Open Access

MT1JP inhibits glioma progression via negative regulation of miR‑24

  • Authors:
    • Jinming Chen
    • Jianyun Lou
    • Shaochun Yang
    • Jun Lou
    • Wei Liao
    • Renxiang Zhou
    • Chuanzhen Qiu
    • Guanfu Ding
  • View Affiliations

  • Published online on: November 13, 2019     https://doi.org/10.3892/ol.2019.11085
  • Pages: 334-342
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Long noncoding RNAs have been reported to be dysregulated and have pivotal roles in various human malignancies, including glioma. Previous studies revealed that metallothionein 1J (MT1JP) has important regulatory functions in the development of gastric cancer. However, the biological role and potential mechanism of MT1JP in glioma remain unknown. The present study suggested that MT1JP expression was significantly downregulated in glioma tissues and glioma cell lines, and the decreased expression of MT1JP was associated with glioma progression and poor survival of patients with glioma. Additionally, overexpression of MT1JP significantly inhibited the proliferation and invasion of glioma cells. Furthermore, it was revealed that MT1JP interacted with microRNA‑24 (miR‑24), which has previously been reported as an oncogene in glioma, negatively regulating its expression level. Rescue experiments revealed that the tumor suppressive functions of MT1JP may be mediated by the negative regulation of miR‑24. Collectively, the data suggested that MT1JP inhibited the progression of glioma by negatively regulating miR‑24 and may serve as a novel diagnostic biomarker and therapeutic target for glioma.
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January-2020
Volume 19 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Chen J, Lou J, Yang S, Lou J, Liao W, Zhou R, Qiu C and Ding G: MT1JP inhibits glioma progression via negative regulation of miR‑24. Oncol Lett 19: 334-342, 2020
APA
Chen, J., Lou, J., Yang, S., Lou, J., Liao, W., Zhou, R. ... Ding, G. (2020). MT1JP inhibits glioma progression via negative regulation of miR‑24. Oncology Letters, 19, 334-342. https://doi.org/10.3892/ol.2019.11085
MLA
Chen, J., Lou, J., Yang, S., Lou, J., Liao, W., Zhou, R., Qiu, C., Ding, G."MT1JP inhibits glioma progression via negative regulation of miR‑24". Oncology Letters 19.1 (2020): 334-342.
Chicago
Chen, J., Lou, J., Yang, S., Lou, J., Liao, W., Zhou, R., Qiu, C., Ding, G."MT1JP inhibits glioma progression via negative regulation of miR‑24". Oncology Letters 19, no. 1 (2020): 334-342. https://doi.org/10.3892/ol.2019.11085