Open Access

Predictive value of immuno‑inflammatory and nutritional measures modulated by neoadjuvant chemotherapy on the response of neoadjuvant chemotherapy and long‑term outcomes in patients with esophageal cancer

  • Authors:
    • Yusuke Ishibashi
    • Hironori Tsujimoto
    • Shuichi Hiraki
    • Keita Kouzu
    • Satoshi Tsuchiya
    • Yujiro Itazaki
    • Yoshihisa Yaguchi
    • Hiroyuki Horiguchi
    • Shinsuke Nomura
    • Nozomi Ito
    • Eiji Shinto
    • Yoji Kishi
    • Hideki Ueno
  • View Affiliations

  • Published online on: November 19, 2019     https://doi.org/10.3892/ol.2019.11122
  • Pages: 487-497
  • Copyright: © Ishibashi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

It has been reported that immuno‑inflammatory and nutritional parameters are associated with long‑term survival in various malignancies. However, little is known regarding the associations between alterations of these parameters during neoadjuvant chemotherapy (NAC) and the response to NAC in patients with esophageal cancer. The present study examined the clinical significance of alterations in these parameters during NAC in terms of the response to NAC and the long‑term outcomes in patients with esophageal cancer. Various systemic immuno‑inflammatory and nutritional measures including the systemic neutrophil‑to‑lymphocyte ratio (NLR), platelet‑to‑lymphocyte ratio (PLR), C‑reactive protein (CRP)‑to‑albumin ratio (CAR) and psoas muscle index (PMI) were examined before and after NAC. Statistical analyses were performed to determine the significance of immuno‑inflammatory and nutritional parameters prior to NAC and alterations during NAC regarding the response to NAC and long‑term outcomes. The NLR, PMI, neutrophil count and platelet count declined significantly following NAC, whereas no alterations in PLR, CAR, lymphocyte counts, CRP levels and albumin concentration were observed. The decreases in NLR and neutrophil counts following NAC were strongly associated with a favorable overall survival (P=0.006). In conclusion, decreases in NLR and neutrophil counts following NAC were clinically significant predictors of the response to NAC and of survival in esophageal cancer, respectively.
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January-2020
Volume 19 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Ishibashi Y, Tsujimoto H, Hiraki S, Kouzu K, Tsuchiya S, Itazaki Y, Yaguchi Y, Horiguchi H, Nomura S, Ito N, Ito N, et al: Predictive value of immuno‑inflammatory and nutritional measures modulated by neoadjuvant chemotherapy on the response of neoadjuvant chemotherapy and long‑term outcomes in patients with esophageal cancer. Oncol Lett 19: 487-497, 2020
APA
Ishibashi, Y., Tsujimoto, H., Hiraki, S., Kouzu, K., Tsuchiya, S., Itazaki, Y. ... Ueno, H. (2020). Predictive value of immuno‑inflammatory and nutritional measures modulated by neoadjuvant chemotherapy on the response of neoadjuvant chemotherapy and long‑term outcomes in patients with esophageal cancer. Oncology Letters, 19, 487-497. https://doi.org/10.3892/ol.2019.11122
MLA
Ishibashi, Y., Tsujimoto, H., Hiraki, S., Kouzu, K., Tsuchiya, S., Itazaki, Y., Yaguchi, Y., Horiguchi, H., Nomura, S., Ito, N., Shinto, E., Kishi, Y., Ueno, H."Predictive value of immuno‑inflammatory and nutritional measures modulated by neoadjuvant chemotherapy on the response of neoadjuvant chemotherapy and long‑term outcomes in patients with esophageal cancer". Oncology Letters 19.1 (2020): 487-497.
Chicago
Ishibashi, Y., Tsujimoto, H., Hiraki, S., Kouzu, K., Tsuchiya, S., Itazaki, Y., Yaguchi, Y., Horiguchi, H., Nomura, S., Ito, N., Shinto, E., Kishi, Y., Ueno, H."Predictive value of immuno‑inflammatory and nutritional measures modulated by neoadjuvant chemotherapy on the response of neoadjuvant chemotherapy and long‑term outcomes in patients with esophageal cancer". Oncology Letters 19, no. 1 (2020): 487-497. https://doi.org/10.3892/ol.2019.11122