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HSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancer

  • Authors:
    • Warne Pedro De Andrade
    • Letícia Da Conceição Braga
    • Nikole Gontijo Gonçales
    • Luciana Maria Silva
    • Agnaldo Lopes Da Silva Filho
  • View Affiliations / Copyright

    Affiliations: Oncology Service, Vera Cruz Hospital, Belo Horizonte, Minas Gerais 30180-090, Brazil, Department of Obstetrics and Gynecology, School of Medicine, São Paulo State University, Botucatu, Sao Paulo 18618‑687, Brazil, Cellular Biology Service, Research and Development Department, Ezequiel Dias Foundation, Belo Horizonte, Minas Gerais 30510‑010, Brazil
    Copyright: © De Andrade et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 359-367
    |
    Published online on: November 14, 2019
       https://doi.org/10.3892/ol.2019.11095
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Abstract

Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, with the presence of chemoresistance contributing to the poor prognosis. Heat Shock Proteins (HSPs) genes are activated in response to pathophysiological stress and serve a role in a variety of stages in carcinogenesis, acting primarily as anti‑apoptotic agents and in chemotherapy resistance in a variety of tumor types. The current study evaluated the HSP gene expression profile in women with ovarian cancer (OC) and their correlation with clinical and pathological aspects of patients with OC. A total of 51 patients included in the current study were divided into four groups: Primary Epithelial Ovarian Cancer (EOC; n=14), metastatic EOC (n=11), ovarian serous cystadenoma (n=7) and no evidence of ovarian malignancy or control groups (n=19). RNA extraction and reverse transcription‑quantitative (RT‑q) PCR was then performed on the samples obtained. RT‑qPCR was performed to compare TNF receptor associated protein 1 (TRAP1), heat shock protein family (HSP) HSPB1, HSPD1, HSPA1A and HSPA1L expression in primary and metastatic EOCs. TRAP1, HSPB1, HSPD1, HSPA1A and HSPA1L gene expression did not differ among groups. HSPA1A, HSPA1L and TRAP1 were revealed to be underexpressed in the primary and metastatic EOC groups, with HSPA1L exhibiting the lowest expression. TRAP1 expression was higher in tumors at stages I/II compared with those at stages III/IV. No correlation was exhibited between HSP expression and age, menarche, menopause, parity, period after menopause initiation, cytoreduction, CA‑125 or overall and disease‑free survival. HSPA1A was negatively correlated with the risk of mortality from OC. The results indicated that the downregulation of HSPA1A, HSPA1L and TRAP1 could be associated with the clinical prognostic features of women with EOC.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Corrado G, Salutari V, Palluzzi E, Distefano MG, Scambia G and Ferrandina G: Optimizing treatment in recurrent epithelial ovarian cancer. Expert Rev Anticancer Ther. 17:1147–1158. 2017. View Article : Google Scholar : PubMed/NCBI

4 

du Bois A, Luck HJ, Meier W, Adams HP, Möbus V, Costa S, Bauknecht T, Richter B, Warm M, Schröder W, et al: A randomized clinical trial of cisplatin/paclitaxel versus carboplatin/paclitaxel as first-line treatment of ovarian cancer. J Natl Cancer Inst. 95:1320–1329. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Agarwal R and Kaye SB: Prognostic factors in ovarian cancer: How close are we to a complete picture? Ann Oncol. 16:4–6. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Wu J, Liu T, Rios Z, Mei Q, Lin X and Cao S: Heat shock proteins and cancer. Trends Pharmacol Sci. 38:226–256. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Ciocca DR, Arrigo AP and Calderwood SK: Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: An update. Arch Toxicol. 87:19–48. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Song TF, Zhang ZF, Liu L, Yang T, Jiang J and Li P: Small interfering RNA-mediated silencing of heat shock protein 27 (HSP27) Increases chemosensitivity to paclitaxel by increasing production of reactive oxygen species in human ovarian cancer cells (HO8910). J Int Med Res. 37:1375–1388. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Landriscina M, Amoroso MR, Piscazzi A and Esposito F: Heat shock proteins, cell survival and drug resistance: The mitochondrial chaperone TRAP1, a potential novel target for ovarian cancer therapy. Gynecol Oncol. 117:177–182. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Elstrand MB, Stavnes HT, Trope CG and Davidson B: Heat shock protein 90 is a putative therapeutic target in patients with recurrent advanced-stage ovarian carcinoma with serous effusions. Hum Pathol. 43:529–535. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Zhao M, Ding JX, Zeng K, Zhao J, Shen F, Yin YX and Chen Q: Heat shock protein 27: A potential biomarker of peritoneal metastasis in epithelial ovarian cancer? Tumour Biol. 35:1051–1056. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Kim HS and Song YS: International federation of gynecology and obstetrics (FIGO) staging system revised: What should be considered critically for gynecologic cancer? J Gynecol Oncol. 20:135–136. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43 (Database Issue):D447–D452. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Montgomery DC, Peck EA and Vining GG: Introduction to linear regression analysis 5th editionJohn Wiley & Sons; New York: 2012

