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A case of gallbladder neuroendocrine carcinoma diagnosed preoperatively using somatostatin receptor scintigraphy

  • Authors:
    • Yusuke Kamikihara
    • Shiroh Tanoue
    • Machiko Kawahira
    • Hiromichi Iwaya
    • Shiho Arima
    • Fumisato Sasaki
    • Yuichiro Nasu
    • Shinichi Hashimoto
    • Shuji Kanmura
    • Michiyo Higashi
    • Kentaro Gejima
    • Akio Ido
  • View Affiliations / Copyright

    Affiliations: Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890‑8544, Japan, Department of Pathology, Kagoshima University Hospital, Kagoshima 890‑8544, Japan, Cardiovascular and Gastroenterological Surgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890‑8544, Japan
    Copyright: © Kamikihara et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 247-254
    |
    Published online on: November 14, 2019
       https://doi.org/10.3892/ol.2019.11101
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Abstract

Gallbladder neuroendocrine carcinoma (NEC) is a rare gallbladder tumor. The current report is a case of a patient preoperatively diagnosed with gallbladder NEC using somatostatin receptor scintigraphy (SRS). A 63‑year‑old man was admitted to our hospital by a family doctor after abdominal ultrasonography revealed thickened walls of the neck of his gallbladder. At Kagoshima University Hospital, CT and MRI of the abdomen and endoscopic ultrasonography confirmed the thickening of the walls of the neck of the gallbladder. However, it did not resemble a typical gallbladder cancer or tumor, such as a neuroendocrine tumor or malignant lymphoma. Positron emission tomography and SRS showed abnormal accumulation at the tumor site. Endoscopic retrograde cholangiopancreatography was performed, adenocarcinoma was suspected based on intra‑gallbladder bile cytology, and a cholecystectomy with lymphadenectomy was performed. The postoperative pathological diagnosis was small cell NEC (pT3a, N0, M0, stage II). Immunohistochemistry indicated that the gallbladder tumor cells were positive for synaptophysin, chromogranin A, and cluster of differentiation (CD) 56, and negative for somatostatin receptors (SSTR) 2 and 5. Gene expression assays revealed the expression of all SSTR subtypes (SSTR1‑5) in the tumor. Generally, NECs exhibit poor accumulation in SRS, however, the results of the current case suggest that SRS may be useful in the preoperative diagnosis of NEC.
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Copy and paste a formatted citation
Spandidos Publications style
Kamikihara Y, Tanoue S, Kawahira M, Iwaya H, Arima S, Sasaki F, Nasu Y, Hashimoto S, Kanmura S, Higashi M, Higashi M, et al: A case of gallbladder neuroendocrine carcinoma diagnosed preoperatively using somatostatin receptor scintigraphy. Oncol Lett 19: 247-254, 2020.
APA
Kamikihara, Y., Tanoue, S., Kawahira, M., Iwaya, H., Arima, S., Sasaki, F. ... Ido, A. (2020). A case of gallbladder neuroendocrine carcinoma diagnosed preoperatively using somatostatin receptor scintigraphy. Oncology Letters, 19, 247-254. https://doi.org/10.3892/ol.2019.11101
MLA
Kamikihara, Y., Tanoue, S., Kawahira, M., Iwaya, H., Arima, S., Sasaki, F., Nasu, Y., Hashimoto, S., Kanmura, S., Higashi, M., Gejima, K., Ido, A."A case of gallbladder neuroendocrine carcinoma diagnosed preoperatively using somatostatin receptor scintigraphy". Oncology Letters 19.1 (2020): 247-254.
Chicago
Kamikihara, Y., Tanoue, S., Kawahira, M., Iwaya, H., Arima, S., Sasaki, F., Nasu, Y., Hashimoto, S., Kanmura, S., Higashi, M., Gejima, K., Ido, A."A case of gallbladder neuroendocrine carcinoma diagnosed preoperatively using somatostatin receptor scintigraphy". Oncology Letters 19, no. 1 (2020): 247-254. https://doi.org/10.3892/ol.2019.11101
Copy and paste a formatted citation
x
Spandidos Publications style
Kamikihara Y, Tanoue S, Kawahira M, Iwaya H, Arima S, Sasaki F, Nasu Y, Hashimoto S, Kanmura S, Higashi M, Higashi M, et al: A case of gallbladder neuroendocrine carcinoma diagnosed preoperatively using somatostatin receptor scintigraphy. Oncol Lett 19: 247-254, 2020.
APA
Kamikihara, Y., Tanoue, S., Kawahira, M., Iwaya, H., Arima, S., Sasaki, F. ... Ido, A. (2020). A case of gallbladder neuroendocrine carcinoma diagnosed preoperatively using somatostatin receptor scintigraphy. Oncology Letters, 19, 247-254. https://doi.org/10.3892/ol.2019.11101
MLA
Kamikihara, Y., Tanoue, S., Kawahira, M., Iwaya, H., Arima, S., Sasaki, F., Nasu, Y., Hashimoto, S., Kanmura, S., Higashi, M., Gejima, K., Ido, A."A case of gallbladder neuroendocrine carcinoma diagnosed preoperatively using somatostatin receptor scintigraphy". Oncology Letters 19.1 (2020): 247-254.
Chicago
Kamikihara, Y., Tanoue, S., Kawahira, M., Iwaya, H., Arima, S., Sasaki, F., Nasu, Y., Hashimoto, S., Kanmura, S., Higashi, M., Gejima, K., Ido, A."A case of gallbladder neuroendocrine carcinoma diagnosed preoperatively using somatostatin receptor scintigraphy". Oncology Letters 19, no. 1 (2020): 247-254. https://doi.org/10.3892/ol.2019.11101
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