces epithelial to mesenchymal transition in renal cancer cells. Tumour Biol. 37:11509–11521. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Koh M, Woo Y, Valiathan RR, Jung HY, Park SY, Kim YN, Kim HR, Fridman R and Moon A: Discoidin domain receptor 1 is a novel transcriptional target of ZEB1 in breast epithelial cells undergoing H-Ras-induced epithelial to mesenchymal transition. Int J Cancer. 136:E508–E520. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Jeon YR, Kim SY, Lee EJ, Kim YN, Noh DY, Park SY and Moon A: Identification of annexin II as a novel secretory biomarker for breast cancer. Proteomics. 13:3145–3156. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Cha Y, Kang Y and Moon A: HER2 induces expression of leptin in human breast epithelial cells. BMB Rep. 45:719–723. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Shin I, Kim S, Song H, Kim HR and Moon A: H-Ras-specific activation of Rac-MKK3/6-p38 pathway: Its critical role in invasion and migration of breast epithelial cells. J Biol Chem. 280:14675–14683. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Kim MS, Lee EJ, Kim HR and Moon A: p38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells. Cancer Res. 63:5454–5461. 2003.PubMed/NCBI

40 

Menyhárt O, Nagy Á and Győrffy B: Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma. Royal Soc Open Sci. 5:1810062018. View Article : Google Scholar

41 

Cancer Genome Atlas Research Network. Electronic address, . simplewheeler@bcm.edu; Cancer Genome Atlas Research Network: Comprehensive and integrative genomic characterization of hepatocellular carcinoma. Cell. 169:1327.e23–1341.e23. 2017.

42 

Gygi SP, Rochon Y, Franza BR and Aebersold R: Correlation between protein and mRNA abundance in yeast. Mol Cell Biol. 19:1720–1730. 1999. View Article : Google Scholar : PubMed/NCBI

43 

Sommers CL, Byers SW, Thompson EW, Torri JA and Gelmann EP: Differentiation state and invasiveness of human breast cancer cell lines. Breast Cancer Res Treat. 31:325–335. 1994. View Article : Google Scholar : PubMed/NCBI

44 

Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global patterns and trends in colorectal cancer incidence and mortality. Gut. 66:683–691. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Wong MCS, Lao XQ, Ho KF, Goggins WB and Tse SLA: Incidence and mortality of lung cancer: Global trends and association with socioeconomic status. Sci Rep. 7:143002017. View Article : Google Scholar : PubMed/NCBI

46 

Fidler IJ: Critical factors in the biology of human cancer metastasis: Twenty-eighth G.H.A. Clowes memorial award lecture. Cancer Res. 50:6130–6138. 1990.PubMed/NCBI

47 

Vleminckx K, Vakaet L Jr, Mareel M, Fiers W and Van Roy F: Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell. 66:107–119. 1991. View Article : Google Scholar : PubMed/NCBI

48 

Perl AK, Wilgenbus P, Dahl U, Semb H and Christofori G: A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature. 392:190–193. 1998. View Article : Google Scholar : PubMed/NCBI

49 

Spaderna S, Schmalhofer O, Wahlbuhl M, Dimmler A, Bauer K, Sultan A, Hlubek F, Jung A, Strand D, Eger A, et al: The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. Cancer Res. 68:537–544. 2008. View Article : Google Scholar : PubMed/NCBI

50 

Wizemenn TM and Pardue ML: Exploring the biological contributions to human health:Does sex matter? Washington DC: Natl Acad Press; 2001

51 

Miller VM: In pursuit of scientific excellence: Sex matters. Adv Physiol Educ. 36:83–84. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Avery B, Jørgensen CB, Madison V and Greve T: Morphological development and sex of bovine in vitro-fertilized embryos. Mol Reprod Dev. 32:265–270. 1992. View Article : Google Scholar : PubMed/NCBI

53 

Pergament E, Fiddler M, Cho N, Johnson D and Holmgren WJ: Sexual differentiation and preimplantation cell growth. Hum Reprod. 9:1730–1732. 1994. View Article : Google Scholar : PubMed/NCBI

54 

Xu KP, Yadav BR, King WA and Betteridge KJ: Sex-related differences in developmental rates of bovine embryos produced and cultured in vitro. Mol Reprod Dev. 31:249–252. 1992. View Article : Google Scholar : PubMed/NCBI

