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Methylation of bone morphogenetic protein 2 is associated with poor prognosis in colorectal cancer

  • Authors:
    • Tomiyuki Miura
    • Megumi Ishiguro
    • Toshiaki Ishikawa
    • Satoshi Okazaki
    • Hironobu Baba
    • Akifumi Kikuchi
    • Shinichi Yamauchi
    • Takatoshi Matsuyama
    • Hiroyuki Uetake
    • Yusuke Kinugasa
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo‑ku, Tokyo 113‑8519, Japan, Department of Translational Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo‑ku, Tokyo 113‑8519, Japan, Department of Specialized Surgeries, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo‑ku, Tokyo 113‑8519, Japan
    Copyright: © Miura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 229-238
    |
    Published online on: November 13, 2019
       https://doi.org/10.3892/ol.2019.11091
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Abstract

The present study investigated aberrant methylation in colorectal cancer (CRC) and its impact on characteristics and prognosis of patients with CRC. Bone morphogenetic protein 2 (BMP2) was identified as a target gene in oligonucleotide microarray expression profiling in a previous study. Subsequently, the BMP2 methylation status was assessed in 498 patients with stage I‑III CRC using methylation‑specific polymerase chain reaction, and the association between BMP2 methylation status, patient characteristics and prognosis was assessed. BMP2 methylation was observed in 302/498 (60.6%) patients and was associated with positive lymph nodes and venous invasion (P<0.05). In the stage III subgroup, overall survival (OS) was significantly worse in the methylated BMP2 group compared with in the unmethylated BMP2 group (P=0.012). BMP2 methylation was identified as an independent factor for poor OS in stage III patients (P=0.041). Notably, in the left‑sided stage III CRC subgroup, relapse‑free survival and OS were significantly worse in the methylated BMP2 group than in the unmethylated group (P=0.048 and P=0.031, respectively). In conclusion, DNA hypermethylation of BMP2 was a poor prognostic factor in patients with stage III disease, particularly in those with left‑sided stage III CRC. BMP2 methylation may be a biomarker for prognosis prediction and treatment decision‑making.
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Copy and paste a formatted citation
Spandidos Publications style
Miura T, Ishiguro M, Ishikawa T, Okazaki S, Baba H, Kikuchi A, Yamauchi S, Matsuyama T, Uetake H, Kinugasa Y, Kinugasa Y, et al: Methylation of bone morphogenetic protein 2 is associated with poor prognosis in colorectal cancer. Oncol Lett 19: 229-238, 2020.
APA
Miura, T., Ishiguro, M., Ishikawa, T., Okazaki, S., Baba, H., Kikuchi, A. ... Kinugasa, Y. (2020). Methylation of bone morphogenetic protein 2 is associated with poor prognosis in colorectal cancer. Oncology Letters, 19, 229-238. https://doi.org/10.3892/ol.2019.11091
MLA
Miura, T., Ishiguro, M., Ishikawa, T., Okazaki, S., Baba, H., Kikuchi, A., Yamauchi, S., Matsuyama, T., Uetake, H., Kinugasa, Y."Methylation of bone morphogenetic protein 2 is associated with poor prognosis in colorectal cancer". Oncology Letters 19.1 (2020): 229-238.
Chicago
Miura, T., Ishiguro, M., Ishikawa, T., Okazaki, S., Baba, H., Kikuchi, A., Yamauchi, S., Matsuyama, T., Uetake, H., Kinugasa, Y."Methylation of bone morphogenetic protein 2 is associated with poor prognosis in colorectal cancer". Oncology Letters 19, no. 1 (2020): 229-238. https://doi.org/10.3892/ol.2019.11091
Copy and paste a formatted citation
x
Spandidos Publications style
Miura T, Ishiguro M, Ishikawa T, Okazaki S, Baba H, Kikuchi A, Yamauchi S, Matsuyama T, Uetake H, Kinugasa Y, Kinugasa Y, et al: Methylation of bone morphogenetic protein 2 is associated with poor prognosis in colorectal cancer. Oncol Lett 19: 229-238, 2020.
APA
Miura, T., Ishiguro, M., Ishikawa, T., Okazaki, S., Baba, H., Kikuchi, A. ... Kinugasa, Y. (2020). Methylation of bone morphogenetic protein 2 is associated with poor prognosis in colorectal cancer. Oncology Letters, 19, 229-238. https://doi.org/10.3892/ol.2019.11091
MLA
Miura, T., Ishiguro, M., Ishikawa, T., Okazaki, S., Baba, H., Kikuchi, A., Yamauchi, S., Matsuyama, T., Uetake, H., Kinugasa, Y."Methylation of bone morphogenetic protein 2 is associated with poor prognosis in colorectal cancer". Oncology Letters 19.1 (2020): 229-238.
Chicago
Miura, T., Ishiguro, M., Ishikawa, T., Okazaki, S., Baba, H., Kikuchi, A., Yamauchi, S., Matsuyama, T., Uetake, H., Kinugasa, Y."Methylation of bone morphogenetic protein 2 is associated with poor prognosis in colorectal cancer". Oncology Letters 19, no. 1 (2020): 229-238. https://doi.org/10.3892/ol.2019.11091
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