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Article Open Access

BATF acts as an oncogene in non‑small cell lung cancer

  • Authors:
    • Yu Feng
    • Liangbin Pan
    • Biao Zhang
    • Haitao Huang
    • Haitao Ma
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215000, P.R. China
    Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 205-210
    |
    Published online on: November 11, 2019
       https://doi.org/10.3892/ol.2019.11075
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Abstract

One of the main causes of cancer incidence and mortality worldwide is lung cancer. This study focused on the function of basic leucine zipper ATF‑like transcription factor (BATF) in non‑small cell lung cancer (NSCLC). Using NSCLC patient data from The Cancer Genome Atlas, the present study demonstrated that BATF expression in NSCLC tissues was significantly higher compared with that in adjacent non‑tumor tissues (P=6.56x10‑6). Lentivirus‑mediated short hairpin RNA (shRNA) was used to knock down BATF expression in the human A549 NSCLC cell line and assessed by reverse transcription‑quantitative PCR and western blotting. Cell proliferation was evaluated by MTT assay and Celigo imaging cytometry. Apoptosis was detected by fluorescence‑activated cell sorting and caspase 3/7 activity analysis. The results revealed that knockdown of BATF inhibited the proliferation of A549 cells. Compared with that of the control group, the apoptosis rate of the BATF‑shRNA group was significantly higher. In summary, knockdown of BATF inhibited the proliferation of A549 cells and promoted apoptosis. These results provide important information about the underlying mechanism of the pathogenesis of NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Feng Y, Pan L, Zhang B, Huang H and Ma H: BATF acts as an oncogene in non‑small cell lung cancer. Oncol Lett 19: 205-210, 2020.
APA
Feng, Y., Pan, L., Zhang, B., Huang, H., & Ma, H. (2020). BATF acts as an oncogene in non‑small cell lung cancer. Oncology Letters, 19, 205-210. https://doi.org/10.3892/ol.2019.11075
MLA
Feng, Y., Pan, L., Zhang, B., Huang, H., Ma, H."BATF acts as an oncogene in non‑small cell lung cancer". Oncology Letters 19.1 (2020): 205-210.
Chicago
Feng, Y., Pan, L., Zhang, B., Huang, H., Ma, H."BATF acts as an oncogene in non‑small cell lung cancer". Oncology Letters 19, no. 1 (2020): 205-210. https://doi.org/10.3892/ol.2019.11075
Copy and paste a formatted citation
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Spandidos Publications style
Feng Y, Pan L, Zhang B, Huang H and Ma H: BATF acts as an oncogene in non‑small cell lung cancer. Oncol Lett 19: 205-210, 2020.
APA
Feng, Y., Pan, L., Zhang, B., Huang, H., & Ma, H. (2020). BATF acts as an oncogene in non‑small cell lung cancer. Oncology Letters, 19, 205-210. https://doi.org/10.3892/ol.2019.11075
MLA
Feng, Y., Pan, L., Zhang, B., Huang, H., Ma, H."BATF acts as an oncogene in non‑small cell lung cancer". Oncology Letters 19.1 (2020): 205-210.
Chicago
Feng, Y., Pan, L., Zhang, B., Huang, H., Ma, H."BATF acts as an oncogene in non‑small cell lung cancer". Oncology Letters 19, no. 1 (2020): 205-210. https://doi.org/10.3892/ol.2019.11075
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