A case of gallbladder neuroendocrine carcinoma diagnosed preoperatively using somatostatin receptor scintigraphy

Kamikihara,Yusuke; Tanoue,Shiroh; Kawahira,Machiko; Iwaya,Hiromichi; Arima,Shiho; Sasaki,Fumisato; Nasu,Yuichiro; Hashimoto,Shinichi; Kanmura,Shuji; Higashi,Michiyo; Gejima,Kentaro; Ido,Akio

doi:10.3892/ol.2019.11101

A case of gallbladder neuroendocrine carcinoma diagnosed preoperatively using somatostatin receptor scintigraphy

Authors:
- Yusuke Kamikihara
- Shiroh Tanoue
- Machiko Kawahira
- Hiromichi Iwaya
- Shiho Arima
- Fumisato Sasaki
- Yuichiro Nasu
- Shinichi Hashimoto
- Shuji Kanmura
- Michiyo Higashi
- Kentaro Gejima
- Akio Ido
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Affiliations: Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890‑8544, Japan, Department of Pathology, Kagoshima University Hospital, Kagoshima 890‑8544, Japan, Cardiovascular and Gastroenterological Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890‑8544, Japan
Published online on: November 14, 2019 https://doi.org/10.3892/ol.2019.11101
Pages: 247-254
Copyright: © Kamikihara et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gallbladder neuroendocrine carcinoma (NEC) is a rare gallbladder tumor. The current report is a case of a patient preoperatively diagnosed with gallbladder NEC using somatostatin receptor scintigraphy (SRS). A 63‑year‑old man was admitted to our hospital by a family doctor after abdominal ultrasonography revealed thickened walls of the neck of his gallbladder. At Kagoshima University Hospital, CT and MRI of the abdomen and endoscopic ultrasonography confirmed the thickening of the walls of the neck of the gallbladder. However, it did not resemble a typical gallbladder cancer or tumor, such as a neuroendocrine tumor or malignant lymphoma. Positron emission tomography and SRS showed abnormal accumulation at the tumor site. Endoscopic retrograde cholangiopancreatography was performed, adenocarcinoma was suspected based on intra‑gallbladder bile cytology, and a cholecystectomy with lymphadenectomy was performed. The postoperative pathological diagnosis was small cell NEC (pT3a, N0, M0, stage II). Immunohistochemistry indicated that the gallbladder tumor cells were positive for synaptophysin, chromogranin A, and cluster of differentiation (CD) 56, and negative for somatostatin receptors (SSTR) 2 and 5. Gene expression assays revealed the expression of all SSTR subtypes (SSTR1‑5) in the tumor. Generally, NECs exhibit poor accumulation in SRS, however, the results of the current case suggest that SRS may be useful in the preoperative diagnosis of NEC.