55 

Yang X, Schadt EE, Wang S, Wang H, Arnold AP, Ingram-Drake L, Drake TA and Lusis AJ: Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res. 16:995–1004. 2006. View Article : Google Scholar : PubMed/NCBI

56 

Shah K, McCormack CE and Bradbury NA: Do you know the sex of your cells? Am J Physiol Cell Physiol. 306:C3–C18. 2014. View Article : Google Scholar : PubMed/NCBI

57 

Ge H, Yan Y, Tian F, Wu D and Huang Y: Prognostic value of estrogen receptor α and estrogen receptor β in gastric cancer based on a meta-analysis and The Cancer Genome Atlas (TCGA) datasets. Int J Surg. 53:24–31. 2018. View Article : Google Scholar : PubMed/NCBI

58 

Huang X, Shu C, Chen L and Yao B: Impact of sex, body mass index and initial pathologic diagnosis age on the incidence and prognosis of different types of cancer. Oncol Rep. 40:1359–1369. 2018.PubMed/NCBI

59 

Xu K, Cui J, Olman V, Yang Q, Puett D and Xu Y: A comparative analysis of gene-expression data of multiple cancer types. PLoS One. 5:e136962010. View Article : Google Scholar : PubMed/NCBI

60 

Martinez-Ledesma E, Verhaak RG and Treviño V: Identification of a multi-cancer gene expression biomarker for cancer clinical outcomes using a network-based algorithm. Sci Rep. 23:119662015. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kim SY, Lee S, Lee E, Lim H, Shin JY, Jung J, Kim SG and Moon A: Sex‑biased differences in the correlation between epithelial‑to‑mesenchymal transition‑associated genes in cancer cell lines. Oncol Lett 18: 6852-6868, 2019.
APA
Kim, S.Y., Lee, S., Lee, E., Lim, H., Shin, J.Y., Jung, J. ... Moon, A. (2019). Sex‑biased differences in the correlation between epithelial‑to‑mesenchymal transition‑associated genes in cancer cell lines. Oncology Letters, 18, 6852-6868. https://doi.org/10.3892/ol.2019.11016
MLA
Kim, S. Y., Lee, S., Lee, E., Lim, H., Shin, J. Y., Jung, J., Kim, S. G., Moon, A."Sex‑biased differences in the correlation between epithelial‑to‑mesenchymal transition‑associated genes in cancer cell lines". Oncology Letters 18.6 (2019): 6852-6868.
Chicago
Kim, S. Y., Lee, S., Lee, E., Lim, H., Shin, J. Y., Jung, J., Kim, S. G., Moon, A."Sex‑biased differences in the correlation between epithelial‑to‑mesenchymal transition‑associated genes in cancer cell lines". Oncology Letters 18, no. 6 (2019): 6852-6868. https://doi.org/10.3892/ol.2019.11016
Copy and paste a formatted citation
x
Spandidos Publications style
Kim SY, Lee S, Lee E, Lim H, Shin JY, Jung J, Kim SG and Moon A: Sex‑biased differences in the correlation between epithelial‑to‑mesenchymal transition‑associated genes in cancer cell lines. Oncol Lett 18: 6852-6868, 2019.
APA
Kim, S.Y., Lee, S., Lee, E., Lim, H., Shin, J.Y., Jung, J. ... Moon, A. (2019). Sex‑biased differences in the correlation between epithelial‑to‑mesenchymal transition‑associated genes in cancer cell lines. Oncology Letters, 18, 6852-6868. https://doi.org/10.3892/ol.2019.11016
MLA
Kim, S. Y., Lee, S., Lee, E., Lim, H., Shin, J. Y., Jung, J., Kim, S. G., Moon, A."Sex‑biased differences in the correlation between epithelial‑to‑mesenchymal transition‑associated genes in cancer cell lines". Oncology Letters 18.6 (2019): 6852-6868.
Chicago
Kim, S. Y., Lee, S., Lee, E., Lim, H., Shin, J. Y., Jung, J., Kim, S. G., Moon, A."Sex‑biased differences in the correlation between epithelial‑to‑mesenchymal transition‑associated genes in cancer cell lines". Oncology Letters 18, no. 6 (2019): 6852-6868. https://doi.org/10.3892/ol.2019.11016
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team