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Identification of a four‑long non‑coding RNA signature in predicting breast cancer survival

  • Authors:
    • Mingjie Zhu
    • Qing Lv
    • Hu Huang
    • Chunlei Sun
    • Da Pang
    • Junqiang Wu
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, The Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu 214035, P.R. China, Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 221-228
    |
    Published online on: November 7, 2019
       https://doi.org/10.3892/ol.2019.11063
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Abstract

Long non‑coding RNAs (lncRNAs) serve key roles in tumorigenesis and are differentially expressed in cancer. Using bioinformatics and statistical methods, the present study aimed to identify an lncRNA signature to predict breast cancer survival. The gene expression data of 768 patients with breast cancer were downloaded from The Cancer Genome Atlas database, and Cox regression, Kaplan‑Meier and receiver operating characteristic (ROC) analyses were performed to construct and validate a predictive model. Gene Ontology term enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analysis were employed to predict the functions of the indicated lncRNAs. A signature consisting of four lncRNAs, including PVT1, MAPT‑AS1, LINC00667 and LINC00938, was identified, and patients were subsequently divided into high‑ and low‑risk groups according to the median risk score. Kaplan‑Meier analysis confirmed that patients in the high‑risk group exhibited significantly poorer overall survival rate in both the training (P=0.0151) and the validation set (P=0.0016); furthermore, ROC analysis confirmed that the model could predict patient survival with a certain sensitivity and specificity. In conclusion, the four‑lncRNA signature presents a potential prognostic biomarker for breast cancer that may be relevant for clinical application.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Michaelson JS, Silverstein M, Wyatt J, Weber G, Moore R, Halpern E, Kopans DB and Hughes K: Predicting the survival of patients with breast carcinoma using tumor size. Cancer. 95:713–723. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Rakha EA, El-Sayed ME, Menon S, Green AR, Lee AH and Ellis IO: Histologic grading is an independent prognostic factor in invasive lobular carcinoma of the breast. Breast Cancer Res Treat. 111:121–127. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Shokouh TZ, Ezatollah A and Barand P: Interrelationships Between Ki67, HER2/neu, p53, ER, and PR Status and their associations with tumor grade and lymph node involvement in breast carcinoma subtypes: Retrospective-observational analytical study. Medicine (Baltimore). 94:e13592015. View Article : Google Scholar : PubMed/NCBI

5 

Ma J, Luo DX, Huang C, Shen Y, Bu Y, Markwell S, Gao J, Liu J, Zu X, Cao Z, et al: AKR1B10 overexpression in breast cancer: Association with tumor size, lymph node metastasis and patient survival and its potential as a novel serum marker. Int J Cancer. 131:E862–E871. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Crabb SJ, Bajdik CD, Leung S, Speers CH, Kennecke H, Huntsman DG and Gelmon KA: Can clinically relevant prognostic subsets of breast cancer patients with four or more involved axillary lymph nodes be identified through immunohistochemical biomarkers? A tissue microarray feasibility study. Breast Cancer Res. 10:R62008. View Article : Google Scholar : PubMed/NCBI

7 

M Braden A, V Stankowski R, M Engel J and A Onitilo A: Breast cancer biomarkers: Risk assessment, diagnosis, prognosis, prediction of treatment efficacy and toxicity, and recurrence. Curr Pharm Des. 20:4879–4898. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Nagini S: Breast Cancer: Current molecular therapeutic targets and new players. Anticancer Agents Med Chem. 17:152–163. 2017. View Article : Google Scholar : PubMed/NCBI

9 

ENCODE Project Consortium, ; Birney E, Stamatoyannopoulos JA, Dutta A, Guigó R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, et al: Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 447:799–816. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Clark MB, Johnston RL, Inostroza-Ponta M, Fox AH, Fortini E, Moscato P, Dinger ME and Mattick JS: Genome-wide analysis of long noncoding RNA stability. Genome Res. 22:885–898. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Prensner JR and Chinnaiyan AM: The emergence of lncRNAs in cancer biology. Cancer Discov. 1:391–407. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Rinn JL and Chang HY: Genome regulation by long noncoding RNAs. Annu Rev Biochem. 81:145–166. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Nagano T and Fraser P: No-nonsense functions for long noncoding RNAs. Cell. 145:178–181. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Yoon JH, Abdelmohsen K, Srikantan S, Yang X, Martindale JL, De S, Huarte M, Zhan M, Becker KG and Gorospe M: LincRNA-p21 suppresses target mRNA translation. Mol Cell. 47:648–655. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Peng WX, Koirala P and Mo YY: LncRNA-mediated regulation of cell signaling in cancer. Oncogene. 36:5661–5667. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Bhan A, Soleimani M and Mandal SS: Long noncoding RNA and cancer: A new paradigm. Cancer Res. 77:3965–3981. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Sanchez Calle A, Kawamura Y, Yamamoto Y, Takeshita F and Ochiya T: Emerging roles of long non-coding RNA in cancer. Cancer Sci. 109:2093–2100. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL, et al: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 464:1071–1076. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Gutschner T, Hammerle M and Diederichs S: MALAT1-a paradigm for long noncoding RNA function in cancer. J Mol Med (Berl). 91:791–801. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Chandra Gupta S and Nandan Tripathi Y: Potential of long non-coding RNAs in cancer patients: From biomarkers to therapeutic targets. Int J Cancer. 140:1955–1967. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Turashvili G, Bouchal J, Baumforth K, Wei W, Dziechciarkova M, Ehrmann J, Klein J, Fridman E, Skarda J, Srovnal J, et al: Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis. BMC Cancer. 7:552007. View Article : Google Scholar : PubMed/NCBI

