Open Access

TBX3 knockdown suppresses the proliferation of hypopharyngeal carcinoma FaDu cells by inducing G1/S cell cycle arrest and apoptosis

  • Authors:
    • Yongjiu Huang
    • Hongmei Zhu
    • Xiaohui Ji
    • Yin Chen
    • Yanhui Zhang
    • Ruofei Huang
    • Jin Xie
    • Pin Dong
  • View Affiliations

  • Published online on: November 13, 2019     https://doi.org/10.3892/ol.2019.11089
  • Pages: 113-120
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The T‑box transcription factor family member TBX3 has been demonstrated to participate in the development of various types of cancer, including head and neck squamous cell carcinoma. However, little is currently known about its role in hypopharyngeal carcinoma. In the present study, the involvement of TBX3 in hypopharyngeal carcinoma was investigated. Immunohistochemical assays revealed that TBX3 levels were increased in hypopharyngeal carcinoma compared with normal tissue samples, accompanied by upregulated N‑cadherin and downregulated E‑cadherin. Lentivirus‑mediated TBX3 knockdown efficiently suppressed its expression and inhibited the proliferation of FaDu cells. The opposite was observed in TBX3‑overexpressing FaDu cells. These results indicate that TBX3 is essential for FaDu cell proliferation. Furthermore, TBX3 silencing led to a disturbance of the cell cycle, leading to a decrease in the G1 phase and an increase in the S phase. In addition, apoptosis was enhanced following TBX3 knockdown. The present results suggest TBX3 as a potential therapeutic target in hypopharyngeal carcinoma.
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January-2020
Volume 19 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Huang Y, Zhu H, Ji X, Chen Y, Zhang Y, Huang R, Xie J and Dong P: TBX3 knockdown suppresses the proliferation of hypopharyngeal carcinoma FaDu cells by inducing G1/S cell cycle arrest and apoptosis. Oncol Lett 19: 113-120, 2020
APA
Huang, Y., Zhu, H., Ji, X., Chen, Y., Zhang, Y., Huang, R. ... Dong, P. (2020). TBX3 knockdown suppresses the proliferation of hypopharyngeal carcinoma FaDu cells by inducing G1/S cell cycle arrest and apoptosis. Oncology Letters, 19, 113-120. https://doi.org/10.3892/ol.2019.11089
MLA
Huang, Y., Zhu, H., Ji, X., Chen, Y., Zhang, Y., Huang, R., Xie, J., Dong, P."TBX3 knockdown suppresses the proliferation of hypopharyngeal carcinoma FaDu cells by inducing G1/S cell cycle arrest and apoptosis". Oncology Letters 19.1 (2020): 113-120.
Chicago
Huang, Y., Zhu, H., Ji, X., Chen, Y., Zhang, Y., Huang, R., Xie, J., Dong, P."TBX3 knockdown suppresses the proliferation of hypopharyngeal carcinoma FaDu cells by inducing G1/S cell cycle arrest and apoptosis". Oncology Letters 19, no. 1 (2020): 113-120. https://doi.org/10.3892/ol.2019.11089