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Article Open Access

LAPTM4B‑35 expression is associated with pathological grades and clinical stages in salivary adenoid cystic carcinoma

  • Authors:
    • Jianlin Fan
    • Jianxin Yang
    • Weiping Qiao
    • Wei Liu
    • Chungen Xing
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China, Department of Stomatology, Wuzhong People's Hospital, Suzhou, Jiangsu 215100, P.R. China, Department of Pathology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China
    Copyright: © Fan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 317-322
    |
    Published online on: November 19, 2019
       https://doi.org/10.3892/ol.2019.11124
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Abstract

Salivary adenoid cystic carcinoma is one of the most common malignancies of the head and neck. The lysosome‑associated protein transmembrane‑4β gene (LAPTM4B) is a novel oncogene that has been found overexpressed in a number of clinically aggressive cancers. This study aimed to investigate the expression of the LAPTM4B‑35 protein in normal salivary gland and salivary adenoid cystic carcinoma, a relatively indolent malignancy, and explore its clinicopathological significance in this malignancy. By immunohistochemical analysis, LAPTM4B‑35 expression was evaluated in 106 cancer tissues, their adjacent non‑cancerous tissues and five normal salivary glands. The correlation of LAPTM4B‑35 expression with clinicopathological parameters was assessed using Chi‑square or Fisher's exact test. The level of LAPTM4B‑35 expression varied among different cell types of normal salivary glands. It was expressed at a fairly low level in serous and mucous acini, at low level in intercalated duct and excretory duct cells and moderately in secretory/striated ducts. In 50% of high grade tumor tissues tested, LAPTM4B‑35 was markedly overexpressed. LAPTM4B‑35 levels were significantly associated with histological grade and clinical stage. LAPTM4B‑35 plays an important role in salivary adenoid cystic carcinoma and may serve as a diagnostic marker and a target for individualized therapy.
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1 

Coca-Pelaz A, Rodrigo JP, Bradley PJ, Vander Poorten V, Triantafyllou A, Hunt JL, Strojan P, Rinaldo A, Haigentz M Jr, Takes RP, et al: Adenoid cystic carcinoma of the head and neck - An update. Oral Oncol. 51:652–661. 2015. View Article : Google Scholar : PubMed/NCBI

2 

International Head; Neck Scientific Group, : Cervical lymph node metastasis in adenoid cystic carcinoma of the sinonasal tract, nasopharynx, lacrimal glands and external auditory canal: A collective international review. J Laryngol Otol. 130:1093–1097. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Togashi Y, Dobashi A, Sakata S, Sato Y, Baba S, Seto A, Mitani H, Kawabata K and Takeuchi K: MYB and MYBL1 in adenoid cystic carcinoma: Diversity in the mode of genomic rearrangement and transcripts. Mod Pathol. 31:934–946. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Shao GZ, Zhou RL, Zhang QY, Zhang Y, Liu JJ, Rui JA, Wei X and Ye DX: Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma. Oncogene. 22:5060–5069. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Liu X, Xiong F, Wei X, Yang H and Zhou R: LAPTM4B-35, a novel tetratransmembrane protein and its PPRP motif play critical roles in proliferation and metastatic potential of hepatocellular carcinoma cells. Cancer Sci. 100:2335–2340. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Liu XR, Zhou RL, Zhang QY, Zhang Y, Jin YY, Lin M, Rui JA and Ye DX: Structure analysis and expressions of a novel tetratransmembrane protein, lysosoma-associated protein transmembrane 4 beta associated with hepatocellular carcinoma. World J Gastroenterol. 10:1555–1559. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Yang H, Xiong F, Qi R, Liu Z, Lin M, Rui J, Su J and Zhou R: LAPTM4B-35 is a novel prognostic factor of hepatocellular carcinoma. J Surg Oncol. 101:363–369. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Yang H, Xiong FX, Lin M, Yang Y, Nie X and Zhou RL: LAPTM4B-35 overexpression is a risk factor for tumor recurrence and poor prognosis in hepatocellular carcinoma. J Cancer Res Clin Oncol. 136:275–281. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Zhou L, He XD, Chen J, Cui QC, Qu Q, Rui JA and Zhao YP: Overexpression of LAPTM4B-35 closely correlated with clinicopathological features and post-resectional survival of gallbladder carcinoma. Eur J Cancer. 43:809–815. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Kang Y, Yin M, Jiang W, Zhang H, Xia B, Xue Y and Huang Y: Overexpression of LAPTM4B-35 is associated with poor prognosis in colorectal carcinoma. Am J Surg. 204:677–683. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Yin M, Li C, Li X, Lou G, Miao B, Liu X, Meng F, Zhang H, Chen X, Sun M, et al: Over-expression of LAPTM4B is associated with poor prognosis and chemotherapy resistance in stages III and IV epithelial ovarian cancer. J Surg Oncol. 104:29–36. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Yang Y, Yang H, McNutt MA, Xiong F, Nie X, Li L and Zhou R: LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma. Oncol Rep. 20:1077–1083. 2008.PubMed/NCBI

13 

Tang H, Tian H, Yue W, Li L, Li S, Gao C, Si L, Qi L and Lu M: Overexpression of LAPTM4B is correlated with tumor angiogenesis and poor prognosis in non-small cell lung cancer. Med Oncol. 31:9742014. View Article : Google Scholar : PubMed/NCBI