16 

Myles H and Wolfe DA: Nonparametric Statistical MethodsJohn Wiley & Sons; New York: 1999

17 

Colosimo EA and Giolo SR: ABE-Projeto FisherEdgard Blücher; 2006

18 

Kaplan EL and Meyer P: Nonparametric estimation from incomplete observations. J Am Stat Assoc. 53:457–481. 1958. View Article : Google Scholar

19 

R Core Team, . A language and environment for statistical computingR Foundation for Statistical Computing; Vienna: 2018

20 

Therneau TM and Grambsch PM: Modeling survival data: Extending the Cox ModelSpringer; New York, NY: 2000

21 

Kurman RJ and Shih Ie M: The origin and pathogenesis of epithelial ovarian cancer: A proposed unifying theory. Am J Surg Pathol. 34:433–443. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Singh MK, Sharma B and Tiwari PK: The small heat shock protein Hsp27: Present understanding and future prospects. J Therm Biol. 69:149–154. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Amoroso MR, Matassa DS, Agliarulo I, Avolio R, Lu H, Sisinni L, Lettini G, Gabra H, Landriscina M and Esposito F: TRAP1 downregulation in human ovarian cancer enhances invasion and epithelial-mesenchymal transition. Cell Death Dis. 7:e25222016. View Article : Google Scholar : PubMed/NCBI

24 

Pfister K, Radons J, Busch R, Tidball JG, Pfeifer M, Freitag L, Feldmann HJ, Milani V, Issels R and Multhoff G: Patient survival by Hsp70 membrane phenotype: Association with different routes of metastasis. Cancer. 110:926–935. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Braga Lda C, Silva LM, Ramos AP, Piedade JB, Vidigal PV, Traiman P and da Silva Filho AL: Single CpG island methylation is not sufficient to maintain the silenced expression of CASPASE-8 apoptosis-related gene among women with epithelial ovarian cancer. Biomed Pharmacother. 68:87–91. 2014. View Article : Google Scholar : PubMed/NCBI

26 

de Lima AB, Silva LM, Goncales NG, Carvalho MRS, da Silva Filho AL and da Conceicao Braga L: Three-dimensional cellular arrangement in epithelial ovarian cancer cell lines TOV-21G and SKOV-3 is associated with apoptosis-related miRNA expression modulation. Cancer Microenviron. 11:85–92. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Arrigo AP and Gibert B: HspB1, HspB5 and HspB4 in human cancers: Potent oncogenic role of some of their client proteins. Cancers (Basel). 6:333–365. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Beere HM: Stressed to death: Regulation of apoptotic signaling pathways by the heat shock proteins. Sci STKE. 2001:re12001.PubMed/NCBI

29 

Khalil AA, Kabapy NF, Deraz SF and Smith C: Heat shock proteins in oncology: Diagnostic biomarkers or therapeutic targets? Biochim Biophys Acta. 1816:89–104. 2011.PubMed/NCBI

30 

Wang X, Chen M, Zhou J and Zhang X: HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy (Review). Int J Oncol. 45:18–30. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Matassa DS, Amoroso MR, Maddalena F, Landriscina M and Esposito F: New insights into TRAP1 pathway. Am J Cancer Res. 2:235–248. 2012.PubMed/NCBI

32 

Costantino E, Maddalena F, Calise S, Piscazzi A, Tirino V, Fersini A, Ambrosi A, Neri V, Esposito F and Landriscina M: TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells. Cancer Lett. 279:39–46. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Aust S, Bachmayr-Heyda A, Pateisky P, Tong D, Darb-Esfahani S, Denkert C, Chekerov R, Sehouli J, Mahner S, Van Gorp T, et al: Role of TRAP1 and estrogen receptor alpha in patients with ovarian cancer-a study of the OVCAD consortium. Mol Cancer. 11:692012. View Article : Google Scholar : PubMed/NCBI