22 

Hortobagyi GN, Edge SB and Giuliano A: New and Important Changes in the TNM staging system for breast cancer. Am Soc Clin Oncol Educ Book. 38:457–467. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Chen G, Wang Z, Wang D, Qiu C, Liu M, Chen X, Zhang Q, Yan G and Cui Q: LncRNA Disease: A database for long-non-coding RNA-associated diseases. Nucleic Acids Res. 41((Database Issue)): D983–D986. 2013.PubMed/NCBI

24 

Zou AE, Ku J, Honda TK, Yu V, Kuo SZ, Zheng H, Xuan Y, Saad MA, Hinton A, Brumund KT, et al: Transcriptome sequencing uncovers novel long noncoding and small nucleolar RNAs dysregulated in head and neck squamous cell carcinoma. RNA. 21:1122–1134. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Ylipää A, Kivinummi K, Kohvakka A, Annala M, Latonen L, Scaravilli M, Kartasalo K, Leppänen SP, Karakurt S, Seppälä J, et al: Transcriptome sequencing reveals PCAT5 as a novel ERG-regulated long noncoding RNA in prostate cancer. Cancer Res. 75:4026–4031. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Gutschner T and Diederichs S: The hallmarks of cancer: A long non-coding RNA point of view. RNA Biol. 9:703–719. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Gibb EA, Brown CJ and Lam WL: The functional role of long non-coding RNA in human carcinomas. Mol Cancer. 10:382011. View Article : Google Scholar : PubMed/NCBI

28 

Song CV, Teo SH, Taib NA and Yip CH: Surgery for BRCA, TP53 and PALB2: A literature review. Ecancermedicalscience. 12:8632018. View Article : Google Scholar : PubMed/NCBI

29 

Sundara Rajan S, Hanby AM, Horgan K, Thygesen HH and Speirs V: The potential utility of geminin as a predictive biomarker in breast cancer. Breast Cancer Res Treat. 143:91–98. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Sørensen KP, Thomassen M, Tan Q, Bak M, Cold S, Burton M, Larsen MJ and Kruse TA: Long non-coding RNA HOTAIR is an independent prognostic marker of metastasis in estrogen receptor-positive primary breast cancer. Breast Cancer Res Treat. 142:529–536. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Yang YF, Liao YY, Yang M, Peng NF, Xie SR and Xie YF: Discordances in ER, PR and HER2 receptors between primary and recurrent/metastatic lesions and their impact on survival in breast cancer patients. Med Oncol. 31:2142014. View Article : Google Scholar : PubMed/NCBI

32 

Wilusz JE, Sunwoo H and Spector DL: Long noncoding RNAs: Functional surprises from the RNA world. Genes Dev. 23:1494–1504. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Tseng YY, Moriarity BS, Gong W, Akiyama R, Tiwari A, Kawakami H, Ronning P, Reuland B, Guenther K, Beadnell TC, et al: PVT1 dependence in cancer with MYC copy-number increase. Nature. 512:82–86. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Coupland KG, Kim WS, Halliday GM, Hallupp M, Dobson-Stone C and Kwok JB: Role of the long non-coding RNA MAPT-AS1 in regulation of microtubule associated protein tau (MAPT) expression in Parkinson's disease. PLoS One. 11:e01579242016. View Article : Google Scholar : PubMed/NCBI

35 

Bradner JE, Hnisz D and Young RA: Transcriptional Addiction in Cancer. Cell. 168:629–643. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Valcarcel-Jimenez L, Gaude E, Torrano V, Frezza C and Carracedo A: Mitochondrial Metabolism: Yin and yang for tumor progression. Trends Endocrinol Metab. 28:748–757. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Aithal MG and Rajeswari N: Role of Notch signalling pathway in cancer and its association with DNA methylation. J Genet. 92:667–675. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhu M, Lv Q, Huang H, Sun C, Pang D and Wu J: Identification of a four‑long non‑coding RNA signature in predicting breast cancer survival. Oncol Lett 19: 221-228, 2020.
APA
Zhu, M., Lv, Q., Huang, H., Sun, C., Pang, D., & Wu, J. (2020). Identification of a four‑long non‑coding RNA signature in predicting breast cancer survival. Oncology Letters, 19, 221-228. https://doi.org/10.3892/ol.2019.11063
MLA
Zhu, M., Lv, Q., Huang, H., Sun, C., Pang, D., Wu, J."Identification of a four‑long non‑coding RNA signature in predicting breast cancer survival". Oncology Letters 19.1 (2020): 221-228.
Chicago
Zhu, M., Lv, Q., Huang, H., Sun, C., Pang, D., Wu, J."Identification of a four‑long non‑coding RNA signature in predicting breast cancer survival". Oncology Letters 19, no. 1 (2020): 221-228. https://doi.org/10.3892/ol.2019.11063
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu M, Lv Q, Huang H, Sun C, Pang D and Wu J: Identification of a four‑long non‑coding RNA signature in predicting breast cancer survival. Oncol Lett 19: 221-228, 2020.
APA
Zhu, M., Lv, Q., Huang, H., Sun, C., Pang, D., & Wu, J. (2020). Identification of a four‑long non‑coding RNA signature in predicting breast cancer survival. Oncology Letters, 19, 221-228. https://doi.org/10.3892/ol.2019.11063
MLA
Zhu, M., Lv, Q., Huang, H., Sun, C., Pang, D., Wu, J."Identification of a four‑long non‑coding RNA signature in predicting breast cancer survival". Oncology Letters 19.1 (2020): 221-228.
Chicago
Zhu, M., Lv, Q., Huang, H., Sun, C., Pang, D., Wu, J."Identification of a four‑long non‑coding RNA signature in predicting breast cancer survival". Oncology Letters 19, no. 1 (2020): 221-228. https://doi.org/10.3892/ol.2019.11063
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