14 

Kong F, Gao F, Chen J, Sun Y, Zhang Y, Liu H, Li X, Yang P, Zheng R, Liu G, et al: Overexpressed LAPTM4B-35 is a risk factor for cancer recurrence and poor prognosis in non-small-cell lung cancer. Oncotarget. 7:56193–56199. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Zhang H, Wei Q, Liu R, Qi S, Liang P, Qi C, Wang A, Sheng B, Li L and Xu Y: Overexpression of LAPTM4B-35: A novel marker of poor prognosis of prostate cancer. PLoS One. 9:e910692014. View Article : Google Scholar : PubMed/NCBI

16 

Meng FL, Yin MZ, Song HT, Yang H, Lou G and Zhou RL: LAPTM4B-35 overexpression is an independent prognostic marker in endometrial carcinoma. Int J Gynecol Cancer. 20:745–750. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Cheng X, Zheng Z, Bu Z, Wu X, Zhang L, Xing X, Wang X, Hu Y, Du H, Li L, et al: LAPTM4B-35, a cancer-related gene, is associated with poor prognosis in TNM stages I–III gastric cancer patients. PLoS One. 10:e01215592015. View Article : Google Scholar : PubMed/NCBI

18 

Liu L, Xu X, Jing L, Zhou G, Cao Z, Han Y and Zhou R: Lysosomal-associated protein transmembrane 4 Beta-35 overexpression is a novel independent prognostic marker for gastric carcinoma. PLoS One. 10:e01180262015. View Article : Google Scholar : PubMed/NCBI

19 

Amit M, Binenbaum Y, Sharma K, Ramer N, Ramer I, Agbetoba A, Glick J, Yang X, Lei D, Bjørndal K, et al: Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study. Head Neck. 37:1032–1037. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Amit M, Binenbaum Y, Trejo-Leider L, Sharma K, Ramer N, Ramer I, Agbetoba A, Miles B, Yang X, Lei D, et al: International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck. Head Neck. 37:1038–1045. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Šteiner P, Andreasen S, Grossmann P, Hauer L, Vaněček T, Miesbauerová M, Santana T, Kiss K, Slouka D and Skálová A: Prognostic significance of 1p36 locus deletion in adenoid cystic carcinoma of the salivary glands. Virchows Arch. 473:471–480. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Ferrarotto R, Mitani Y, Diao L, Guijarro I, Wang J, Zweidler- McKay P, Bell D, William WN Jr, Glisson BS, Wick MJ, et al: Activating NOTCH1 mutations define a distinct subgroup of patients with adenoid cystic carcinoma who have poor prognosis, propensity to bone and liver metastasis, and potential responsiveness to Notch1 inhibitors. J Clin Oncol. 35:352–360. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Li ZR: LAPTM4B: A novel diagnostic biomarker and therapeutic target for hepatocellular carcinoma. Hepatocellular Carcinoma. Lau WY: InTech Press; Melbourne, FL: pp. 1–34. 2012

24 

Yang H, Xiong F, Wei X, Yang Y, McNutt MA and Zhou R: Overexpression of LAPTM4B-35 promotes growth and metastasis of hepatocellular carcinoma in vitro and in vivo. Cancer Lett. 294:236–244. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fan J, Yang J, Qiao W, Liu W and Xing C: LAPTM4B‑35 expression is associated with pathological grades and clinical stages in salivary adenoid cystic carcinoma. Oncol Lett 19: 317-322, 2020.
APA
Fan, J., Yang, J., Qiao, W., Liu, W., & Xing, C. (2020). LAPTM4B‑35 expression is associated with pathological grades and clinical stages in salivary adenoid cystic carcinoma. Oncology Letters, 19, 317-322. https://doi.org/10.3892/ol.2019.11124
MLA
Fan, J., Yang, J., Qiao, W., Liu, W., Xing, C."LAPTM4B‑35 expression is associated with pathological grades and clinical stages in salivary adenoid cystic carcinoma". Oncology Letters 19.1 (2020): 317-322.
Chicago
Fan, J., Yang, J., Qiao, W., Liu, W., Xing, C."LAPTM4B‑35 expression is associated with pathological grades and clinical stages in salivary adenoid cystic carcinoma". Oncology Letters 19, no. 1 (2020): 317-322. https://doi.org/10.3892/ol.2019.11124
Copy and paste a formatted citation
x
Spandidos Publications style
Fan J, Yang J, Qiao W, Liu W and Xing C: LAPTM4B‑35 expression is associated with pathological grades and clinical stages in salivary adenoid cystic carcinoma. Oncol Lett 19: 317-322, 2020.
APA
Fan, J., Yang, J., Qiao, W., Liu, W., & Xing, C. (2020). LAPTM4B‑35 expression is associated with pathological grades and clinical stages in salivary adenoid cystic carcinoma. Oncology Letters, 19, 317-322. https://doi.org/10.3892/ol.2019.11124
MLA
Fan, J., Yang, J., Qiao, W., Liu, W., Xing, C."LAPTM4B‑35 expression is associated with pathological grades and clinical stages in salivary adenoid cystic carcinoma". Oncology Letters 19.1 (2020): 317-322.
Chicago
Fan, J., Yang, J., Qiao, W., Liu, W., Xing, C."LAPTM4B‑35 expression is associated with pathological grades and clinical stages in salivary adenoid cystic carcinoma". Oncology Letters 19, no. 1 (2020): 317-322. https://doi.org/10.3892/ol.2019.11124
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