34 

Han JJ, Baek SK, Lee JJ, Kim GY, Kim SY and Lee SH: Combination of TRAP1 and ERCC1 expression predicts clinical outcomes in metastatic colorectal cancer treated with Oxaliplatin/5-Fluorouracil. Cancer Res Treat. 46:55–64. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Cappello F, Di Stefano A, David S, Rappa F, Anzalone R, La Rocca G, D'Anna SE, Magno F, Donner CF, Balbi B and Zummo G: Hsp60 and Hsp10 down-regulation predicts bronchial epithelial carcinogenesis in smokers with chronic obstructive pulmonary disease. Cancer. 107:2417–2424. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Matassa DS, Amoroso MR, Lu H, Avolio R, Arzeni D, Procaccini C, Faicchia D, Maddalena F, Simeon V, Agliarulo I, et al: Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer. Cell Death Differ. 23:1542–1554. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Vidyasagar A, Wilson NA and Djamali A: Heat shock protein 27 (HSP27): Biomarker of disease and therapeutic target. Fibrogenesis Tissue Repair. 5:72012. View Article : Google Scholar : PubMed/NCBI

38 

Elstrand MB, Kleinberg L, Kohn EC, Trope CG and Davidson B: Expression and clinical role of antiapoptotic proteins of the bag, heat shock, and Bcl-2 families in effusions, primary tumors, and solid metastases in ovarian carcinoma. Int J Gynecol Pathol. 28:211–221. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Langdon SP, Rabiasz GJ, Hirst GL, King RJ, Hawkins RA, Smyth JF and Miller WR: Expression of the heat shock protein HSP27 in human ovarian cancer. Clin Cancer Res. 1:1603–1609. 1995.PubMed/NCBI

40 

Olejek A, Damasiewicz-Bodzek A, Bodzek P, Wielkoszyński T, Zamłyński J, Stołtny P and Skutil M: Concentrations of antibodies against heat shock protein 27 in the sera of women with ovarian carcinoma. Int J Gynecol Cancer. 19:1516–1520. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Geisler JP, Tammela JE, Manahan KJ, Geisler HE, Miller GA, Zhou Z and Wiemann MC: HSP27 in patients with ovarian carcinoma: Still an independent prognostic indicator at 60 months follow-up. Eur J Gynaecol Oncol. 25:165–168. 2004.PubMed/NCBI

42 

Schneider J, Jimenez E, Marenbach K, Marx D and Meden H: Co-expression of the MDR1 gene and HSP27 in human ovarian cancer. Anticancer Res. 18:2967–2971. 1998.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
De Andrade WP, Braga LD, Gonçales NG, Silva LM and Da Silva Filho AL: HSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancer. Oncol Lett 19: 359-367, 2020.
APA
De Andrade, W.P., Braga, L.D., Gonçales, N.G., Silva, L.M., & Da Silva Filho, A.L. (2020). HSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancer. Oncology Letters, 19, 359-367. https://doi.org/10.3892/ol.2019.11095
MLA
De Andrade, W. P., Braga, L. D., Gonçales, N. G., Silva, L. M., Da Silva Filho, A. L."HSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancer". Oncology Letters 19.1 (2020): 359-367.
Chicago
De Andrade, W. P., Braga, L. D., Gonçales, N. G., Silva, L. M., Da Silva Filho, A. L."HSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancer". Oncology Letters 19, no. 1 (2020): 359-367. https://doi.org/10.3892/ol.2019.11095
Copy and paste a formatted citation
x
Spandidos Publications style
De Andrade WP, Braga LD, Gonçales NG, Silva LM and Da Silva Filho AL: HSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancer. Oncol Lett 19: 359-367, 2020.
APA
De Andrade, W.P., Braga, L.D., Gonçales, N.G., Silva, L.M., & Da Silva Filho, A.L. (2020). HSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancer. Oncology Letters, 19, 359-367. https://doi.org/10.3892/ol.2019.11095
MLA
De Andrade, W. P., Braga, L. D., Gonçales, N. G., Silva, L. M., Da Silva Filho, A. L."HSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancer". Oncology Letters 19.1 (2020): 359-367.
Chicago
De Andrade, W. P., Braga, L. D., Gonçales, N. G., Silva, L. M., Da Silva Filho, A. L."HSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancer". Oncology Letters 19, no. 1 (2020): 359-367. https://doi.org/10.3892/ol.2019.11095
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