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1	Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A and Evans DB: One hundred years after ‘carcinoid’: Epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 26:3063–3072. 2008. View Article : Google Scholar : PubMed/NCBI
2	Eltawil KM, Gustafsson BI, Kidd M and Modlin IM: Neuroendocrine tumors of the gallbladder: An evaluation and reassessment of management strategy. J Clin Gastroenterol. 44:687–695. 2010.PubMed/NCBI
3	Mizutani G, Nakanishi Y, Watanabe N, Honma T, Obana Y, Seki T, Ohni S and Nemoto N: Expression of somatostatin receptor (SSTR) subtypes (SSTR-1, 2A, 3, 4 and 5) in neuroendocrine tumors using real-time RT-PCR method and immunohistochemistry. Acta Histochem Cytochem. 45:167–176. 2012. View Article : Google Scholar : PubMed/NCBI
4	Ayiomamitis GD, Notas G, Zaravinos A, Drygiannakis I, Georgiadou M, Sfakianaki O, Mastrodimou N, Thermos K and Kouroumalis E: Effects of octreotide and insulin on colon cancer cellular proliferation and correlation with hTERT activity. Oncoscience. 1:457–467. 2014. View Article : Google Scholar : PubMed/NCBI
5	Colucci R, Blandizzi C, Ghisu N, Florio T and Del Tacca M: Somatostatin inhibits colon cancer cell growth through cyclooxygenase-2 downregulation. Br J Phasrmacol. 155:198–209. 2008. View Article : Google Scholar
6	Albores-Saavedra J, Batich K, Hossain S, Henson DE and Schwartz AM: Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: A comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program. Ann Diagn Pathol. 13:378–383. 2009. View Article : Google Scholar : PubMed/NCBI
7	Yun SP, Shin N and Seo HI: Clinical outcomes of small cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder. World J Gastroenterol. 21:269–275. 2015. View Article : Google Scholar : PubMed/NCBI
8	Hamilton SR and Aaltonen LA: World health organization classification of tumours. Pathology and genetics of tumours of the digestive system. Hamilton SR and Aaltonen LA: IARC Press; Lyon: pp. 20002000
9	Adachi T, Haraguchi M, Irie J, Yoshimoto T, Uehara R, Ito S, Tokai H, Noda K, Tada N and Hirabaru M: Gallbladder small cell carcinoma: A case report and literature review. Surg Case Rep. 2:712016. View Article : Google Scholar : PubMed/NCBI
10	Horiguchi S: A case of neuroendocrine carcinoma of gallbladder. Tando. 30:290–297. 2016.
11	Chen C, Wang L, Liu X, Zhang G, Zhao Y and Geng Z: Gallbladder neuroendocrine carcinoma: Report of 10 cases and comparision of clinicopathologic features with gallbladder adenocarcinoma. Int J Clin Exp Pathol. 8:8218–8226. 2015.PubMed/NCBI
12	El Fattach H, Guerrache Y, Eveno C, Pocard M, Kaci R, Shaar-Chneker C, Dautry R, Boudiaf M, Dohan A and Soyer P: Primary neuroendocrine tumors of the gallbladder: Ultrasonographic and MDCT features with pathologic correlation. Diagn Interv Imaging. 96:499–502. 2015. View Article : Google Scholar : PubMed/NCBI
13	Murawaki Y, Miura M, Otani Y and Yoshida M: A case of adenoendocrine cell carcinoma of the gallbladder complicated by pancreaticobiliary maljunction, whereby differences in tissue composition could be identified on diffusion-weighted MRI. Tando. 27:200–204. 2013.
14	Ogawa T, Horaguchi J, Fujita N, Noda Y, Kobayashi G, Ito K, Koshita S, Kanno Y, Masu K and Sugita R: High b-value diffusion-weighted magnetic resonance imaging for gallbladder lesions: Differentiation between benignity and malignancy. J Gastroenterol. 47:1352–1360. 2012. View Article : Google Scholar : PubMed/NCBI
15	O'Toole D, Kianmanesh R and Caplin M: ENETS 2016 consensus guidelines for the management of patients with digestive neuroendocrine tumors: An update. Neuroendocrinology. 103:117–118. 2016. View Article : Google Scholar : PubMed/NCBI
16	van Essen M, Sundin A, Krenning EP and Kwekkeboom DJ: Neuroendocrine tumours: The role of imaging for diagnosis and therapy. Nat Rev Endocrinol. 10:102–114. 2014. View Article : Google Scholar : PubMed/NCBI
17	Binderup T, Knigge U, Loft A, Mortensen J, Pfeifer A, Federspiel B, Hansen CP, Højgaard L and Kjaer A: Functional imaging of neuroendocrine tumors: A head-to-head comparison of somatostatin receptor scintigraphy, 123I-MIBG Scintigraphy, and 18F-FDG PET. J Nucl Med. 51:704–712. 2010. View Article : Google Scholar : PubMed/NCBI
18	Kubota K, Okasaki M, Minamimoto R, Miyata Y, Morooka M, Nakajima K and Sato T: Lesion-based analysis of (18)F-FDG uptake and (111)In-Pentetreotide uptake by neuroendocrine tumors. Ann Nucl Med. 28:1004–1010. 2014. View Article : Google Scholar : PubMed/NCBI
19	Volante M, Brizzi MP, Faggiano A, La Rosa S, Rapa I, Ferrero A, Mansueto G, Righi L, Garancini S, Capella C, et al: Somatostatin receptor type 2A immunohistochemistry in neuroendocrine tumors: A proposal of scoring system correlated with somatostatin receptor scintigraphy. Mod Pathol. 20:1172–1182. 2007. View Article : Google Scholar : PubMed/NCBI