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Article

Survival benefit of nephron‑sparing surgery for patients with pT1b renal cell carcinoma: A population‑based study

  • Authors:
    • Xiaode Liu
    • Xuemei Huang
    • Pan Zhao
    • Peng Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Radiation Oncology, Sichuan Cancer Center, Sichuan Cancer Hospital and Institute, School of Medicine University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China
  • Pages: 498-504
    |
    Published online on: November 7, 2019
       https://doi.org/10.3892/ol.2019.11065
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Abstract

The use of partial nephrectomy (PN) to treat patients with large renal cell carcinoma (RCC) remains controversial, particularly among elderly patients. The present study compared the improvement in cancer‑specific survival (CSS) in patients with pT1b RCC who underwent either PN or radical nephrectomy (RN) and investigated the effects of age and sex on CSS. A total of 20,343 patients were identified in the Surveillance, Epidemiology and End Results database. Kaplan‑Meier curves and Cox regression analysis were used to compare the CSS of patients who received PN vs. those who received RN. In total, 5,375 (26.42%) and 14,968 (73.58%) patients with pT1b RCC received PN and RN, respectively. Kaplan‑Meier and Cox regression analysis indicated that PN resulted in an improved CSS compared with RN (P<0.001). In addition, PN was observed to be beneficial in male (P<0.001) and female patients <75 years of age. However, it was not beneficial for female patients of ≥75 years of age (P=0.197). These preliminary results warrant further investigation in clinical trials.
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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Huang X, Zhao P and Zhang P: Survival benefit of nephron‑sparing surgery for patients with pT1b renal cell carcinoma: A population‑based study. Oncol Lett 19: 498-504, 2020.
APA
Liu, X., Huang, X., Zhao, P., & Zhang, P. (2020). Survival benefit of nephron‑sparing surgery for patients with pT1b renal cell carcinoma: A population‑based study. Oncology Letters, 19, 498-504. https://doi.org/10.3892/ol.2019.11065
MLA
Liu, X., Huang, X., Zhao, P., Zhang, P."Survival benefit of nephron‑sparing surgery for patients with pT1b renal cell carcinoma: A population‑based study". Oncology Letters 19.1 (2020): 498-504.
Chicago
Liu, X., Huang, X., Zhao, P., Zhang, P."Survival benefit of nephron‑sparing surgery for patients with pT1b renal cell carcinoma: A population‑based study". Oncology Letters 19, no. 1 (2020): 498-504. https://doi.org/10.3892/ol.2019.11065
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Huang X, Zhao P and Zhang P: Survival benefit of nephron‑sparing surgery for patients with pT1b renal cell carcinoma: A population‑based study. Oncol Lett 19: 498-504, 2020.
APA
Liu, X., Huang, X., Zhao, P., & Zhang, P. (2020). Survival benefit of nephron‑sparing surgery for patients with pT1b renal cell carcinoma: A population‑based study. Oncology Letters, 19, 498-504. https://doi.org/10.3892/ol.2019.11065
MLA
Liu, X., Huang, X., Zhao, P., Zhang, P."Survival benefit of nephron‑sparing surgery for patients with pT1b renal cell carcinoma: A population‑based study". Oncology Letters 19.1 (2020): 498-504.
Chicago
Liu, X., Huang, X., Zhao, P., Zhang, P."Survival benefit of nephron‑sparing surgery for patients with pT1b renal cell carcinoma: A population‑based study". Oncology Letters 19, no. 1 (2020): 498-504. https://doi.org/10.3892/ol.2019.11065
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