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Article

Plasma aromatase as a sensitive and selective potential biomarker of bladder cancer and its role in tumorigenesis

  • Authors:
    • Tomasz Guszcz
    • Beata Szymańska
    • Robert Kozlowski
    • Zenon Lukaszewski
    • Pawel Laskowski
    • Ewa Gorodkiewicz
  • View Affiliations / Copyright

    Affiliations: Department of Urology, J. Sniadecki Provincial Hospital of Białystok, 15‑950 Białystok, Poland, Institute of Chemistry, University of Białystok, 15‑245 Białystok, Poland, Faculty of Chemical Technology, Poznan University of Technology, 60‑965 Poznan, Poland, Department of Human Anatomy, Medical University of Białystok, 15‑230 Białystok, Poland
  • Pages: 562-568
    |
    Published online on: November 11, 2019
       https://doi.org/10.3892/ol.2019.11080
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Abstract

Bladder cancer (BCa) is the ninth most common cancer in the world and its early detection is crucial for successful therapy. Unfortunately, there are no satisfactory tools to detect BCa at early stages and BCa's confirmation muscle‑invasive. The search for a suitable biomarker is therefore necessary and aromatase is a potential candidate. The purpose of the current study was to determine if aromatase serves as a biomarker of BCa. A Surface Plasmon Resonance Imaging biosensor was applied for the quantification and determination of aromatase. A total of 3 µl blood plasma was used for a single measurement. The results revealed that the aromatase concentration in the plasma of patients with BCa (n=78) ranged from 17.41‑57.44 ng/ml. The range determined in healthy donors (n=18) was 2.59‑7.74 ng/ml. Additionally, it was revealed that muscle invasive BCa samples exhibited elevated, statistically significant (P=0.01) average aromatase concentrations in blood plasma (38.64 ng/ml) when compared with non‑muscle invasive samples (29.83 ng/ml). The results demonstrated that plasma aromatase may serve as an excellent bimarker of BCa with 100% sensitivity, 100% selectivity and an area under the curve value of the reciever operating characteristic curve equal to 1.0. Furthermore, the marker differenciated between muscle‑invasive and non muscle‑invasive BCa with a sensitivity of 60% and a specificity of 81%. In conclusion, aromatase may serve a role in bladder tumorigenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Guszcz T, Szymańska B, Kozlowski R, Lukaszewski Z, Laskowski P and Gorodkiewicz E: Plasma aromatase as a sensitive and selective potential biomarker of bladder cancer and its role in tumorigenesis. Oncol Lett 19: 562-568, 2020.
APA
Guszcz, T., Szymańska, B., Kozlowski, R., Lukaszewski, Z., Laskowski, P., & Gorodkiewicz, E. (2020). Plasma aromatase as a sensitive and selective potential biomarker of bladder cancer and its role in tumorigenesis. Oncology Letters, 19, 562-568. https://doi.org/10.3892/ol.2019.11080
MLA
Guszcz, T., Szymańska, B., Kozlowski, R., Lukaszewski, Z., Laskowski, P., Gorodkiewicz, E."Plasma aromatase as a sensitive and selective potential biomarker of bladder cancer and its role in tumorigenesis". Oncology Letters 19.1 (2020): 562-568.
Chicago
Guszcz, T., Szymańska, B., Kozlowski, R., Lukaszewski, Z., Laskowski, P., Gorodkiewicz, E."Plasma aromatase as a sensitive and selective potential biomarker of bladder cancer and its role in tumorigenesis". Oncology Letters 19, no. 1 (2020): 562-568. https://doi.org/10.3892/ol.2019.11080
Copy and paste a formatted citation
x
Spandidos Publications style
Guszcz T, Szymańska B, Kozlowski R, Lukaszewski Z, Laskowski P and Gorodkiewicz E: Plasma aromatase as a sensitive and selective potential biomarker of bladder cancer and its role in tumorigenesis. Oncol Lett 19: 562-568, 2020.
APA
Guszcz, T., Szymańska, B., Kozlowski, R., Lukaszewski, Z., Laskowski, P., & Gorodkiewicz, E. (2020). Plasma aromatase as a sensitive and selective potential biomarker of bladder cancer and its role in tumorigenesis. Oncology Letters, 19, 562-568. https://doi.org/10.3892/ol.2019.11080
MLA
Guszcz, T., Szymańska, B., Kozlowski, R., Lukaszewski, Z., Laskowski, P., Gorodkiewicz, E."Plasma aromatase as a sensitive and selective potential biomarker of bladder cancer and its role in tumorigenesis". Oncology Letters 19.1 (2020): 562-568.
Chicago
Guszcz, T., Szymańska, B., Kozlowski, R., Lukaszewski, Z., Laskowski, P., Gorodkiewicz, E."Plasma aromatase as a sensitive and selective potential biomarker of bladder cancer and its role in tumorigenesis". Oncology Letters 19, no. 1 (2020): 562-568. https://doi.org/10.3892/ol.2019.11080
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