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Decreased DC‑SIGNR expression in hepatocellular carcinoma predicts poor patient prognosis

  • Authors:
    • Hai‑Bing Xia
    • Hui‑Ju Wang
    • Shu‑Shu Song
    • Jun‑Gang Zhang
    • Xiang‑Lei He
    • Zhi‑Ming Hu
    • Cheng‑Wu Zhang
    • Dong‑Sheng Huang
    • Xiao‑Zhou Mou
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang 311200, P.R. China, Clinical Research Institute, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China, College of Life Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China, Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, P.R. China, Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Hangzhou, Zhejiang 310014, P.R. China
    Copyright: © Xia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 69-76
    |
    Published online on: November 11, 2019
       https://doi.org/10.3892/ol.2019.11074
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Abstract

Dendritic cell‑specific intercellular adhesion molecule‑grabbing non‑integrin‑related protein (DC‑SIGNR) is a transmembrane receptor primarily involved in pathogen recognition by the innate immune system, with particular importance for viral recognition. DC‑SIGNR may also be associated with tumorigenesis. The aim of the present study was to investigate the association between DC‑SIGNR expression, development of hepatocellular carcinoma (HCC), and clinicopathological features. Immunohistochemistry was used to assess DC‑SIGNR protein expression in HCC and paired non‑cancerous tissue samples. DC‑SIGNR expression was lower in HCC tissues compared with adjacent non‑tumor tissue samples. The expression of DC‑SIGNR was associated with small tumor size, low Edmondson grade and high patient long term survival rates. Bioinformatics analyses were performed on several datasets to assess the potential function of DC‑SIGNR and related genes; the data revealed that DC‑SIGNR mRNA expression was lower in HCC tissues compared with non‑cancerous controls, and analyses of ten‑year survival rates indicated patients with low DC‑SIGNR expression exhibited shorter average survival times. In conclusion, decreased DC‑SIGNR expression in HCC tissues may be a relevant predictive biomarker of clinical prognosis, in addition to being a viable therapeutic target for HCC treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Xia HB, Wang HJ, Song SS, Zhang JG, He XL, Hu ZM, Zhang CW, Huang DS and Mou XZ: Decreased DC‑SIGNR expression in hepatocellular carcinoma predicts poor patient prognosis. Oncol Lett 19: 69-76, 2020.
APA
Xia, H., Wang, H., Song, S., Zhang, J., He, X., Hu, Z. ... Mou, X. (2020). Decreased DC‑SIGNR expression in hepatocellular carcinoma predicts poor patient prognosis. Oncology Letters, 19, 69-76. https://doi.org/10.3892/ol.2019.11074
MLA
Xia, H., Wang, H., Song, S., Zhang, J., He, X., Hu, Z., Zhang, C., Huang, D., Mou, X."Decreased DC‑SIGNR expression in hepatocellular carcinoma predicts poor patient prognosis". Oncology Letters 19.1 (2020): 69-76.
Chicago
Xia, H., Wang, H., Song, S., Zhang, J., He, X., Hu, Z., Zhang, C., Huang, D., Mou, X."Decreased DC‑SIGNR expression in hepatocellular carcinoma predicts poor patient prognosis". Oncology Letters 19, no. 1 (2020): 69-76. https://doi.org/10.3892/ol.2019.11074
Copy and paste a formatted citation
x
Spandidos Publications style
Xia HB, Wang HJ, Song SS, Zhang JG, He XL, Hu ZM, Zhang CW, Huang DS and Mou XZ: Decreased DC‑SIGNR expression in hepatocellular carcinoma predicts poor patient prognosis. Oncol Lett 19: 69-76, 2020.
APA
Xia, H., Wang, H., Song, S., Zhang, J., He, X., Hu, Z. ... Mou, X. (2020). Decreased DC‑SIGNR expression in hepatocellular carcinoma predicts poor patient prognosis. Oncology Letters, 19, 69-76. https://doi.org/10.3892/ol.2019.11074
MLA
Xia, H., Wang, H., Song, S., Zhang, J., He, X., Hu, Z., Zhang, C., Huang, D., Mou, X."Decreased DC‑SIGNR expression in hepatocellular carcinoma predicts poor patient prognosis". Oncology Letters 19.1 (2020): 69-76.
Chicago
Xia, H., Wang, H., Song, S., Zhang, J., He, X., Hu, Z., Zhang, C., Huang, D., Mou, X."Decreased DC‑SIGNR expression in hepatocellular carcinoma predicts poor patient prognosis". Oncology Letters 19, no. 1 (2020): 69-76. https://doi.org/10.3892/ol.2019.11074
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