Open Access

LAPTM4B‑35 expression is associated with pathological grades and clinical stages in salivary adenoid cystic carcinoma

  • Authors:
    • Jianlin Fan
    • Jianxin Yang
    • Weiping Qiao
    • Wei Liu
    • Chungen Xing
  • View Affiliations

  • Published online on: November 19, 2019     https://doi.org/10.3892/ol.2019.11124
  • Pages: 317-322
  • Copyright: © Fan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Salivary adenoid cystic carcinoma is one of the most common malignancies of the head and neck. The lysosome‑associated protein transmembrane‑4β gene (LAPTM4B) is a novel oncogene that has been found overexpressed in a number of clinically aggressive cancers. This study aimed to investigate the expression of the LAPTM4B‑35 protein in normal salivary gland and salivary adenoid cystic carcinoma, a relatively indolent malignancy, and explore its clinicopathological significance in this malignancy. By immunohistochemical analysis, LAPTM4B‑35 expression was evaluated in 106 cancer tissues, their adjacent non‑cancerous tissues and five normal salivary glands. The correlation of LAPTM4B‑35 expression with clinicopathological parameters was assessed using Chi‑square or Fisher's exact test. The level of LAPTM4B‑35 expression varied among different cell types of normal salivary glands. It was expressed at a fairly low level in serous and mucous acini, at low level in intercalated duct and excretory duct cells and moderately in secretory/striated ducts. In 50% of high grade tumor tissues tested, LAPTM4B‑35 was markedly overexpressed. LAPTM4B‑35 levels were significantly associated with histological grade and clinical stage. LAPTM4B‑35 plays an important role in salivary adenoid cystic carcinoma and may serve as a diagnostic marker and a target for individualized therapy.
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January-2020
Volume 19 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Fan J, Yang J, Qiao W, Liu W and Xing C: LAPTM4B‑35 expression is associated with pathological grades and clinical stages in salivary adenoid cystic carcinoma. Oncol Lett 19: 317-322, 2020
APA
Fan, J., Yang, J., Qiao, W., Liu, W., & Xing, C. (2020). LAPTM4B‑35 expression is associated with pathological grades and clinical stages in salivary adenoid cystic carcinoma. Oncology Letters, 19, 317-322. https://doi.org/10.3892/ol.2019.11124
MLA
Fan, J., Yang, J., Qiao, W., Liu, W., Xing, C."LAPTM4B‑35 expression is associated with pathological grades and clinical stages in salivary adenoid cystic carcinoma". Oncology Letters 19.1 (2020): 317-322.
Chicago
Fan, J., Yang, J., Qiao, W., Liu, W., Xing, C."LAPTM4B‑35 expression is associated with pathological grades and clinical stages in salivary adenoid cystic carcinoma". Oncology Letters 19, no. 1 (2020): 317-322. https://doi.org/10.3892/ol.2019.11124