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High expression of fibronectin 1 indicates poor prognosis in gastric cancer

  • Authors:
    • Yang Sun
    • Chunlin Zhao
    • Yanwei Ye
    • Zhen Wang
    • Yuanhang He
    • Yulin Li
    • Haoxun Mao
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 93-102
    |
    Published online on: November 13, 2019
       https://doi.org/10.3892/ol.2019.11088
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Abstract

Fibronectin 1 (FN1) is involved in the occurrence and development of various tumors and is upregulated in multiple cancer types. FN1 has been demonstrated to promote cell proliferation and migration in gastric cancer cell lines. However, the relationship between the expression of FN1 and clinicopathological factors and prognosis is not clear in gastric cancer (GC). The aim of the present study was to investigate the association between FN1 expression and clinicopathology and prognosis of gastric cancer. In this study, 17 publicly available GC cohorts (n=2,376) with gene expression data from the Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA) and Oncomine databases were tested. In addition, FN1 protein expression was validated by immunohistochemistry in a separate cohort (n=190). The meta‑analysis results demonstrated an increase in FN1 expression at the protein and mRNA level in GC tissues, and the FN1 gene was highly expressed at the mRNA level in the advanced T stage (T2 + T3 + T4) group compared with that in the early T stage (T1) group. In addition, the expression of epithelial FN1 at the protein level was positively correlated with tumor size. FN1 expression at the protein and mRNA level was a predictor of poor prognosis following radical resection of GC. In conclusion, the expression of FN1 in GC tissues is upregulated compared with adjacent normal tissues, and it is a potential biomarker of poor prognosis in patients with GC.
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Copy and paste a formatted citation
Spandidos Publications style
Sun Y, Zhao C, Ye Y, Wang Z, He Y, Li Y and Mao H: High expression of fibronectin 1 indicates poor prognosis in gastric cancer. Oncol Lett 19: 93-102, 2020.
APA
Sun, Y., Zhao, C., Ye, Y., Wang, Z., He, Y., Li, Y., & Mao, H. (2020). High expression of fibronectin 1 indicates poor prognosis in gastric cancer. Oncology Letters, 19, 93-102. https://doi.org/10.3892/ol.2019.11088
MLA
Sun, Y., Zhao, C., Ye, Y., Wang, Z., He, Y., Li, Y., Mao, H."High expression of fibronectin 1 indicates poor prognosis in gastric cancer". Oncology Letters 19.1 (2020): 93-102.
Chicago
Sun, Y., Zhao, C., Ye, Y., Wang, Z., He, Y., Li, Y., Mao, H."High expression of fibronectin 1 indicates poor prognosis in gastric cancer". Oncology Letters 19, no. 1 (2020): 93-102. https://doi.org/10.3892/ol.2019.11088
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Y, Zhao C, Ye Y, Wang Z, He Y, Li Y and Mao H: High expression of fibronectin 1 indicates poor prognosis in gastric cancer. Oncol Lett 19: 93-102, 2020.
APA
Sun, Y., Zhao, C., Ye, Y., Wang, Z., He, Y., Li, Y., & Mao, H. (2020). High expression of fibronectin 1 indicates poor prognosis in gastric cancer. Oncology Letters, 19, 93-102. https://doi.org/10.3892/ol.2019.11088
MLA
Sun, Y., Zhao, C., Ye, Y., Wang, Z., He, Y., Li, Y., Mao, H."High expression of fibronectin 1 indicates poor prognosis in gastric cancer". Oncology Letters 19.1 (2020): 93-102.
Chicago
Sun, Y., Zhao, C., Ye, Y., Wang, Z., He, Y., Li, Y., Mao, H."High expression of fibronectin 1 indicates poor prognosis in gastric cancer". Oncology Letters 19, no. 1 (2020): 93-102. https://doi.org/10.3892/ol.2019.11088
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